Abstract:
PURPOSE OF REVIEW:This review will summarize the most recent preclinical data from the leading US laboratories regarding the application of gene therapy to the treatment of erectile dysfunction. The implications of these findings in the field of gene therapy in general, and more specifically to the treatment of non-life threatening disorders such as erectile dysfunction, will be outlined. RECENT FINDINGS:The preclinical work of several laboratories has clearly documented 'proof-of-concept' for the utility of gene therapy for the treatment of erectile dysfunction. A variety of vectors and several distinct molecular targets have been successfully leveraged. Such observations suggest that numerous potential strategies may exist for gene-based treatments of erectile dysfunction. SUMMARY:The apparent preclinical success of most, if not all, gene-based strategies for the treatment of erectile dysfunction is consistent with the multifactorial regulatory mechanisms governing the erectile process. The bottleneck in the gene therapy clinical development process therefore apparently will not lie in the ability to identify relevant molecular targets that are amenable to gene therapy for erectile dysfunction, but rather in the safety, specificity and longevity of those targets. That is, the next technical hurdle is to find the strategy(ies) that has the best safety profile, the greatest specificity for altering (increasing) intracavernous pressure 'on demand' and, furthermore, the most appropriate (longest?) half-life. While these criteria may correspond to intuition, finding molecular targets that clear these clinical hurdles may place restrictions on the molecular choices for gene transfer.
journal_name
Curr Opin Uroljournal_title
Current opinion in urologyauthors
Christ GJdoi
10.1097/00042307-200211000-00010subject
Has Abstractpub_date
2002-11-01 00:00:00pages
497-501issue
6eissn
0963-0643issn
1473-6586journal_volume
12pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Radical prostatectomy is the standard treatment for localized prostate cancer; its translation to a laparoscopic approach is considered today not only as feasible and reproducible but also as a valid and teachable alternative to its open counterpart. Beyond the "classical" transperitoneal antegrade ro...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.mou.0000160621.05742.a4
更新日期:2005-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Partial nephrectomy provides equivalent long-term oncologic and superior functional outcomes as radical nephrectomy for T1a renal masses. Herein, we review the various vascular clamping techniques employed during minimally invasive partial nephrectomy, describe the evolution of our partial nephrectomy...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000140
更新日期:2015-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Electrosurgical transurethral resection (TUR) of the prostate (TURP) has dominated symptomatic benign prostatic hyperplasia (s-BPH) surgical treatment for almost a century. We analysed recent TURP publications, with emphasis on durability, morbidity, new technology advantages, future generation traini...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3283411455
更新日期:2011-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To identify the latest progression on medical treatment of urinary stones. RECENT FINDINGS:Nonsteroidal anti-inflammatory drugs should be the preferred analgesic option for patients presenting to the emergency department with renal colic. A-blockers could be of patient benefit when used for distal ur...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000523
更新日期:2018-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Underactive bladder (UAB) is a clinical symptom complex only recently gaining recognition as a clinical diagnosis. Lack of consensus agreement on a definition of UAB has limited its recognition and diagnosis in clinical practice. The purposes of this review are to: present existing definitions of UAB,...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000280
更新日期:2016-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The implementation of novel technologies and refinements in the surgical technique are continuously changing the urological surgical scenario. The purpose of this review is to provide surgeons with the latest and most relevant updates in the field of robot-assisted radical prostatectomy (RARP) occurre...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000564
更新日期:2019-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Patients who undergo urinary tract diversion are at an increased risk of urolithiasis for various reasons. The purpose of this article is to provide an up-to-date summary of the progress that has been made in the pathogenesis, diagnosis and treatment of stones in patients with urinary diversions. Fina...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200207000-00007
更新日期:2002-07-01 00:00:00
abstract::Advances in the diagnosis of early stage disease, and particularly the introduction of prostate-specific antigen (PSA) testing, have had a dramatic effect on the presentation and clinical management of prostate cancer during the past ten years. As a result, there have been significant epidemiological changes in countr...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200007000-00006
更新日期:2000-07-01 00:00:00
abstract::Recent developments in renal magnetic resonance angiography have led to a significant improvement in the technical success rate and diagnostic accuracy of the methods. Specifically, three-dimensional contrast-enhanced magnetic resonance angiography methods have been shown to provide a more reliable depiction of renal ...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/00042307-199803000-00006
更新日期:1998-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to summarize recent developments in the array of devices which are commonly used by urologists in the surgical management of kidney stones. To accomplish this goal, an extensive review of recent endourology literature, conference abstracts, and publicly available document...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000710
更新日期:2020-03-01 00:00:00
abstract::Approximately 5% of all hypertensive patients have renovascular hypertension, although its true incidence is unknown. The pathophysiology of renovascular hypertension has been linked to other intrarenal systems, the lipoxygenase pathway, and renin angiotensin. Many advances have been made in this field, but emphasis i...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-199903000-00004
更新日期:1999-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Minimally invasive options to treat low-risk prostate cancer are more desirable than radical therapy. Technological improvements in cryotherapy have increased its use, and long-term data on its efficacy are emerging. In this review, we discuss contemporary data on cryotherapy with specific focus on st...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/mou.0b013e32831e16ce
更新日期:2009-03-01 00:00:00
abstract:PURPOSE OF REVIEW:A large number of related articles published within the last year were reviewed. Different types of intracorporeal lithotripter devices were compared according to their advantages, disadvantages, efficacy, safety and clinical applications. General directions of future developments are discussed. RECE...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200305000-00014
更新日期:2003-05-01 00:00:00
abstract::This review discusses the contemporary management of urethral trauma and post-traumatic urethral strictures occurring in both the anterior and posterior urethra. Experience in the full spectrum of urethral reconstructive procedures is important. The initial management of patients relies upon adequate drainage of the b...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-199905000-00011
更新日期:1999-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Nonmuscle invasive bladder cancer is a common malignancy, usually treated by transurethral resection and adjuvant intravesical instillations of chemotherapy or immunotherapy. Appropriate adjuvant treatment can be selected based on several prognostic factors that determine risk for recurrence or progre...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3281c55f2b
更新日期:2007-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To perform a bicenter, retrospective study of perioperative outcomes of retroperitoneal versus transperitoneal robotic-assisted laparoscopic partial nephrectomy (RALPN) and assess costs using time-driven activity-based costing (TDABC). We identified 355 consecutive patients who underwent RALPN at Univ...
journal_title:Current opinion in urology
pub_type: 杂志文章,多中心研究
doi:10.1097/MOU.0000000000000483
更新日期:2018-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This review aims to analyze and discuss all recently published articles associated with neurogenic voiding discussion providing readers with the most updated knowledge and trigger for further research. RECENT FINDINGS:They include the proposal of a novel classification system for the pathophysiology ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000392
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Surgical training has dramatically changed over the last decade. It has become not only the way to prepare surgeons for their everyday work, but also a way to certify their skills thus increasing patient safety. This article reviews advances in the use of machine learning and artificial intelligence a...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/MOU.0000000000000824
更新日期:2020-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review was to report on the latest world literature relating to paediatric stone disease. Inevitably, because of the small numbers, the literature is limited and consists mainly of case series from individual centres. There is also a wide variation in criteria and techniques, makin...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3283353b80
更新日期:2010-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The difficulties of defining and evaluating bladder outlet obstruction (BOO) in the female patient have been described for several years. This review aims to examine recent literature to summarize progress in the area. RECENT FINDINGS:Within the last 2 years, functional causes of female BOO have been...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000182
更新日期:2015-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Functional imaging with PET combined with computed tomography (CT) is of emerging interest in prostate cancer (PCa). Development of prostate-specific membrane antigen (PSMA) radiolabelled ligands has thrust PET/CT into the limelight as an alternative to conventional imaging techniques, and the evidenc...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000677
更新日期:2019-11-01 00:00:00
abstract:PURPOSE OF REVIEW:In recent years, robotic partial nephrectomy has emerged as a technique for treatment of small renal masses alongside laparoscopic and open partial nephrectomy. Since this technique is still in a phase of adoption, many technical improvements, alterations and early experiences are published. We aim to...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32833c7af0
更新日期:2010-09-01 00:00:00
abstract:PURPOSE OF REVIEW:In 2012, the United States Preventive Services Task Force (USPSTF) issued a grade 'D' recommendation against the use of routine prostate-specific antigen (PSA)-based screening for any men. This recommendation reflects critical misinterpretations of the available evidence base regarding benefits and ha...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000383
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To give insight into the current literature on feasibility, safety and outcome of presurgical targeted molecular therapies (TMTs) before nephron-sparing surgery (NSS) in patients with renal cell carcinoma. RECENT FINDINGS:Presurgical TMTs have been proven to be effective and well tolerated for patien...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32836320a7
更新日期:2013-09-01 00:00:00
abstract::Magnetic resonance imaging provides the most accurate, versatile and safe imaging of the pelvic floor. Images can be produced to show sections in any plane and even in three dimensions. The resolution is such that detail as good as that seen in histological sections is possible. Once standardization of data acquisitio...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200203000-00009
更新日期:2002-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Several novel treatment modalities have been introduced for patients across all renal cell carcinoma stages. Observation or a variety of minimally invasive approaches can be applied to small renal masses. Conversely, aggressive loco-regional resections may be performed for locally advanced disease. Cy...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3282a4a6b7
更新日期:2007-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Testicular microlithiasis becomes a greater interdisciplinary issue among urologists, andrologists, gynecologists dedicated to reproductive medicine, pediatricians, radiologists and pathologists. Proposed management ranges from benign neglect, instructing self-examination over follow-up once, regular ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3283314a1d
更新日期:2009-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Metastatic or unresectable urothelial cancer of the urinary bladder has traditionally been treated with systemic chemotherapy, which is most often platinum-based. The long-term survival data and the associated toxicities from this form of therapy have spurred continuing interest in finding novel treat...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.mou.0000176047.23089.c7
更新日期:2005-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Overactive bladder affects 10-12% of men, of which 13% are refractory to medical therapy and seek second-line treatment. This places a substantial clinical and economic burden on the National Health Service United Kingdom. RECENT FINDINGS:This review identifies current evidence for the use of onabotu...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.MOU.0000434594.87575.26
更新日期:2013-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Ongoing controversy exists as to the extent of the necessary evaluation of the female presenting with lower urinary tract symptoms. Most would agree that a detailed history, a physical examination and a urine analysis are essential components of the initial evaluation of lower urinary tract symptoms i...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200307000-00002
更新日期:2003-07-01 00:00:00