Recent developments in advanced urothelial cancer.

Abstract:

PURPOSE OF REVIEW:Metastatic or unresectable urothelial cancer of the urinary bladder has traditionally been treated with systemic chemotherapy, which is most often platinum-based. The long-term survival data and the associated toxicities from this form of therapy have spurred continuing interest in finding novel treatment options for this malignancy. RECENT FINDINGS:Recently, trials of new chemotherapy combinations, many incorporating platinum analogs or deleting platinum entirely, have been reported. None has yet been shown to be superior to cisplatin-based regimens. In addition, recent advances in imaging and laboratory technologies have provided new avenues to understand urothelial cancer behavior and prognosis. These advances provide optimism for improvements in the diagnosis, staging, and ultimately, selection of therapy for patients with urothelial cancer. SUMMARY:This review will summarize recent developments (circa 2004) in the diagnosis and management of advanced bladder cancer.

journal_name

Curr Opin Urol

authors

Chee KG,Cambio A,Lara PN Jr

doi

10.1097/01.mou.0000176047.23089.c7

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

342-9

issue

5

eissn

0963-0643

issn

1473-6586

pii

00042307-200509000-00011

journal_volume

15

pub_type

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