Abstract:
PURPOSE OF REVIEW:To understand the molecular mechanisms of bladder carcinogenesis in relation to environmental carcinogens in order to provide a given population with a preventive value of bladder cancer. RECENT FINDINGS:Cigarette smoking, aromatic amines contained in dyes, chronic inflammation due to infection such as schistosomiasis, anticancer drugs, drug abuse of analgesic, and radiation are considered as well known risk factors of bladder cancer. Several environmental factors are supposed to be involved in carcinogenesis, cancer progression, and patient's prognosis in bladder cancer. On the basis of the results of recent genetic studies in relation to bladder carcinogenesis, several genetic polymorphisms of detoxification or DNA repair such as N-acetyltransferase 2, glutathione S-transferases, and human 8-oxoguanine DNA glycosylase 1 give us important information in relation to environmental risk factors and ethnic differences for predicting the prognosis of patients with bladder cancer. SUMMARY:Prevention of environmental carcinogens is important from the viewpoint of the social and clinical problems since elucidation of the correlation between epidemiologic and genetic phenomenon enable us to improve the life expectancy and quality of life of bladder cancer patients.
journal_name
Curr Opin Uroljournal_title
Current opinion in urologyauthors
Hirao Y,Kim WJ,Fujimoto Kdoi
10.1097/MOU.0b013e32832eb4efsubject
Has Abstractpub_date
2009-09-01 00:00:00pages
494-9issue
5eissn
0963-0643issn
1473-6586journal_volume
19pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:To provide an overview of relevant data available and updated recommendations for management of pediatric patients with pheochromocytoma (PCC). RECENT FINDINGS:Much of the available data surrounding pediatric PCC is in the form of case reports and case series. With the accumulation of data over time,...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000650
更新日期:2019-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Better understanding of renal cell carcinoma biology has led to a new era of targeted therapy in the management of metastatic renal cell carcinoma. This review provides an updated survey of the recently reported and ongoing clinical trials that will help to further define the role of these novel drugs...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32833c86f8
更新日期:2010-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Examine and discuss novel focal therapy treatment options for prostate cancer. RECENT FINDINGS:With the widespread adoption of mpMRI-guided biopsies for prostate cancer, use of image-guided treatment of prostate cancer has increased. Focal therapies leading to partial gland ablation such as partial p...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000469
更新日期:2018-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Benign prostatic hyperplasia is the most common human neoplasm and it is the most frequent tumour requiring surgical treatment in men. Not surprisingly, interest centres on either understanding of prostatic growth during ageing or on various medical or interventional treatments. RECENT FINDINGS:Recen...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200301000-00003
更新日期:2003-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this study is to review and discuss recently published studies of therapeutic options in cases with the combination of severe sphincteric damage and recurrent stricture of the bladder neck or anastomosis in patients with postradical prostatectomy. RECENT FINDINGS:Recent focus has been ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000185
更新日期:2015-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Radical cystectomy and urinary diversion is the accepted standard of care for invasive bladder cancer. Although orthotopic neobladder is the preferred method of urinary diversion in men, less experience is available for women. Recent studies and reports on this subject are summarized and reviewed. RE...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32834b31c4
更新日期:2011-11-01 00:00:00
abstract::Pharmacotherapy for men experiencing erectile dysfunction has undergone dramatic advances over the past 5 years with the introduction of an effective oral agent. Sildenafil has increased the pool of couples seeking treatment for this important health issue as well as expanding the numbers of physicians treating it. Re...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200111000-00011
更新日期:2001-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Small renal masses (SRMs) are frequently encountered due to the ubiquitous use of abdominal cross-sectional imaging. Enhanced risk prediction in the management of SRMs would allow for a more informed decision of which, if any, patients would benefit from the available intervention modalities. RECENT ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e328355ede9
更新日期:2012-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This review focuses on novel imaging techniques used for guiding urologic procedures that are likely to provide additional opportunities to physicians in the years to come. RECENT FINDINGS:In the past, most image-guided urologic procedures have utilized two-dimensional x-ray images. This review will ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3282f1c5d3
更新日期:2008-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Transurethral resection of prostate is the gold standard for the surgical management of benign prostate hyperplasia. Bipolar devices allow transurethral resection of prostate with saline irrigation, which lessens water intoxication and negates the need for diathermy pad and unwanted stimulation of the...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3282f194db
更新日期:2008-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Immunotherapies for urological malignancies have made tremendous progress by targeting immune checkpoints and have been implemented in clinical practice nowadays. Though siginifcant number of patients does not respond to immunotherapy. Biomarkers could help to predict response to treatment, but are st...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000465
更新日期:2018-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Focal therapy presents an alternative option for disease-targeted therapy while preserving erectile and urinary function without compromising oncological outcome. Such treatment, which preserves normal prostate parenchyma, presents a clinical challenge to the urologist, as typical disease surveillance...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000052
更新日期:2014-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Surgery is the mainstay for treating postprostatectomy stress urinary incontinence. Although the artificial urinary sphincter (AUS) remains a popular treatment option, a decade worth of innovations have expanded the role of male sling surgery. RECENT FINDINGS:AUS surgery has an approximately 80-85% s...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e328339b795
更新日期:2010-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Minimally invasive options to treat low-risk prostate cancer are more desirable than radical therapy. Technological improvements in cryotherapy have increased its use, and long-term data on its efficacy are emerging. In this review, we discuss contemporary data on cryotherapy with specific focus on st...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/mou.0b013e32831e16ce
更新日期:2009-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Laparoscopic retroperitoneal lymph node dissection was first described in 1992, and has become more commonly practiced at certain centers. Laparoscopic retroperitoneal lymph node dissection may be less morbid than open retroperitoneal lymph node dissection, but more costly. Controversy exists, however...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3282f4a880
更新日期:2008-03-01 00:00:00
abstract:PURPOSE OF REVIEW:High-risk prostate cancers (PCa), that is, those with prostate-specific antigen greater than 20 ng/dl, Gleason Score of at least 8, or extraprostatic spread, are nowadays commonly treated by surgery and radiotherapy combined with a fixed period of systemic treatment. Implementing these strategies requ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e328361d451
更新日期:2013-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To determine whether alpha-blockers, commonly used for the treatment of benign prostatic hyperplasia, are associated with prostate cancer risk. RECENT FINDINGS:Alpha-blockers have been associated with a reduced risk of prostate cancer aggressiveness in some observational studies and an increased risk...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32835abcf2
更新日期:2013-01-01 00:00:00
abstract::'Lower urinary tract symptoms' is a term that describes symptoms related to both the storage and emptying phases of the micturition cycle. Storage symptoms include urinary frequency urgency, urge incontinence, nocturia, dysuria and other kinds of pain emanating from the bladder or urethra. Emptying symptoms consist of...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200107000-00010
更新日期:2001-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide discussion on several recently published case series describing complete intracorporeal robotic cystectomy. Are we making a complex and expensive procedure more challenging or are there patient benefits to be realized from a complete minimally invasive approach? We discuss how effective and...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32835d4cda
更新日期:2013-03-01 00:00:00
abstract::Urinary tract infection is a common problem in children. The combination of vesico-ureteric reflux (VUR) and urinary tract infection may predispose children to pyelonephritis and subsequent complications. This review outlines the modifications suggested in the recent literature in the protocol for investigations and d...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200011000-00009
更新日期:2000-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Robotic-assisted laparoscopic retroperitoneal lymph node dissection (R-RPLND) is gaining acceptance as an alternative to open and laparoscopic RPLND for the treatment of testicular cancer. We discuss the current state of R-RPLND and summarize the latest relevant literature regarding the feasibility of...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000582
更新日期:2019-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Secondary data analysis has become increasingly common in health services research, specifically comparative effectiveness research. While a comprehensive study of the techniques and methods for secondary data analysis is a wide-ranging topic, we sought to perform a descriptive study of some key metho...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000407
更新日期:2017-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Metastatic or unresectable urothelial cancer of the urinary bladder has traditionally been treated with systemic chemotherapy, which is most often platinum-based. The long-term survival data and the associated toxicities from this form of therapy have spurred continuing interest in finding novel treat...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.mou.0000176047.23089.c7
更新日期:2005-09-01 00:00:00
abstract::In the present review the eligible data on urethral pathologies are critically analysed, with special attention given to unresolved controversies in this topic. The entities discussed are as follows: female circumcision as a ritualistic tradition, with many associated complications; prostatourethritis and urethral syn...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200009000-00004
更新日期:2000-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize the recent literature on the topic of residual stone fragments in particular novel developments in this field. RECENT FINDINGS:The urological position towards residual fragments has shifted in recent years from observation, to active retrieval with innovative methods, to algorithm-based ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000571
更新日期:2019-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Ureteral stents are a mainstay of today's urological armamentarium. This review critically evaluates the recent literature and provides a concise summary of the use of stents in urology today. While stents are used in many reconstructive urologic procedures, this review focuses on the use of stents in...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200403000-00011
更新日期:2004-03-01 00:00:00
abstract:PURPOSE OF REVIEW:A dedicated operating room with fluoroscopic imaging capability and adequate data connectivity is important to the success of any endourology program. Proper understanding of the recent developments in technology in relation to operating room is necessary before planning an endourology operating room....
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32835d3133
更新日期:2013-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to identify possible reasons why prostate cancer suboptimally responds to immune therapies. RECENT FINDINGS:Interrogation of the intraprostatic milieu suggests that within the normal prostate, foci of tumor can be surrounded by inflammatory cells that may or may not repr...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000334
更新日期:2016-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to look into recent updates on the management of neurogenic stress urinary incontinence (NSUI) in adult females. RECENT FINDINGS:Recently, a small number of studies have investigated different surgical modalities in treatment of NSUI in adult females including artificial ur...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000785
更新日期:2020-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Ongoing controversy exists as to the extent of the necessary evaluation of the female presenting with lower urinary tract symptoms. Most would agree that a detailed history, a physical examination and a urine analysis are essential components of the initial evaluation of lower urinary tract symptoms i...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200307000-00002
更新日期:2003-07-01 00:00:00