Novel focal therapy treatment options for prostate cancer.

Abstract:

PURPOSE OF REVIEW:Examine and discuss novel focal therapy treatment options for prostate cancer. RECENT FINDINGS:With the widespread adoption of mpMRI-guided biopsies for prostate cancer, use of image-guided treatment of prostate cancer has increased. Focal therapies leading to partial gland ablation such as partial prostatectomy, focal laser ablation, irreversible electroporation, vascular targeted photodynamic therapy, and focal radiofrequency ablation have emerged and begun to be properly evaluated. This review covers published phase 1 and 2 trials of each treatment and discusses potential limitations of each modality. SUMMARY:Focal therapy of prostate cancer is being actively investigated. On the basis of limited published data, the treatments appear to be well tolerated and have an acceptable side effect profile. Importantly, short-term oncologic control has been mixed and there are no long-term outcomes. The acquisition of more data is essential to evaluate these novel technology platforms.

journal_name

Curr Opin Urol

authors

Werntz RP,Eggener SE

doi

10.1097/MOU.0000000000000469

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

178-183

issue

2

eissn

0963-0643

issn

1473-6586

journal_volume

28

pub_type

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