The Y chromosome and male infertility.

Abstract:

PURPOSE OF REVIEW:Therapies for the treatment of severe male factor infertility have advanced well beyond our knowledge of the conditions we are treating. An intact Y chromosome is necessary for optimal spermatogenesis. It is imperative for the clinician to understand the molecular basis and clinical implications of anomalies that might afflict the Y chromosome. RECENT FINDINGS:The molecular geography of the Y chromosome has recently been described, allowing correlations to be made to various clinical states of severe spermatogenic compromise. Microdeletions of parts of the Y chromosome are found in a small number of men with spermatogenic failure involving, predominantly, three regions termed AZFa, AZFb, and AZFc. SUMMARY:It is necessary that a Y chromosomal microdeletion assay be carried out prior to any intervention using ejaculated sperm or prior to any surgical procedure to try to find spermatozoa in an azoospermic man.

journal_name

Curr Opin Urol

authors

Sadeghi-Nejad H,Oates RD

doi

10.1097/MOU.0b013e32831367dc

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

628-32

issue

6

eissn

0963-0643

issn

1473-6586

pii

00042307-200811000-00014

journal_volume

18

pub_type

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