Abstract:
PURPOSE OF REVIEW:High-risk prostate cancer often represents a lethal disease requiring timely diagnosis and effective therapy. Standardized criteria that define high-risk prostate cancer have yet to be established, rendering the discrimination of high-risk from nonhigh-risk patients a challenge. This review summarizes the contemporary definitions of high-risk prostate cancer and their clinical utility. RECENT FINDINGS:As currently defined, high-risk prostate cancer constitutes a heterogeneous group of tumors with varying pathological features and inconsistent outcomes. Some high-risk patients may harbor systemic disease and relapse after local definitive therapy, whereas a substantial proportion have localized cancers and may be cured by surgery alone. If properly identified, these high-risk patients should be deemed candidates for curative treatment and spared the morbidity of systemic therapy. Additional information derived from systematic prostate biopsy, magnetic resonance findings, and, possibly, pretreatment prostate-specific antigen kinetics may be incorporated into the currently available models to yield a better prediction and to allow more informed decision-making. SUMMARY:The quandary of how to define high-risk prostate cancer is pertinent. Various contemporary definitions of high-risk prostate cancer are available, most of which lack adequate sensitivity and specificity. Patients with high-risk clinically localized prostate cancer, by any of the current definitions, should not be uniformly disqualified from local definitive therapy with curative intent.
journal_name
Curr Opin Uroljournal_title
Current opinion in urologyauthors
Goldberg H,Baniel J,Yossepowitch Odoi
10.1097/MOU.0b013e328361dba6subject
Has Abstractpub_date
2013-07-01 00:00:00pages
337-41issue
4eissn
0963-0643issn
1473-6586journal_volume
23pub_type
杂志文章,评审abstract::Recent years have seen notable advances in virtual reality technology and increased interest in potential medical applications. Computed tomography and magnetic resonance imaging data sets, historically viewed as axial images, may now be used to construct a virtual reality endoscopic image, and navigator software syst...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200103000-00010
更新日期:2001-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The recent publication of The Cancer Genome Atlas molecular taxonomy of primary prostate cancer highlights the increased understanding of the genomic basis of human prostate cancer, but also emphasizes the complexity and heterogeneity of prostate cancer. RECENT FINDINGS:Seven molecular subclasses hav...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000285
更新日期:2016-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The recent increase in research with regard to premature ejaculation has led to a significant number of new papers looking at the diagnosis, definition, aetiology and management of this condition. RECENT FINDINGS:The intravaginal ejaculatory latency time remains the primary measure of ejaculatory tim...
journal_title:Current opinion in urology
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doi:10.1097/01.mou.0000186844.40506.98
更新日期:2005-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Laparoscopic retroperitoneal lymph node dissection was first described in 1992, and has become more commonly practiced at certain centers. Laparoscopic retroperitoneal lymph node dissection may be less morbid than open retroperitoneal lymph node dissection, but more costly. Controversy exists, however...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3282f4a880
更新日期:2008-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The role of lymph node dissection (LND) is uncertain for patients diagnosed with renal cell carcinoma (RCC). The aim of the current review is to discuss the available literature considering the role and the impact of LND in RCC patients elected for surgical treatment. Controversies, uncertainties as w...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000312
更新日期:2016-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Update on recent regenerative medicine approaches to the treatment of stress urinary incontinence (SUI) caused by intrinsic sphincter deficiency (ISD). RECENT FINDINGS:In the treatment of female SUI/ISD, results using different types of cellular therapy have been disappointing, and new approaches are...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/MOU.0000000000000617
更新日期:2019-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Urethrovaginal fistulae are a rare condition. It is a conceptual mistake to consider urethrovaginal fistulae to be synonymous with vesicovaginal fistulae. Urethrovaginal fistulae are a different entity requiring special attention and treatment. Due to the wide variety and individuality of the clinical...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3282feedd4
更新日期:2008-07-01 00:00:00
abstract:PURPOSE OF REVIEW:A dedicated operating room with fluoroscopic imaging capability and adequate data connectivity is important to the success of any endourology program. Proper understanding of the recent developments in technology in relation to operating room is necessary before planning an endourology operating room....
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32835d3133
更新日期:2013-03-01 00:00:00
abstract:PURPOSE OF REVIEW:State-of-the-art proteomics technologies are currently being assessed for utility in the study of prostatic malignancy. This review aims to provide background information on the current proteomics techniques employed in prostate cancer research, recent reports showing the potential application of prot...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.mou.0000165547.48922.12
更新日期:2005-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Cytoreductive nephrectomy has an established role in management of metastatic renal cell carcinoma when performed in properly selected patients prior to administration of systemic cytokine therapy. Within the past several years, novel molecular targeted agents have not only revolutionized management o...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32830a4f21
更新日期:2008-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To determine that GreenLight laser therapy is now an established treatment option for men with lower urinary tract symptoms (LUTS) associated with benign prostatic enlargement (BPE). RECENT FINDINGS:The three generations of the GreenLight laser, 80, 120 and 180 W, have been studied for efficacy and s...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000124
更新日期:2015-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Surgery is the mainstay for treating postprostatectomy stress urinary incontinence. Although the artificial urinary sphincter (AUS) remains a popular treatment option, a decade worth of innovations have expanded the role of male sling surgery. RECENT FINDINGS:AUS surgery has an approximately 80-85% s...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e328339b795
更新日期:2010-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the reported effectiveness and safety of transobturator (TransOburator route, TOR) versus retropubic (retropubic tape) synthetic mid-urethral slings discussing the controversy existing on which of these procedures is best. RECENT FINDINGS:From August 2009 to January 2011 three meta-analyses...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3283476edb
更新日期:2011-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To perform a bicenter, retrospective study of perioperative outcomes of retroperitoneal versus transperitoneal robotic-assisted laparoscopic partial nephrectomy (RALPN) and assess costs using time-driven activity-based costing (TDABC). We identified 355 consecutive patients who underwent RALPN at Univ...
journal_title:Current opinion in urology
pub_type: 杂志文章,多中心研究
doi:10.1097/MOU.0000000000000483
更新日期:2018-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Overactive bladder affects 10-12% of men, of which 13% are refractory to medical therapy and seek second-line treatment. This places a substantial clinical and economic burden on the National Health Service United Kingdom. RECENT FINDINGS:This review identifies current evidence for the use of onabotu...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.MOU.0000434594.87575.26
更新日期:2013-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The incidence of renal cell carcinoma and the detection of incidental small renal masses are rising. Urologists are faced with difficult management decisions on how to treat patients with small renal masses. Traditionally, the treatment of suspicious renal masses was radical nephrectomy. However, neph...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3283551f84
更新日期:2012-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This review will summarize the most recent preclinical data from the leading US laboratories regarding the application of gene therapy to the treatment of erectile dysfunction. The implications of these findings in the field of gene therapy in general, and more specifically to the treatment of non-lif...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200211000-00010
更新日期:2002-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize the current knowledge about smoking carcinogenesis in bladder cancer (BCa), individual susceptibility and impact of smoking on incidence and outcomes of nonmuscle invasive BCa (NMIBC) and muscle-invasive BCa (MIBC). To assess the impact of smoking cessation on oncological outcomes. RECEN...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000453
更新日期:2018-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Electrosurgical transurethral resection (TUR) of the prostate (TURP) has dominated symptomatic benign prostatic hyperplasia (s-BPH) surgical treatment for almost a century. We analysed recent TURP publications, with emphasis on durability, morbidity, new technology advantages, future generation traini...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3283411455
更新日期:2011-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize the recent literature on the topic of residual stone fragments in particular novel developments in this field. RECENT FINDINGS:The urological position towards residual fragments has shifted in recent years from observation, to active retrieval with innovative methods, to algorithm-based ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000571
更新日期:2019-03-01 00:00:00
abstract::Molecularly based novel therapeutic agents are needed to address the problem of locally recurrent, or metastatic, advanced hormone-refractory prostate cancer. Recent basic science advances in mechanisms of gene expression, vector delivery, and targeting have rendered clinically relevant gene therapy to the prostatic f...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200109000-00007
更新日期:2001-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the scientific literature on clinical applications of spectroscopy within urologic oncology. Specifically, we address the role of spectroscopy as a novel intraoperative or intraprocedural modality for the management of urothelial carcinoma, renal cell carcinoma, and prostate adenocarcinoma. ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000281
更新日期:2016-05-01 00:00:00
abstract:PURPOSE OF REVIEW:In the absence of an effective and well tolerated drug for stress urinary incontinence, pharmacological therapy for this condition has remained in the off-label prescription of some products particularly estrogens and alpha-adrenergic agonists. In this review we provide an update of the most recent de...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.mou.0000172394.60481.47
更新日期:2005-07-01 00:00:00
abstract:PURPOSE OF REVIEW:High-risk prostate cancers (PCa), that is, those with prostate-specific antigen greater than 20 ng/dl, Gleason Score of at least 8, or extraprostatic spread, are nowadays commonly treated by surgery and radiotherapy combined with a fixed period of systemic treatment. Implementing these strategies requ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e328361d451
更新日期:2013-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Immunotherapies for urological malignancies have made tremendous progress by targeting immune checkpoints and have been implemented in clinical practice nowadays. Though siginifcant number of patients does not respond to immunotherapy. Biomarkers could help to predict response to treatment, but are st...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000465
更新日期:2018-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To identify the latest progression on medical treatment of urinary stones. RECENT FINDINGS:Nonsteroidal anti-inflammatory drugs should be the preferred analgesic option for patients presenting to the emergency department with renal colic. A-blockers could be of patient benefit when used for distal ur...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000523
更新日期:2018-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Ongoing controversy exists as to the extent of the necessary evaluation of the female presenting with lower urinary tract symptoms. Most would agree that a detailed history, a physical examination and a urine analysis are essential components of the initial evaluation of lower urinary tract symptoms i...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200307000-00002
更新日期:2003-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to identify classification and grading systems of percutaneous nephrolithotomy-related complications and evidence for the prevention and treatment of these complications. RECENT FINDINGS:A total complication rate of up to 83% following percutaneous nephrolithotomy was recog...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3282f46afc
更新日期:2008-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Issues relating to the disease are critical in the diagnosis, management, and prognostication of prostate cancer. RECENT FINDINGS:New data have emerged regarding the disease of prostate cancer and its precursors. The diagnosis of prostate cancer on needle biopsy has been refined because of the recent...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.mou.0000193389.31727.9b
更新日期:2006-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Postbiopsy infections (PBIs) are among the most common complications associated with transrectal ultrasound-guided prostate biopsy (TRUSPB). This article discusses the pathogenesis of TRUSPB-associated infectious complications and reviews the most recent findings on techniques to prevent PBIs. RECENT...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000507
更新日期:2018-07-01 00:00:00