Abstract:
PURPOSE OF REVIEW:In the absence of an effective and well tolerated drug for stress urinary incontinence, pharmacological therapy for this condition has remained in the off-label prescription of some products particularly estrogens and alpha-adrenergic agonists. In this review we provide an update of the most recent developments on the pharmacological therapy for stress urinary incontinence. RECENT FINDINGS:In recent years studies have uncovered a role for central neurotransmitters in control of the lower urinary tract and specific targets for pharmacological intervention have been identified. Duloxetine inhibits presynaptic neuron reuptake of serotonin and norepinephrine, in the sacral spinal cord, increasing urethral closure forces and thereby reducing episodes of stress urinary incontinence. In clinical trials in women with stress urinary incontinence, duloxetine has demonstrated efficacy in reducing incontinence episodes and increasing quality of life with no serious adverse effects. Nausea was the most common adverse event, being reported as mild-to moderate in severity and transient in most of patients. SUMMARY:Although estrogens produce some effects on the urethral epithelium and may be useful in patients with atrophic vaginitis, at present, there is no good evidence supporting its use in women with stress urinary incontinence. Alpha-adrenoreceptor agonists have been found to be effective in stress urinary incontinence, but the use of these drugs is limited due to some major safety concerns related to cardiovascular side effects. Duloxetine is a new selective norepinephrine and serotonin reuptake inhibitor that has proven efficacy for the treatment of stress urinary incontinence in women.
journal_name
Curr Opin Uroljournal_title
Current opinion in urologyauthors
Castro-Diaz D,Amoros MAdoi
10.1097/01.mou.0000172394.60481.47subject
Has Abstractpub_date
2005-07-01 00:00:00pages
227-30issue
4eissn
0963-0643issn
1473-6586pii
00042307-200507000-00006journal_volume
15pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Robotic assisted simple prostatectomy (RASP) represents a minimally invasive evolution of traditional open simple prostatectomy for the surgical treatment of severe lower urinary tract symptoms (LUTS) because of benign prostatic enlargement (BPE). Aim of the present review is to summarize the most rec...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000499
更新日期:2018-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The present article reviews the history of mesh-related complications and regulations in SUI and POP repair settings, clinical outcomes associated with the use of biologic and synthetic mesh materials, and novel approaches using modified mesh materials. RECENT FINDINGS:Treatment of pelvic floor disor...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000645
更新日期:2019-07-01 00:00:00
abstract::Advances in the diagnosis of early stage disease, and particularly the introduction of prostate-specific antigen (PSA) testing, have had a dramatic effect on the presentation and clinical management of prostate cancer during the past ten years. As a result, there have been significant epidemiological changes in countr...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200007000-00006
更新日期:2000-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Bladder cancer is a very frequent disease and represents the second most common genitourinary neoplasm. The most prevalent form of the disease, superficial bladder cancer, can recur in more than 70% of cases, despite correct management. Any way to improve our disease diagnostic and treatment policy is...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200309000-00001
更新日期:2003-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Management of men with benign prostatic hyperplasia should reduce the lifetime risk of acute urinary retention and the need for benign prostatic hyperplasia-related surgery. A number of recent studies demonstrate that 5alpha-reductase inhibitors are unique in providing a long-term combination of impro...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200401000-00010
更新日期:2004-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Benign prostatic hyperplasia is the most common human neoplasm and it is the most frequent tumour requiring surgical treatment in men. Not surprisingly, interest centres on either understanding of prostatic growth during ageing or on various medical or interventional treatments. RECENT FINDINGS:Recen...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200301000-00003
更新日期:2003-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Extracorporeal shock wave lithotripsy (ESWL) is the preferred modality for the treatment of renal and upper ureteric calculi. The present review focuses on the limitations of ESWL, where recent developments have tried to identify patients who are unlikely to succeed with ESWL and where improvements in...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32802b70bc
更新日期:2007-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To determine whether alpha-blockers, commonly used for the treatment of benign prostatic hyperplasia, are associated with prostate cancer risk. RECENT FINDINGS:Alpha-blockers have been associated with a reduced risk of prostate cancer aggressiveness in some observational studies and an increased risk...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32835abcf2
更新日期:2013-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the treatment options in metastatic renal cell carcinoma (mRCC) in the light of new immunotherapy results. RECENT FINDINGS:Second-line treatment strategies for treatment of mRCC after progression on first-line VEGF-targeted therapy have recently undergone a major change. Treatment guideline...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000456
更新日期:2018-01-01 00:00:00
abstract::Magnetic resonance imaging provides the most accurate, versatile and safe imaging of the pelvic floor. Images can be produced to show sections in any plane and even in three dimensions. The resolution is such that detail as good as that seen in histological sections is possible. Once standardization of data acquisitio...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200203000-00009
更新日期:2002-03-01 00:00:00
abstract::Although there has been a recent surge of interest in chronic prostatitis, which hopefully will translate into advances in our understanding of the distribution and determinants of this condition, at present there is a scarcity of published epidemiologic research on chronic prostatitis. However, from the currently ava...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/00042307-199801000-00007
更新日期:1998-01-01 00:00:00
abstract::Hand-assisted laparoscopy has been successfully applied to various applications within the field of urology. Many authors have proved the safety and efficacy of this technique, as well as demonstrating improved patient recovery for such procedures as radical nephrectomy, radical nephroureterectomy and donor nephrectom...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200205000-00010
更新日期:2002-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Training in female urology in Europe so far has been a national focus of individual European countries. Because of reasons like differentiation in pathology, activities of other specialisms like gynaecology and reimbursement issues, the way in which extra training in female urology is organized varies...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32832ae1a4
更新日期:2009-07-01 00:00:00
abstract:PURPOSE OF REVIEW:A public health emergency has been declared in response to rising opioid addiction and opioid-related deaths in the United States. As kidney stones have been identified as an important source of initial and repeated opioid exposures, this review seeks to describe the scope of the problem and report re...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000705
更新日期:2020-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Immunotherapies for urological malignancies have made tremendous progress by targeting immune checkpoints and have been implemented in clinical practice nowadays. Though siginifcant number of patients does not respond to immunotherapy. Biomarkers could help to predict response to treatment, but are st...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000465
更新日期:2018-01-01 00:00:00
abstract:PURPOSE OF REVIEW:In 2012, the United States Preventive Services Task Force (USPSTF) issued a grade 'D' recommendation against the use of routine prostate-specific antigen (PSA)-based screening for any men. This recommendation reflects critical misinterpretations of the available evidence base regarding benefits and ha...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000383
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Systemic treatment options for metastatic hormone-sensitive prostate cancer (mHSPC) have recently shifted from the traditional androgen deprivation therapy (ADT) monotherapy to multidrug approaches incorporating drugs initially approved for castration-resistant state and ADT. However, clinicians have ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000778
更新日期:2020-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to outline the initial development of histotripsy, a noninvasive image-guided focused ultrasound technology that mechanically homogenizes targeted tissues and to describe the results of preclinical translational research directed toward urologic applications. RECENT FINDING...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000001
更新日期:2014-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To identify the latest progression on medical treatment of urinary stones. RECENT FINDINGS:Nonsteroidal anti-inflammatory drugs should be the preferred analgesic option for patients presenting to the emergency department with renal colic. A-blockers could be of patient benefit when used for distal ur...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000523
更新日期:2018-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Examine and discuss novel focal therapy treatment options for prostate cancer. RECENT FINDINGS:With the widespread adoption of mpMRI-guided biopsies for prostate cancer, use of image-guided treatment of prostate cancer has increased. Focal therapies leading to partial gland ablation such as partial p...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000469
更新日期:2018-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Total adrenalectomy has been the standard treatment for small adrenal masses for years. In recent times, however, partial adrenalectomy and cortex-preserving strategies are gaining more importance. Therefore, we evaluated indications, techniques and outcome of partial adrenalectomy. RECENT FINDINGS:W...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000147
更新日期:2015-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The incidence of renal cell carcinoma and the detection of incidental small renal masses are rising. Urologists are faced with difficult management decisions on how to treat patients with small renal masses. Traditionally, the treatment of suspicious renal masses was radical nephrectomy. However, neph...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3283551f84
更新日期:2012-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This article discusses enucleation and vaporization procedures which have been developed on the surgical techniques of holmium laser enucleation of the prostate (HoLEP) and photoselective vaporization of the prostate (PVP) by reviewing the most recent publications. RECENT FINDINGS:Enucleation procedu...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000125
更新日期:2015-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The recent publication of The Cancer Genome Atlas molecular taxonomy of primary prostate cancer highlights the increased understanding of the genomic basis of human prostate cancer, but also emphasizes the complexity and heterogeneity of prostate cancer. RECENT FINDINGS:Seven molecular subclasses hav...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000285
更新日期:2016-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Robotic-assisted laparoscopic retroperitoneal lymph node dissection (R-RPLND) is gaining acceptance as an alternative to open and laparoscopic RPLND for the treatment of testicular cancer. We discuss the current state of R-RPLND and summarize the latest relevant literature regarding the feasibility of...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000582
更新日期:2019-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To evaluate and present the evidence for the use of different investigation modalities in men with benign prostatic hyperplasia/lower urinary tract symptoms (LUTS) in 2014. RECENT FINDINGS:Cystometry remains the gold standard in differentiating obstructed from nonobstructed men with LUTS. Prostatic u...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000013
更新日期:2014-01-01 00:00:00
abstract::As a result of the recent resurgence of interest in interstitial brachytherapy, extended follow-up studies of early experience in this field are now being reported. However, such outcomes must be evaluated within the context of recent comprehensive assessments of the age-specific natural history of conservatively mana...
journal_title:Current opinion in urology
pub_type: 社论,评审
doi:10.1097/00042307-199905000-00001
更新日期:1999-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the progress of the genitourinary SPORE (Specialized Program of Research Excellence) in bladder cancer. RECENT FINDINGS:The optimal management of bladder cancer depends on the accurate assessment of the biological potential of the disease. Methotrexate, vincristine, adriamycin and cisplatin...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200409000-00008
更新日期:2004-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Ongoing controversy exists as to the extent of the necessary evaluation of the female presenting with lower urinary tract symptoms. Most would agree that a detailed history, a physical examination and a urine analysis are essential components of the initial evaluation of lower urinary tract symptoms i...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200307000-00002
更新日期:2003-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide discussion on several recently published case series describing complete intracorporeal robotic cystectomy. Are we making a complex and expensive procedure more challenging or are there patient benefits to be realized from a complete minimally invasive approach? We discuss how effective and...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32835d4cda
更新日期:2013-03-01 00:00:00