Molecular subtyping of prostate cancer.

Abstract:

PURPOSE OF REVIEW:The recent publication of The Cancer Genome Atlas molecular taxonomy of primary prostate cancer highlights the increased understanding of the genomic basis of human prostate cancer, but also emphasizes the complexity and heterogeneity of prostate cancer. RECENT FINDINGS:Seven molecular subclasses have been defined on the basis of early genomic alterations, which are largely mutually exclusive. SUMMARY:We review the recent advances in the genomic understanding of human prostate cancer, with focus on molecular subclassification. Broadly, prostate cancer can be classified based upon whether specific genomic rearrangements, such as the Transmembrane Protease, Serine 2-ETS-related gene fusion occur or whether specific alterations such as Speckle-type POZ protein and forkhead box A1 mutations occur. The molecular drivers remain to be identified in a further quarter of human prostate cancers. Depending upon the molecular subclassification and the coincident genomic alterations, specific clinical insights can be gained from this information, including associations with pathologic factors, race, and prognosis, as well as the possibility for future precision therapies.

journal_name

Curr Opin Urol

authors

Kaffenberger SD,Barbieri CE

doi

10.1097/MOU.0000000000000285

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

213-8

issue

3

eissn

0963-0643

issn

1473-6586

journal_volume

26

pub_type

杂志文章,评审
  • Management of superficial bladder cancer: what is new?

    abstract::The management of superficial bladder cancer has not changed much during the last years. Transurethral resections with adjuvant intravesical instillation to risk groups have been standard therapy. Cystoscopy and cytology have been used for follow-up. Recently combinations of drugs for instillation and new urinary mark...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/00042307-200009000-00014

    authors: Malmström PU

    更新日期:2000-09-01 00:00:00

  • The Y chromosome and male infertility.

    abstract:PURPOSE OF REVIEW:Therapies for the treatment of severe male factor infertility have advanced well beyond our knowledge of the conditions we are treating. An intact Y chromosome is necessary for optimal spermatogenesis. It is imperative for the clinician to understand the molecular basis and clinical implications of an...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e32831367dc

    authors: Sadeghi-Nejad H,Oates RD

    更新日期:2008-11-01 00:00:00

  • Nomograms are superior to staging and risk grouping systems for identifying high-risk patients: preoperative application in prostate cancer.

    abstract:PURPOSE OF REVIEW:We outline a generic approach to using a nomogram to predict a continuous probability of failure in high-risk patients (rather than putting patients into groups), in order to identify patients whose risk exceeds a cutoff point. We discuss the goals of any staging system, what markers should be include...

    journal_title:Current opinion in urology

    pub_type: 杂志文章

    doi:10.1097/00042307-200303000-00005

    authors: Kattan MW

    更新日期:2003-03-01 00:00:00

  • Magnetic resonance imaging for urinary incontinence.

    abstract::Magnetic resonance imaging provides the most accurate, versatile and safe imaging of the pelvic floor. Images can be produced to show sections in any plane and even in three dimensions. The resolution is such that detail as good as that seen in histological sections is possible. Once standardization of data acquisitio...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/00042307-200203000-00009

    authors: Stewart LH,Brush JP

    更新日期:2002-03-01 00:00:00

  • Tissue engineering in urology.

    abstract::Techniques that are aimed at regeneration of human tissues and organs (tissue engineering) have recently entered into clinical practice. Tissue engineering is currently among the fastest growing areas in medicine, and involves the application of the principles of biology and engineering to the development of functiona...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/00042307-200105000-00006

    authors: Gustafson CJ,Kratz G

    更新日期:2001-05-01 00:00:00

  • Renal magnetic resonance angiography: an update.

    abstract::Recent developments in renal magnetic resonance angiography have led to a significant improvement in the technical success rate and diagnostic accuracy of the methods. Specifically, three-dimensional contrast-enhanced magnetic resonance angiography methods have been shown to provide a more reliable depiction of renal ...

    journal_title:Current opinion in urology

    pub_type: 杂志文章

    doi:10.1097/00042307-199803000-00006

    authors: Grist TM

    更新日期:1998-03-01 00:00:00

  • Management of stones in renal transplant.

    abstract:PURPOSE OF REVIEW:Increasingly, screening of both deceased and living donor organs has led to the early detection of kidney stones prior to donation. A number of transplant recipients will still present with donor-gifted and de-novo stones. A range of treatment modalities is available in the management of renal transpl...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e32835d3097

    authors: Wong KA,Olsburgh J

    更新日期:2013-03-01 00:00:00

  • Clinical update on testicular microlithiasis.

    abstract:PURPOSE OF REVIEW:Testicular microlithiasis becomes a greater interdisciplinary issue among urologists, andrologists, gynecologists dedicated to reproductive medicine, pediatricians, radiologists and pathologists. Proposed management ranges from benign neglect, instructing self-examination over follow-up once, regular ...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e3283314a1d

    authors: Meissner A,Mamoulakis C,de la Rosette JJ,Pes MP

    更新日期:2009-11-01 00:00:00

  • Laparoscopic radical prostatectomy: transperitoneal versus retroperitoneal approach: is there an advantage for the patient?

    abstract:PURPOSE OF REVIEW:Radical prostatectomy is the standard treatment for localized prostate cancer; its translation to a laparoscopic approach is considered today not only as feasible and reproducible but also as a valid and teachable alternative to its open counterpart. Beyond the "classical" transperitoneal antegrade ro...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mou.0000160621.05742.a4

    authors: van Velthoven RF

    更新日期:2005-03-01 00:00:00

  • Medical treatment of urinary stones.

    abstract:PURPOSE OF REVIEW:To identify the latest progression on medical treatment of urinary stones. RECENT FINDINGS:Nonsteroidal anti-inflammatory drugs should be the preferred analgesic option for patients presenting to the emergency department with renal colic. A-blockers could be of patient benefit when used for distal ur...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0000000000000523

    authors: Skolarikos A

    更新日期:2018-09-01 00:00:00

  • Paediatric oncology.

    abstract::Recent research into paediatric urologic oncology has identified a number of certain subgroups of neuroblastoma and Wilms' tumour, which allows a more tailored treatment of the individual child with respect to treatment sequelae and finance issues. The importance of surgery, radiotherapy and cytostatic treatment has t...

    journal_title:Current opinion in urology

    pub_type: 杂志文章

    doi:10.1097/00042307-199811000-00007

    authors: Humpl T,Gutjahr P

    更新日期:1998-11-01 00:00:00

  • Salvage therapeutic strategies for bacillus Calmette-Guerin failure.

    abstract:PURPOSE OF REVIEW:To give an overview of current options for conservative treatment of patients failing intravesical bacillus Calmette-Guerin (BCG) and to discuss emerging approaches with potential future clinical applications. RECENT FINDINGS:Radical cystectomy is the standard-of-care for patients failing BCG therapy...

    journal_title:Current opinion in urology

    pub_type: 杂志文章

    doi:10.1097/MOU.0000000000000593

    authors: Hassler MR,Shariat SF,Soria F

    更新日期:2019-05-01 00:00:00

  • Defining high-risk prostate cancer.

    abstract:PURPOSE OF REVIEW:High-risk prostate cancer often represents a lethal disease requiring timely diagnosis and effective therapy. Standardized criteria that define high-risk prostate cancer have yet to be established, rendering the discrimination of high-risk from nonhigh-risk patients a challenge. This review summarizes...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e328361dba6

    authors: Goldberg H,Baniel J,Yossepowitch O

    更新日期:2013-07-01 00:00:00

  • The use of mesh in vaginal prolapse repair: do the benefits justify the risks?

    abstract:PURPOSE OF REVIEW:Due to the desire for improved outcomes, the use of synthetic materials in vaginal prolapse repair has been increasing despite the lack of sound evidence of their efficacy and safety. RECENT FINDINGS:Given the limited number of randomized controlled trials evaluating repair of vaginal prolapse with t...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e32833a5120

    authors: Morrisroe S,Lee U,Raz S

    更新日期:2010-07-01 00:00:00

  • The use of preoperative targeted molecular therapy to allow nephron sparing for T1b tumors.

    abstract:PURPOSE OF REVIEW:To give insight into the current literature on feasibility, safety and outcome of presurgical targeted molecular therapies (TMTs) before nephron-sparing surgery (NSS) in patients with renal cell carcinoma. RECENT FINDINGS:Presurgical TMTs have been proven to be effective and well tolerated for patien...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e32836320a7

    authors: Cost NG,Krabbe LM,Bagrodia A,Margulis V

    更新日期:2013-09-01 00:00:00

  • Strategies to prevent progression of high-risk bladder cancer at initial diagnosis.

    abstract:PURPOSE OF REVIEW:As high-risk nonmuscle invasive bladder cancer (NMIBC) has a high propensity to recur and progress, the primary therapeutic goal in patients with high-risk NMIBC is the prevention or delay of disease recurrence and progression. RECENT FINDINGS:For improving transurethral resection quality, new optica...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e328356adff

    authors: Ku JH,Lerner SP

    更新日期:2012-09-01 00:00:00

  • The prospect of gene therapy for prostate cancer: update on theory and status.

    abstract::Molecularly based novel therapeutic agents are needed to address the problem of locally recurrent, or metastatic, advanced hormone-refractory prostate cancer. Recent basic science advances in mechanisms of gene expression, vector delivery, and targeting have rendered clinically relevant gene therapy to the prostatic f...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/00042307-200109000-00007

    authors: Koeneman KS,Hsieh JT

    更新日期:2001-09-01 00:00:00

  • Novel imaging techniques reshape the landscape in high-risk prostate cancers.

    abstract:PURPOSE OF REVIEW:High-risk prostate cancers (PCa), that is, those with prostate-specific antigen greater than 20 ng/dl, Gleason Score of at least 8, or extraprostatic spread, are nowadays commonly treated by surgery and radiotherapy combined with a fixed period of systemic treatment. Implementing these strategies requ...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e328361d451

    authors: Lecouvet FE,Lhommel R,Pasoglou V,Larbi A,Jamar F,Tombal B

    更新日期:2013-07-01 00:00:00

  • New diagnostic strategies in the detection and staging of bladder cancer.

    abstract:PURPOSE OF REVIEW:Bladder cancer is a very frequent disease and represents the second most common genitourinary neoplasm. The most prevalent form of the disease, superficial bladder cancer, can recur in more than 70% of cases, despite correct management. Any way to improve our disease diagnostic and treatment policy is...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/00042307-200309000-00001

    authors: Jichlinski P

    更新日期:2003-09-01 00:00:00

  • Morphological and biological predictors for treatment outcome of transurethral microwave thermotherapy.

    abstract::The proliferation of prostatic tissue as a result of ageing typically leads to prostatic enlargement, which often causes obstruction of urine outflow from the bladder, clinically lower urinary tract symptoms, detrusor instability, incomplete bladder emptying, urinary infection, and finally acute urinary retention. The...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/00042307-200201000-00006

    authors: Seitz C,Djavan B,Marberger M

    更新日期:2002-01-01 00:00:00

  • Important factors in the diagnosis and primary staging of testicular tumours.

    abstract:PURPOSE OF REVIEW:In the present review we outline the use of different staging methods and highlight future possibilities in the management of testicular germ cell cancer. RECENT FINDINGS:The 5-year survival for testicular cancer has improved dramatically over the past 30 years, with cure rates approaching 95%. This ...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/00042307-200209000-00009

    authors: Spermon JR,Debruyne FM,Witjes JA

    更新日期:2002-09-01 00:00:00

  • Recent advances in robot-assisted radical cystectomy.

    abstract:PURPOSE OF REVIEW:The prevalence of robot-assisted radical cystectomy is steadily increasing. We review the recent literature evaluating this technique as a minimally invasive alternative to open radical cystectomy for the treatment of bladder cancer. RECENT FINDINGS:Within the last year, numerous robot-assisted radic...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/mou.0b013e32834112a3

    authors: Cha EK,Wiklund NP,Scherr DS

    更新日期:2011-01-01 00:00:00

  • Underactive bladder in women: is there any evidence?

    abstract:PURPOSE OF REVIEW:Underactive bladder (UAB) is a clinical symptom complex only recently gaining recognition as a clinical diagnosis. Lack of consensus agreement on a definition of UAB has limited its recognition and diagnosis in clinical practice. The purposes of this review are to: present existing definitions of UAB,...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0000000000000280

    authors: Cohn JA,Brown ET,Kaufman MR,Dmochowski RR,Reynolds WS

    更新日期:2016-07-01 00:00:00

  • Advances in laparoscopic partial nephrectomy.

    abstract:PURPOSE OF REVIEW:The advantages of the laparoscopic approach in the management of kidney tumors are unequivocal and the role of laparoscopy in nephron-sparing surgery is evolving. In a selected group of patients with small exophytic renal tumors laparoscopic partial nephrectomy became an alternative to open partial ne...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mou.0000135079.98882.6d

    authors: Touijer K,Guillonneau B

    更新日期:2004-07-01 00:00:00

  • Gene therapy for erectile dysfunction: where is it going?

    abstract:PURPOSE OF REVIEW:This review will summarize the most recent preclinical data from the leading US laboratories regarding the application of gene therapy to the treatment of erectile dysfunction. The implications of these findings in the field of gene therapy in general, and more specifically to the treatment of non-lif...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/00042307-200211000-00010

    authors: Christ GJ

    更新日期:2002-11-01 00:00:00

  • Is robotic sacrocolpopexy a marketing gimmick or a technological advancement?

    abstract:PURPOSE OF REVIEW:Robot-assisted laparoscopic sacrocolpopexy (RALS) is a new surgical technique for the treatment of symptomatic vaginal vault prolapse that is rapidly gaining popularity among both urologists and gynecologists. This article will summarize the available published data to assess the potential advantages ...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e32833aaa2b

    authors: Kim JH,Anger JT

    更新日期:2010-07-01 00:00:00

  • Clinical implications of genitourinary embryology.

    abstract:PURPOSE OF REVIEW:This review focuses on recent advances in molecular embryology of the upper and lower urinary tract with an emphasis on clinical correlation in order to gain a better understanding for the mechanism of congenital anomalies. RECENT FINDINGS:Normal morphogenesis of the kidney, ureteral bud differentiat...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e32832c90ff

    authors: Shapiro E

    更新日期:2009-07-01 00:00:00

  • GreenLight laser vaporization of the prostate: has it come of age?

    abstract:PURPOSE OF REVIEW:To determine that GreenLight laser therapy is now an established treatment option for men with lower urinary tract symptoms (LUTS) associated with benign prostatic enlargement (BPE). RECENT FINDINGS:The three generations of the GreenLight laser, 80, 120 and 180 W, have been studied for efficacy and s...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0000000000000124

    authors: Gomez-Sancha F

    更新日期:2015-01-01 00:00:00

  • Stones in urinary diversions: update on medical and surgical issues.

    abstract:PURPOSE OF REVIEW:Patients who undergo urinary tract diversion are at an increased risk of urolithiasis for various reasons. The purpose of this article is to provide an up-to-date summary of the progress that has been made in the pathogenesis, diagnosis and treatment of stones in patients with urinary diversions. Fina...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/00042307-200207000-00007

    authors: Beiko DT,Razvi H

    更新日期:2002-07-01 00:00:00

  • Carcinoma in situ of the bladder: why is it underdetected?

    abstract:PURPOSE OF REVIEW:The standard diagnosis of carcinoma in situ (CIS) of the bladder, based on white light cystoscopy and urine cytology, is limited because CIS can vary from normal-appearing mucosa to a lesion indistinguishable from an inflammatory process. Intravesical instillation of Bacillus Calmette-Guerin (BCG) rem...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0000000000000758

    authors: Subiela JD,Rodríguez Faba Ó,Guerrero-Ramos F,Aumatell J,Breda A,Palou J

    更新日期:2020-05-01 00:00:00