Abstract:
PURPOSE OF REVIEW:We outline a generic approach to using a nomogram to predict a continuous probability of failure in high-risk patients (rather than putting patients into groups), in order to identify patients whose risk exceeds a cutoff point. We discuss the goals of any staging system, what markers should be included, and models of markers. RECENT FINDINGS:Selection of high-risk patients for any cancer has traditionally been accomplished by the creation of risk groups, or perhaps clinical stages. Ideally, high-risk patients should be identified as accurately as possible, because of the treatment and psychological implications for the patient. We argue that a continuous multivariable prediction model, such as a nomogram, is the most appropriate and accurate way to select high-risk patients. This type of model predicts outcome more accurately than risk grouping or staging systems. As an example, we use our preoperative prostatic specific antigen recurrence nomogram to identify patients at high risk of biochemical failure, who are in need of an effective neoadjuvant therapy. SUMMARY:It will follow from our discussion that identification of high-risk patients should follow four simple steps. First, select the endpoint of interest for the trial or the patient. Second, select the method that predicts the endpoint as accurately as possible. Third, determine the cutoff of predicted probability beyond which it makes sense to give the patient experimental therapy. Fourth, offer the novel therapy to the patient whose prediction of the endpoint, using the most accurate prediction method, exceeds the threshold.
journal_name
Curr Opin Uroljournal_title
Current opinion in urologyauthors
Kattan MWdoi
10.1097/00042307-200303000-00005subject
Has Abstractpub_date
2003-03-01 00:00:00pages
111-6issue
2eissn
0963-0643issn
1473-6586journal_volume
13pub_type
杂志文章abstract:PURPOSE OF REVIEW:The pace of technology development with single-use endoscopy has led to a range of disposable ureteroscopes. We review the development of single-use scopes, deconstruct the basic design and functional characteristics of available devices, and discuss future directions for next-generation platforms. R...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/MOU.0000000000000852
更新日期:2021-03-01 00:00:00
abstract::Techniques that are aimed at regeneration of human tissues and organs (tissue engineering) have recently entered into clinical practice. Tissue engineering is currently among the fastest growing areas in medicine, and involves the application of the principles of biology and engineering to the development of functiona...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200105000-00006
更新日期:2001-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to summarize recent developments in the array of devices which are commonly used by urologists in the surgical management of kidney stones. To accomplish this goal, an extensive review of recent endourology literature, conference abstracts, and publicly available document...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000710
更新日期:2020-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to outline the initial development of histotripsy, a noninvasive image-guided focused ultrasound technology that mechanically homogenizes targeted tissues and to describe the results of preclinical translational research directed toward urologic applications. RECENT FINDING...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000001
更新日期:2014-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Prostate cancer screening has shifted the diagnosis of prostate cancer to lower grade, organ confined disease. Radical prostatectomy or radiation therapy has been shown to be overtreatment in 30% of patients. In this review, we will discuss targeted focal therapy (TFT) using the modalities of cryother...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32832a2c4a
更新日期:2009-05-01 00:00:00
abstract:PURPOSE OF REVIEW:High-risk prostate cancers (PCa), that is, those with prostate-specific antigen greater than 20 ng/dl, Gleason Score of at least 8, or extraprostatic spread, are nowadays commonly treated by surgery and radiotherapy combined with a fixed period of systemic treatment. Implementing these strategies requ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e328361d451
更新日期:2013-07-01 00:00:00
abstract:PURPOSE OF REVIEW:This article discusses enucleation and vaporization procedures which have been developed on the surgical techniques of holmium laser enucleation of the prostate (HoLEP) and photoselective vaporization of the prostate (PVP) by reviewing the most recent publications. RECENT FINDINGS:Enucleation procedu...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000125
更新日期:2015-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Focal therapy presents an alternative option for disease-targeted therapy while preserving erectile and urinary function without compromising oncological outcome. Such treatment, which preserves normal prostate parenchyma, presents a clinical challenge to the urologist, as typical disease surveillance...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000052
更新日期:2014-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Better understanding of renal cell carcinoma biology has led to a new era of targeted therapy in the management of metastatic renal cell carcinoma. This review provides an updated survey of the recently reported and ongoing clinical trials that will help to further define the role of these novel drugs...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32833c86f8
更新日期:2010-09-01 00:00:00
abstract:PURPOSE OF REVIEW:A public health emergency has been declared in response to rising opioid addiction and opioid-related deaths in the United States. As kidney stones have been identified as an important source of initial and repeated opioid exposures, this review seeks to describe the scope of the problem and report re...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000705
更新日期:2020-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This review aims to analyze and discuss all recently published articles associated with neurogenic voiding discussion providing readers with the most updated knowledge and trigger for further research. RECENT FINDINGS:They include the proposal of a novel classification system for the pathophysiology ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000392
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Tissue engineering is a rapidly advancing technology that is shifting from the laboratory to urological practice. The review explores recent developments and considers the relationship to existing treatments. RECENT FINDINGS:Different strategies to generate transplantable tissue grafts in vitro and h...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32830f9402
更新日期:2008-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The recent increase in research with regard to premature ejaculation has led to a significant number of new papers looking at the diagnosis, definition, aetiology and management of this condition. RECENT FINDINGS:The intravaginal ejaculatory latency time remains the primary measure of ejaculatory tim...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.mou.0000186844.40506.98
更新日期:2005-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To identify the latest progression on medical treatment of urinary stones. RECENT FINDINGS:Nonsteroidal anti-inflammatory drugs should be the preferred analgesic option for patients presenting to the emergency department with renal colic. A-blockers could be of patient benefit when used for distal ur...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000523
更新日期:2018-09-01 00:00:00
abstract::This review discusses the contemporary management of urethral trauma and post-traumatic urethral strictures occurring in both the anterior and posterior urethra. Experience in the full spectrum of urethral reconstructive procedures is important. The initial management of patients relies upon adequate drainage of the b...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-199905000-00011
更新日期:1999-05-01 00:00:00
abstract::Recent developments in renal magnetic resonance angiography have led to a significant improvement in the technical success rate and diagnostic accuracy of the methods. Specifically, three-dimensional contrast-enhanced magnetic resonance angiography methods have been shown to provide a more reliable depiction of renal ...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/00042307-199803000-00006
更新日期:1998-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Electrosurgical transurethral resection (TUR) of the prostate (TURP) has dominated symptomatic benign prostatic hyperplasia (s-BPH) surgical treatment for almost a century. We analysed recent TURP publications, with emphasis on durability, morbidity, new technology advantages, future generation traini...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3283411455
更新日期:2011-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Serenoa repens extract is a popular phytotherapeutic agent in men with lower urinary tract symptoms. Although the exact mechanism of action is unknown, the agent is generally well accepted for its easy availability and good tolerability. This paper reviews the evidence of its efficacy in comparison wi...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200501000-00011
更新日期:2005-01-01 00:00:00
abstract:PURPOSE OF REVIEW:We summarize the evidence on accurate target definition, precise imaging, and guiding systems that are a necessary ground to targeted focal therapy. RECENT FINDINGS:Accurate target detection is based on the ability of imaging to locate and characterize precisely the tumor burden and differentiation i...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/MOU.0000000000000560
更新日期:2019-01-01 00:00:00
abstract::After more than 100 years of innovation in hypospadias repair, new concepts regarding penile curvature, the urethral plate, and the means for urethroplasty are changing surgical practices. With the introduction of the tubularized incised plate technique it is possible to simplify decision-making algorithms in hypospad...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/00042307-199911000-00004
更新日期:1999-11-01 00:00:00
abstract:PURPOSE OF REVIEW:We review recent advancements in staging and imaging of penile cancer, including surveillance after therapy. RECENT FINDINGS:For cN0 patients, the sentinel lymph node biopsy is currently considered the preferred way for invasive staging. It has largely replaced other modalities such as staging inguin...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000447
更新日期:2017-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Monitoring and improving the quality of healthcare is an evolving process that involves patients, physicians, and healthcare purchasers. Growing interest is seen in addressing quality concerns with policy changes. Surgeon and hospital volumes for specific high-risk procedures have been shown to be pre...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.mou.0000240307.85829.7a
更新日期:2006-09-01 00:00:00
abstract:PURPOSE OF REVIEW:In the present review we outline the use of different staging methods and highlight future possibilities in the management of testicular germ cell cancer. RECENT FINDINGS:The 5-year survival for testicular cancer has improved dramatically over the past 30 years, with cure rates approaching 95%. This ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200209000-00009
更新日期:2002-09-01 00:00:00
abstract:PURPOSE OF REVIEW:A dedicated operating room with fluoroscopic imaging capability and adequate data connectivity is important to the success of any endourology program. Proper understanding of the recent developments in technology in relation to operating room is necessary before planning an endourology operating room....
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32835d3133
更新日期:2013-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Update on recent regenerative medicine approaches to the treatment of stress urinary incontinence (SUI) caused by intrinsic sphincter deficiency (ISD). RECENT FINDINGS:In the treatment of female SUI/ISD, results using different types of cellular therapy have been disappointing, and new approaches are...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/MOU.0000000000000617
更新日期:2019-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Systemic treatment options for metastatic hormone-sensitive prostate cancer (mHSPC) have recently shifted from the traditional androgen deprivation therapy (ADT) monotherapy to multidrug approaches incorporating drugs initially approved for castration-resistant state and ADT. However, clinicians have ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000778
更新日期:2020-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the most current literature regarding the management of neurogenic bladder in children. RECENT FINDINGS:Several recent papers have addressed the investigation and management of children with neurogenic bladder. Bladder wall thickness as measured by ultrasound may identify the children with ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32832c9178
更新日期:2009-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an overview on the available clinical and pathological factors in high-risk nonmuscle invasive bladder cancer (NMIBC) patients that help to approximate the risk of progression to muscle invasion and identify 'the' patients requiring timely cystectomy. The value of a high-quality transurethr...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e328363e46f
更新日期:2013-09-01 00:00:00
abstract:PURPOSE OF REVIEW:In 2012, the United States Preventive Services Task Force (USPSTF) issued a grade 'D' recommendation against the use of routine prostate-specific antigen (PSA)-based screening for any men. This recommendation reflects critical misinterpretations of the available evidence base regarding benefits and ha...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000383
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this study is to provide an overview of the current status of novel cognitive training approaches in surgery and to investigate the potential role of cognitive training in surgical education. RECENT FINDINGS:Kinematics of end-effector trajectories, as well as cognitive state features of su...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000408
更新日期:2017-07-01 00:00:00