Abstract:
PURPOSE OF REVIEW:Tissue engineering is a rapidly advancing technology that is shifting from the laboratory to urological practice. The review explores recent developments and considers the relationship to existing treatments. RECENT FINDINGS:Different strategies to generate transplantable tissue grafts in vitro and harness host regenerative processes for integration of grafts and biomaterials in vivo are common themes in the recent literature. Highlights include dynamic cell culture to precondition grafts and the use of omental wrapping to promote vascularization. Emphasis on specific cell culture conditions is set to shift towards the monitoring of differentiation and functional outcome. The future might encompass the use of stem cells to overcome the issues of harvesting cells from diseased tissues. Improved understandings of scaffold and cell interactions are particularly important to advance graft development and outcome. Recent trials give some indication of clinical outcome for tissue-engineered treatments, but patient benefit could be difficult to interpret in salvage cases. SUMMARY:Tissue engineering applications can be broken down into tissue- or organ-based approaches, only through examining these in clinical settings can potential success can be judged. Treatments must be appropriately evaluated for risk/benefit in comparison to existing treatments. This approach requires open and robust debate amongst clinicians and scientists.
journal_name
Curr Opin Uroljournal_title
Current opinion in urologyauthors
Wood D,Southgate Jdoi
10.1097/MOU.0b013e32830f9402subject
Has Abstractpub_date
2008-11-01 00:00:00pages
564-9issue
6eissn
0963-0643issn
1473-6586pii
00042307-200811000-00004journal_volume
18pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Serenoa repens extract is a popular phytotherapeutic agent in men with lower urinary tract symptoms. Although the exact mechanism of action is unknown, the agent is generally well accepted for its easy availability and good tolerability. This paper reviews the evidence of its efficacy in comparison wi...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200501000-00011
更新日期:2005-01-01 00:00:00
abstract::Although there has been a recent surge of interest in chronic prostatitis, which hopefully will translate into advances in our understanding of the distribution and determinants of this condition, at present there is a scarcity of published epidemiologic research on chronic prostatitis. However, from the currently ava...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/00042307-199801000-00007
更新日期:1998-01-01 00:00:00
abstract::Pharmacotherapy for men experiencing erectile dysfunction has undergone dramatic advances over the past 5 years with the introduction of an effective oral agent. Sildenafil has increased the pool of couples seeking treatment for this important health issue as well as expanding the numbers of physicians treating it. Re...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200111000-00011
更新日期:2001-11-01 00:00:00
abstract:PURPOSE OF REVIEW:In the present review we outline the use of different staging methods and highlight future possibilities in the management of testicular germ cell cancer. RECENT FINDINGS:The 5-year survival for testicular cancer has improved dramatically over the past 30 years, with cure rates approaching 95%. This ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200209000-00009
更新日期:2002-09-01 00:00:00
abstract::Approximately 5% of all hypertensive patients have renovascular hypertension, although its true incidence is unknown. The pathophysiology of renovascular hypertension has been linked to other intrarenal systems, the lipoxygenase pathway, and renin angiotensin. Many advances have been made in this field, but emphasis i...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-199903000-00004
更新日期:1999-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Transurethral resection of prostate is the gold standard for the surgical management of benign prostate hyperplasia. Bipolar devices allow transurethral resection of prostate with saline irrigation, which lessens water intoxication and negates the need for diathermy pad and unwanted stimulation of the...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3282f194db
更新日期:2008-01-01 00:00:00
abstract::Urinary tract infection is a common problem in children. The combination of vesico-ureteric reflux (VUR) and urinary tract infection may predispose children to pyelonephritis and subsequent complications. This review outlines the modifications suggested in the recent literature in the protocol for investigations and d...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200011000-00009
更新日期:2000-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Evidence is accumulating to consider erectile dysfunction as a vascular problem. This review focuses on background, pathophysiological mechanisms and clinical evidence of the link between erectile dysfunction and coronary artery disease. RECENT FINDINGS:The link between erectile dysfunction and coron...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200411000-00012
更新日期:2004-11-01 00:00:00
abstract:PURPOSE OF REVIEW:High-risk prostate cancer often represents a lethal disease requiring timely diagnosis and effective therapy. Standardized criteria that define high-risk prostate cancer have yet to be established, rendering the discrimination of high-risk from nonhigh-risk patients a challenge. This review summarizes...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e328361dba6
更新日期:2013-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The role of lymph node dissection (LND) is uncertain for patients diagnosed with renal cell carcinoma (RCC). The aim of the current review is to discuss the available literature considering the role and the impact of LND in RCC patients elected for surgical treatment. Controversies, uncertainties as w...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000312
更新日期:2016-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Functional imaging with PET combined with computed tomography (CT) is of emerging interest in prostate cancer (PCa). Development of prostate-specific membrane antigen (PSMA) radiolabelled ligands has thrust PET/CT into the limelight as an alternative to conventional imaging techniques, and the evidenc...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000677
更新日期:2019-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the treatment options in metastatic renal cell carcinoma (mRCC) in the light of new immunotherapy results. RECENT FINDINGS:Second-line treatment strategies for treatment of mRCC after progression on first-line VEGF-targeted therapy have recently undergone a major change. Treatment guideline...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000456
更新日期:2018-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Despite standard treatment with transurethral resection (TUR) and adjuvant Bacillus Calmette-Guérin (BCG), a large percentage of high-risk bladder cancer (HRBC) recur, and some progress. On the basis of review of the current guidelines and literature, we have developed actualized clinical and molecula...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e328356ac20
更新日期:2012-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Overall survival remains the benchmark in phase III settings of novel agents in castration-resistant metastatic prostate cancer. This review highlights many of the current potential early measures of response and clinical benefit that are worthy of future study and validation in this disease. RECENT ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3282fb7807
更新日期:2008-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Better understanding of renal cell carcinoma biology has led to a new era of targeted therapy in the management of metastatic renal cell carcinoma. This review provides an updated survey of the recently reported and ongoing clinical trials that will help to further define the role of these novel drugs...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32833c86f8
更新日期:2010-09-01 00:00:00
abstract::Recent developments in renal magnetic resonance angiography have led to a significant improvement in the technical success rate and diagnostic accuracy of the methods. Specifically, three-dimensional contrast-enhanced magnetic resonance angiography methods have been shown to provide a more reliable depiction of renal ...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/00042307-199803000-00006
更新日期:1998-03-01 00:00:00
abstract::Techniques that are aimed at regeneration of human tissues and organs (tissue engineering) have recently entered into clinical practice. Tissue engineering is currently among the fastest growing areas in medicine, and involves the application of the principles of biology and engineering to the development of functiona...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200105000-00006
更新日期:2001-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Trimodal therapy (TMT) is considered the most effective bladder-sparing approach for muscle-invasive urothelial carcinoma of the bladder (MIBC) and an alternative to radical cystectomy. The purpose of this article was to review and summarize the current knowledge on the equivalence of TMT and radical ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000203
更新日期:2015-09-01 00:00:00
abstract:PURPOSE OF REVIEW:We summarize the evidence on accurate target definition, precise imaging, and guiding systems that are a necessary ground to targeted focal therapy. RECENT FINDINGS:Accurate target detection is based on the ability of imaging to locate and characterize precisely the tumor burden and differentiation i...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/MOU.0000000000000560
更新日期:2019-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize pathologic features of low-volume, low-risk prostate cancer relevant to the development of patient selection criteria and treatment strategies for focal therapy of prostate cancer, as an alternative to whole-gland radical treatments. RECENT FINDINGS:Prostate cancer characteristically pre...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e328323f62b
更新日期:2009-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The present article reviews the history of mesh-related complications and regulations in SUI and POP repair settings, clinical outcomes associated with the use of biologic and synthetic mesh materials, and novel approaches using modified mesh materials. RECENT FINDINGS:Treatment of pelvic floor disor...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000645
更新日期:2019-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The advantages of the laparoscopic approach in the management of kidney tumors are unequivocal and the role of laparoscopy in nephron-sparing surgery is evolving. In a selected group of patients with small exophytic renal tumors laparoscopic partial nephrectomy became an alternative to open partial ne...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.mou.0000135079.98882.6d
更新日期:2004-07-01 00:00:00
abstract::In the past few years it has been clearly demonstrated that the concept of bacterial biofilm production permits an understanding and provides some explanation of the pathogenesis, diagnosis and treatment of catheter-associated urinary tract infections. This concept describes the colonization of catheter surfaces and t...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200101000-00011
更新日期:2001-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Since the first laparoscopic pediatric nephrectomy was performed in 1992, many articles have reported the feasibility of minimally invasive nephrectomy, heminephrectomy, and nephroureterectomy in children. This article reviews the literature related to minimally invasive nephrectomy, including robot-a...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.mou.0000172404.77514.9c
更新日期:2005-07-01 00:00:00
abstract::The artificial urinary sphincter has been in use for more than 25 years as a treatment for urinary incontinence due to intrinsic sphincter deficiency. Recent clinical studies have increased our knowledge concerning its use in children and in adult patient populations. Particularly, more long-term data and data on the ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200005000-00006
更新日期:2000-05-01 00:00:00
abstract:PURPOSE OF REVIEW:A large number of related articles published within the last year were reviewed. Different types of intracorporeal lithotripter devices were compared according to their advantages, disadvantages, efficacy, safety and clinical applications. General directions of future developments are discussed. RECE...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200305000-00014
更新日期:2003-05-01 00:00:00
abstract:PURPOSE OF REVIEW:With the expanding use of new technology in the treatment of clinically localized prostate cancer (PCa), the financial burden on the healthcare system and the individual has been important. Robotics offer many potential advantages to the surgeon and the patient. We assessed the potential cost-effectiv...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32834d543f
更新日期:2012-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To determine that GreenLight laser therapy is now an established treatment option for men with lower urinary tract symptoms (LUTS) associated with benign prostatic enlargement (BPE). RECENT FINDINGS:The three generations of the GreenLight laser, 80, 120 and 180 W, have been studied for efficacy and s...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000124
更新日期:2015-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Phosphodiesterase 5 (PDE-5) inhibitors are established as first-line therapy in erectile dysfunction. There is emerging evidence that they may have a role in treating patients with lower urinary tract symptoms (LUTS) from benign prostatic hypertrophy. RECENT FINDINGS:All three commonly used PDE-5 inh...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e328316c357
更新日期:2009-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The standard diagnosis of carcinoma in situ (CIS) of the bladder, based on white light cystoscopy and urine cytology, is limited because CIS can vary from normal-appearing mucosa to a lesion indistinguishable from an inflammatory process. Intravesical instillation of Bacillus Calmette-Guerin (BCG) rem...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000758
更新日期:2020-05-01 00:00:00