The challenge of stress incontinence and pelvic organ prolapse: revisiting biologic mesh materials.

Abstract:

PURPOSE OF REVIEW:The present article reviews the history of mesh-related complications and regulations in SUI and POP repair settings, clinical outcomes associated with the use of biologic and synthetic mesh materials, and novel approaches using modified mesh materials. RECENT FINDINGS:Treatment of pelvic floor disorders, such as stress urinary incontinence (SUI) and pelvic organ prolapse (POP) commonly involves implantation of synthetic surgical mesh materials like polypropylene. Many synthetic mesh materials, however, are associated with a foreign body response upon implantation, which is characterized by fibrotic encapsulation. Complications, including erosion, infections, bleeding, and chronic pain, have led to warnings by regulatory agencies and the recall of several mesh products. To mitigate such complications, biologic mesh materials have been proposed as alternatives for SUI and POP repair. SUMMARY:Clinical outcomes of surgical repair of POP/SUI are similar between biologic and synthetic meshes, but biologic meshes have a lower incidence of adverse effects. Several strategies for modifying or functionalizing biological and synthetic meshes have shown promising results in preclinical studies.

journal_name

Curr Opin Urol

authors

D'Angelo W,Dziki J,Badylak SF

doi

10.1097/MOU.0000000000000645

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

437-442

issue

4

eissn

0963-0643

issn

1473-6586

journal_volume

29

pub_type

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