Phosphodiesterase 5 inhibitors in the management of benign prostatic hyperplasia and erectile dysfunction: the best of both worlds.

Abstract:

PURPOSE OF REVIEW:Phosphodiesterase 5 (PDE-5) inhibitors are established as first-line therapy in erectile dysfunction. There is emerging evidence that they may have a role in treating patients with lower urinary tract symptoms (LUTS) from benign prostatic hypertrophy. RECENT FINDINGS:All three commonly used PDE-5 inhibitors (sildenafil, vardenafil and tadalafil) appear to improve LUTS as measured by the International Prostate Symptom Score. However, to date, no change in urinary flow rates have been demonstrated. SUMMARY:Erectile dysfunction and LUTS frequently coexist in men of advancing age. There appears to be an emerging role for PDE-5 inhibitors as a treatment for both conditions. Further studies are required to elicit the exact mechanism of action in LUTS.

journal_name

Curr Opin Urol

authors

Wong P,Lawrentschuk N,Bolton DM

doi

10.1097/MOU.0b013e328316c357

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

7-12

issue

1

eissn

0963-0643

issn

1473-6586

pii

00042307-200901000-00004

journal_volume

19

pub_type

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