Clinical endpoints for drug development in prostate cancer.

abstract：PURPOSE OF REVIEW:The treatment options in urolithiasis in kidneys with abnormalities of form and location can be challenging due to abnormal anatomy (calyceal and renal orientation), relative immobility interfering with movement of equipment, and abnormal relation with other visceral organs. RECENT FINDINGS:In this r...

journal_title：Current opinion in urology

authors： Ganpule AP,Desai MR

更新日期：2011-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Adolescent varicocele is a common lesion which remains poorly understood. Recent research in pathophysiology and surgical management has shed new light on this increasingly diagnosed clinical entity. RECENT FINDINGS:Recent research demonstrates the potential importance of heat and oxidative stress pa...

journal_title：Current opinion in urology

authors： Diamond DA

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Androgen deprivation therapy is the cornerstone treatment for men with de novo or recurrent metastatic prostate cancer. Unfortunately, androgen deprivation therapy is primarily palliative, with nearly all men progressing to an androgen-independent state. Hormone-refractory prostate cancer presents sig...

journal_title：Current opinion in urology

authors： Kasamon KM,Dawson NA

更新日期：2004-05-01 00:00:00

abstract：:Testicular microlithiasis is an uncommon condition that is characterized by calcifications within the lumina of seminiferous tubules. It is usually an incidental finding on high frequency scrotal sonography. Testicular microlithiasis is a benign condition but is associated with testicular malignancies. Recent reports ...

journal_title：Current opinion in urology

authors： Ganem JP

更新日期：2000-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Radical cystectomy with pelvic lymph node dissection (PLND) is the preferred treatment for invasive bladder cancer. It not only results in the best disease-free term survival rates, but also provides the most accurate disease staging and most effective local symptom control. Recent investigations have...

journal_title：Current opinion in urology

authors： Dorin RP,Skinner EC

更新日期：2010-09-01 00:00:00

abstract：:Urinary tract infection is a common problem in children. The combination of vesico-ureteric reflux (VUR) and urinary tract infection may predispose children to pyelonephritis and subsequent complications. This review outlines the modifications suggested in the recent literature in the protocol for investigations and d...

journal_title：Current opinion in urology

authors： Agarwal S

更新日期：2000-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the recent literature on the topic of residual stone fragments in particular novel developments in this field. RECENT FINDINGS:The urological position towards residual fragments has shifted in recent years from observation, to active retrieval with innovative methods, to algorithm-based ...

journal_title：Current opinion in urology

authors： Suarez-Ibarrola R,Hein S,Miernik A

更新日期：2019-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to identify possible reasons why prostate cancer suboptimally responds to immune therapies. RECENT FINDINGS:Interrogation of the intraprostatic milieu suggests that within the normal prostate, foci of tumor can be surrounded by inflammatory cells that may or may not repr...

journal_title：Current opinion in urology

authors： Slovin SF

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Testicular microlithiasis becomes a greater interdisciplinary issue among urologists, andrologists, gynecologists dedicated to reproductive medicine, pediatricians, radiologists and pathologists. Proposed management ranges from benign neglect, instructing self-examination over follow-up once, regular ...

journal_title：Current opinion in urology

authors： Meissner A,Mamoulakis C,de la Rosette JJ,Pes MP

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To understand the molecular mechanisms of bladder carcinogenesis in relation to environmental carcinogens in order to provide a given population with a preventive value of bladder cancer. RECENT FINDINGS:Cigarette smoking, aromatic amines contained in dyes, chronic inflammation due to infection such ...

journal_title：Current opinion in urology

authors： Hirao Y,Kim WJ,Fujimoto K

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The standard diagnosis of carcinoma in situ (CIS) of the bladder, based on white light cystoscopy and urine cytology, is limited because CIS can vary from normal-appearing mucosa to a lesion indistinguishable from an inflammatory process. Intravesical instillation of Bacillus Calmette-Guerin (BCG) rem...

journal_title：Current opinion in urology

authors： Subiela JD,Rodríguez Faba Ó,Guerrero-Ramos F,Aumatell J,Breda A,Palou J

更新日期：2020-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Issues relating to the disease are critical in the diagnosis, management, and prognostication of prostate cancer. RECENT FINDINGS:New data have emerged regarding the disease of prostate cancer and its precursors. The diagnosis of prostate cancer on needle biopsy has been refined because of the recent...

journal_title：Current opinion in urology

authors： Epstein JI

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Radical cystectomy and urinary diversion is the accepted standard of care for invasive bladder cancer. Although orthotopic neobladder is the preferred method of urinary diversion in men, less experience is available for women. Recent studies and reports on this subject are summarized and reviewed. RE...

journal_title：Current opinion in urology

authors： Kübler H,Gschwend JE

更新日期：2011-11-01 00:00:00

abstract：:Pharmacotherapy for men experiencing erectile dysfunction has undergone dramatic advances over the past 5 years with the introduction of an effective oral agent. Sildenafil has increased the pool of couples seeking treatment for this important health issue as well as expanding the numbers of physicians treating it. Re...

journal_title：Current opinion in urology

authors： Brock GB,Bochinski D

更新日期：2001-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Robotic assisted simple prostatectomy (RASP) represents a minimally invasive evolution of traditional open simple prostatectomy for the surgical treatment of severe lower urinary tract symptoms (LUTS) because of benign prostatic enlargement (BPE). Aim of the present review is to summarize the most rec...

journal_title：Current opinion in urology

authors： Vince R,Hampton LJ,Vartolomei MD,Shariat SF,Porpiglia F,Autorino R

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Minimally invasive options to treat low-risk prostate cancer are more desirable than radical therapy. Technological improvements in cryotherapy have increased its use, and long-term data on its efficacy are emerging. In this review, we discuss contemporary data on cryotherapy with specific focus on st...

journal_title：Current opinion in urology

authors： Ritch CR,Katz AE

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe mechanisms behind and extent of overdetection in prostate cancer screening as well as possible ways to avoid unnecessary overdiagnosis. RECENT FINDINGS:Overdetection and overtreatment is common in many areas of modern medicine. Current prostate-specific antigen (PSA) testing has resulted ...

journal_title：Current opinion in urology

authors： Hugosson J,Carlsson S

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will summarize the most recent preclinical data from the leading US laboratories regarding the application of gene therapy to the treatment of erectile dysfunction. The implications of these findings in the field of gene therapy in general, and more specifically to the treatment of non-lif...

journal_title：Current opinion in urology

authors： Christ GJ

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Extracorporeal shock wave lithotripsy (ESWL) is the preferred modality for the treatment of renal and upper ureteric calculi. The present review focuses on the limitations of ESWL, where recent developments have tried to identify patients who are unlikely to succeed with ESWL and where improvements in...

journal_title：Current opinion in urology

authors： Madaan S,Joyce AD

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Overdiagnosis has become a major problem in medicine in general and cancer in particular. This is a summary of this problem. RECENT FINDINGS:Because of earlier detection, the nature of cancer has changed, from a disease usually diagnosed at a late and incurable stage to a heterogeneous condition that...

journal_title：Current opinion in urology

authors： Klotz L

更新日期：2012-05-01 00:00:00

abstract：:Since Sternberg et al. in 1985 first published preliminary results of polychemotherapy in patients with metastatic bladder cancer, it became apparent that transitional carcinoma of the bladder is highly responsive to chemotherapy. Response rates up to 70% with combination therapy regimens like methotrexate, vinblastin...

journal_title：Current opinion in urology

authors： Schultz-Lampel D,Lampel A

更新日期：1999-09-01 00:00:00

abstract：:'Lower urinary tract symptoms' is a term that describes symptoms related to both the storage and emptying phases of the micturition cycle. Storage symptoms include urinary frequency urgency, urge incontinence, nocturia, dysuria and other kinds of pain emanating from the bladder or urethra. Emptying symptoms consist of...

journal_title：Current opinion in urology

authors： Chaikin DC,Blaivas JG

更新日期：2001-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Partial nephrectomy has become the standard of treatment for renal tumors less than 4 cm in size. Recent reports have even applied this technique for T1b lesions as well. With advancement in minimally invasive techniques, laparoscopic and robotic surgeries are performed with the advantage of decreased...

journal_title：Current opinion in urology

authors： Hsieh TC,Jarrett TW,Pinto PA

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The objective of this article is to examine the safety of prostate biopsy and discuss the emerging role of MRI-ultrasound fusion technology in improving diagnostic accuracy. RECENT FINDINGS:Men undergoing prostate biopsy frequently experience minor complications, including hematospermia, hematuria, a...

journal_title：Current opinion in urology

authors： Jones TA,Radtke JP,Hadaschik B,Marks LS

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Partial nephrectomy provides equivalent long-term oncologic and superior functional outcomes as radical nephrectomy for T1a renal masses. Herein, we review the various vascular clamping techniques employed during minimally invasive partial nephrectomy, describe the evolution of our partial nephrectomy...

journal_title：Current opinion in urology

authors： Azhar RA,Metcalfe C,Gill IS

更新日期：2015-03-01 00:00:00

abstract：:Recent developments in renal magnetic resonance angiography have led to a significant improvement in the technical success rate and diagnostic accuracy of the methods. Specifically, three-dimensional contrast-enhanced magnetic resonance angiography methods have been shown to provide a more reliable depiction of renal ...

journal_title：Current opinion in urology

authors： Grist TM

更新日期：1998-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This article discusses enucleation and vaporization procedures which have been developed on the surgical techniques of holmium laser enucleation of the prostate (HoLEP) and photoselective vaporization of the prostate (PVP) by reviewing the most recent publications. RECENT FINDINGS:Enucleation procedu...

journal_title：Current opinion in urology

authors： Netsch C,Bach T

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Underactive bladder (UAB) is a clinical symptom complex only recently gaining recognition as a clinical diagnosis. Lack of consensus agreement on a definition of UAB has limited its recognition and diagnosis in clinical practice. The purposes of this review are to: present existing definitions of UAB,...

journal_title：Current opinion in urology

authors： Cohn JA,Brown ET,Kaufman MR,Dmochowski RR,Reynolds WS

更新日期：2016-07-01 00:00:00

abstract：:Data are reviewed relating to the safety and efficacy of minimally invasive transurethral microwave thermotherapy and medical management in patients with lower urinary tract symptoms of benign prostatic hyperplasia. Recent evidence is summarized indicating more pronounced long-term beneficial effects of microwave trea...

journal_title：Current opinion in urology

authors： Djavan B,Marberger M

更新日期：2001-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Benign prostatic hyperplasia is the most common human neoplasm and it is the most frequent tumour requiring surgical treatment in men. Not surprisingly, interest centres on either understanding of prostatic growth during ageing or on various medical or interventional treatments. RECENT FINDINGS:Recen...

journal_title：Current opinion in urology

authors： Klingler HC

更新日期：2003-01-01 00:00:00