Prostate-specific membrane antigen PET/computed tomography for staging prostate cancer.

Abstract:

PURPOSE OF REVIEW:Molecular imaging with PET/CT targeting the prostate-specific membrane antigen (PSMA) receptor is increasingly utilized in men with prostate cancer (PCa), with clinical indications now expanding beyond biochemical recurrence. PSMA PET/CT often detects sub-centimetre size pathologic nodes and low-volume bone marrow disease that are occult on conventional imaging when the lesion does not cause sclerosis or osteoblastic reaction in surrounding bone. This review focuses on recent evidence for PSMA PET/CT in initial disease staging. RECENT FINDINGS:Several recent studies including a large randomized trial have evaluated the clinical impact of PSMA PET/CT in initial staging of PCa. PSMA PET/CT is more sensitive and accurate than the conventional imaging standard of CT and bone scan. Change in treatment plan or modality of therapy occurs frequently when PSMA PET/CT forms part of the diagnostic algorithm. Hybrid PET/MRI also has potential utility, particularly in evaluating pelvic disease, but evidence base remains very limited. SUMMARY:PSMA PET/CT has emerged as a new standard in primary staging of PCa. Reimbursement by national funding bodies and incorporation into international clinical guidelines is anticipated within the next few years.

journal_name

Curr Opin Urol

authors

Ravi Kumar AS,Lawrentschuk N,Hofman MS

doi

10.1097/MOU.0000000000000799

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

628-634

issue

5

eissn

0963-0643

issn

1473-6586

journal_volume

30

pub_type

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