Current strategies for first and second line intravesical therapy for nonmuscle invasive bladder cancer.

Abstract:

PURPOSE OF REVIEW:Nonmuscle invasive bladder cancer is a common malignancy, usually treated by transurethral resection and adjuvant intravesical instillations of chemotherapy or immunotherapy. Appropriate adjuvant treatment can be selected based on several prognostic factors that determine risk for recurrence or progression. We discuss options for first-line and second-line adjuvant therapy for nonmuscle invasive bladder cancer. RECENT FINDINGS:Mitomycin-C and epirubicin are the mostly used adjuvant chemotherapeutic drugs for tumours of low and intermediate risk. Bacillus Calmette-Guérin remains first-choice therapy in high-risk nonmuscle invasive bladder cancer. Gemcitabine and apaziquone are especially promising for treatment of intermediate risk nonmuscle invasive bladder cancer but require further study. Device-assisted therapies, such as thermochemotherapy and electromotive drug administration, have yielded good results in high-risk nonmuscle invasive bladder cancer and could be considered second-line therapy in this setting. SUMMARY:Primary problems in nonmuscle invasive bladder cancer are its tendency to recur and its elusiveness (especially high-risk nonmuscle invasive bladder cancer) of progression to muscle invasive disease. First-line adjuvant therapies are well established but suboptimal. Some second-line therapies are promising but should be used cautiously, because in some patients the best option is not always the conservative one.

journal_name

Curr Opin Urol

authors

Hendricksen K,Witjes JA

doi

10.1097/MOU.0b013e3281c55f2b

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

352-7

issue

5

eissn

0963-0643

issn

1473-6586

pii

00042307-200709000-00012

journal_volume

17

pub_type

杂志文章,评审
  • Overdetection in screening for prostate cancer.

    abstract:PURPOSE OF REVIEW:To describe mechanisms behind and extent of overdetection in prostate cancer screening as well as possible ways to avoid unnecessary overdiagnosis. RECENT FINDINGS:Overdetection and overtreatment is common in many areas of modern medicine. Current prostate-specific antigen (PSA) testing has resulted ...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0000000000000054

    authors: Hugosson J,Carlsson S

    更新日期:2014-05-01 00:00:00

  • Prediction of shockwave failure in patients with urinary tract stones.

    abstract:PURPOSE OF REVIEW:To evaluate recent developments in predicting the failure of shockwave lithotripsy when treating patients with urinary tract stones. RECENT FINDINGS:Although the features of patients with stones, as well as of the stones themselves, associated with refractoriness to shockwave lithotripsy are fairly w...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mou.0000193373.22318.68

    authors: Kim FJ,Rice KR

    更新日期:2006-03-01 00:00:00

  • Concept and design engineering: endourology operating room.

    abstract:PURPOSE OF REVIEW:A dedicated operating room with fluoroscopic imaging capability and adequate data connectivity is important to the success of any endourology program. Proper understanding of the recent developments in technology in relation to operating room is necessary before planning an endourology operating room....

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e32835d3133

    authors: Sabnis R,Ganesamoni R,Mishra S,Sinha L,Desai MR

    更新日期:2013-03-01 00:00:00

  • Current status of robotic partial nephrectomy.

    abstract:PURPOSE OF REVIEW:In recent years, robotic partial nephrectomy has emerged as a technique for treatment of small renal masses alongside laparoscopic and open partial nephrectomy. Since this technique is still in a phase of adoption, many technical improvements, alterations and early experiences are published. We aim to...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e32833c7af0

    authors: Van Haute W,Gavazzi A,Dasgupta P

    更新日期:2010-09-01 00:00:00

  • Proteomics in prostate cancer.

    abstract:PURPOSE OF REVIEW:State-of-the-art proteomics technologies are currently being assessed for utility in the study of prostatic malignancy. This review aims to provide background information on the current proteomics techniques employed in prostate cancer research, recent reports showing the potential application of prot...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mou.0000165547.48922.12

    authors: Bañez LL,Srivastava S,Moul JW

    更新日期:2005-05-01 00:00:00

  • Ureteroscopic lithotripsy.

    abstract::The indications for ureteroscopic lithotripsy have increased with endoscope miniaturization and powerful, precise endoscopic lithotrites like the holmium: yttrium-aluminum-garnet laser. Successful ureteropyeloscopic treatment with the currently available instrumentation and techniques is independent of the size, compo...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/00042307-199907000-00010

    authors: Grasso M 3rd

    更新日期:1999-07-01 00:00:00

  • Neurogenic voiding dysfunction.

    abstract:PURPOSE OF REVIEW:This review aims to analyze and discuss all recently published articles associated with neurogenic voiding discussion providing readers with the most updated knowledge and trigger for further research. RECENT FINDINGS:They include the proposal of a novel classification system for the pathophysiology ...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0000000000000392

    authors: Georgopoulos P,Apostolidis A

    更新日期:2017-05-01 00:00:00

  • Voiding dysfunction: definitions.

    abstract::'Lower urinary tract symptoms' is a term that describes symptoms related to both the storage and emptying phases of the micturition cycle. Storage symptoms include urinary frequency urgency, urge incontinence, nocturia, dysuria and other kinds of pain emanating from the bladder or urethra. Emptying symptoms consist of...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/00042307-200107000-00010

    authors: Chaikin DC,Blaivas JG

    更新日期:2001-07-01 00:00:00

  • Testicular microlithiasis.

    abstract::Testicular microlithiasis is an uncommon condition that is characterized by calcifications within the lumina of seminiferous tubules. It is usually an incidental finding on high frequency scrotal sonography. Testicular microlithiasis is a benign condition but is associated with testicular malignancies. Recent reports ...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/00042307-200003000-00009

    authors: Ganem JP

    更新日期:2000-03-01 00:00:00

  • Should we train urologists in female urology? A European view.

    abstract:PURPOSE OF REVIEW:Training in female urology in Europe so far has been a national focus of individual European countries. Because of reasons like differentiation in pathology, activities of other specialisms like gynaecology and reimbursement issues, the way in which extra training in female urology is organized varies...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e32832ae1a4

    authors: Heesakkers JP,Costantini E,Oelke M

    更新日期:2009-07-01 00:00:00

  • Catheter-associated urinary tract infections.

    abstract::In the past few years it has been clearly demonstrated that the concept of bacterial biofilm production permits an understanding and provides some explanation of the pathogenesis, diagnosis and treatment of catheter-associated urinary tract infections. This concept describes the colonization of catheter surfaces and t...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/00042307-200101000-00011

    authors: Liedl B

    更新日期:2001-01-01 00:00:00

  • Urethral pathology.

    abstract::In the present review the eligible data on urethral pathologies are critically analysed, with special attention given to unresolved controversies in this topic. The entities discussed are as follows: female circumcision as a ritualistic tradition, with many associated complications; prostatourethritis and urethral syn...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/00042307-200009000-00004

    authors: El-Mekresh M

    更新日期:2000-09-01 00:00:00

  • Medical treatment of urinary stones.

    abstract:PURPOSE OF REVIEW:To identify the latest progression on medical treatment of urinary stones. RECENT FINDINGS:Nonsteroidal anti-inflammatory drugs should be the preferred analgesic option for patients presenting to the emergency department with renal colic. A-blockers could be of patient benefit when used for distal ur...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0000000000000523

    authors: Skolarikos A

    更新日期:2018-09-01 00:00:00

  • Imaging for urolithiasis: standards, trends, and radiation exposure.

    abstract:PURPOSE OF REVIEW:To discuss current trends in imaging for urolithiasis and review the recent scientific literature surrounding this topic. Specifically, to address the efforts urologist should be making to reduce the use of ionizing radiation and to examine alternatives to computerized tomography (CT) scan in diagnosi...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0000000000000241

    authors: Lipkin M,Ackerman A

    更新日期:2016-01-01 00:00:00

  • Evaluation of obstructed voiding in the female: how close are we to a definition?

    abstract:PURPOSE OF REVIEW:The difficulties of defining and evaluating bladder outlet obstruction (BOO) in the female patient have been described for several years. This review aims to examine recent literature to summarize progress in the area. RECENT FINDINGS:Within the last 2 years, functional causes of female BOO have been...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0000000000000182

    authors: Gammie A,Kirschner-Hermanns R,Rademakers K

    更新日期:2015-07-01 00:00:00

  • Surgery for urogenital rhabdomyosarcoma.

    abstract::The treatment and prognosis of rhabdomyosarcoma of the urogenital tract have changed dramatically over the past few decades. Until the 1970s radical cystectomy and pelvic exenteration were the only therapeutic options in rhabdomyosarcoma of the bladder/prostate and of the vagina/uterus. Since then, multiagent chemothe...

    journal_title:Current opinion in urology

    pub_type: 社论,评审

    doi:10.1097/00042307-200111000-00001

    authors: Filipas D

    更新日期:2001-11-01 00:00:00

  • The role of prostate-specific membrane antigen PET/computed tomography in primary staging of prostate cancer.

    abstract:PURPOSE OF REVIEW:Functional imaging with PET combined with computed tomography (CT) is of emerging interest in prostate cancer (PCa). Development of prostate-specific membrane antigen (PSMA) radiolabelled ligands has thrust PET/CT into the limelight as an alternative to conventional imaging techniques, and the evidenc...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0000000000000677

    authors: Koschel S,Murphy DG,Hofman MS,Wong LM

    更新日期:2019-11-01 00:00:00

  • Is robotic sacrocolpopexy a marketing gimmick or a technological advancement?

    abstract:PURPOSE OF REVIEW:Robot-assisted laparoscopic sacrocolpopexy (RALS) is a new surgical technique for the treatment of symptomatic vaginal vault prolapse that is rapidly gaining popularity among both urologists and gynecologists. This article will summarize the available published data to assess the potential advantages ...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e32833aaa2b

    authors: Kim JH,Anger JT

    更新日期:2010-07-01 00:00:00

  • Improving quality through clinical registries in urology.

    abstract:PURPOSE OF REVIEW:In this review, we highlight the use of clinical registries for quality improvement and research purposes in urology. We focus on national and regional clinical database registries, such as the National Surgical Quality Improvement Programme, the Cancer of the Prostate Strategic Urologic Research Ende...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0000000000000406

    authors: Tyson MD,Barocas DA

    更新日期:2017-07-01 00:00:00

  • Alternative methods for management of prostatic outflow obstruction.

    abstract::During the past year no new therapies for prostatic outflow obstruction were introduced. Instead, research focused on refinement of treatments previously available. Further reports on the efficacy and safety of alpha 1-adrenergic receptor subtype selective agents have appeared. The long-term effects of finasteride on ...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/00042307-199901000-00007

    authors: Donatucci CF

    更新日期:1999-01-01 00:00:00

  • The devastated bladder outlet: treatment options.

    abstract:PURPOSE OF REVIEW:The purpose of this study is to review and discuss recently published studies of therapeutic options in cases with the combination of severe sphincteric damage and recurrent stricture of the bladder neck or anastomosis in patients with postradical prostatectomy. RECENT FINDINGS:Recent focus has been ...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0000000000000185

    authors: Riedmiller H,Kocot A

    更新日期:2015-07-01 00:00:00

  • Clinical implications of genitourinary embryology.

    abstract:PURPOSE OF REVIEW:This review focuses on recent advances in molecular embryology of the upper and lower urinary tract with an emphasis on clinical correlation in order to gain a better understanding for the mechanism of congenital anomalies. RECENT FINDINGS:Normal morphogenesis of the kidney, ureteral bud differentiat...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e32832c90ff

    authors: Shapiro E

    更新日期:2009-07-01 00:00:00

  • Intracorporeal lithotripsy: which modality is best?

    abstract:PURPOSE OF REVIEW:A large number of related articles published within the last year were reviewed. Different types of intracorporeal lithotripter devices were compared according to their advantages, disadvantages, efficacy, safety and clinical applications. General directions of future developments are discussed. RECE...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/00042307-200305000-00014

    authors: Leveillee RJ,Lobik L

    更新日期:2003-05-01 00:00:00

  • Robotic inferior vena cava thrombus surgery: novel strategies.

    abstract:PURPOSE OF REVIEW:Kidney cancer is associated with renal vein or inferior vena cava (IVC) thrombus in up to 10% of cases. The management of these cases is complex, and thus typically performed open surgically. At selected institutions, the robotic approach is being explored. We review the literature on robotic IVC surg...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0000000000000033

    authors: Sun Y,de Castro Abreu AL,Gill IS

    更新日期:2014-03-01 00:00:00

  • Robotic assisted simple prostatectomy: recent advances.

    abstract:PURPOSE OF REVIEW:Robotic assisted simple prostatectomy (RASP) represents a minimally invasive evolution of traditional open simple prostatectomy for the surgical treatment of severe lower urinary tract symptoms (LUTS) because of benign prostatic enlargement (BPE). Aim of the present review is to summarize the most rec...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0000000000000499

    authors: Vince R,Hampton LJ,Vartolomei MD,Shariat SF,Porpiglia F,Autorino R

    更新日期:2018-05-01 00:00:00

  • The prognostic value of hematological and systemic inflammatory disorders in invasive bladder cancer.

    abstract:PURPOSE OF REVIEW:In contrast to the large amount of evidence reporting on the oncological significance of various clinicopathological and molecular parameters for survival in invasive bladder cancer, alterations of preoperative hematological and systemic inflammatory parameters have not been sufficiently addressed in ...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e32834966fa

    authors: Gakis G,Todenhöfer T,Stenzl A

    更新日期:2011-09-01 00:00:00

  • Ileal neobladder in women with bladder cancer: cancer control and functional aspects.

    abstract:PURPOSE OF REVIEW:Radical cystectomy and urinary diversion is the accepted standard of care for invasive bladder cancer. Although orthotopic neobladder is the preferred method of urinary diversion in men, less experience is available for women. Recent studies and reports on this subject are summarized and reviewed. RE...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e32834b31c4

    authors: Kübler H,Gschwend JE

    更新日期:2011-11-01 00:00:00

  • Integrating basic science and clinical research in bladder cancer: update from the first bladder Specialized Program of Research Excellence (SPORE).

    abstract:PURPOSE OF REVIEW:To review the progress of the genitourinary SPORE (Specialized Program of Research Excellence) in bladder cancer. RECENT FINDINGS:The optimal management of bladder cancer depends on the accurate assessment of the biological potential of the disease. Methotrexate, vincristine, adriamycin and cisplatin...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/00042307-200409000-00008

    authors: Highshaw RA,McConkey DJ,Dinney CP

    更新日期:2004-09-01 00:00:00

  • Applications of spectroscopy in diagnosis, staging, and treatment of urologic malignancies.

    abstract:PURPOSE OF REVIEW:To review the scientific literature on clinical applications of spectroscopy within urologic oncology. Specifically, we address the role of spectroscopy as a novel intraoperative or intraprocedural modality for the management of urothelial carcinoma, renal cell carcinoma, and prostate adenocarcinoma. ...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0000000000000281

    authors: Seltz LM,Herrell SD

    更新日期:2016-05-01 00:00:00

  • Targeted focal therapy for prostate cancer: a review.

    abstract:PURPOSE OF REVIEW:Prostate cancer screening has shifted the diagnosis of prostate cancer to lower grade, organ confined disease. Radical prostatectomy or radiation therapy has been shown to be overtreatment in 30% of patients. In this review, we will discuss targeted focal therapy (TFT) using the modalities of cryother...

    journal_title:Current opinion in urology

    pub_type: 杂志文章,评审

    doi:10.1097/MOU.0b013e32832a2c4a

    authors: Hou AH,Sullivan KF,Crawford ED

    更新日期:2009-05-01 00:00:00