Prostate cancer prevention with 5-alpha reductase inhibitors: concepts and controversies.

Abstract:

PURPOSE OF REVIEW:We review the concepts surrounding prostate cancer prevention strategies with 5-alpha reductase inhibitors (5-ARIs) and the controversies associated with their use. RECENT FINDINGS:Updated data have shown no increased risk of death from the diagnosis of higher risk cancer; however, 5-ARIs remain controversial and not approved for prostate cancer prevention. SUMMARY:The main theme of the review identifies the success of reducing insignificant prostate cancer and the controversy with the increased association of higher risk prostate cancer by approximately 20%. The reduction was shown to be most significant reduction in low-grade prostate cancer. The initial concern about 5-ARI use was that it could potentially increase high-risk prostate cancer leading to higher mortality in those men. Higher mortality has not been seen in follow-up data; however, 5-ARIs continue to have a black box warning and are not approved for prostate cancer prevention.

journal_name

Curr Opin Urol

authors

Liss MA,Thompson IM

doi

10.1097/MOU.0000000000000464

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

42-45

issue

1

eissn

0963-0643

issn

1473-6586

journal_volume

28

pub_type

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