Epidemiology and aetiology of encephalitis in Canada, 1994-2008: a case for undiagnosed arboviral agents?

Abstract:

:Encephalitis is a clinical syndrome often associated with infectious agents. This study describes the epidemiology and disease burden associated with encephalitis in Canada and explores possible associations with arboviral causes. Encephalitis-associated hospitalizations, 1994-2008, were analysed according to aetiological category (based on ICD-9/ICD-10 codes) and other factors using multivariate logistic regression for grouped (blocked) data and negative binomial regression. A discrete Poisson model tested spatio-temporal clustering of hospitalizations associated with unclassified and arboviral encephalitis aetiologies. Encephalitis accounted for an estimated 24028 hospitalizations in Canada (5·2/100 000 population) and unknown aetiologies represented 50% of these hospitalizations. In 2003, clusters of unclassified encephalitis were identified in the summer and early autumn months signifying potential underlying arboviral aetiologies. Spatio-temporal patterns in encephalitis hospitalizations may help us to better understand the disease burden associated with arboviruses and other zoonotic pathogens in Canada and to develop appropriate surveillance systems.

journal_name

Epidemiol Infect

authors

Kulkarni MA,Lecocq AC,Artsob H,Drebot MA,Ogden NH

doi

10.1017/S095026881200252X

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

2243-55

issue

11

eissn

0950-2688

issn

1469-4409

pii

S095026881200252X

journal_volume

141

pub_type

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