Abstract:
:Seasonal influenza virus epidemics have a major impact on healthcare systems. Data on population susceptibility to emerging influenza virus strains during the interepidemic period can guide planning for resource allocation of an upcoming influenza season. This study sought to assess the population susceptibility to representative emerging influenza virus strains collected during the interepidemic period. The microneutralisation antibody titers (MN titers) of a human serum panel against representative emerging influenza strains collected during the interepidemic period before the 2018/2019 winter influenza season (H1N1-inter and H3N2-inter) were compared with those against influenza strains representative of previous epidemics (H1N1-pre and H3N2-pre). A multifaceted approach, incorporating both genetic and antigenic data, was used in selecting these representative influenza virus strains for the MN assay. A significantly higher proportion of individuals had a ⩾four-fold reduction in MN titers between H1N1-inter and H1N1-pre than that between H3N2-inter and H3N2-pre (28.5% (127/445) vs. 4.9% (22/445), P < 0.001). The geometric mean titer (GMT) of H1N1-inter was significantly lower than that of H1N1-pre (381 (95% CI 339-428) vs. 713 (95% CI 641-792), P < 0.001), while there was no significant difference in the GMT between H3N2-inter and H3N2-pre. Since A(H1N1) predominated the 2018-2019 winter influenza epidemic, our results corroborated the epidemic subtype.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Chen LL,Wu WL,Chan WM,Fong CHY,Ng ACK,Ip JD,Lu L,Dissanayake TK,Ding X,Cai JP,Zhang AJX,Tam S,Hung IFN,Chan KH,Yuen KY,To KKWdoi
10.1017/S0950268819001717subject
Has Abstractpub_date
2019-09-26 00:00:00pages
e279eissn
0950-2688issn
1469-4409pii
S0950268819001717journal_volume
147pub_type
杂志文章abstract::Herpes simplex virus (HSV) is one of the most commonly identified infectious aetiologies of encephalitis in North America and Europe. The epidemiology of encephalitis beyond these regions, however, is poorly defined. During 2009-2012 we enrolled 313 patients in a multicentre prospective study of encephalitis in Peru, ...
journal_title:Epidemiology and infection
pub_type: 杂志文章,多中心研究
doi:10.1017/S0950268815003222
更新日期:2016-06-01 00:00:00
abstract::We examined the prevalence, correlates and trends of H. pylori infection in Israel using residual sera obtained in 2007-2008 from 1466 Jewish subjects aged 0-77 years and 897 Arabs aged 0-19 years, and in 2000-2001 from 627 Jewish and 575 Arab subjects aged 0-19 years. H. pylori IgG antibodies were measured by ELISA. ...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268811002081
更新日期:2012-07-01 00:00:00
abstract::False-positive serological reactions (FPSR) due to infections with Yersinia enterocolitica serotype Oratio9 (YeOratio9) are a problem in tests for brucellosis. In the present study, FPSR in classical and novel tests for brucellosis following experimental infections of pigs with YeOratio9 were compared with responses o...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S095026880500511X
更新日期:2006-04-01 00:00:00
abstract::This study aimed to estimate the natural history and transmission parameters based on experimental viral shedding and symptom dynamics in order to understand the key epidemiological factors that characterize influenza (sub)type epidemics. A simple statistical algorithm was developed by combining a well-defined mathema...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268809991178
更新日期:2010-06-01 00:00:00
abstract::In contrast to bacteraemic pneumococcal community-acquired pneumonia (CAP), there is a paucity of data on the clinical characteristics and outcomes of non-bacteraemic pneumococcal CAP. This retrospective study compared the outcome of hospitalized patients with bacteraemic and non-bacteraemic pneumococcal CAP treated a...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268810002402
更新日期:2011-09-01 00:00:00
abstract::Studying the epidemiology of pertussis and impact of differing vaccine schedules is difficult because of differing methods of case ascertainment. The advent of internationally standardized serological diagnosis for recent infection has allowed comparison of age-specific pertussis infection among European countries and...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S095026880600625X
更新日期:2006-12-01 00:00:00
abstract::Using the dengue surveillance program, we prospectively collected data on all the suspected and confirmed cases of dengue in Barbados from 2006 to 2015. Data were analysed for demographic, seasonal and temporal dynamics of this disease in this country. The overall mean annual incidence rate of suspected and confirmed ...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268818000900
更新日期:2018-06-01 00:00:00
abstract::West Nile virus (WNV) is now endemic in the USA. After the widespread surge of virus activity across the USA, research has flourished, and our knowledge base has significantly expanded over the past 10 years since WNV was first recognized in New York City. This article provides a review of the virology of WNV, history...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268811000185
更新日期:2011-06-01 00:00:00
abstract::The screening of 2000 women of childbearing age in Cork between 2004 and 2006 produced 37 erythromycin-resistant group B streptococcus (GBS) isolates. PCR analysis was performed to determine the basis for erythromycin resistance. The ermTR gene was most frequently expressed (n = 19), followed by the ermB gene (n = 8)....
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268809990392
更新日期:2010-02-01 00:00:00
abstract::Annual overviews of waterborne disease outbreaks associated with untreated recreational water use provided by authorities responsible for bathing-water quality and public health in The Netherlands revealed 742 outbreaks during 1991-2007 mainly comprising of skin conditions (48%) and gastroenteritis (31%) and involving...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268810002347
更新日期:2011-07-01 00:00:00
abstract::Twenty progesterone-treated TO mice were infected intravaginally with Mycoplasma pulmonis. One month later, ten of the mice were given oestradiol which changed the reproductive cycle to the oestrous phase and within a week resulted in eradication of the organisms from six of them; vaginal persistence in the other mice...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268800047749
更新日期:1990-08-01 00:00:00
abstract::We investigated the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) carriage in a convenience sample of purposely selected populations of dogs, cats and horses in the Greater London area. Swabs from carriage sites were pooled, enriched and processed by standard bacteriological methods. The presence of...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S095026881000227X
更新日期:2011-07-01 00:00:00
abstract::An epidemiological model was developed for rabies, linking the risk of disease in a secondary species (cats) to the temporal dynamics of disease in a wildlife reservoir (raccoons). Data were obtained from cats, raccoons, and skunks tested for rabies in the northeastern United States during 1992-2000. An epizootic algo...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268804002067
更新日期:2004-06-01 00:00:00
abstract::Human cytomegalovirus (CMV) is a common herpesvirus establishing lifelong persisting infection, which has been implicated in immunosenescence and mortality in the elderly. Little is known about how and when susceptibility to CMV infection is determined. We measured CMV seroprevalence in two genetically informative coh...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268811001397
更新日期:2012-05-01 00:00:00
abstract::The notification rate of Legionnaires' disease (LD) in France was 2.4/100 000 population in 2010, varying across regions with an increasing rate from west to east. Two sources [mandatory notifications (MN) and a survey of hospital laboratories] were used in a capture-recapture study to estimate the number of LD cases ...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268813000502
更新日期:2013-12-01 00:00:00
abstract::This study investigated the extent to which proximity to cattle and weather events in Alberta predispose human populations to E. coli O157 disease. Cases of human E. coli O157 infection in Alberta between 2004 and 2011 were obtained from the province's Communicable Disease Reporting System and Discharge Abstract Datab...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268813002781
更新日期:2014-11-01 00:00:00
abstract::This study aimed to examine trends in incidence, geographical distribution, and survival of classic and AIDS-related Kaposi's sarcoma (KS) in the general US population using Surveillance, Epidemiology, and End Results (SEER) tumour registries with 12 066 patients diagnosed with KS between 1975 and 2005. Although the a...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268812000325
更新日期:2013-01-01 00:00:00
abstract::A retrospective cohort study was conducted from 1 January 2006 to 31 December 2009 in Michigan to estimate the prevalence of HIV and hepatitis co-infection and identify associated factors. The prevalence of co-infection was 4.1% [95% confidence interval (CI) 3.8-4.5]. Multivariable logistic regression analysis reveale...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268813000538
更新日期:2013-12-01 00:00:00
abstract::Fifty-four isolates of Salmonella enterica subsp. diarizonae (IIIb) in Norway, Sweden, England, the United States, France and Australia were characterized by pulsed-field gel electrophoresis (PFGE). This study focuses on serovar 61:k:1,5,(7) [S. IIIb 61:k:1,5,(7)] isolated from sheep. Digestion of the bacterial DNA wi...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268803001717
更新日期:2004-04-01 00:00:00
abstract::This article examines the evaluation of a bancroftian filariasis control programme undertaken in Pondicherry from 1981-5. Integrated vector management was applied in one half of the town, and routine operations under the national programme (larviciding and chemotherapy) continued in the comparison area. The programme ...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268800031095
更新日期:1989-12-01 00:00:00
abstract::There is concern that widespread usage of ertapenem may promote cross-resistance to other carbapenems. To analyse the impact that adding ertapenem to our hospital formulary had on usage of other broad-spectrum agents and on susceptibilities of nosocomial Enterobacteriaceae and Pseudomonas isolates, we performed interr...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268811000082
更新日期:2012-01-01 00:00:00
abstract::We describe here an examination of the validity of molecular types of Campylobacter jejuni as defined by separation of SmaI-digested DNA using pulsed-field gel electrophoresis (PFGE), recently suggested as part of a molecular subtyping scheme. Thirty-four Danish strains from humans, water, poultry and cattle were assi...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268898008668
更新日期:1998-06-01 00:00:00
abstract::Multiple introductions of methicillin-resistant Staphylococcus aureus (MRSA) strains occurred to a new hospital in Hong Kong. Two years of clinical microbiological surveillance of the resulting outbreaks was combined with laboratory investigation by phage and antibiogram typing, and plasmid profiling. The outbreaks on...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268800047828
更新日期:1990-10-01 00:00:00
abstract::The minimum inhibitory concentration (MIC) of five antibiotics and the presence of resistance genes was determined in 163 Haemophilus influenzae isolates collected over 13 years (1987-2000) in four two-yearly sampling periods from patients with respiratory tract infections. The prevalence of beta-lactamase-negative am...
journal_title:Epidemiology and infection
pub_type: 临床试验,杂志文章
doi:10.1017/S0950268806007023
更新日期:2007-05-01 00:00:00
abstract::Although Lyme borreliosis is increasingly diagnosed in the United Kingdom, few systematic studies have been performed there. UK data suggest that the commonest complications are neurological, but inadequate information exists about their nature and the incidence of late neuroborreliosis. Local data are necessary becau...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268808000472
更新日期:2008-12-01 00:00:00
abstract::Ribotype, biotype and resistance phenotype were used to characterize 37 Acinetobacter baumannii-A. calcoaceticus complex isolates responsible for nosocomial infections in Buenos Aires. Nineteen isolates were recovered from endemic infections at 2 hospitals and 18 represent an intensive care unit outbreak that occurred...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268800051979
更新日期:1995-02-01 00:00:00
abstract::The spread of COVID-19 is recent in India, which has within 4 months caused over 190 000 infections, as of 1 June 2020, despite four stringent lockdowns. With the current rate of the disease transmission in India, which is home to over 1.35 billion people, the infection spread is predicted to be worse than the USA in ...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268820001776
更新日期:2020-08-11 00:00:00
abstract::To determine the extent age, sex and co-infection affect morbidity in people infected with hepatitis C virus (HCV), we performed a population-based study linking HCV notifications in New South Wales, Australia with their hospital (July 2000 to June 2006), hepatitis B virus (HBV) and HIV notification, and death records...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S095026881000258X
更新日期:2011-08-01 00:00:00
abstract::The inhibitory influence of cyanuric acid on the virucidal effect of chlorine was studied. The time required for 99.9% inactivation of ten enteroviruses and two adenoviruses by 0.5 mg/l free available chlorine at pH 7.0 and 25 degrees C was prolonged approximately 4.8-28.8 times by the addition of 30 mg/l cyanuric aci...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268800029502
更新日期:1988-12-01 00:00:00
abstract::Eradication of poliomyelitis most likely will occur. In fact, it is almost gone from the Western Hemisphere. Health workers in Sweden, Finland, and the Netherlands routinely vaccinate almost all children with the inactivated poliovaccines (IPV). Despite good vaccination coverage, polio can still occur. For example...
journal_title:Epidemiology and infection
pub_type: 杂志文章,评审
doi:10.1017/s0950268800049451
更新日期:1992-02-01 00:00:00