Abstract：
:Etoposide is a semisynthetic compound, widely used in treatment of non small cell lung cancer. However, frequent dosing and adverse effects remain a major concern in the use of etoposide. Liposomal systems for pulmonary drug delivery have been particularly attractive because of their compatibility with lung surfactant components. In the present investigation, pulmonary liposomal delivery system of etoposide was prepared by film hydration method. Various parameters were optimized with respect to entrapment efficiency as well as particle size of etoposide liposomes. For better shelf life of etoposide liposomes, freeze drying using trehalose as cryoprotectant was carried out. The liposomes were characterized for entrapment efficiency, particle size, surface topography, and in vitro drug release was carried out in simulated lung fluid at 37° at pH 7.4. The respirable or fine particle fraction was determined by using twin stage impinger. The stability study of freeze dried as well as aqueous liposomal systems was carried out at 2-8° and at ambient temperature (28±4°). The freeze dried liposomes showed better fine particle fraction and drug content over the period of six months at ambient as well as at 2-8° storage condition compared to aqueous dispersion of liposomes.
journal_name
Indian J Pharm Scijournal_title
Indian journal of pharmaceutical sciencesauthors
Parmar JJ,Singh DJ,Lohade AA,Hegde DD,Soni PS,Samad A,Menon MDdoi
10.4103/0250-474X.100240subject
Has Abstractpub_date
2011-11-01 00:00:00pages
656-62issue
6eissn
0250-474Xissn
1998-3743pii
IJPhS-73-656journal_volume
73pub_type
杂志文章abstract：:The study was undertaken to evaluate various aspects of self-medication in medical students. A prospective, cross-sectional, questionnaire-based study was carried out among 488 medical students selected by simple random sampling from January 2013 to June 2013. Data was collected and analyzed for counts and percentage....
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474x.156569
更新日期：2015-03-01 00:00:00
abstract：:WHO reports estimate poisoning as one of the most common causes of increased morbidity and mortality rate world-wide. Various agents such as pesticides, drugs have been used for intentional and accidental poisoning in different countries. In the Indian scenario, pesticides are the most commonly used poisoning agents. ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.78525
更新日期：2010-09-01 00:00:00
abstract：:Ethyl naphtho[2,1-b]furan-2-carboxylate (2) on reaction with hydrazine hydrate in presence of acid catalyst in ethanol medium affords naphtho[2,1-b]furan-2-carbohydrazide (3). The reaction of substituted acetophenones (4a-c) with aromatic aldehydes (5a-e) produces chalcones (6a-o) via the Claisen condensation. The rea...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.49090
更新日期：2008-11-01 00:00:00
abstract：:The present study is designed to evaluate the efficacy of heptoplus a polyherbal formulation as an oral supplementary agent for isoniazid and rifampicin induced hepatotoxicity in rats. 50 and 100 mg/kg of heptoplus supplement were fed orally to the rats along with isoniazid and rifampicin and compared to rats treated ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474x.169028
更新日期：2015-09-01 00:00:00
abstract：:Bacteria have developed multidrug resistance against available antimicrobial agents. Infectious diseases caused by these multidrug-resistant bacteria are major causes of morbidity and mortality in human beings. Synthetic drugs are expensive and inadequate for the treatment of diseases, causing side effects and ineffec...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.174991
更新日期：2015-11-01 00:00:00
abstract：:A simple, sensitive, rapid, accurate and precise spectrophotometric method has been developed for the estimation of bicalutamide in bulk and pharmaceutical dosage forms. Bicalutamide shows maximum absorbance at 272 nm with molar absorptivity of 2.3399×10(4) l/mol/cm. Beer's law was obeyed in the concentration range of...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.49131
更新日期：2008-11-01 00:00:00
abstract：:A high-performance liquid chromatographic method for the estimation of berberine in the stem of Tinospora cordifolia (Willd.) Miers. ex Hook.f. and Thoms. and Tinospora sinensis (Lour.) Merrill is described. The dried stems of T. cordifolia and T. sinensis were defatted with petroleum ether (60-80 degrees ). The marc ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.40341
更新日期：2008-01-01 00:00:00
abstract：:The objective of this work was to increase the amount of acyclovir in the basal epidermis, site of herpes virus simplex infection, using the solid lipid nanoparticles loaded gel cream as carriers. Solid lipid nanoparticles were prepared by high pressure homogenisation method and incorporated in a semisolid submicron g...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：:Sarpagandha ghanvati is a classical Ayurvedic formulation widely prescribed for anxiety and insomnia. It contains Sarpagandha (roots of Rauwolfia serpentina L. (Benth.) Ex Kurz; Family: Apocyanaceae), Khurasani ajowan (Hyocyamus niger L.; Family: Solanaceae) seeds, Jatamansi (Nardostachys jatamansi DC. Family: Valeria...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474x.169029
更新日期：2015-09-01 00:00:00
abstract：:Supercritical fluid extract of leaves of Vitex negundo was tested for its antimicrobial potential and was compared with that of ethanol extract, ether extract and hydrodistilled oil of leaves. The chemical constituents of extracts were studied by chromatographic techniques. Extracts were evaluated for antimicrobial po...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.78537
更新日期：2010-09-01 00:00:00
abstract：:Modification of polymers by covalent attachment of thiol bearing pendant groups is reported to impart many beneficial properties to them. Hence in the present study, sodium alginate-cysteine conjugate was synthesized by carbodiimide mediated coupling under varying reaction conditions and the derivatives characterized ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.84590
更新日期：2010-11-01 00:00:00
abstract：:A reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of atorvastatin calcium and fenofibrate in tablet formulation. The separation was achieved by Luna C18 column and methanol:acetate buffer pH 3.7 (82:18 v/v) as mobile phase, at a flow rate of 1.5 ml/min. Detect...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.41473
更新日期：2008-03-01 00:00:00
abstract：:Manjisthadi churna has been traditionally used in the Ayurvedic system of medicine and by traditional medical practices of India to treat hyperlipidemia. A rapid, simple and accurate method with high performance thin layer chromatography has been developed to standardised Manjisthadi churna using rubiadin, sennoside a...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.113541
更新日期：2013-01-01 00:00:00
abstract：:A simple, precise, and accurate isocratic reversed-phase (RP) stability-indicating HPLC assay method was developed and validated for determination of Aripiprazole in bulk and solid pharmaceutical dosage form. A reversed-phase C8 (250×4.0 mm, 5 μm particle size) column for HPLC and C8 (50×2.1mm, 1.7 μm particle size) f...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.95638
更新日期：2011-07-01 00:00:00
abstract：:The petroleum ether leaf extract of Ficus krishnae has been evaluated for the management of diabetes in alloxan induced diabetic rats. Phytochemical screening of the leaf extract for various chemical compounds has also been carried out. Leaf extract was administered continuously for 21 days orally at a dose of 200 mg/...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：
更新日期：2014-07-01 00:00:00
abstract：:A rapid and sensitive reverse phase high performance liquid chromatographic method is depicted for the qualitative and quantitative assay of letrozole in pharmaceutical dosage forms. Letrozole was chromatographed on a reverse phase C18 column with a mobile phase consisting of acetonitrile and phosphate buffer (pH 7.8)...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.43019
更新日期：2008-05-01 00:00:00
abstract：:A series of novel 2,3-disubstitutedquinazolin-4(3H)-ones have been synthesized by condensation of 2-substituted benzo[1,3]oxazine-4-ones and anthranilic acid. Synthesized compounds were evaluated for in vitro antiviral activity against HIV, HSV and vaccinia viruses. 5-Bromo-2-(6-bromo-4-oxo-2-phenyl-4H-quinazolin-3-yl...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.84603
更新日期：2010-11-01 00:00:00
abstract：:Various (4-substituted) phenyl-3-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]propionylamido-1,3-thiazolidine-4-ones (3a-x) and 1-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]-propionylamido-3-chloro-4-(4-substituted)phenyl-azetidin-2-ones (4a-x) have been synthesised by the cyclocondensation of ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.95654
更新日期：2011-07-01 00:00:00
abstract：:The present study depicts the development of a validated RP-HPLC method for the determination of the pamabrom in presence of degradation products or other pharmaceutical excipients. Stress study was performed on pamabrom and it was found that it degrade sufficiently in acidic, alkali and oxidative condition but less d...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：
更新日期：2014-05-01 00:00:00
abstract：:In the current research work an attempt was made to develop "Melt in mouth pellets" (Meltlets(®)) containing 40% herbal extract of soy isoflavones that served to provide antioxidants activity in menopausal women. The process of extrusion-spheronization was optimized for extruder speed, extruder screen size, spheroniza...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.119831
更新日期：2013-07-01 00:00:00
abstract：:The genome of rabies virus encodes five proteins; the nucleoprotein, the phosphoprotein, the matrix protein, the glycoprotein, and the RNA-dependent RNA polymerase. Among these, the glycoprotein is the most important as it is the major contributor to pathogenicity and virus neutralizing antibody response. Keeping in m...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.73905
更新日期：2010-07-01 00:00:00
abstract：:A gradient reversed phase HPLC method was developed and validated for the analysis of related substances in zonisamide (1,2-benzisoxazole-3-methanesulfonamide), using a Waters Symmetry C8 (150*3.9 mm) column with a flow rate of 1.0 ml/min and detection at 280 nm. The mobile phase component A consisted of a mixture of ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.58183
更新日期：2009-09-01 00:00:00
abstract：:A field experiment on the effect of time of harvesting on yield and quality of Melissa officinalis L. was conducted under the agroclimatic conditions of Doon valley, Uttarakhand in order to assess the performance of four harvesting times (H1-120 days, H2-140 days, H3-160 days and H4-180 days after planting). The fresh...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：
更新日期：2014-09-01 00:00:00
abstract：:An in vitro evaluation of the anti-microbial activity of medicated soaps was conducted using ditch-plate and hand washing techniques. Strains of reference microbes namely Candida albicans (ATCC90028), Staphylococcus aureus (ATCC25923), Pseudomonas aureginosa (ATCC27853) and Escherichia coli (ATCC25922) were tested at ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.89765
更新日期：2011-01-01 00:00:00
abstract：:A mucoadhesive drug delivery system for systemic delivery of nitrendipine, a calcium channel blocker through buccal route was formulated. Mucoadhesive polymers like hydroxypropylmethylcellulose K-100, hydroxypropylcellulose, sodium carboxymethylcellulose, sodium alginate, polyvinyl alcohol, polyvinyl pyrrolidone K-30 ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.45402
更新日期：2008-09-01 00:00:00
abstract：:The aim of the present study was to monitor adverse drug reactions associated with antihypertensive drugs. The study was conducted in medicine out patient department of 150-bed Majeedia Hospital at Hamdard University Campus in New Delhi. The study was conducted by way of one to one patient interview by a registered ph...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.56018
更新日期：2009-05-01 00:00:00
abstract：:A simple, sensitive, rapid, accurate and precise spectrophotometric method has been developed for estimation of ropinirole hydrochloride in bulk and tablet dosage forms. Ropinirole hydrochloride shows maximum absorbance at 250 nm with molar absorptivity of 8.703x10(3) l/mol.cm. Beer's law was obeyed in the concentrati...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.51962
更新日期：2009-01-01 00:00:00
abstract：:The present work describes a simple, precise and accurate HPLC method for estimation of montelukast sodium in bulk and in tablet dosage form. The separation was achieved by using octadecylsilane column (C18) and acetonitrile:1 mM sodium acetate adjusted to pH 6.3 with acetic acid in proportion of 90:10 v/v as mobile p...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.65023
更新日期：2010-03-01 00:00:00
abstract：:The objective of this study was to prepare and characterise nevirapine nanosuspensions so as to improve the dissolution rate of nevirapine. Nevirapine is a nonnucleoside reverse transcriptase inhibitor of immunodeficiency virus type-1 and it is poorly water-soluble antiretroviral drug. The low solubility of nevirapine...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:A derivative UV spectrophotometric and a reversed phase high-performance liquid chromatographic method for the determination of ciprofibrate in tablets was developed. The first-order derivative UV spectrophotometric method was found to be accurate with 100.57±0.97 recovery and precise with a coefficient of variation o...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.103855
更新日期：2012-03-01 00:00:00
