Abstract:
:The objective of this study was to prepare and characterise nevirapine nanosuspensions so as to improve the dissolution rate of nevirapine. Nevirapine is a nonnucleoside reverse transcriptase inhibitor of immunodeficiency virus type-1 and it is poorly water-soluble antiretroviral drug. The low solubility of nevirapine can lead to decreased and variable oral bioavailability. Nanosuspension can overcome the oral bioavailability problem of nevirapine. Nevirapine nanosuspensions were prepared using nanoedge method. The suspensions were stabilised using surfactants Lutrol F 127 or Poloxamer 407 and hydroxypropyl methyl cellulose. The nanosuspension was characterised for particle size, polydispersibility index, crystalline state, particle morphology, in vitro drug release and pharmacokinetics in rats after oral administration. The results support the claim for the preparation of nanosuspensions with enhanced solubility and bioavailability.
journal_name
Indian J Pharm Scijournal_title
Indian journal of pharmaceutical sciencesauthors
Raju A,Reddy AJ,Satheesh J,Jithan AVsubject
Has Abstractpub_date
2014-01-01 00:00:00pages
62-71issue
1eissn
0250-474Xissn
1998-3743journal_volume
76pub_type
杂志文章abstract::Various (4-substituted) phenyl-3-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]propionylamido-1,3-thiazolidine-4-ones (3a-x) and 1-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]-propionylamido-3-chloro-4-(4-substituted)phenyl-azetidin-2-ones (4a-x) have been synthesised by the cyclocondensation of ...
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journal_title:Indian journal of pharmaceutical sciences
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journal_title:Indian journal of pharmaceutical sciences
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doi:10.4103/0250-474X.51944
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journal_title:Indian journal of pharmaceutical sciences
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doi:
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journal_title:Indian journal of pharmaceutical sciences
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journal_title:Indian journal of pharmaceutical sciences
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journal_title:Indian journal of pharmaceutical sciences
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journal_title:Indian journal of pharmaceutical sciences
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journal_title:Indian journal of pharmaceutical sciences
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pub_type: 杂志文章
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abstract::The genome of rabies virus encodes five proteins; the nucleoprotein, the phosphoprotein, the matrix protein, the glycoprotein, and the RNA-dependent RNA polymerase. Among these, the glycoprotein is the most important as it is the major contributor to pathogenicity and virus neutralizing antibody response. Keeping in m...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
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