Preparation and characterisation of nevirapine oral nanosuspensions.

Abstract:

:The objective of this study was to prepare and characterise nevirapine nanosuspensions so as to improve the dissolution rate of nevirapine. Nevirapine is a nonnucleoside reverse transcriptase inhibitor of immunodeficiency virus type-1 and it is poorly water-soluble antiretroviral drug. The low solubility of nevirapine can lead to decreased and variable oral bioavailability. Nanosuspension can overcome the oral bioavailability problem of nevirapine. Nevirapine nanosuspensions were prepared using nanoedge method. The suspensions were stabilised using surfactants Lutrol F 127 or Poloxamer 407 and hydroxypropyl methyl cellulose. The nanosuspension was characterised for particle size, polydispersibility index, crystalline state, particle morphology, in vitro drug release and pharmacokinetics in rats after oral administration. The results support the claim for the preparation of nanosuspensions with enhanced solubility and bioavailability.

journal_name

Indian J Pharm Sci

authors

Raju A,Reddy AJ,Satheesh J,Jithan AV

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

62-71

issue

1

eissn

0250-474X

issn

1998-3743

journal_volume

76

pub_type

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