Synthesis and Activity Evaluation of 2-(1-naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles.

abstract：:The present study evaluated the in vitro antioxidant potential of different parts of Oroxylum indicum. 2,2-diphelyl 1-picrylhydrazyl (DPPH), nitric oxide, superoxide anion and hydroxyl radical scavenging potential and reductive ability assay of methanol extract of different parts i.e. root, root bark, stem, stem bark,...

journal_title：Indian journal of pharmaceutical sciences

authors： Mishra SL,Sinhamahapatra PK,Nayak A,Das R,Sannigrahi S

更新日期：2010-03-01 00:00:00

abstract：:A novel reversed-phase HPLC method has been developed and validated for the simultaneous determination of 2-phenoxyethanol, methylparaben, ethylparaben and propylparaben preservatives. The method uses a Lichrosorb C8 (150×4.6 mm, 5 µm) column and isocratic elution. The mobile phase consisted of a mixture of acetonitri...

journal_title：Indian journal of pharmaceutical sciences

authors： Shabir GA

更新日期：2010-07-01 00:00:00

abstract：:A simple, sensitive, rapid, accurate and precise spectrophotometric method has been developed for the estimation of bicalutamide in bulk and pharmaceutical dosage forms. Bicalutamide shows maximum absorbance at 272 nm with molar absorptivity of 2.3399×10(4) l/mol/cm. Beer's law was obeyed in the concentration range of...

journal_title：Indian journal of pharmaceutical sciences

authors： Sancheti PP,Vyas VM,Shah M,Karekar P,Pore YV

更新日期：2008-11-01 00:00:00

abstract：:The petroleum ether leaf extract of Ficus krishnae has been evaluated for the management of diabetes in alloxan induced diabetic rats. Phytochemical screening of the leaf extract for various chemical compounds has also been carried out. Leaf extract was administered continuously for 21 days orally at a dose of 200 mg/...

journal_title：Indian journal of pharmaceutical sciences

authors： Sidhu MC,Sharma T

更新日期：2014-07-01 00:00:00

abstract：:In the present study, 2,5-disubstituted-1,3,4-oxadiazoles (3a-o) have been synthesized by the condensation of 4-methoxybenzohydrazide (1) with different aromatic acids (2a-o) in presence of phosphoryl chloride. The structural assignment of this compound (3a-o) has been made on the basis of elemental analysis, UV, IR, ...

journal_title：Indian journal of pharmaceutical sciences

authors： Nagalakshmi G

更新日期：2008-01-01 00:00:00

abstract：:Recent studies have shown that gallic acid and its alkylesters induce apoptosis in different cell lines. Since new compounds with biological activity and less cytotoxicity to normal cells are necessary for cancer therapy, the aim of this study was to evaluate the cytotoxic effect of 1-(3,4,5-trihydroxyphenyl)-dodecylb...

journal_title：Indian journal of pharmaceutical sciences

authors： Maioral MF,Bubniak LD,Marzarotto MA,De Moraes AC,Leal P,Nunes R,Yunes RA,Santos-Silva MC

更新日期：2016-01-01 00:00:00

abstract：:Supercritical fluid extract of leaves of Vitex negundo was tested for its antimicrobial potential and was compared with that of ethanol extract, ether extract and hydrodistilled oil of leaves. The chemical constituents of extracts were studied by chromatographic techniques. Extracts were evaluated for antimicrobial po...

journal_title：Indian journal of pharmaceutical sciences

authors： Nagarsekar KS,Nagarsenker MS,Kulkarni SR

更新日期：2010-09-01 00:00:00

abstract：:Tuberculosis is one of the major public health problems faced globally. Resistance of Mycobacterium tuberculosis to antitubercular agents has called for an urgent need to investigate newer drugs to combat tuberculosis. Garlic (Allium sativum) is an edible plant which has generated a lot of curiosity throughout human h...

journal_title：Indian journal of pharmaceutical sciences

authors： Viswanathan V,Phadatare AG,Mukne A

更新日期：2014-05-01 00:00:00

abstract：:Alpinia officinarum is a rhizome belonging to the family zingeberaeceae. Hydro alcoholic extract by hot and cold maceration and methanol extract by percolation process Qualitative phytochemical analysis of extract of Alpinia officinarum rhizome showed a majority of the compound including tannins, alkaloids, flavonoids...

journal_title：Indian journal of pharmaceutical sciences

authors： Srividya AR,Dhanabal SP,Misra VK,Suja G

更新日期：2010-01-01 00:00:00

abstract：:A gradient reversed phase HPLC method was developed and validated for the analysis of related substances in zonisamide (1,2-benzisoxazole-3-methanesulfonamide), using a Waters Symmetry C8 (150*3.9 mm) column with a flow rate of 1.0 ml/min and detection at 280 nm. The mobile phase component A consisted of a mixture of ...

journal_title：Indian journal of pharmaceutical sciences

authors： Vijayakumar EK,Dhore DM,Kumar M

更新日期：2009-09-01 00:00:00

abstract：:The aim of this research was to investigate the technique for preparation of coated valproic acid and sodium valproate sustained-release matrix tablets. Different diluents were tested and selected as the effective absorbent for oily valproic acid. Effect of the amount of absorbent and hydroxypropylmethylcellulose on d...

journal_title：Indian journal of pharmaceutical sciences

authors： Phaechamud T,Mueannoom W,Tuntarawongsa S,Chitrattha S

更新日期：2010-03-01 00:00:00

abstract：:Two UV Spectrophotometric and one reverse phase high performance liquid chromatography methods have been developed for the simultaneous estimation of amlodipine besilate and olmesartan medoxomil in tablet dosage form. First UV spectrophotometric method was a determination using the simultaneous equation method at 237....

journal_title：Indian journal of pharmaceutical sciences

authors： Wankhede SB,Wadkar SB,Raka KC,Chitlange SS

更新日期：2009-09-01 00:00:00

abstract：:Ivermectin, chloramphenicol, ampicillin and tetracycline HCl are common drugs in human and veterinary practice. The purpose of this study is to investigate the possible binding interactions between ivermectin and the antibiotics chloramphenicol, ampicillin and tetracycline HCl. Isothermal titration calorimetry was use...

journal_title：Indian journal of pharmaceutical sciences

authors： Kandeel M,Elgazar W,Kitade Y

更新日期：2012-11-01 00:00:00

abstract：:Mebeverine hydrochloride is known to suffer from extensive first pass effect. In an attempt to improve its oral bioavailability and possibility to restrict its absorption only to the colon, mebeverine microspheres were prepared by emulsion solvent evaporation method. Four formulations were prepared with varying drug a...

journal_title：Indian journal of pharmaceutical sciences

authors： Dandagi PM,Mastiholimath VS,Gadad AP,Kulkarni AR,Konnur BK

更新日期：2009-07-01 00:00:00

abstract：:Asymmetric membrane capsules are a type of osmotic drug delivery systems. They are nondisintegrating capsules, which utilize osmotic pressure to drive the drug outwards for controlled delivery. Preceded by systems such as elementary osmotic pump, controlled porosity osmotic pump, single composition osmotic tablet this...

journal_title：Indian journal of pharmaceutical sciences

authors： Sahoo PK,Makar H

更新日期：2013-03-01 00:00:00

abstract：:A series of novel N-Sulphonamidomethyl piperzinyl fluoroquinolones were synthesized and screened antiviral activity. Eight compounds were synthesized through modifying the N(4)-hydrogen of piperazine in fluoroquinolones with formaldehyde and sulphanomides by Mannich reactions. The structures of the synthesized compoun...

journal_title：Indian journal of pharmaceutical sciences

authors： Selvam P,Rathore P,Karthikumar S,Velkumar K,Palanisamy P,Vijayalakhsmi S,Witvrouw M

更新日期：2009-07-01 00:00:00

abstract：:A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of esomeprazole and domperidone. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 301 nm and 284 nm, lambda max of esomeprazole and domperidone respecti...

journal_title：Indian journal of pharmaceutical sciences

authors： Prabu SL,Shirwaikar A,Shirwaikar A,Kumar CD,Joseph A,Kumar R

更新日期：2008-01-01 00:00:00

abstract：:Malnutrition is widely prevalent among patients on hemodialysis. Malnutrition can be estimated using a fully quantitative scoring system Subjective Global Assessment-Dialysis Malnutrition Score which is simple, reliable and dynamic. The primary objective of the study was to assess the severity of malnutrition in patie...

journal_title：Indian journal of pharmaceutical sciences

authors： Janardhan V,Soundararajan P,Rani NV,Kannan G,Thennarasu P,Chacko RA,Reddy CU

更新日期：2011-01-01 00:00:00

abstract：:Mitochondrial sodium calcium exchange inhibitors are novel agents in the treatment of type-II diabetes due to their glucose dependent efficacy. While the compounds of this class are expected to correct hyperglycemia, they do not lower basal blood glucose level, thus avoiding the serious consequences of hypoglycemia. T...

journal_title：Indian journal of pharmaceutical sciences

authors： Dasoondi AS,Singh V,Voleti SR,Tiwari M

更新日期：2008-03-01 00:00:00

abstract：:An in vitro evaluation of the anti-microbial activity of medicated soaps was conducted using ditch-plate and hand washing techniques. Strains of reference microbes namely Candida albicans (ATCC90028), Staphylococcus aureus (ATCC25923), Pseudomonas aureginosa (ATCC27853) and Escherichia coli (ATCC25922) were tested at ...

journal_title：Indian journal of pharmaceutical sciences

authors： Mwambete KD,Lyombe F

更新日期：2011-01-01 00:00:00

abstract：:The antibacterial activity of leaf extract of mangroves, namely, Rhizophora mucronata, Sonneratia alba and Exoecaria agallocha from Chorao island, Goa was investigated against human bacterial pathogens Staphylococcus aureus, Streptococcus sp., Salmonella typhi, Proteus vulgaris and Proteus mirabilis. As compared to aq...

journal_title：Indian journal of pharmaceutical sciences

authors： Sahoo G,Mulla NS,Ansari ZA,Mohandass C

更新日期：2012-07-01 00:00:00

abstract：:The aim of the present study was the determination of formulation factors and the in vitro evaluation of an extended release dosage form of a freely soluble weakly basic drug (alfuzosin hydrochloride). Binary mixer of one hydrophilic polymer (hydroxypropylmethylcellulose) and one directly compressible Eudragit (RS PO)...

journal_title：Indian journal of pharmaceutical sciences

authors： Roni MA,Kibria G,Jalil R

更新日期：2009-05-01 00:00:00

abstract：:A simple HPLC method was developed and validated for the quantification of zanamivir in permeability studies using Caco-2 cell culture model. Chromatographic resolution was achieved using 98% (v/v) ultrapure water and 2% (v/v) acetonitrile as mobile phase with flow rate of 0.5 ml/min on a BDS Hypersil Cyano column (le...

journal_title：Indian journal of pharmaceutical sciences

authors： Boonyapiwat B,Sarisuta N,Ma Y,Steventon GB

更新日期：2011-09-01 00:00:00

abstract：:Crystal form can be crucial to the performance of a dosage form. This is especially true for compounds that have intrinsic barriers to drug delivery, such as low aqueous solubility, slow dissolution in gastrointestinal media, low permeability and first-pass metabolism. The nature of the physical form and formulation t...

journal_title：Indian journal of pharmaceutical sciences

authors： Yadav AV,Shete AS,Dabke AP,Kulkarni PV,Sakhare SS

更新日期：2009-07-01 00:00:00

abstract：:Present study reports the development and validation of a simultaneous estimation of metformin and gliclazide in human plasma using supercritical fluid chromatography followed by tandem mass spectrometry. Acetonitrile:water (80:20) mixture was used as a mobile phase along with liquid CO(2) in supercritical fluid chrom...

journal_title：Indian journal of pharmaceutical sciences

authors： Agrawal YK,Gogoi PJ,Manna K,Bhatt HG,Jain VK

更新日期：2010-01-01 00:00:00

abstract：:The objective of this work was to increase the amount of acyclovir in the basal epidermis, site of herpes virus simplex infection, using the solid lipid nanoparticles loaded gel cream as carriers. Solid lipid nanoparticles were prepared by high pressure homogenisation method and incorporated in a semisolid submicron g...

journal_title：Indian journal of pharmaceutical sciences

authors： Gide PS,Gidwani SK,Kothule KU

更新日期：2013-03-01 00:00:00

abstract：:Ethanol extract of leaves of Clerodendron phlomoidis L. subjected to preliminary qualitative phytochemical investigations showed the presence of alkaloids, phytosterols, glycosides, saponins, phenolic compounds, proteins and flavonoids. The extract was screened for hypoglycemic activity in alloxan-induced diabetic rat...

journal_title：Indian journal of pharmaceutical sciences

authors： Dhanabal SP,Mohan Marugaraja MK,Suresh B

更新日期：2008-11-01 00:00:00

abstract：:The formulations consisting of a hydrophilic and hydrophobic material were investigated for effect on drug-release pattern from the matrices. Gum damar and gum copal being water-insoluble were used to study the efficiency of combined matrices to sustain the release of drug. Hydroxypropyl methylcellulose K100M and dicl...

journal_title：Indian journal of pharmaceutical sciences

authors： Fulbandhe VM,Jobanputra CR,Wadher KJ,Umekar MJ,Bhoyar GS

更新日期：2012-05-01 00:00:00

abstract：:Etoposide is a semisynthetic compound, widely used in treatment of non small cell lung cancer. However, frequent dosing and adverse effects remain a major concern in the use of etoposide. Liposomal systems for pulmonary drug delivery have been particularly attractive because of their compatibility with lung surfactant...

journal_title：Indian journal of pharmaceutical sciences

authors： Parmar JJ,Singh DJ,Lohade AA,Hegde DD,Soni PS,Samad A,Menon MD

更新日期：2011-11-01 00:00:00

abstract：:Fast dissolving tablets of clonazepam were prepared by sublimation method with a view to enhance patient compliance. A 3(2) full factorial design was applied to investigate the combined effect of two formulation variables: amount of croscarmellose sodium and camphor. Croscarmellose sodium (2-8% w/w) was used as superd...

journal_title：Indian journal of pharmaceutical sciences

authors： Shirsand SB,Suresh S,Kusumdevi V,Swamy PV

更新日期：2011-09-01 00:00:00