Synthesis and Activity Evaluation of 2-(1-naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles.

Abstract:

:Ethyl naphtho[2,1-b]furan-2-carboxylate (2) on reaction with hydrazine hydrate in presence of acid catalyst in ethanol medium affords naphtho[2,1-b]furan-2-carbohydrazide (3). The reaction of substituted acetophenones (4a-c) with aromatic aldehydes (5a-e) produces chalcones (6a-o) via the Claisen condensation. The reaction of naphtho[2,1-b]furan-2-carbohydrazide (3) with chalcones (6a-6o) in presence of acetic acid as catalyst in dioxane produces 1-(naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles (7a-o). The structures of newly synthesized compounds have been established by elemental analysis and spectral studies. The compounds 7a-o have been evaluated for their antimicrobial activity and some selected compounds evaluated for antiinflammatory, analgesic, anthelmintic, diuretic and antipyretic activities.

journal_name

Indian J Pharm Sci

authors

Kumaraswamy MN,Chandrashekhar C,Shivakumar H,Prathima Mathias DA,Mahadevan KM,Vaidya VP

doi

10.4103/0250-474X.49090

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

715-20

issue

6

eissn

0250-474X

issn

1998-3743

journal_volume

70

pub_type

杂志文章
  • Evaluation of Composition and Antimicrobial Activity of Supercritical Fluid Extract of Leaves of Vitex negundo.

    abstract::Supercritical fluid extract of leaves of Vitex negundo was tested for its antimicrobial potential and was compared with that of ethanol extract, ether extract and hydrodistilled oil of leaves. The chemical constituents of extracts were studied by chromatographic techniques. Extracts were evaluated for antimicrobial po...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.78537

    authors: Nagarsekar KS,Nagarsenker MS,Kulkarni SR

    更新日期:2010-09-01 00:00:00

  • Spectrophotometric estimation of olmesartan medoxomil and hydrochlorothiazide in tablet.

    abstract::A simultaneous determination of olmesartan medoxomil and hydrochlorothiazide by absorption ratio spectrophotometric method has been developed in combined tablet dosage form. The method is based on measurements of absorbance at isoabsoptive point. The Beer's law obeys in the range of 10-30 mug/ml for both olmesartan me...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.62245

    authors: Rote AR,Bari PD

    更新日期:2010-01-01 00:00:00

  • Simultaneous analysis and quantification of markers of manjisthadi churna using high performance thin layer chromatography.

    abstract::Manjisthadi churna has been traditionally used in the Ayurvedic system of medicine and by traditional medical practices of India to treat hyperlipidemia. A rapid, simple and accurate method with high performance thin layer chromatography has been developed to standardised Manjisthadi churna using rubiadin, sennoside a...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.113541

    authors: Patel VR,Patel RK

    更新日期:2013-01-01 00:00:00

  • Preparation and evaluation of transdermal drug delivery system of etoricoxib using modified chitosan.

    abstract::In the present investigation chitosan has been chemically modified by treating with two different aldehydes like acetaldehyde and propionaldehyde to form Schiff's bases. Schiff's bases of chitosan with acetaldehyde and propionaldehyde were named as polymer A and polymer B, respectively. Fourier Transform Infra Red (FT...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.44593

    authors: Wahid A,Sridhar BK,Shivakumar S

    更新日期:2008-07-01 00:00:00

  • Assessment of prevalence and mortality incidences due to poisoning in a South Indian tertiary care teaching hospital.

    abstract::WHO reports estimate poisoning as one of the most common causes of increased morbidity and mortality rate world-wide. Various agents such as pesticides, drugs have been used for intentional and accidental poisoning in different countries. In the Indian scenario, pesticides are the most commonly used poisoning agents. ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.78525

    authors: Jesslin J,Adepu R,Churi S

    更新日期:2010-09-01 00:00:00

  • Investigation of release pattern of a drug with low solubility through asymmetric membrane capsules.

    abstract::Asymmetric membrane capsules are a type of osmotic drug delivery systems. They are nondisintegrating capsules, which utilize osmotic pressure to drive the drug outwards for controlled delivery. Preceded by systems such as elementary osmotic pump, controlled porosity osmotic pump, single composition osmotic tablet this...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Sahoo PK,Makar H

    更新日期:2013-03-01 00:00:00

  • FTIR Spectroscopy: A Tool for Quantitative Analysis of Ciprofloxacin in Tablets.

    abstract::A simple, accurate and sensitive spectroscopic method has been proposed for the assay of ciprofloxacin in tablet by least square treatment of fourier transform infrared spectrometric data obtained at the wavenumber corresponding to the carbonyl group centered at 1707 cm(-1). The method involves the extraction of the a...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.102551

    authors: Pandey S,Pandey P,Tiwari G,Tiwari R,Rai AK

    更新日期:2012-01-01 00:00:00

  • Optimization of Physical and Nutritional Parameters for Hyaluronidase Production by Streptococcus mitis.

    abstract::The effect of some physical and nutritional parameters were studied for the optimum production of extracellular enzyme hyaluronidase employing Streptococcus mitis MTCC*2695 by submerged fermentation. The effects of initial pH, incubation temperature and time, inoculum level and age of inoculum were studied. The maximu...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.45412

    authors: Sahoo S,Panda PK,Mishra SR,Nayak A,Dash SK,Ellaiah P

    更新日期:2008-09-01 00:00:00

  • Fluorimetric quantification of brimonidine tartrate in eye drops.

    abstract::A simple and sensitive spectrofluorimetric method has been developed for the estimation of brimonidine tartrate in pure and eye drops. Linearity was obeyed in the range of 0.2-3.0 ΅g/ml in dimethyl formamide as solvent at an emission wavelength (λem) of 530 nm after excitation wavelength (λex) of 389 nm with good corr...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Sunitha G,Bhagirath R,Alapati VR,Ramakrishna K,Subrahmanyam CV,Anumolu PD

    更新日期:2013-11-01 00:00:00

  • Synthesis and Antiviral Studies of Novel N-Sulphonamidomethyl piperazinyl Fluoroquinolones.

    abstract::A series of novel N-Sulphonamidomethyl piperzinyl fluoroquinolones were synthesized and screened antiviral activity. Eight compounds were synthesized through modifying the N(4)-hydrogen of piperazine in fluoroquinolones with formaldehyde and sulphanomides by Mannich reactions. The structures of the synthesized compoun...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.57293

    authors: Selvam P,Rathore P,Karthikumar S,Velkumar K,Palanisamy P,Vijayalakhsmi S,Witvrouw M

    更新日期:2009-07-01 00:00:00

  • Effect of 2-Hydroxy-4-methoxy Benzoic Acid Isolated from Hemidesmus indicus on Erythrocyte Membrane Bound Enzymes and Antioxidant Status in Streptozotocin-induced Diabetic Rats.

    abstract::In the present study, the effect of 2-hydroxy-4-methoxy benzoic acid isolated from roots of Hemisdesmus indicus on the erythrocyte membrane bound enzymes and antioxidant status in streptozotocin-induced diabetic rats was investigated. The streptozotocin-induced diabetic rats were treated with 2-hydroxy-4-methoxy benzo...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.108438

    authors: Gayathri M,Kannabiran K

    更新日期:2012-09-01 00:00:00

  • A pharmacovigilance study of antihypertensive medicines at a South delhi hospital.

    abstract::The aim of the present study was to monitor adverse drug reactions associated with antihypertensive drugs. The study was conducted in medicine out patient department of 150-bed Majeedia Hospital at Hamdard University Campus in New Delhi. The study was conducted by way of one to one patient interview by a registered ph...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.56018

    authors: Hussain A,Aqil M,Alam MS,Khan MR,Kapur P,Pillai KK

    更新日期:2009-05-01 00:00:00

  • In vivo Antimalarial Activities of Russelia Equisetiformis in Plasmodium Berghei Infected Mice.

    abstract::The rising problem of resistance to most commonly used antimalarials remains a major challenge in the control of malaria suggesting the need for new antimalarial agents. This work explores the antiplasmodial potential of ethanol extract of Russelia equisetiformis in chloroquine Plasmodium berghei infected mice. Swiss ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.164787

    authors: Ojurongbe O,Ojo JA,Adefokun DI,Abiodun OO,Odewale G,Awe EO

    更新日期:2015-07-01 00:00:00

  • A Sensitive RP-HPLC Method for Simultaneous Estimation of Diethylcarbamazine and Levocetirizine in Tablet Formulation.

    abstract::A simple, sensitive and reproducible method was developed and validated for the simultaneous estimation of diethylcarbamazine and levocetirizine in its tablet formulation by reverse phase high performance liquid chromatography using Waters1515 HPLC with UV detector at the λ(max) of 224 nm, using Princeton Sphere-100 C...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.93517

    authors: Reddy JM,Jeyaprakash MR,Madhuri K,Meyyanathan SN,Elango K

    更新日期:2011-05-01 00:00:00

  • Preparation of Coated Valproic Acid and Sodium Valproate Sustained-release Matrix Tablets.

    abstract::The aim of this research was to investigate the technique for preparation of coated valproic acid and sodium valproate sustained-release matrix tablets. Different diluents were tested and selected as the effective absorbent for oily valproic acid. Effect of the amount of absorbent and hydroxypropylmethylcellulose on d...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.65026

    authors: Phaechamud T,Mueannoom W,Tuntarawongsa S,Chitrattha S

    更新日期:2010-03-01 00:00:00

  • Spectrofluorimetric method for determination of duloxetine hydrochloride in bulk and pharmaceutical dosage forms.

    abstract::A simple accurate, sensitive and reproducible spectrofluorimetric method was developed for the analysis of duloxetine hydrochloride in pure and pharmaceutical dosage form. Duloxetine hydrochloride showed strong native fluorescence in 0.05 M acetic acid having excitation at 225 nm and emission at 340 nm. Effect of diff...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.44603

    authors: Prabu SL,Shahnawaz S,Kumar CD,Shirwaikar A

    更新日期:2008-07-01 00:00:00

  • Simultaneous Determination of Valsartan and Hydrochlorothiazide in Tablets by RP-HPLC.

    abstract::A simple, reproducible and efficient reverse phase high performance liquid chromatographic method was developed for simultaneous determination of valsartan and hydrochlorothiazide in tablets. A column having 200 x 4.6 mm i.d. in isocratic mode with mobile phase containing methanol:acetonitrile:water:isopropylalcohol (...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.43006

    authors: Tian DF,Tian XL,Tian T,Wang ZY,Mo FK

    更新日期:2008-05-01 00:00:00

  • Antioxidant Activity and Gas Chromatographic-Mass Spectrometric Analysis of Extracts of the Marine Algae, Caulerpa peltata and Padina Gymnospora.

    abstract::The results of our previous investigations on extracts of selected marine algae showed that Caulerpa peltata and Padina gymnospora had more promising antiproliferative and antioxidant activities than Gelidiella acerosa and Sargassum wightii. Based on these results, the more active chloroform extract of C. peltata and ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Murugan K,Iyer VV

    更新日期:2014-11-01 00:00:00

  • Wound healing potential of formulated extract from hibiscus sabdariffa calyx.

    abstract::Wound healing agents support the natural healing process, reduce trauma and likelihood of secondary infections and hasten wound closure. The wound healing activities of water in oil cream of the methanol extract of Hibiscus sabdariffa L. (Malvaceae) was evaluated in rats with superficial skin excision wounds. Antibact...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.113549

    authors: Builders PF,Kabele-Toge B,Builders M,Chindo BA,Anwunobi PA,Isimi YC

    更新日期:2013-01-01 00:00:00

  • Development and in vitro/in vivo Evaluation of a Silastic Intravaginal Ring for Mifepristone Delivery.

    abstract::Preparation and in vitro/in vivo evaluation of mifepristone intravaginal ring formulations were investigated. In the present study, it is reported that a mifepristone intravaginal ring of reservoir design comprising of a mifepristone silicone elastomer core enclosed in a silicone layer. During the preparation of intra...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.159671

    authors: Duan X,Ning M

    更新日期:2015-05-01 00:00:00

  • Evaluation of Antiseizure Activity of Essential Oil from Roots of Angelica archangelica Linn. in Mice.

    abstract::In the present study, the effect of essential oil of the root of Angelica archangelica Linn. was evaluated against electrically and chemically induced seizures. The seizures were induced in mice by maximal electroshock and pentylenetetrazol. The effect of essential oil of the root of Angelica archangelica on seizures ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.70487

    authors: Pathak S,Wanjari MM,Jain SK,Tripathi M

    更新日期:2010-05-01 00:00:00

  • A Chromatographic Determination of Aripiprazole using HPLC and UPLC: A Comparative Validation Study.

    abstract::A simple, precise, and accurate isocratic reversed-phase (RP) stability-indicating HPLC assay method was developed and validated for determination of Aripiprazole in bulk and solid pharmaceutical dosage form. A reversed-phase C8 (250×4.0 mm, 5 μm particle size) column for HPLC and C8 (50×2.1mm, 1.7 μm particle size) f...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.95638

    authors: Thakkar RS,Saravaia HT,Ambasana MA,Kaila HO,Shah AK

    更新日期:2011-07-01 00:00:00

  • Formulation design and optimization of fast dissolving clonazepam tablets by sublimation method.

    abstract::Fast dissolving tablets of clonazepam were prepared by sublimation method with a view to enhance patient compliance. A 3(2) full factorial design was applied to investigate the combined effect of two formulation variables: amount of croscarmellose sodium and camphor. Croscarmellose sodium (2-8% w/w) was used as superd...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.98984

    authors: Shirsand SB,Suresh S,Kusumdevi V,Swamy PV

    更新日期:2011-09-01 00:00:00

  • The Binding Interactions of the Macrolide Endectocide Ivermectin with the Antibiotics Ampicillin, Chloramphenicol and Tetracycline HCL.

    abstract::Ivermectin, chloramphenicol, ampicillin and tetracycline HCl are common drugs in human and veterinary practice. The purpose of this study is to investigate the possible binding interactions between ivermectin and the antibiotics chloramphenicol, ampicillin and tetracycline HCl. Isothermal titration calorimetry was use...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.110635

    authors: Kandeel M,Elgazar W,Kitade Y

    更新日期:2012-11-01 00:00:00

  • Triterpenoids from Schleichera oleosa of Darjeeling Foothills and Their Antimicrobial Activity.

    abstract::Two triterpenoids, taraxerone and tricadenic acid A were isolated from the methanol extract of the outer bark of Schleichera oleosa available in Darjeeling foothills. A preliminary study on their antimicrobial activities was also performed against some fungal and bacterial species. The structure of these compounds was...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.91568

    authors: Ghosh P,Chakraborty P,Mandal A,Rasul MG,Chakraborty M,Saha A

    更新日期:2011-03-01 00:00:00

  • Development and Validation of HPTLC Method for Estimation of Tenoxicam and its Formulations.

    abstract::A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed and validated for the estimation of tenoxicam in the microemulsion gels. Tenoxicam was chromatographed on silica gel 60 F(254) TLC plate, as a stationary phase. The mobile phase was toluene: ethyl acetate: formi...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.102541

    authors: Chandel S,Barhate CR,Srivastava AR,Kulkarni SR,Kapadia CJ

    更新日期:2012-01-01 00:00:00

  • Antihyperglycemic Activity of Petroleum Ether Leaf Extract of Ficus krishnae L. on Alloxan-induced Diabetic Rats.

    abstract::The petroleum ether leaf extract of Ficus krishnae has been evaluated for the management of diabetes in alloxan induced diabetic rats. Phytochemical screening of the leaf extract for various chemical compounds has also been carried out. Leaf extract was administered continuously for 21 days orally at a dose of 200 mg/...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Sidhu MC,Sharma T

    更新日期:2014-07-01 00:00:00

  • A Novel Metabolite from Aspergillus ochraceus JGI 25 Showing Cytotoxicity to Hela Cells.

    abstract::This study aims at the isolation of filamentous fungi, extraction of metabolites, and evaluation of the cytotoxic properties on HeLa cells and normal human lymphocytes. We isolated fungi from the soil by serial dilution method. One of the isolates was chosen and identified as Aspergillus ochraceus Wilhelm (Trichocomac...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Nadumane VK,Venkat P,Pal A,Dharod H,Shukla M,Prashanthi K

    更新日期:2013-09-01 00:00:00

  • Antibacterial Activity of Mangrove Leaf Extracts against Human Pathogens.

    abstract::The antibacterial activity of leaf extract of mangroves, namely, Rhizophora mucronata, Sonneratia alba and Exoecaria agallocha from Chorao island, Goa was investigated against human bacterial pathogens Staphylococcus aureus, Streptococcus sp., Salmonella typhi, Proteus vulgaris and Proteus mirabilis. As compared to aq...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.107068

    authors: Sahoo G,Mulla NS,Ansari ZA,Mohandass C

    更新日期:2012-07-01 00:00:00

  • Synthesis and biological evaluation of some novel 3,4-disubstituted isocoumarins.

    abstract::In this paper we report the synthesis of a new family of 4-alkyl isocoumarin derivatives having bromo carbonyl and amino carbonyl group at 3(rd) position of the heterocyclic ring. Synthesis, spectral analysis and bioactivity of new isocoumarin derivatives are discussed in this paper. Some of the synthesized compounds ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.91586

    authors: Yadav P,Purohit NV

    更新日期:2011-03-01 00:00:00