Abstract:
:The objective of this work was to increase the amount of acyclovir in the basal epidermis, site of herpes virus simplex infection, using the solid lipid nanoparticles loaded gel cream as carriers. Solid lipid nanoparticles were prepared by high pressure homogenisation method and incorporated in a semisolid submicron gel cream. Acyclovir distribution into rat skin after topical application of solid lipid nanoparticles loaded gel cream was determined by fabricated Franz diffusion cell. The results showed that, the quantity of the acyclovir in the basal epidermis with the solid lipid nanoparticles loaded submicron gel cream was two folds times more than marketed acyclovir gel cream. This type of carrier can improve acyclovir loaded therapy since it increases drug retention in the basal epidermis.
journal_name
Indian J Pharm Scijournal_title
Indian journal of pharmaceutical sciencesauthors
Gide PS,Gidwani SK,Kothule KUsubject
Has Abstractpub_date
2013-03-01 00:00:00pages
138-42issue
2eissn
0250-474Xissn
1998-3743journal_volume
75pub_type
杂志文章abstract::WHO reports estimate poisoning as one of the most common causes of increased morbidity and mortality rate world-wide. Various agents such as pesticides, drugs have been used for intentional and accidental poisoning in different countries. In the Indian scenario, pesticides are the most commonly used poisoning agents. ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.78525
更新日期:2010-09-01 00:00:00
abstract::A reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of atorvastatin calcium and fenofibrate in tablet formulation. The separation was achieved by Luna C18 column and methanol:acetate buffer pH 3.7 (82:18 v/v) as mobile phase, at a flow rate of 1.5 ml/min. Detect...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.41473
更新日期:2008-03-01 00:00:00
abstract::Various (4-substituted) phenyl-3-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]propionylamido-1,3-thiazolidine-4-ones (3a-x) and 1-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]-propionylamido-3-chloro-4-(4-substituted)phenyl-azetidin-2-ones (4a-x) have been synthesised by the cyclocondensation of ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.95654
更新日期:2011-07-01 00:00:00
abstract::Modification of polymers by covalent attachment of thiol bearing pendant groups is reported to impart many beneficial properties to them. Hence in the present study, sodium alginate-cysteine conjugate was synthesized by carbodiimide mediated coupling under varying reaction conditions and the derivatives characterized ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.84590
更新日期:2010-11-01 00:00:00
abstract::A derivative UV spectrophotometric and a reversed phase high-performance liquid chromatographic method for the determination of ciprofibrate in tablets was developed. The first-order derivative UV spectrophotometric method was found to be accurate with 100.57±0.97 recovery and precise with a coefficient of variation o...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.103855
更新日期:2012-03-01 00:00:00
abstract::Essential oils extracted from flower petals of palmarosa (Cymbopogon martini), evening primrose (Primula rosea), lavender (Lavandula angustifolia) and tuberose (Polianthus tuberosa) were tested for their antibacterial activities against gram-positive and gram-negative bacteria. Different concentrations of each essenti...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.54278
更新日期:2009-03-01 00:00:00
abstract::The antibacterial activity of leaf extract of mangroves, namely, Rhizophora mucronata, Sonneratia alba and Exoecaria agallocha from Chorao island, Goa was investigated against human bacterial pathogens Staphylococcus aureus, Streptococcus sp., Salmonella typhi, Proteus vulgaris and Proteus mirabilis. As compared to aq...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.107068
更新日期:2012-07-01 00:00:00
abstract::In this paper we report the synthesis of a new family of 4-alkyl isocoumarin derivatives having bromo carbonyl and amino carbonyl group at 3(rd) position of the heterocyclic ring. Synthesis, spectral analysis and bioactivity of new isocoumarin derivatives are discussed in this paper. Some of the synthesized compounds ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474x.91586
更新日期:2011-03-01 00:00:00
abstract::Ivermectin, chloramphenicol, ampicillin and tetracycline HCl are common drugs in human and veterinary practice. The purpose of this study is to investigate the possible binding interactions between ivermectin and the antibiotics chloramphenicol, ampicillin and tetracycline HCl. Isothermal titration calorimetry was use...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.110635
更新日期:2012-11-01 00:00:00
abstract::Antianthelmintic activity of successive extracts (chloroform, acetone, ethanol and aqueous) of Nauclea orientalis leaves were evaluated separately on adult Indian earthworm (Pheretima posthuma) and compared with that of albendazole. It was found that the extracts exhibited, respectively dose-dependent action and inhib...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.73932
更新日期:2010-07-01 00:00:00
abstract::A field experiment on the effect of time of harvesting on yield and quality of Melissa officinalis L. was conducted under the agroclimatic conditions of Doon valley, Uttarakhand in order to assess the performance of four harvesting times (H1-120 days, H2-140 days, H3-160 days and H4-180 days after planting). The fresh...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:
更新日期:2014-09-01 00:00:00
abstract::Supercritical fluid extract of leaves of Vitex negundo was tested for its antimicrobial potential and was compared with that of ethanol extract, ether extract and hydrodistilled oil of leaves. The chemical constituents of extracts were studied by chromatographic techniques. Extracts were evaluated for antimicrobial po...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.78537
更新日期:2010-09-01 00:00:00
abstract::The effectiveness of liposome-mediated gene transfer methods hinges, in part, on the nature of the interaction between the DNA cargo and the liposomes. Here we have examined the effect of quaternization of the cytofectin cationic head group on this interaction and the effect of concentration of the biocompatible, prot...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.95613
更新日期:2011-07-01 00:00:00
abstract::This study aims at the isolation of filamentous fungi, extraction of metabolites, and evaluation of the cytotoxic properties on HeLa cells and normal human lymphocytes. We isolated fungi from the soil by serial dilution method. One of the isolates was chosen and identified as Aspergillus ochraceus Wilhelm (Trichocomac...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:
更新日期:2013-09-01 00:00:00
abstract::A simple and sensitive spectrofluorimetric method has been developed for the estimation of brimonidine tartrate in pure and eye drops. Linearity was obeyed in the range of 0.2-3.0 ΅g/ml in dimethyl formamide as solvent at an emission wavelength (λem) of 530 nm after excitation wavelength (λex) of 389 nm with good corr...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:
更新日期:2013-11-01 00:00:00
abstract::Gastroretentive bimodal drug delivery systems of lamotrigine were developed using immediate release and extended release segments incorporated in a hydroxypropyl methylcellulose capsule and in vitro and in vivo evaluations were conducted. In vivo radiographic studies were carried out for the optimized formulation in h...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:
更新日期:2014-11-01 00:00:00
abstract::A simple, sensitive, rapid, accurate and precise spectrophotometric method has been developed for estimation of ropinirole hydrochloride in bulk and tablet dosage forms. Ropinirole hydrochloride shows maximum absorbance at 250 nm with molar absorptivity of 8.703x10(3) l/mol.cm. Beer's law was obeyed in the concentrati...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.51962
更新日期:2009-01-01 00:00:00
abstract::A few flavanones were synthesised by cyclisation of corresponding 3-(heteroaryl)-1(2-hydroxyphenyl) prop-2-en-1-one with sodium acetate in alcohol-water and evaluated for activity. Synthesised compounds were assayed for their in vitro anticancer activity against three human cancer cell lines, mammary adenocarcinoma (M...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:
更新日期:2014-03-01 00:00:00
abstract::The present study evaluated the in vitro antioxidant potential of different parts of Oroxylum indicum. 2,2-diphelyl 1-picrylhydrazyl (DPPH), nitric oxide, superoxide anion and hydroxyl radical scavenging potential and reductive ability assay of methanol extract of different parts i.e. root, root bark, stem, stem bark,...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.65013
更新日期:2010-03-01 00:00:00
abstract::In the present investigation chitosan has been chemically modified by treating with two different aldehydes like acetaldehyde and propionaldehyde to form Schiff's bases. Schiff's bases of chitosan with acetaldehyde and propionaldehyde were named as polymer A and polymer B, respectively. Fourier Transform Infra Red (FT...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.44593
更新日期:2008-07-01 00:00:00
abstract::Two triterpenoids, taraxerone and tricadenic acid A were isolated from the methanol extract of the outer bark of Schleichera oleosa available in Darjeeling foothills. A preliminary study on their antimicrobial activities was also performed against some fungal and bacterial species. The structure of these compounds was...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474x.91568
更新日期:2011-03-01 00:00:00
abstract::Mitochondrial sodium calcium exchange inhibitors are novel agents in the treatment of type-II diabetes due to their glucose dependent efficacy. While the compounds of this class are expected to correct hyperglycemia, they do not lower basal blood glucose level, thus avoiding the serious consequences of hypoglycemia. T...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.41453
更新日期:2008-03-01 00:00:00
abstract::A simple, precise, and accurate isocratic reversed-phase (RP) stability-indicating HPLC assay method was developed and validated for determination of Aripiprazole in bulk and solid pharmaceutical dosage form. A reversed-phase C8 (250×4.0 mm, 5 μm particle size) column for HPLC and C8 (50×2.1mm, 1.7 μm particle size) f...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.95638
更新日期:2011-07-01 00:00:00
abstract::A simple, reproducible and efficient reverse phase high performance liquid chromatographic method was developed for simultaneous determination of valsartan and hydrochlorothiazide in tablets. A column having 200 x 4.6 mm i.d. in isocratic mode with mobile phase containing methanol:acetonitrile:water:isopropylalcohol (...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.43006
更新日期:2008-05-01 00:00:00
abstract::A set of seventy four molecules belonging to the class of thioglitazones were subjected to the QSAR analysis for their antihyperglycemic activity. All the molecules were subjected to energy minimization to get 3D structures, followed by conformational analysis to get the conformation of the molecule associated with th...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.45392
更新日期:2008-09-01 00:00:00
abstract::Present study aims to prepare and evaluate niacin microspheres. Niacin-ethyl cellulose microspheres were prepared by water-in-oil-in-oil double emulsion solvent diffusion method. Spherical, free flowing microspheres having an entrapment efficiency of 72% were obtained. The effect of polymer-drug ratio, surfactant conc...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.59549
更新日期:2009-11-01 00:00:00
abstract::Asymmetric membrane capsules are a type of osmotic drug delivery systems. They are nondisintegrating capsules, which utilize osmotic pressure to drive the drug outwards for controlled delivery. Preceded by systems such as elementary osmotic pump, controlled porosity osmotic pump, single composition osmotic tablet this...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:
更新日期:2013-03-01 00:00:00
abstract::A simple, rapid, specific and sensitive liquid chromatography tandem mass spectrometric method has been developed and validated for the determination of doxycycline from the human plasma. Doxycycline is extracted from human plasma by solid phase extraction. Demeclocycline was used as an internal standard. Detection wa...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.110599
更新日期:2012-11-01 00:00:00
abstract::Several 4-arylidene-2-phenyl-1-(2,4,5-trichlorophenyl)-1H-imidazol-5(4H)-ones (4a-q), N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-4-chlorobenzamides (5a-o) and N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-2,4-dichlorobenzamides (6a-m) were prepared. All newly synthesized compounds have been ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.51953
更新日期:2009-01-01 00:00:00
abstract::Fast dissolving tablets of clonazepam were prepared by sublimation method with a view to enhance patient compliance. A 3(2) full factorial design was applied to investigate the combined effect of two formulation variables: amount of croscarmellose sodium and camphor. Croscarmellose sodium (2-8% w/w) was used as superd...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.98984
更新日期:2011-09-01 00:00:00