Abstract:
:Fast dissolving tablets of clonazepam were prepared by sublimation method with a view to enhance patient compliance. A 3(2) full factorial design was applied to investigate the combined effect of two formulation variables: amount of croscarmellose sodium and camphor. Croscarmellose sodium (2-8% w/w) was used as superdisintegrant and camphor (20-40% w/w) was used as subliming agent, to increase the porosity of the tablets, since it helps water to penetrate into the tablets, along with directly compressible mannitol to enhance mouth feel. The tablets were evaluated for hardness, friability, thickness, drug content uniformity, in vitro dispersion time, wetting time and water absorption ratio. Based on in vitro dispersion time (approximately 11 s); the formulation containing 5% w/w croscarmellose sodium and 40% w/w camphor was found to be promising and tested for in vitro drug release pattern (in pH 6.8 phosphate buffer). Short-term stability (at 40°/75% relative humidity for 3 mo) and drug-excipient interaction. Surface response plots are presented to graphically represent the effect of independent variables on the in vitro dispersion time. The validity of the generated mathematical model was tested by preparing two extra-design checkpoints. The optimized tablet formulation was compared with conventional commercial tablet formulation for drug release profiles. This formulation showed nearly nine-fold faster drug release (t(50%) 1.8 min) compared to the conventional commercial tablet formulation (t(50%) 16.4 min). Short-term stability studies on the formulation indicated that there are no significant changes in drug content and in vitro dispersion time (P<0.05).
journal_name
Indian J Pharm Scijournal_title
Indian journal of pharmaceutical sciencesauthors
Shirsand SB,Suresh S,Kusumdevi V,Swamy PVdoi
10.4103/0250-474X.98984subject
Has Abstractpub_date
2011-09-01 00:00:00pages
491-6issue
5eissn
0250-474Xissn
1998-3743pii
IJPhS-73-491journal_volume
73pub_type
杂志文章abstract::It is now known that vitamin D deficiency is a worldwide health problem. In our country, as food fortification is lacking, supplementation with pharmaceutical preparations is the only means of treatment of vitamin D deficiency. We aimed to study the composition and availability of various vitamin D preparations in the...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474x.180248
更新日期:2016-01-01 00:00:00
abstract::Aqueous extract of leaves of Nelumbo nucifera was investigated on acute stress (immobilization stress)-induced biochemical alterations in Swiss mice. The animals were also subjected to acute physical stress (swimming endurance test) and acute chemical stress (writhing test) to gauge the antistress potential of the ext...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.42982
更新日期:2008-05-01 00:00:00
abstract::In the current research work an attempt was made to develop "Melt in mouth pellets" (Meltlets(®)) containing 40% herbal extract of soy isoflavones that served to provide antioxidants activity in menopausal women. The process of extrusion-spheronization was optimized for extruder speed, extruder screen size, spheroniza...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.119831
更新日期:2013-07-01 00:00:00
abstract::WHO reports estimate poisoning as one of the most common causes of increased morbidity and mortality rate world-wide. Various agents such as pesticides, drugs have been used for intentional and accidental poisoning in different countries. In the Indian scenario, pesticides are the most commonly used poisoning agents. ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.78525
更新日期:2010-09-01 00:00:00
abstract::Preparation and in vitro/in vivo evaluation of mifepristone intravaginal ring formulations were investigated. In the present study, it is reported that a mifepristone intravaginal ring of reservoir design comprising of a mifepristone silicone elastomer core enclosed in a silicone layer. During the preparation of intra...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474x.159671
更新日期:2015-05-01 00:00:00
abstract::Several 4-arylidene-2-phenyl-1-(2,4,5-trichlorophenyl)-1H-imidazol-5(4H)-ones (4a-q), N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-4-chlorobenzamides (5a-o) and N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-2,4-dichlorobenzamides (6a-m) were prepared. All newly synthesized compounds have been ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.51953
更新日期:2009-01-01 00:00:00
abstract::This study aims at the isolation of filamentous fungi, extraction of metabolites, and evaluation of the cytotoxic properties on HeLa cells and normal human lymphocytes. We isolated fungi from the soil by serial dilution method. One of the isolates was chosen and identified as Aspergillus ochraceus Wilhelm (Trichocomac...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:
更新日期:2013-09-01 00:00:00
abstract::Etoposide is a semisynthetic compound, widely used in treatment of non small cell lung cancer. However, frequent dosing and adverse effects remain a major concern in the use of etoposide. Liposomal systems for pulmonary drug delivery have been particularly attractive because of their compatibility with lung surfactant...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.100240
更新日期:2011-11-01 00:00:00
abstract::The present study depicts the development of a validated RP-HPLC method for the determination of the pamabrom in presence of degradation products or other pharmaceutical excipients. Stress study was performed on pamabrom and it was found that it degrade sufficiently in acidic, alkali and oxidative condition but less d...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:
更新日期:2014-05-01 00:00:00
abstract::A few flavanones were synthesised by cyclisation of corresponding 3-(heteroaryl)-1(2-hydroxyphenyl) prop-2-en-1-one with sodium acetate in alcohol-water and evaluated for activity. Synthesised compounds were assayed for their in vitro anticancer activity against three human cancer cell lines, mammary adenocarcinoma (M...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:
更新日期:2014-03-01 00:00:00
abstract::Tuberculosis is one of the major public health problems faced globally. Resistance of Mycobacterium tuberculosis to antitubercular agents has called for an urgent need to investigate newer drugs to combat tuberculosis. Garlic (Allium sativum) is an edible plant which has generated a lot of curiosity throughout human h...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:
更新日期:2014-05-01 00:00:00
abstract::The study was undertaken to evaluate various aspects of self-medication in medical students. A prospective, cross-sectional, questionnaire-based study was carried out among 488 medical students selected by simple random sampling from January 2013 to June 2013. Data was collected and analyzed for counts and percentage....
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474x.156569
更新日期:2015-03-01 00:00:00
abstract::The objective of this study was to prepare and characterise nevirapine nanosuspensions so as to improve the dissolution rate of nevirapine. Nevirapine is a nonnucleoside reverse transcriptase inhibitor of immunodeficiency virus type-1 and it is poorly water-soluble antiretroviral drug. The low solubility of nevirapine...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract::An oral controlled release suspension of chlorpheniramine maleate was prepared using ion-exchange resin technology. A strong cation exchange resin Indion 244 was utilized for the sorption of the drug and the drug resinates was evaluated for various physical and chemical parameters. The drug-resinate complex was microe...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.44613
更新日期:2008-07-01 00:00:00
abstract::Two UV Spectrophotometric and one reverse phase high performance liquid chromatography methods have been developed for the simultaneous estimation of amlodipine besilate and olmesartan medoxomil in tablet dosage form. First UV spectrophotometric method was a determination using the simultaneous equation method at 237....
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.58190
更新日期:2009-09-01 00:00:00
abstract::Supercritical fluid extract of leaves of Vitex negundo was tested for its antimicrobial potential and was compared with that of ethanol extract, ether extract and hydrodistilled oil of leaves. The chemical constituents of extracts were studied by chromatographic techniques. Extracts were evaluated for antimicrobial po...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.78537
更新日期:2010-09-01 00:00:00
abstract::In the present study, 2,5-disubstituted-1,3,4-oxadiazoles (3a-o) have been synthesized by the condensation of 4-methoxybenzohydrazide (1) with different aromatic acids (2a-o) in presence of phosphoryl chloride. The structural assignment of this compound (3a-o) has been made on the basis of elemental analysis, UV, IR, ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.40331
更新日期:2008-01-01 00:00:00
abstract::Mebeverine hydrochloride is known to suffer from extensive first pass effect. In an attempt to improve its oral bioavailability and possibility to restrict its absorption only to the colon, mebeverine microspheres were prepared by emulsion solvent evaporation method. Four formulations were prepared with varying drug a...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.57303
更新日期:2009-07-01 00:00:00
abstract::The aim of the present study was the determination of formulation factors and the in vitro evaluation of an extended release dosage form of a freely soluble weakly basic drug (alfuzosin hydrochloride). Binary mixer of one hydrophilic polymer (hydroxypropylmethylcellulose) and one directly compressible Eudragit (RS PO)...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.56019
更新日期:2009-05-01 00:00:00
abstract::Wound healing agents support the natural healing process, reduce trauma and likelihood of secondary infections and hasten wound closure. The wound healing activities of water in oil cream of the methanol extract of Hibiscus sabdariffa L. (Malvaceae) was evaluated in rats with superficial skin excision wounds. Antibact...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.113549
更新日期:2013-01-01 00:00:00
abstract::Crystal form can be crucial to the performance of a dosage form. This is especially true for compounds that have intrinsic barriers to drug delivery, such as low aqueous solubility, slow dissolution in gastrointestinal media, low permeability and first-pass metabolism. The nature of the physical form and formulation t...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.57283
更新日期:2009-07-01 00:00:00
abstract::Objective of the present study was to develop and evaluate vaginal films with essential in vitro studies. Films were developed using hydroxypropyl methylcellulose as a polymer and formulations were coded. The developed films were evaluated with Fourier transform infrared spectroscopy, drug content, viscosity, surface ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:
更新日期:2013-09-01 00:00:00
abstract::Various (4-substituted) phenyl-3-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]propionylamido-1,3-thiazolidine-4-ones (3a-x) and 1-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]-propionylamido-3-chloro-4-(4-substituted)phenyl-azetidin-2-ones (4a-x) have been synthesised by the cyclocondensation of ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.95654
更新日期:2011-07-01 00:00:00
abstract::The antibacterial activity of leaf extract of mangroves, namely, Rhizophora mucronata, Sonneratia alba and Exoecaria agallocha from Chorao island, Goa was investigated against human bacterial pathogens Staphylococcus aureus, Streptococcus sp., Salmonella typhi, Proteus vulgaris and Proteus mirabilis. As compared to aq...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.107068
更新日期:2012-07-01 00:00:00
abstract::A novel reversed-phase HPLC method has been developed and validated for the simultaneous determination of 2-phenoxyethanol, methylparaben, ethylparaben and propylparaben preservatives. The method uses a Lichrosorb C8 (150×4.6 mm, 5 µm) column and isocratic elution. The mobile phase consisted of a mixture of acetonitri...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.73906
更新日期:2010-07-01 00:00:00
abstract::A field experiment on the effect of time of harvesting on yield and quality of Melissa officinalis L. was conducted under the agroclimatic conditions of Doon valley, Uttarakhand in order to assess the performance of four harvesting times (H1-120 days, H2-140 days, H3-160 days and H4-180 days after planting). The fresh...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:
更新日期:2014-09-01 00:00:00
abstract::Antianthelmintic activity of successive extracts (chloroform, acetone, ethanol and aqueous) of Nauclea orientalis leaves were evaluated separately on adult Indian earthworm (Pheretima posthuma) and compared with that of albendazole. It was found that the extracts exhibited, respectively dose-dependent action and inhib...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.73932
更新日期:2010-07-01 00:00:00
abstract::Gastroretentive bimodal drug delivery systems of lamotrigine were developed using immediate release and extended release segments incorporated in a hydroxypropyl methylcellulose capsule and in vitro and in vivo evaluations were conducted. In vivo radiographic studies were carried out for the optimized formulation in h...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:
更新日期:2014-11-01 00:00:00
abstract::The petroleum ether leaf extract of Ficus krishnae has been evaluated for the management of diabetes in alloxan induced diabetic rats. Phytochemical screening of the leaf extract for various chemical compounds has also been carried out. Leaf extract was administered continuously for 21 days orally at a dose of 200 mg/...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:
更新日期:2014-07-01 00:00:00
abstract::Alpinia officinarum is a rhizome belonging to the family zingeberaeceae. Hydro alcoholic extract by hot and cold maceration and methanol extract by percolation process Qualitative phytochemical analysis of extract of Alpinia officinarum rhizome showed a majority of the compound including tannins, alkaloids, flavonoids...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.62233
更新日期:2010-01-01 00:00:00