Abstract：
:The petroleum ether leaf extract of Ficus krishnae has been evaluated for the management of diabetes in alloxan induced diabetic rats. Phytochemical screening of the leaf extract for various chemical compounds has also been carried out. Leaf extract was administered continuously for 21 days orally at a dose of 200 mg/kg. Along with this, the blood glucose level was monitored at regular intervals to understand the activity of the extract. The leaf extract has decreased the blood glucose level of diabetic rats which was comparable to an antidiabetic standard drug, glibenclamide, given at a dose of 2.5 mg/kg. It has been observed that the leaves of Ficus krishnae possess antidiabetic activity and it reduces the blood glucose level significantly. The phytochemical screening of leaf has revealed the presence of carbohydrates, flavonoids, tannins, glycosides, terpenoids, steroids, alkaloids, gums and mucilage, phlobatannins, reducing sugars and phenolic compounds. The Fourier Transform Infrared analysis of glibenclamide and leaf powder has displayed some common absorption spectra. This shows that leaf powder has a molecule which is close to glibenclamide. Wavelength Dispersive X-Ray Fluorescence spectroscopy have shown the presence of cellulose, Ca, Si, K, Cl, Mg, P, S, Al, Fe, Na, Sr, Pd, Zn, Mn, Cr, Mo, Br, Ni, Rb and Zr. It is assumed that these elements alongwith other chemical compounds of the plant species may play a role in the management of diabetes. The Raman Specta of both glibenclamide and leaf powder has also shown some similarities. The results obtained during the present investigation have revealed the antidiabetic activity of Ficus krishnae leaves. The phytochemical screening has indicated the various chemical constituents likely to be responsible for this activity. The Fourier Transform Infrared, Wavelength Dispersive X-Ray Fluorescence and Raman Specta of the leaf powder suggested that there is some glibenclamide like molecule or its derivatives which is imparting antidiabetic activity.
journal_name
Indian J Pharm Scijournal_title
Indian journal of pharmaceutical sciencesauthors
Sidhu MC,Sharma Tsubject
Has Abstractpub_date
2014-07-01 00:00:00pages
323-31issue
4eissn
0250-474Xissn
1998-3743journal_volume
76pub_type
杂志文章abstract：:Tuberculosis is one of the major public health problems faced globally. Resistance of Mycobacterium tuberculosis to antitubercular agents has called for an urgent need to investigate newer drugs to combat tuberculosis. Garlic (Allium sativum) is an edible plant which has generated a lot of curiosity throughout human h...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：
更新日期：2014-05-01 00:00:00
abstract：:Mitochondrial sodium calcium exchange inhibitors are novel agents in the treatment of type-II diabetes due to their glucose dependent efficacy. While the compounds of this class are expected to correct hyperglycemia, they do not lower basal blood glucose level, thus avoiding the serious consequences of hypoglycemia. T...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.41453
更新日期：2008-03-01 00:00:00
abstract：:A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of esomeprazole and domperidone. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 301 nm and 284 nm, lambda max of esomeprazole and domperidone respecti...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.40351
更新日期：2008-01-01 00:00:00
abstract：:The aim of this research was to investigate the technique for preparation of coated valproic acid and sodium valproate sustained-release matrix tablets. Different diluents were tested and selected as the effective absorbent for oily valproic acid. Effect of the amount of absorbent and hydroxypropylmethylcellulose on d...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.65026
更新日期：2010-03-01 00:00:00
abstract：:Bacteria have developed multidrug resistance against available antimicrobial agents. Infectious diseases caused by these multidrug-resistant bacteria are major causes of morbidity and mortality in human beings. Synthetic drugs are expensive and inadequate for the treatment of diseases, causing side effects and ineffec...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.174991
更新日期：2015-11-01 00:00:00
abstract：:The effect of some physical and nutritional parameters were studied for the optimum production of extracellular enzyme hyaluronidase employing Streptococcus mitis MTCC*2695 by submerged fermentation. The effects of initial pH, incubation temperature and time, inoculum level and age of inoculum were studied. The maximu...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.45412
更新日期：2008-09-01 00:00:00
abstract：:Etoposide is a semisynthetic compound, widely used in treatment of non small cell lung cancer. However, frequent dosing and adverse effects remain a major concern in the use of etoposide. Liposomal systems for pulmonary drug delivery have been particularly attractive because of their compatibility with lung surfactant...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.100240
更新日期：2011-11-01 00:00:00
abstract：:Fexofenadine is a selective histamine H(1) receptor antagonist, used for relief of the symptoms of allergy. However its aqueous solubility is very poor. Solid inclusion complexes of fexofenadine and β-cyclodextrin were prepared at the molar ratios of 1:1 and 1:2 by kneading, and coprecipitation methods to improve its ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.70477
更新日期：2010-05-01 00:00:00
abstract：:Present study aims to prepare and evaluate niacin microspheres. Niacin-ethyl cellulose microspheres were prepared by water-in-oil-in-oil double emulsion solvent diffusion method. Spherical, free flowing microspheres having an entrapment efficiency of 72% were obtained. The effect of polymer-drug ratio, surfactant conc...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.59549
更新日期：2009-11-01 00:00:00
abstract：:Present study reports the development and validation of a simultaneous estimation of metformin and gliclazide in human plasma using supercritical fluid chromatography followed by tandem mass spectrometry. Acetonitrile:water (80:20) mixture was used as a mobile phase along with liquid CO(2) in supercritical fluid chrom...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.62231
更新日期：2010-01-01 00:00:00
abstract：:A rapid and sensitive reverse phase high performance liquid chromatographic method is depicted for the qualitative and quantitative assay of letrozole in pharmaceutical dosage forms. Letrozole was chromatographed on a reverse phase C18 column with a mobile phase consisting of acetonitrile and phosphate buffer (pH 7.8)...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.43019
更新日期：2008-05-01 00:00:00
abstract：:Essential oils extracted from flower petals of palmarosa (Cymbopogon martini), evening primrose (Primula rosea), lavender (Lavandula angustifolia) and tuberose (Polianthus tuberosa) were tested for their antibacterial activities against gram-positive and gram-negative bacteria. Different concentrations of each essenti...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.54278
更新日期：2009-03-01 00:00:00
abstract：:A simple, accurate and precise spectrophotometric method has been developed for simultaneous estimation of escitalopram oxalate and clonazepam in combined dosage form. Simultaneous equation method is employed for simultaneous determination of escitalopram oxalate and clonazepam from combined dosage forms. In this meth...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.59559
更新日期：2009-11-01 00:00:00
abstract：:The results of our previous investigations on extracts of selected marine algae showed that Caulerpa peltata and Padina gymnospora had more promising antiproliferative and antioxidant activities than Gelidiella acerosa and Sargassum wightii. Based on these results, the more active chloroform extract of C. peltata and ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：
更新日期：2014-11-01 00:00:00
abstract：:Several 4-arylidene-2-phenyl-1-(2,4,5-trichlorophenyl)-1H-imidazol-5(4H)-ones (4a-q), N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-4-chlorobenzamides (5a-o) and N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-2,4-dichlorobenzamides (6a-m) were prepared. All newly synthesized compounds have been ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.51953
更新日期：2009-01-01 00:00:00
abstract：:An in vitro evaluation of the anti-microbial activity of medicated soaps was conducted using ditch-plate and hand washing techniques. Strains of reference microbes namely Candida albicans (ATCC90028), Staphylococcus aureus (ATCC25923), Pseudomonas aureginosa (ATCC27853) and Escherichia coli (ATCC25922) were tested at ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.89765
更新日期：2011-01-01 00:00:00
abstract：:Fast dissolving tablets of clonazepam were prepared by sublimation method with a view to enhance patient compliance. A 3(2) full factorial design was applied to investigate the combined effect of two formulation variables: amount of croscarmellose sodium and camphor. Croscarmellose sodium (2-8% w/w) was used as superd...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.98984
更新日期：2011-09-01 00:00:00
abstract：:A derivative UV spectrophotometric and a reversed phase high-performance liquid chromatographic method for the determination of ciprofibrate in tablets was developed. The first-order derivative UV spectrophotometric method was found to be accurate with 100.57±0.97 recovery and precise with a coefficient of variation o...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.103855
更新日期：2012-03-01 00:00:00
abstract：:The objective of this work was to increase the amount of acyclovir in the basal epidermis, site of herpes virus simplex infection, using the solid lipid nanoparticles loaded gel cream as carriers. Solid lipid nanoparticles were prepared by high pressure homogenisation method and incorporated in a semisolid submicron g...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：:In the present study, the effect of 2-hydroxy-4-methoxy benzoic acid isolated from roots of Hemisdesmus indicus on the erythrocyte membrane bound enzymes and antioxidant status in streptozotocin-induced diabetic rats was investigated. The streptozotocin-induced diabetic rats were treated with 2-hydroxy-4-methoxy benzo...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.108438
更新日期：2012-09-01 00:00:00
abstract：:A simple, reproducible and efficient reverse phase high performance liquid chromatographic method was developed for simultaneous determination of valsartan and hydrochlorothiazide in tablets. A column having 200 x 4.6 mm i.d. in isocratic mode with mobile phase containing methanol:acetonitrile:water:isopropylalcohol (...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.43006
更新日期：2008-05-01 00:00:00
abstract：:The objective of this study was to prepare and characterise nevirapine nanosuspensions so as to improve the dissolution rate of nevirapine. Nevirapine is a nonnucleoside reverse transcriptase inhibitor of immunodeficiency virus type-1 and it is poorly water-soluble antiretroviral drug. The low solubility of nevirapine...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:In the present study petroleum ether and alcoholic extracts of Centratherum anthelminticum (L) Kuntze seed (100 mg and 200 mg/kg p.o.) were evaluated for antiinflammatory activity in acute and subacute models of inflammation. It was found that both petroleum ether and alcoholic extracts showed significant reduction in...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.84577
更新日期：2010-11-01 00:00:00
abstract：:Recent studies have shown that gallic acid and its alkylesters induce apoptosis in different cell lines. Since new compounds with biological activity and less cytotoxicity to normal cells are necessary for cancer therapy, the aim of this study was to evaluate the cytotoxic effect of 1-(3,4,5-trihydroxyphenyl)-dodecylb...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474x.180255
更新日期：2016-01-01 00:00:00
abstract：:Two triterpenoids, taraxerone and tricadenic acid A were isolated from the methanol extract of the outer bark of Schleichera oleosa available in Darjeeling foothills. A preliminary study on their antimicrobial activities was also performed against some fungal and bacterial species. The structure of these compounds was...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474x.91568
更新日期：2011-03-01 00:00:00
abstract：:A stability-indicating reversed-phase liquid chromatographic method has been developed and validated for simultaneous determination of losartan potassium and ramipril. Separations were achieved using a C(18) column with mobile phase consisting of acetonitrile and (0.2% v/v, pH 2.5) aqueous trifluoroacetic acid (45:55,...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.106061
更新日期：2012-05-01 00:00:00
abstract：:Gastroretentive bimodal drug delivery systems of lamotrigine were developed using immediate release and extended release segments incorporated in a hydroxypropyl methylcellulose capsule and in vitro and in vivo evaluations were conducted. In vivo radiographic studies were carried out for the optimized formulation in h...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：
更新日期：2014-11-01 00:00:00
abstract：:A simultaneous determination of olmesartan medoxomil and hydrochlorothiazide by absorption ratio spectrophotometric method has been developed in combined tablet dosage form. The method is based on measurements of absorbance at isoabsoptive point. The Beer's law obeys in the range of 10-30 mug/ml for both olmesartan me...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.62245
更新日期：2010-01-01 00:00:00
abstract：:Various (4-substituted) phenyl-3-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]propionylamido-1,3-thiazolidine-4-ones (3a-x) and 1-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]-propionylamido-3-chloro-4-(4-substituted)phenyl-azetidin-2-ones (4a-x) have been synthesised by the cyclocondensation of ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.95654
更新日期：2011-07-01 00:00:00
abstract：:In this paper we report the synthesis of a new family of 4-alkyl isocoumarin derivatives having bromo carbonyl and amino carbonyl group at 3(rd) position of the heterocyclic ring. Synthesis, spectral analysis and bioactivity of new isocoumarin derivatives are discussed in this paper. Some of the synthesized compounds ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474x.91586
更新日期：2011-03-01 00:00:00
