QSAR Study on Thiazolidine-2,4-dione Derivatives for Antihyperglycemic Activity.

Abstract:

:A set of seventy four molecules belonging to the class of thioglitazones were subjected to the QSAR analysis for their antihyperglycemic activity. All the molecules were subjected to energy minimization to get 3D structures, followed by conformational analysis to get the conformation of the molecule associated with the least energy and highest stability. Various physico-chemical parameters were then calculated using ALCHEMY 2000 software, namely, thermodynamic parameters, structure-dependant parameters, topological parameters and charge-dependant parameters. Multiple linear regression analysis was carried out on all the molecules. The final equation was developed by choosing optimal combination of descriptors after removing the outliers. Cross validation was performed by leave one out method to arrive at the final QSAR model for the chosen set of molecules to exhibit antihyperglycemic activity.

journal_name

Indian J Pharm Sci

authors

Prashantha Kumar BR,Nanjan MJ

doi

10.4103/0250-474X.45392

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

565-71

issue

5

eissn

0250-474X

issn

1998-3743

journal_volume

70

pub_type

杂志文章
  • HPLC method for simultaneous determination of impurities and degradation products in zonisamide.

    abstract::A gradient reversed phase HPLC method was developed and validated for the analysis of related substances in zonisamide (1,2-benzisoxazole-3-methanesulfonamide), using a Waters Symmetry C8 (150*3.9 mm) column with a flow rate of 1.0 ml/min and detection at 280 nm. The mobile phase component A consisted of a mixture of ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.58183

    authors: Vijayakumar EK,Dhore DM,Kumar M

    更新日期:2009-09-01 00:00:00

  • Synthesis, Antiviral and Cytotoxic Activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one Derivatives.

    abstract::A series of novel 2,3-disubstitutedquinazolin-4(3H)-ones have been synthesized by condensation of 2-substituted benzo[1,3]oxazine-4-ones and anthranilic acid. Synthesized compounds were evaluated for in vitro antiviral activity against HIV, HSV and vaccinia viruses. 5-Bromo-2-(6-bromo-4-oxo-2-phenyl-4H-quinazolin-3-yl...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.84603

    authors: Selvam P,Murugesh N,Chandramohan M,Pannecouque C,DE Clercq E

    更新日期:2010-11-01 00:00:00

  • Antidiabetic Activity of Clerodendron phlomoidis Leaf Extract in Alloxan-Induced Diabetic Rats.

    abstract::Ethanol extract of leaves of Clerodendron phlomoidis L. subjected to preliminary qualitative phytochemical investigations showed the presence of alkaloids, phytosterols, glycosides, saponins, phenolic compounds, proteins and flavonoids. The extract was screened for hypoglycemic activity in alloxan-induced diabetic rat...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.49141

    authors: Dhanabal SP,Mohan Marugaraja MK,Suresh B

    更新日期:2008-11-01 00:00:00

  • Hypoglycemic Effect of the Methanol flower Extract of Piper Claussenianum and the Major Constituent 2',6'-dihydroxy-4'-methoxychalcone in Streptozotocin Diabetic Rats.

    abstract::Piper claussenianum inflorescences crude methanol extract was tested for hypoglycemic effect in streptozotocin-induced diabetic rats. The blood glucose levels of rats treated with methanol extract were reduced from 318.4±28.1 mg/dl before treatment to 174.2±38.3 mg/dl after 12 days of treatment (P<0.05). Phytochemical...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.156624

    authors: Marques AM,Pereira SL,Paiva RA,Cavalcante CV,Sudo SZ,Tinoco LW,Moreira DL,Guimaraes EF,Sudo RT,Kaplan MA,Sudo GZ

    更新日期:2015-03-01 00:00:00

  • Synthesis and evaluation of flavanones as anticancer agents.

    abstract::A few flavanones were synthesised by cyclisation of corresponding 3-(heteroaryl)-1(2-hydroxyphenyl) prop-2-en-1-one with sodium acetate in alcohol-water and evaluated for activity. Synthesised compounds were assayed for their in vitro anticancer activity against three human cancer cell lines, mammary adenocarcinoma (M...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Murti Y,Mishra P

    更新日期:2014-03-01 00:00:00

  • Selective HPLC method development for soy phosphatidylcholine Fatty acids and its mass spectrometry.

    abstract::A novel, efficient and simple approach for soy phosphatidylcholine analysis according to its fatty acid composition was studied with reverse-phase high-performance liquid chromatography. The reverse-phase high-performance liquid chromatography analysis was performed isocratically using UV detector and simple mobile ph...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.117435

    authors: Jangle RD,Galge RV,Patil VV,Thorat BN

    更新日期:2013-05-01 00:00:00

  • Studies on formulation and in vitro evaluation of floating matrix tablets of domperidone.

    abstract::Floating matrix tablets of domperidone were developed to prolong gastric residence time and thereby increased drug bioavailability. Domperidone was chosen as a model drug because it is poorly absorbed from the lower gastrointestinal tract. The tablets were prepared by wet granulation technique, using polymers such as ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.51944

    authors: Prajapati ST,Patel LD,Patel DM

    更新日期:2009-01-01 00:00:00

  • Development and Validation of RP-HPLC Method for Simultaneous Estimation of Atorvastatin Calcium and Fenofibrate in Tablet Dosage Forms.

    abstract::A reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of atorvastatin calcium and fenofibrate in tablet formulation. The separation was achieved by Luna C18 column and methanol:acetate buffer pH 3.7 (82:18 v/v) as mobile phase, at a flow rate of 1.5 ml/min. Detect...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.41473

    authors: Jain N,Raghuwanshi R,Jain D

    更新日期:2008-03-01 00:00:00

  • Meltlets(®) of soy isoflavones: process optimization and the effect of extrusion spheronization process parameters on antioxidant activity.

    abstract::In the current research work an attempt was made to develop "Melt in mouth pellets" (Meltlets(®)) containing 40% herbal extract of soy isoflavones that served to provide antioxidants activity in menopausal women. The process of extrusion-spheronization was optimized for extruder speed, extruder screen size, spheroniza...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.119831

    authors: Deshmukh K,Amin P

    更新日期:2013-07-01 00:00:00

  • Preparation and evaluation of transdermal drug delivery system of etoricoxib using modified chitosan.

    abstract::In the present investigation chitosan has been chemically modified by treating with two different aldehydes like acetaldehyde and propionaldehyde to form Schiff's bases. Schiff's bases of chitosan with acetaldehyde and propionaldehyde were named as polymer A and polymer B, respectively. Fourier Transform Infra Red (FT...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.44593

    authors: Wahid A,Sridhar BK,Shivakumar S

    更新日期:2008-07-01 00:00:00

  • Design, Synthesis and antiHIV activity of Novel Isatine-Sulphonamides.

    abstract::A series of novel isatine-sulphonamide derivatives have been synthesized by combining isatin derivatives with sulphonamides. The structure of the synthesized compounds were elucidated by spectral analysis (IR, NMR and Mass). Investigation of anti-HIV activity was done against HIV-1(IIIB) in MT-4 cells and HIV integras...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.49121

    authors: Selvam P,Murugesh N,Chandramohan M,Debyser Z,Witvrouw M

    更新日期:2008-11-01 00:00:00

  • Effect of 2-Hydroxy-4-methoxy Benzoic Acid Isolated from Hemidesmus indicus on Erythrocyte Membrane Bound Enzymes and Antioxidant Status in Streptozotocin-induced Diabetic Rats.

    abstract::In the present study, the effect of 2-hydroxy-4-methoxy benzoic acid isolated from roots of Hemisdesmus indicus on the erythrocyte membrane bound enzymes and antioxidant status in streptozotocin-induced diabetic rats was investigated. The streptozotocin-induced diabetic rats were treated with 2-hydroxy-4-methoxy benzo...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.108438

    authors: Gayathri M,Kannabiran K

    更新日期:2012-09-01 00:00:00

  • Molecular Cytotoxic Mechanisms of 1-(3,4,5-Trihydroxyphenyl)-dodecylbenzoate in Human Leukemia Cell Lines.

    abstract::Recent studies have shown that gallic acid and its alkylesters induce apoptosis in different cell lines. Since new compounds with biological activity and less cytotoxicity to normal cells are necessary for cancer therapy, the aim of this study was to evaluate the cytotoxic effect of 1-(3,4,5-trihydroxyphenyl)-dodecylb...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.180255

    authors: Maioral MF,Bubniak LD,Marzarotto MA,De Moraes AC,Leal P,Nunes R,Yunes RA,Santos-Silva MC

    更新日期:2016-01-01 00:00:00

  • Fluorimetric quantification of brimonidine tartrate in eye drops.

    abstract::A simple and sensitive spectrofluorimetric method has been developed for the estimation of brimonidine tartrate in pure and eye drops. Linearity was obeyed in the range of 0.2-3.0 ΅g/ml in dimethyl formamide as solvent at an emission wavelength (λem) of 530 nm after excitation wavelength (λex) of 389 nm with good corr...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Sunitha G,Bhagirath R,Alapati VR,Ramakrishna K,Subrahmanyam CV,Anumolu PD

    更新日期:2013-11-01 00:00:00

  • Neuroprotective Activity of Pongamia pinnata in Monosodium Glutamate-induced Neurotoxicity in Rats.

    abstract::This study was designed to evaluate the neuroprotective activity of ethanol extract of Pongamia pinnata stem bark in monosodium glutamate-induced neurotoxicity in rats. Neurotoxicity was induced by intraperitoneal injection of monosodium glutamate 2 g per kg body weight daily for 7 days. Ethanol extract of Pongamia pi...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Swamy AH,Patel NL,Gadad PC,Koti BC,Patel UM,Thippeswamy AH,Manjula DV

    更新日期:2013-11-01 00:00:00

  • Optimization of Physical and Nutritional Parameters for Hyaluronidase Production by Streptococcus mitis.

    abstract::The effect of some physical and nutritional parameters were studied for the optimum production of extracellular enzyme hyaluronidase employing Streptococcus mitis MTCC*2695 by submerged fermentation. The effects of initial pH, incubation temperature and time, inoculum level and age of inoculum were studied. The maximu...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.45412

    authors: Sahoo S,Panda PK,Mishra SR,Nayak A,Dash SK,Ellaiah P

    更新日期:2008-09-01 00:00:00

  • Antimicrobial Activity of Medicated Soaps Commonly Used By Dar es Salaam Residents in Tanzania.

    abstract::An in vitro evaluation of the anti-microbial activity of medicated soaps was conducted using ditch-plate and hand washing techniques. Strains of reference microbes namely Candida albicans (ATCC90028), Staphylococcus aureus (ATCC25923), Pseudomonas aureginosa (ATCC27853) and Escherichia coli (ATCC25922) were tested at ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.89765

    authors: Mwambete KD,Lyombe F

    更新日期:2011-01-01 00:00:00

  • A Chromatographic Determination of Aripiprazole using HPLC and UPLC: A Comparative Validation Study.

    abstract::A simple, precise, and accurate isocratic reversed-phase (RP) stability-indicating HPLC assay method was developed and validated for determination of Aripiprazole in bulk and solid pharmaceutical dosage form. A reversed-phase C8 (250×4.0 mm, 5 μm particle size) column for HPLC and C8 (50×2.1mm, 1.7 μm particle size) f...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.95638

    authors: Thakkar RS,Saravaia HT,Ambasana MA,Kaila HO,Shah AK

    更新日期:2011-07-01 00:00:00

  • Simultaneous Determination of Valsartan and Hydrochlorothiazide in Tablets by RP-HPLC.

    abstract::A simple, reproducible and efficient reverse phase high performance liquid chromatographic method was developed for simultaneous determination of valsartan and hydrochlorothiazide in tablets. A column having 200 x 4.6 mm i.d. in isocratic mode with mobile phase containing methanol:acetonitrile:water:isopropylalcohol (...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.43006

    authors: Tian DF,Tian XL,Tian T,Wang ZY,Mo FK

    更新日期:2008-05-01 00:00:00

  • Preparation and characterisation of fluconazole vaginal films for the treatment of vaginal candidiasis.

    abstract::Objective of the present study was to develop and evaluate vaginal films with essential in vitro studies. Films were developed using hydroxypropyl methylcellulose as a polymer and formulations were coded. The developed films were evaluated with Fourier transform infrared spectroscopy, drug content, viscosity, surface ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Kumar L,Reddy MS,Shirodkar RK,Pai GK,Krishna VT,Verma R

    更新日期:2013-09-01 00:00:00

  • Assessment of prevalence and mortality incidences due to poisoning in a South Indian tertiary care teaching hospital.

    abstract::WHO reports estimate poisoning as one of the most common causes of increased morbidity and mortality rate world-wide. Various agents such as pesticides, drugs have been used for intentional and accidental poisoning in different countries. In the Indian scenario, pesticides are the most commonly used poisoning agents. ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.78525

    authors: Jesslin J,Adepu R,Churi S

    更新日期:2010-09-01 00:00:00

  • In vivo Antimalarial Activities of Russelia Equisetiformis in Plasmodium Berghei Infected Mice.

    abstract::The rising problem of resistance to most commonly used antimalarials remains a major challenge in the control of malaria suggesting the need for new antimalarial agents. This work explores the antiplasmodial potential of ethanol extract of Russelia equisetiformis in chloroquine Plasmodium berghei infected mice. Swiss ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.164787

    authors: Ojurongbe O,Ojo JA,Adefokun DI,Abiodun OO,Odewale G,Awe EO

    更新日期:2015-07-01 00:00:00

  • A novel and rapid method to determine doxycycline in human plasma by liquid chromatography tandem mass spectrometry.

    abstract::A simple, rapid, specific and sensitive liquid chromatography tandem mass spectrometric method has been developed and validated for the determination of doxycycline from the human plasma. Doxycycline is extracted from human plasma by solid phase extraction. Demeclocycline was used as an internal standard. Detection wa...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.110599

    authors: Krishna AC,Sathiyaraj M,Saravanan RS,Chelladurai R,Vignesh R

    更新日期:2012-11-01 00:00:00

  • Antihyperglycemic Activity of Petroleum Ether Leaf Extract of Ficus krishnae L. on Alloxan-induced Diabetic Rats.

    abstract::The petroleum ether leaf extract of Ficus krishnae has been evaluated for the management of diabetes in alloxan induced diabetic rats. Phytochemical screening of the leaf extract for various chemical compounds has also been carried out. Leaf extract was administered continuously for 21 days orally at a dose of 200 mg/...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Sidhu MC,Sharma T

    更新日期:2014-07-01 00:00:00

  • Formulation and evaluation of nitrendipine buccal films.

    abstract::A mucoadhesive drug delivery system for systemic delivery of nitrendipine, a calcium channel blocker through buccal route was formulated. Mucoadhesive polymers like hydroxypropylmethylcellulose K-100, hydroxypropylcellulose, sodium carboxymethylcellulose, sodium alginate, polyvinyl alcohol, polyvinyl pyrrolidone K-30 ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.45402

    authors: Nappinnai M,Chandanbala R,Balaijirajan R

    更新日期:2008-09-01 00:00:00

  • Prediction of Malnutrition Using Modified Subjective Global Assessment-dialysis Malnutrition Score in Patients on Hemodialysis.

    abstract::Malnutrition is widely prevalent among patients on hemodialysis. Malnutrition can be estimated using a fully quantitative scoring system Subjective Global Assessment-Dialysis Malnutrition Score which is simple, reliable and dynamic. The primary objective of the study was to assess the severity of malnutrition in patie...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.89755

    authors: Janardhan V,Soundararajan P,Rani NV,Kannan G,Thennarasu P,Chacko RA,Reddy CU

    更新日期:2011-01-01 00:00:00

  • Synthesis and biological evaluation of some novel 3,4-disubstituted isocoumarins.

    abstract::In this paper we report the synthesis of a new family of 4-alkyl isocoumarin derivatives having bromo carbonyl and amino carbonyl group at 3(rd) position of the heterocyclic ring. Synthesis, spectral analysis and bioactivity of new isocoumarin derivatives are discussed in this paper. Some of the synthesized compounds ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.91586

    authors: Yadav P,Purohit NV

    更新日期:2011-03-01 00:00:00

  • Evaluation of Antiseizure Activity of Essential Oil from Roots of Angelica archangelica Linn. in Mice.

    abstract::In the present study, the effect of essential oil of the root of Angelica archangelica Linn. was evaluated against electrically and chemically induced seizures. The seizures were induced in mice by maximal electroshock and pentylenetetrazol. The effect of essential oil of the root of Angelica archangelica on seizures ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.70487

    authors: Pathak S,Wanjari MM,Jain SK,Tripathi M

    更新日期:2010-05-01 00:00:00

  • Inhalational system for Etoposide liposomes: formulation development and in vitro deposition.

    abstract::Etoposide is a semisynthetic compound, widely used in treatment of non small cell lung cancer. However, frequent dosing and adverse effects remain a major concern in the use of etoposide. Liposomal systems for pulmonary drug delivery have been particularly attractive because of their compatibility with lung surfactant...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.100240

    authors: Parmar JJ,Singh DJ,Lohade AA,Hegde DD,Soni PS,Samad A,Menon MD

    更新日期:2011-11-01 00:00:00

  • Molecular docking studies with rabies virus glycoprotein to design viral therapeutics.

    abstract::The genome of rabies virus encodes five proteins; the nucleoprotein, the phosphoprotein, the matrix protein, the glycoprotein, and the RNA-dependent RNA polymerase. Among these, the glycoprotein is the most important as it is the major contributor to pathogenicity and virus neutralizing antibody response. Keeping in m...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.73905

    authors: Tomar NR,Singh V,Marla SS,Chandra R,Kumar R,Kumar A

    更新日期:2010-07-01 00:00:00