Spectrophotometric estimation of bicalutamide in tablets.

Abstract:

:A simple, sensitive, rapid, accurate and precise spectrophotometric method has been developed for the estimation of bicalutamide in bulk and pharmaceutical dosage forms. Bicalutamide shows maximum absorbance at 272 nm with molar absorptivity of 2.3399×10(4) l/mol/cm. Beer's law was obeyed in the concentration range of 1.5-18 μg/ml. The limit of detection and limit of quantification were found to be 0.1 and 0.4 μg/ml, respectively. Results of analysis were validated statistically and by recovery studies.

journal_name

Indian J Pharm Sci

authors

Sancheti PP,Vyas VM,Shah M,Karekar P,Pore YV

doi

10.4103/0250-474X.49131

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

810-2

issue

6

eissn

0250-474X

issn

1998-3743

journal_volume

70

pub_type

杂志文章
  • Antibacterial Activity of Mangrove Leaf Extracts against Human Pathogens.

    abstract::The antibacterial activity of leaf extract of mangroves, namely, Rhizophora mucronata, Sonneratia alba and Exoecaria agallocha from Chorao island, Goa was investigated against human bacterial pathogens Staphylococcus aureus, Streptococcus sp., Salmonella typhi, Proteus vulgaris and Proteus mirabilis. As compared to aq...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.107068

    authors: Sahoo G,Mulla NS,Ansari ZA,Mohandass C

    更新日期:2012-07-01 00:00:00

  • Wound healing potential of formulated extract from hibiscus sabdariffa calyx.

    abstract::Wound healing agents support the natural healing process, reduce trauma and likelihood of secondary infections and hasten wound closure. The wound healing activities of water in oil cream of the methanol extract of Hibiscus sabdariffa L. (Malvaceae) was evaluated in rats with superficial skin excision wounds. Antibact...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.113549

    authors: Builders PF,Kabele-Toge B,Builders M,Chindo BA,Anwunobi PA,Isimi YC

    更新日期:2013-01-01 00:00:00

  • Co-crystals: a novel approach to modify physicochemical properties of active pharmaceutical ingredients.

    abstract::Crystal form can be crucial to the performance of a dosage form. This is especially true for compounds that have intrinsic barriers to drug delivery, such as low aqueous solubility, slow dissolution in gastrointestinal media, low permeability and first-pass metabolism. The nature of the physical form and formulation t...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.57283

    authors: Yadav AV,Shete AS,Dabke AP,Kulkarni PV,Sakhare SS

    更新日期:2009-07-01 00:00:00

  • Development and validation of a HPTLC method for Estimation of Duloxetine Hydrochloride in Bulk Drug and in Tablet Dosage Form.

    abstract::Duloxetine hydrochloride is a potent dual reuptake inhibitor of serotonin and norepinephrine used to treat major depressive disorders. The present work describes a simple, precise and accurate HPTLC method for its estimation as bulk and in tablet dosage form. The chromatographic separation was carried out on precoated...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.41463

    authors: Dhaneshwar SS,Deshpande P,Patil M,Vadnerkar G,Dhaneshwar SR

    更新日期:2008-03-01 00:00:00

  • Design, Synthesis and antiHIV activity of Novel Isatine-Sulphonamides.

    abstract::A series of novel isatine-sulphonamide derivatives have been synthesized by combining isatin derivatives with sulphonamides. The structure of the synthesized compounds were elucidated by spectral analysis (IR, NMR and Mass). Investigation of anti-HIV activity was done against HIV-1(IIIB) in MT-4 cells and HIV integras...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.49121

    authors: Selvam P,Murugesh N,Chandramohan M,Debyser Z,Witvrouw M

    更新日期:2008-11-01 00:00:00

  • Triterpenoids from Schleichera oleosa of Darjeeling Foothills and Their Antimicrobial Activity.

    abstract::Two triterpenoids, taraxerone and tricadenic acid A were isolated from the methanol extract of the outer bark of Schleichera oleosa available in Darjeeling foothills. A preliminary study on their antimicrobial activities was also performed against some fungal and bacterial species. The structure of these compounds was...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.91568

    authors: Ghosh P,Chakraborty P,Mandal A,Rasul MG,Chakraborty M,Saha A

    更新日期:2011-03-01 00:00:00

  • Quantitative Determination of Ciprofibrate in Tablets by Derivative UV Spectroscopy and RP-HPLC Method.

    abstract::A derivative UV spectrophotometric and a reversed phase high-performance liquid chromatographic method for the determination of ciprofibrate in tablets was developed. The first-order derivative UV spectrophotometric method was found to be accurate with 100.57±0.97 recovery and precise with a coefficient of variation o...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.103855

    authors: Jain PS,Jivani HN,Khatal RN,Surana SJ

    更新日期:2012-03-01 00:00:00

  • Fluorimetric quantification of brimonidine tartrate in eye drops.

    abstract::A simple and sensitive spectrofluorimetric method has been developed for the estimation of brimonidine tartrate in pure and eye drops. Linearity was obeyed in the range of 0.2-3.0 ΅g/ml in dimethyl formamide as solvent at an emission wavelength (λem) of 530 nm after excitation wavelength (λex) of 389 nm with good corr...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Sunitha G,Bhagirath R,Alapati VR,Ramakrishna K,Subrahmanyam CV,Anumolu PD

    更新日期:2013-11-01 00:00:00

  • Synthesis and antimicrobial activity of 5-imidazolinone derivatives.

    abstract::Several 4-arylidene-2-phenyl-1-(2,4,5-trichlorophenyl)-1H-imidazol-5(4H)-ones (4a-q), N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-4-chlorobenzamides (5a-o) and N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-2,4-dichlorobenzamides (6a-m) were prepared. All newly synthesized compounds have been ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.51953

    authors: Desai NC,Bhavsar AM,Baldaniya BB

    更新日期:2009-01-01 00:00:00

  • Preparation of evodiamine solid dispersions and its pharmacokinetics.

    abstract::In order to increase the dissolution rate and bioavailability, solid dispersions of evodiamine in PVP K(30) with different enriched samples of evodiamine to PVP K(30) ratios were prepared by solvent method. Our studies showed that the dissolution rate of evodiamine was significantly higher in the solid dispersion syst...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.93511

    authors: Xu H,Zhang T,Yang H,Xiao X,Bian Y,Si D,Liu C

    更新日期:2011-05-01 00:00:00

  • Studies on formulation and in vitro evaluation of floating matrix tablets of domperidone.

    abstract::Floating matrix tablets of domperidone were developed to prolong gastric residence time and thereby increased drug bioavailability. Domperidone was chosen as a model drug because it is poorly absorbed from the lower gastrointestinal tract. The tablets were prepared by wet granulation technique, using polymers such as ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.51944

    authors: Prajapati ST,Patel LD,Patel DM

    更新日期:2009-01-01 00:00:00

  • In vivo Antimalarial Activities of Russelia Equisetiformis in Plasmodium Berghei Infected Mice.

    abstract::The rising problem of resistance to most commonly used antimalarials remains a major challenge in the control of malaria suggesting the need for new antimalarial agents. This work explores the antiplasmodial potential of ethanol extract of Russelia equisetiformis in chloroquine Plasmodium berghei infected mice. Swiss ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.164787

    authors: Ojurongbe O,Ojo JA,Adefokun DI,Abiodun OO,Odewale G,Awe EO

    更新日期:2015-07-01 00:00:00

  • A Validated HPLC Method for Zanamivir and its Application to In vitro Permeability Study in Caco-2 Culture Model.

    abstract::A simple HPLC method was developed and validated for the quantification of zanamivir in permeability studies using Caco-2 cell culture model. Chromatographic resolution was achieved using 98% (v/v) ultrapure water and 2% (v/v) acetonitrile as mobile phase with flow rate of 0.5 ml/min on a BDS Hypersil Cyano column (le...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.99015

    authors: Boonyapiwat B,Sarisuta N,Ma Y,Steventon GB

    更新日期:2011-09-01 00:00:00

  • Effect of 2-Hydroxy-4-methoxy Benzoic Acid Isolated from Hemidesmus indicus on Erythrocyte Membrane Bound Enzymes and Antioxidant Status in Streptozotocin-induced Diabetic Rats.

    abstract::In the present study, the effect of 2-hydroxy-4-methoxy benzoic acid isolated from roots of Hemisdesmus indicus on the erythrocyte membrane bound enzymes and antioxidant status in streptozotocin-induced diabetic rats was investigated. The streptozotocin-induced diabetic rats were treated with 2-hydroxy-4-methoxy benzo...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.108438

    authors: Gayathri M,Kannabiran K

    更新日期:2012-09-01 00:00:00

  • Bimodal gastroretentive drug delivery systems of lamotrigine: formulation and evaluation.

    abstract::Gastroretentive bimodal drug delivery systems of lamotrigine were developed using immediate release and extended release segments incorporated in a hydroxypropyl methylcellulose capsule and in vitro and in vivo evaluations were conducted. In vivo radiographic studies were carried out for the optimized formulation in h...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Poonuru RR,Gonugunta CS

    更新日期:2014-11-01 00:00:00

  • A novel and rapid method to determine doxycycline in human plasma by liquid chromatography tandem mass spectrometry.

    abstract::A simple, rapid, specific and sensitive liquid chromatography tandem mass spectrometric method has been developed and validated for the determination of doxycycline from the human plasma. Doxycycline is extracted from human plasma by solid phase extraction. Demeclocycline was used as an internal standard. Detection wa...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.110599

    authors: Krishna AC,Sathiyaraj M,Saravanan RS,Chelladurai R,Vignesh R

    更新日期:2012-11-01 00:00:00

  • Self Medication Practices among Medical Students of a Private Institute.

    abstract::The study was undertaken to evaluate various aspects of self-medication in medical students. A prospective, cross-sectional, questionnaire-based study was carried out among 488 medical students selected by simple random sampling from January 2013 to June 2013. Data was collected and analyzed for counts and percentage....

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.156569

    authors: Kasulkar AA,Gupta M

    更新日期:2015-03-01 00:00:00

  • Simultaneous Determination of Valsartan and Hydrochlorothiazide in Tablets by RP-HPLC.

    abstract::A simple, reproducible and efficient reverse phase high performance liquid chromatographic method was developed for simultaneous determination of valsartan and hydrochlorothiazide in tablets. A column having 200 x 4.6 mm i.d. in isocratic mode with mobile phase containing methanol:acetonitrile:water:isopropylalcohol (...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.43006

    authors: Tian DF,Tian XL,Tian T,Wang ZY,Mo FK

    更新日期:2008-05-01 00:00:00

  • Antioxidant and Antimicrobial Activity of Alpinia officinarum.

    abstract::Alpinia officinarum is a rhizome belonging to the family zingeberaeceae. Hydro alcoholic extract by hot and cold maceration and methanol extract by percolation process Qualitative phytochemical analysis of extract of Alpinia officinarum rhizome showed a majority of the compound including tannins, alkaloids, flavonoids...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.62233

    authors: Srividya AR,Dhanabal SP,Misra VK,Suja G

    更新日期:2010-01-01 00:00:00

  • Preparation of Coated Valproic Acid and Sodium Valproate Sustained-release Matrix Tablets.

    abstract::The aim of this research was to investigate the technique for preparation of coated valproic acid and sodium valproate sustained-release matrix tablets. Different diluents were tested and selected as the effective absorbent for oily valproic acid. Effect of the amount of absorbent and hydroxypropylmethylcellulose on d...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.65026

    authors: Phaechamud T,Mueannoom W,Tuntarawongsa S,Chitrattha S

    更新日期:2010-03-01 00:00:00

  • Development and Validation of RP-HPLC Method for Simultaneous Estimation of Atorvastatin Calcium and Fenofibrate in Tablet Dosage Forms.

    abstract::A reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of atorvastatin calcium and fenofibrate in tablet formulation. The separation was achieved by Luna C18 column and methanol:acetate buffer pH 3.7 (82:18 v/v) as mobile phase, at a flow rate of 1.5 ml/min. Detect...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.41473

    authors: Jain N,Raghuwanshi R,Jain D

    更新日期:2008-03-01 00:00:00

  • Antihyperglycemic Activity of Petroleum Ether Leaf Extract of Ficus krishnae L. on Alloxan-induced Diabetic Rats.

    abstract::The petroleum ether leaf extract of Ficus krishnae has been evaluated for the management of diabetes in alloxan induced diabetic rats. Phytochemical screening of the leaf extract for various chemical compounds has also been carried out. Leaf extract was administered continuously for 21 days orally at a dose of 200 mg/...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Sidhu MC,Sharma T

    更新日期:2014-07-01 00:00:00

  • Vitamin D Supplements in the Indian Market.

    abstract::It is now known that vitamin D deficiency is a worldwide health problem. In our country, as food fortification is lacking, supplementation with pharmaceutical preparations is the only means of treatment of vitamin D deficiency. We aimed to study the composition and availability of various vitamin D preparations in the...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.180248

    authors: Lhamo Y,Chugh PK,Tripathi CD

    更新日期:2016-01-01 00:00:00

  • Preparation and evaluation of transdermal drug delivery system of etoricoxib using modified chitosan.

    abstract::In the present investigation chitosan has been chemically modified by treating with two different aldehydes like acetaldehyde and propionaldehyde to form Schiff's bases. Schiff's bases of chitosan with acetaldehyde and propionaldehyde were named as polymer A and polymer B, respectively. Fourier Transform Infra Red (FT...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.44593

    authors: Wahid A,Sridhar BK,Shivakumar S

    更新日期:2008-07-01 00:00:00

  • A Sensitive RP-HPLC Method for Simultaneous Estimation of Diethylcarbamazine and Levocetirizine in Tablet Formulation.

    abstract::A simple, sensitive and reproducible method was developed and validated for the simultaneous estimation of diethylcarbamazine and levocetirizine in its tablet formulation by reverse phase high performance liquid chromatography using Waters1515 HPLC with UV detector at the λ(max) of 224 nm, using Princeton Sphere-100 C...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.93517

    authors: Reddy JM,Jeyaprakash MR,Madhuri K,Meyyanathan SN,Elango K

    更新日期:2011-05-01 00:00:00

  • pH-Sensitive Mebeverine Microspheres for Colon Delivery.

    abstract::Mebeverine hydrochloride is known to suffer from extensive first pass effect. In an attempt to improve its oral bioavailability and possibility to restrict its absorption only to the colon, mebeverine microspheres were prepared by emulsion solvent evaporation method. Four formulations were prepared with varying drug a...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.57303

    authors: Dandagi PM,Mastiholimath VS,Gadad AP,Kulkarni AR,Konnur BK

    更新日期:2009-07-01 00:00:00

  • Molecular Cytotoxic Mechanisms of 1-(3,4,5-Trihydroxyphenyl)-dodecylbenzoate in Human Leukemia Cell Lines.

    abstract::Recent studies have shown that gallic acid and its alkylesters induce apoptosis in different cell lines. Since new compounds with biological activity and less cytotoxicity to normal cells are necessary for cancer therapy, the aim of this study was to evaluate the cytotoxic effect of 1-(3,4,5-trihydroxyphenyl)-dodecylb...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.180255

    authors: Maioral MF,Bubniak LD,Marzarotto MA,De Moraes AC,Leal P,Nunes R,Yunes RA,Santos-Silva MC

    更新日期:2016-01-01 00:00:00

  • Hepatoprotective Activity of Heptoplus on Isoniazid and Rifampicin Induced Liver Damage in Rats.

    abstract::The present study is designed to evaluate the efficacy of heptoplus a polyherbal formulation as an oral supplementary agent for isoniazid and rifampicin induced hepatotoxicity in rats. 50 and 100 mg/kg of heptoplus supplement were fed orally to the rats along with isoniazid and rifampicin and compared to rats treated ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.169028

    authors: Sankar M,Rajkumar J,Sridhar D

    更新日期:2015-09-01 00:00:00

  • Development and evaluation of oral controlled release chlorpheniramine-ion exchange resinate suspension.

    abstract::An oral controlled release suspension of chlorpheniramine maleate was prepared using ion-exchange resin technology. A strong cation exchange resin Indion 244 was utilized for the sorption of the drug and the drug resinates was evaluated for various physical and chemical parameters. The drug-resinate complex was microe...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.44613

    authors: Kadam AU,Sakarkar DM,Kawtikwar PS

    更新日期:2008-07-01 00:00:00

  • In vitro Antibacterial Activity of Aqueous and Ethanol Extracts of Aristolochia indica and Toddalia asiatica Against Multidrug-Resistant Bacteria.

    abstract::Bacteria have developed multidrug resistance against available antimicrobial agents. Infectious diseases caused by these multidrug-resistant bacteria are major causes of morbidity and mortality in human beings. Synthetic drugs are expensive and inadequate for the treatment of diseases, causing side effects and ineffec...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.174991

    authors: Venkatadri B,Arunagirinathan N,Rameshkumar MR,Ramesh L,Dhanasezhian A,Agastian P

    更新日期:2015-11-01 00:00:00