Abstract：
:The present study is designed to evaluate the efficacy of heptoplus a polyherbal formulation as an oral supplementary agent for isoniazid and rifampicin induced hepatotoxicity in rats. 50 and 100 mg/kg of heptoplus supplement were fed orally to the rats along with isoniazid and rifampicin and compared to rats treated with 100 mg/kg Liv 52 standard drug. Rats treated with isoniazid and rifampicin suffered from severe oxidative stress by the virtue of free radicals induced lipid per oxidation. As a result abnormal index of serum biochemical markers for liver function and increased liver lysosomal enzymes activity was observed. However rats nourished with 100 mg/kg of heptoplus and Liv 52 protected the liver from oxidative damage by maintaining normal antioxidant profile status and restored normal serum liver biochemical markers. Increased liver lysosomal enzymes activity is prevented in the rats supplemented with heptoplus and Liv 52. Histopathological analysis also revealed severe vascular changes and lobular necrosis in the treatment of isoniazid and rifampicin. Heptoplus (100 mg/kg) and Liv 52 supplemented rats liver apparently revealed normal architecture of liver. This study confirms that heptoplus has liver protective activity against Isoniazid and Rifampicin induced liver injury in rats, in par with Liv 52.
journal_name
Indian J Pharm Scijournal_title
Indian journal of pharmaceutical sciencesauthors
Sankar M,Rajkumar J,Sridhar Ddoi
10.4103/0250-474x.169028subject
Has Abstractpub_date
2015-09-01 00:00:00pages
556-62issue
5eissn
0250-474Xissn
1998-3743journal_volume
77pub_type
杂志文章abstract：:Ethanol extract of Passiflora edulis Sims was analyzed for its antioxidant (1,1-diphenyl-2-picryl hydrazyl radical reducing power methods) and phytochemical analysis. The extract was found effective against the antioxidant test models exhibiting an IC(50) value of 875+/-87.83 mug/ml and showed strong potential antioxi...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.56038
更新日期：2009-05-01 00:00:00
abstract：:The petroleum ether leaf extract of Ficus krishnae has been evaluated for the management of diabetes in alloxan induced diabetic rats. Phytochemical screening of the leaf extract for various chemical compounds has also been carried out. Leaf extract was administered continuously for 21 days orally at a dose of 200 mg/...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：
更新日期：2014-07-01 00:00:00
abstract：:Wound healing agents support the natural healing process, reduce trauma and likelihood of secondary infections and hasten wound closure. The wound healing activities of water in oil cream of the methanol extract of Hibiscus sabdariffa L. (Malvaceae) was evaluated in rats with superficial skin excision wounds. Antibact...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.113549
更新日期：2013-01-01 00:00:00
abstract：:A simple, precise, and accurate isocratic reversed-phase (RP) stability-indicating HPLC assay method was developed and validated for determination of Aripiprazole in bulk and solid pharmaceutical dosage form. A reversed-phase C8 (250×4.0 mm, 5 μm particle size) column for HPLC and C8 (50×2.1mm, 1.7 μm particle size) f...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.95638
更新日期：2011-07-01 00:00:00
abstract：:Piper claussenianum inflorescences crude methanol extract was tested for hypoglycemic effect in streptozotocin-induced diabetic rats. The blood glucose levels of rats treated with methanol extract were reduced from 318.4±28.1 mg/dl before treatment to 174.2±38.3 mg/dl after 12 days of treatment (P<0.05). Phytochemical...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474x.156624
更新日期：2015-03-01 00:00:00
abstract：:Several 4-arylidene-2-phenyl-1-(2,4,5-trichlorophenyl)-1H-imidazol-5(4H)-ones (4a-q), N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-4-chlorobenzamides (5a-o) and N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-2,4-dichlorobenzamides (6a-m) were prepared. All newly synthesized compounds have been ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.51953
更新日期：2009-01-01 00:00:00
abstract：:Preparation and in vitro/in vivo evaluation of mifepristone intravaginal ring formulations were investigated. In the present study, it is reported that a mifepristone intravaginal ring of reservoir design comprising of a mifepristone silicone elastomer core enclosed in a silicone layer. During the preparation of intra...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474x.159671
更新日期：2015-05-01 00:00:00
abstract：:Supercritical fluid extract of leaves of Vitex negundo was tested for its antimicrobial potential and was compared with that of ethanol extract, ether extract and hydrodistilled oil of leaves. The chemical constituents of extracts were studied by chromatographic techniques. Extracts were evaluated for antimicrobial po...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.78537
更新日期：2010-09-01 00:00:00
abstract：:A gradient reversed phase HPLC method was developed and validated for the analysis of related substances in zonisamide (1,2-benzisoxazole-3-methanesulfonamide), using a Waters Symmetry C8 (150*3.9 mm) column with a flow rate of 1.0 ml/min and detection at 280 nm. The mobile phase component A consisted of a mixture of ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.58183
更新日期：2009-09-01 00:00:00
abstract：:A derivative UV spectrophotometric and a reversed phase high-performance liquid chromatographic method for the determination of ciprofibrate in tablets was developed. The first-order derivative UV spectrophotometric method was found to be accurate with 100.57±0.97 recovery and precise with a coefficient of variation o...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.103855
更新日期：2012-03-01 00:00:00
abstract：:Sarpagandha ghanvati is a classical Ayurvedic formulation widely prescribed for anxiety and insomnia. It contains Sarpagandha (roots of Rauwolfia serpentina L. (Benth.) Ex Kurz; Family: Apocyanaceae), Khurasani ajowan (Hyocyamus niger L.; Family: Solanaceae) seeds, Jatamansi (Nardostachys jatamansi DC. Family: Valeria...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474x.169029
更新日期：2015-09-01 00:00:00
abstract：:The aim of the present study was the determination of formulation factors and the in vitro evaluation of an extended release dosage form of a freely soluble weakly basic drug (alfuzosin hydrochloride). Binary mixer of one hydrophilic polymer (hydroxypropylmethylcellulose) and one directly compressible Eudragit (RS PO)...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.56019
更新日期：2009-05-01 00:00:00
abstract：:Duloxetine hydrochloride is a potent dual reuptake inhibitor of serotonin and norepinephrine used to treat major depressive disorders. The present work describes a simple, precise and accurate HPTLC method for its estimation as bulk and in tablet dosage form. The chromatographic separation was carried out on precoated...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.41463
更新日期：2008-03-01 00:00:00
abstract：:The genome of rabies virus encodes five proteins; the nucleoprotein, the phosphoprotein, the matrix protein, the glycoprotein, and the RNA-dependent RNA polymerase. Among these, the glycoprotein is the most important as it is the major contributor to pathogenicity and virus neutralizing antibody response. Keeping in m...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.73905
更新日期：2010-07-01 00:00:00
abstract：:The results of our previous investigations on extracts of selected marine algae showed that Caulerpa peltata and Padina gymnospora had more promising antiproliferative and antioxidant activities than Gelidiella acerosa and Sargassum wightii. Based on these results, the more active chloroform extract of C. peltata and ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：
更新日期：2014-11-01 00:00:00
abstract：:Present study aims to prepare and evaluate niacin microspheres. Niacin-ethyl cellulose microspheres were prepared by water-in-oil-in-oil double emulsion solvent diffusion method. Spherical, free flowing microspheres having an entrapment efficiency of 72% were obtained. The effect of polymer-drug ratio, surfactant conc...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.59549
更新日期：2009-11-01 00:00:00
abstract：:The aim of this research was to investigate the technique for preparation of coated valproic acid and sodium valproate sustained-release matrix tablets. Different diluents were tested and selected as the effective absorbent for oily valproic acid. Effect of the amount of absorbent and hydroxypropylmethylcellulose on d...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.65026
更新日期：2010-03-01 00:00:00
abstract：:In the present study, 2,5-disubstituted-1,3,4-oxadiazoles (3a-o) have been synthesized by the condensation of 4-methoxybenzohydrazide (1) with different aromatic acids (2a-o) in presence of phosphoryl chloride. The structural assignment of this compound (3a-o) has been made on the basis of elemental analysis, UV, IR, ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.40331
更新日期：2008-01-01 00:00:00
abstract：:Etoposide is a semisynthetic compound, widely used in treatment of non small cell lung cancer. However, frequent dosing and adverse effects remain a major concern in the use of etoposide. Liposomal systems for pulmonary drug delivery have been particularly attractive because of their compatibility with lung surfactant...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.100240
更新日期：2011-11-01 00:00:00
abstract：:Antianthelmintic activity of successive extracts (chloroform, acetone, ethanol and aqueous) of Nauclea orientalis leaves were evaluated separately on adult Indian earthworm (Pheretima posthuma) and compared with that of albendazole. It was found that the extracts exhibited, respectively dose-dependent action and inhib...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.73932
更新日期：2010-07-01 00:00:00
abstract：:A series of novel N-Sulphonamidomethyl piperzinyl fluoroquinolones were synthesized and screened antiviral activity. Eight compounds were synthesized through modifying the N(4)-hydrogen of piperazine in fluoroquinolones with formaldehyde and sulphanomides by Mannich reactions. The structures of the synthesized compoun...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.57293
更新日期：2009-07-01 00:00:00
abstract：:A set of seventy four molecules belonging to the class of thioglitazones were subjected to the QSAR analysis for their antihyperglycemic activity. All the molecules were subjected to energy minimization to get 3D structures, followed by conformational analysis to get the conformation of the molecule associated with th...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.45392
更新日期：2008-09-01 00:00:00
abstract：:The antihyperlipidemic activity of resinoids of guggul (Commiphora mukul/Commiphora wightii), belonging to family Burseraceae (Genus: Commiphora), collected from different parts of India (Gujarat, Madhya Pradesh and Rajasthan), was studied on cholesterol-rich high fat diet-induced model of hyperlipidemia in rats. The ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.108417
更新日期：2012-09-01 00:00:00
abstract：:A novel, efficient and simple approach for soy phosphatidylcholine analysis according to its fatty acid composition was studied with reverse-phase high-performance liquid chromatography. The reverse-phase high-performance liquid chromatography analysis was performed isocratically using UV detector and simple mobile ph...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.117435
更新日期：2013-05-01 00:00:00
abstract：:Pyrazinamide, a highly specific agent against Mycobacterium tuberculosis is used as first-line drug to treat tuberculosis. The current work aims to formulate polymeric nanoparticles based drug delivery system to sustain the release profile and reduce the dosing frequency of pyrazinamide. Further aim was to target the ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474x.159602
更新日期：2015-05-01 00:00:00
abstract：:Tuberculosis is one of the major public health problems faced globally. Resistance of Mycobacterium tuberculosis to antitubercular agents has called for an urgent need to investigate newer drugs to combat tuberculosis. Garlic (Allium sativum) is an edible plant which has generated a lot of curiosity throughout human h...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：
更新日期：2014-05-01 00:00:00
abstract：:A mucoadhesive drug delivery system for systemic delivery of nitrendipine, a calcium channel blocker through buccal route was formulated. Mucoadhesive polymers like hydroxypropylmethylcellulose K-100, hydroxypropylcellulose, sodium carboxymethylcellulose, sodium alginate, polyvinyl alcohol, polyvinyl pyrrolidone K-30 ...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.45402
更新日期：2008-09-01 00:00:00
abstract：:In the present study, the effect of 2-hydroxy-4-methoxy benzoic acid isolated from roots of Hemisdesmus indicus on the erythrocyte membrane bound enzymes and antioxidant status in streptozotocin-induced diabetic rats was investigated. The streptozotocin-induced diabetic rats were treated with 2-hydroxy-4-methoxy benzo...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.4103/0250-474X.108438
更新日期：2012-09-01 00:00:00
abstract：:A few flavanones were synthesised by cyclisation of corresponding 3-(heteroaryl)-1(2-hydroxyphenyl) prop-2-en-1-one with sodium acetate in alcohol-water and evaluated for activity. Synthesised compounds were assayed for their in vitro anticancer activity against three human cancer cell lines, mammary adenocarcinoma (M...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：
更新日期：2014-03-01 00:00:00
abstract：:A field experiment on the effect of time of harvesting on yield and quality of Melissa officinalis L. was conducted under the agroclimatic conditions of Doon valley, Uttarakhand in order to assess the performance of four harvesting times (H1-120 days, H2-140 days, H3-160 days and H4-180 days after planting). The fresh...
journal_title：Indian journal of pharmaceutical sciences
pub_type： 杂志文章
doi：
更新日期：2014-09-01 00:00:00
