Abstract:
:A mucoadhesive drug delivery system for systemic delivery of nitrendipine, a calcium channel blocker through buccal route was formulated. Mucoadhesive polymers like hydroxypropylmethylcellulose K-100, hydroxypropylcellulose, sodium carboxymethylcellulose, sodium alginate, polyvinyl alcohol, polyvinyl pyrrolidone K-30 and carbopol-934P were used for film fabrication. The films were evaluated for their weight, thickness, percentage moisture absorbed and lost, surface pH, folding endurance, drug content uniformity, In vitro residence time, In vitro release and ex vivo permeation. Based on the evaluation of these results, it was concluded that buccal films made of hydroxylpropylcellulose and sodium carboxymethylcellulose (5±2% w/v; F-4), which showed moderate drug release (50% w/w at the end of 2 h) and satisfactory film characteristics could be selected as the best among the formulations studied.
journal_name
Indian J Pharm Scijournal_title
Indian journal of pharmaceutical sciencesauthors
Nappinnai M,Chandanbala R,Balaijirajan Rdoi
10.4103/0250-474X.45402subject
Has Abstractpub_date
2008-09-01 00:00:00pages
631-5issue
5eissn
0250-474Xissn
1998-3743journal_volume
70pub_type
杂志文章abstract::In this paper we report the synthesis of a new family of 4-alkyl isocoumarin derivatives having bromo carbonyl and amino carbonyl group at 3(rd) position of the heterocyclic ring. Synthesis, spectral analysis and bioactivity of new isocoumarin derivatives are discussed in this paper. Some of the synthesized compounds ...
journal_title:Indian journal of pharmaceutical sciences
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更新日期:2010-07-01 00:00:00
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journal_title:Indian journal of pharmaceutical sciences
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doi:
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journal_title:Indian journal of pharmaceutical sciences
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abstract::A series of novel N-Sulphonamidomethyl piperzinyl fluoroquinolones were synthesized and screened antiviral activity. Eight compounds were synthesized through modifying the N(4)-hydrogen of piperazine in fluoroquinolones with formaldehyde and sulphanomides by Mannich reactions. The structures of the synthesized compoun...
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更新日期:2009-07-01 00:00:00
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journal_title:Indian journal of pharmaceutical sciences
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更新日期:2015-01-01 00:00:00
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journal_title:Indian journal of pharmaceutical sciences
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abstract::Ethanol extract of leaves of Clerodendron phlomoidis L. subjected to preliminary qualitative phytochemical investigations showed the presence of alkaloids, phytosterols, glycosides, saponins, phenolic compounds, proteins and flavonoids. The extract was screened for hypoglycemic activity in alloxan-induced diabetic rat...
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journal_title:Indian journal of pharmaceutical sciences
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更新日期:2012-05-01 00:00:00
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journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
abstract::An oral controlled release suspension of chlorpheniramine maleate was prepared using ion-exchange resin technology. A strong cation exchange resin Indion 244 was utilized for the sorption of the drug and the drug resinates was evaluated for various physical and chemical parameters. The drug-resinate complex was microe...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.44613
更新日期:2008-07-01 00:00:00
abstract::Breast cancer is the foremost common malignancy among the female population around the world. Female breast cancer incidence rates have increased since 1980, slowed in 1990, the rate of increase have leveled off since 2001. In spite of the advances in the early detection, treatment, surgery and radiation support, almo...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章,评审
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更新日期:2013-05-01 00:00:00
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journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:
更新日期:2013-09-01 00:00:00
abstract::Preparation and in vitro/in vivo evaluation of mifepristone intravaginal ring formulations were investigated. In the present study, it is reported that a mifepristone intravaginal ring of reservoir design comprising of a mifepristone silicone elastomer core enclosed in a silicone layer. During the preparation of intra...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474x.159671
更新日期:2015-05-01 00:00:00
abstract::Modification of polymers by covalent attachment of thiol bearing pendant groups is reported to impart many beneficial properties to them. Hence in the present study, sodium alginate-cysteine conjugate was synthesized by carbodiimide mediated coupling under varying reaction conditions and the derivatives characterized ...
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pub_type: 杂志文章
doi:10.4103/0250-474X.84590
更新日期:2010-11-01 00:00:00
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journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
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更新日期:2009-09-01 00:00:00
abstract::A gradient reversed phase HPLC method was developed and validated for analysis of betamethasone dipropionate, its related substances and degradation products, using Altima C(18) column (250×4.6 mm, 5 μm) with a flow rate of 1.0 ml/min and detection wavelength of 240 nm. The mobile phase A is a mixture of water, tetrah...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.103840
更新日期:2012-03-01 00:00:00
abstract::Various (4-substituted) phenyl-3-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]propionylamido-1,3-thiazolidine-4-ones (3a-x) and 1-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]-propionylamido-3-chloro-4-(4-substituted)phenyl-azetidin-2-ones (4a-x) have been synthesised by the cyclocondensation of ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.95654
更新日期:2011-07-01 00:00:00