Pharmacodynamics and pharmacokinetics of epidural ropivacaine in humans.

abstract：:Clinical and metabolic responses to three types of premedication were studied in ASA physical status I patients given any one of the following: (a) 0.5 mg of atropine and 50 mg of meperidine given intramuscularly plus an oral placebo tablet (n = 14), (b) 10 mg of oral diazepam and an intramuscular placebo (2 mL NaCl, ...

journal_title：Anesthesia and analgesia

authors： Kirvelä OA,Kanto JH

更新日期：1991-07-01 00:00:00

abstract：:Lung dysfunction after cardiopulmonary bypass and lung transplantation results from oxidant-mediated cellular damage. Previously, we observed the shedding of angiotensin-converting enzyme (ACE) from the endothelial cell surface to be a more sensitive and earlier marker of oxidative lung endothelial injury than lung we...

journal_title：Anesthesia and analgesia

authors： Balyasnikova IV,Visintine DJ,Gunnerson HB,Paisansathan C,Baughman VL,Minshall RD,Danilov SM

更新日期：2005-04-01 00:00:00

abstract：UNLABELLED:Despite the widespread use of methadone for the treatment of acute and chronic pain, the hemodynamic effects of methadone administered by IV bolus have not been studied. We compared the hemodynamic effects of an IV bolus of methadone 20 mg with those of fentanyl 10 microg/kg for the induction of anesthesia i...

journal_title：Anesthesia and analgesia

authors： Bowdle TA,Even A,Shen DD,Swardstrom M

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Midazolam is the most commonly used premedication in children. It has been shown to be more effective than parental presence or placebo in reducing anxiety and improving compliance at induction of anesthesia. Clonidine, an alpha(2) agonist, has been suggested as an alternative. Dexmedetomidine is a more alph...

journal_title：Anesthesia and analgesia

authors： Yuen VM,Hui TW,Irwin MG,Yuen MK

更新日期：2008-06-01 00:00:00

abstract：UNLABELLED:The effect of opioid administration on the bispectral index (BIS) during general anesthesia is controversial. Several investigators have reported BIS to be insensitive to opioid addition, whereas others have found a hypnotic response. We designed this study to examine the effect of remifentanil on BIS during...

journal_title：Anesthesia and analgesia

authors： Koitabashi T,Johansen JW,Sebel PS

更新日期：2002-06-01 00:00:00

abstract：UNLABELLED:The visual analog scale (VAS) is a tool widely used to measure pain, yet controversy surrounds whether the VAS score is ratio or ordinal data. We studied 52 postoperative patients and measured their pain intensity using the VAS. We then asked them to consider different amounts of pain (conceptually twice as ...

journal_title：Anesthesia and analgesia

authors： Myles PS,Troedel S,Boquest M,Reeves M

更新日期：1999-12-01 00:00:00

abstract：:The effect of the alpha 2-agonist dexmedetomidine on the cerebral blood flow (CBF) and the metabolic rate for oxygen was studied by a sagittal sinus outflow technique in dogs during halothane anesthesia. Dexmedetomidine was given in a dose (10 micrograms/kg) reported to reduce the anesthetic requirement of halothane b...

journal_title：Anesthesia and analgesia

authors： Karlsson BR,Forsman M,Roald OK,Heier MS,Steen PA

更新日期：1990-08-01 00:00:00

abstract：IMPLICATIONS:The performance of regional blockade on a patient with a preexisting neurologic condition or a history of neurologic complications after regional anesthesia is controversial. We present a case of recurring brachial plexus neuropathy in a diabetic patient after two shoulder procedures performed 4 mo apart. ...

journal_title：Anesthesia and analgesia

authors： Horlocker TT,O'Driscoll SW,Dinapoli RP

更新日期：2000-09-01 00:00:00

abstract：UNLABELLED:Nonpharmacologic techniques may be effective in preventing postoperative nausea and vomiting (PONV). This sham-controlled, double-blinded study was designed to examine the antiemetic efficacy of transcutaneous acupoint electrical stimulation (TAES) in a surgical population at high risk of developing PONV. We...

journal_title：Anesthesia and analgesia

authors： Zárate E,Mingus M,White PF,Chiu JW,Scuderi P,Loskota W,Daneshgari V

更新日期：2001-03-01 00:00:00

abstract：:Previous in vivo studies of the coronary vascular effects of halothane (HAL) were complicated by varying hemodynamic conditions and global cardiac work demands. Accordingly, the current study evaluated changes in coronary blood flow (CBF) and associated variables during selective intracoronary administrations of HAL i...

journal_title：Anesthesia and analgesia

authors： Crystal GJ,Khoury E,Gurevicius J,Salem MR

更新日期：1995-02-01 00:00:00

abstract：:A newly developed transtracheal Doppler (TTD) computer for cardiac output determination was studied in nine patients after open heart surgery (coronary artery bypass grafting, n = 4; mitral valve replacement, n = 5). The measurements were compared with those simultaneously obtained by thermodilation. Doppler signals w...

journal_title：Anesthesia and analgesia

authors： Hausen B,Schäfers HJ,Rohde R,Haverich A

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Tumor necrosis factor alpha (TNF-alpha) could trigger p38 mitogen-activated protein kinase (MAPK) activation. Conversely phosphorylated p38 (p-p38) could induce the upregulation of TNF-alpha. In this study, we examined the hypothesis that chronic constrictive injury (CCI) of the sciatic nerve could promote s...

journal_title：Anesthesia and analgesia

authors： Xu L,Huang Y,Yu X,Yue J,Yang N,Zuo P

更新日期：2007-12-01 00:00:00

abstract：UNLABELLED:Several factors are responsible for hypercarbia during laparoscopic procedures. This study was undertaken because we observed a sudden increase in PaCO(2) in children with portal hypertension (PHT), which was unusual in healthy children undergoing laparoscopic procedures. Fifty-seven children underwent lapar...

journal_title：Anesthesia and analgesia

authors： Bozkurt P,Kaya G,Yeker Y,Sarimurat N,Yesildag E,Tekant G,Emir H,Senyuz OF

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Dosing subcutaneous (SC) unfractionated heparin (UFH) 3 times a day (TID) for deep venous thrombosis prophylaxis is used for patients in the United States undergoing nonorthopedic surgery. There is a lack of data on the risks of neuraxial techniques in patients receiving TID SC UFH; however, concerns have be...

journal_title：Anesthesia and analgesia

authors： Pace M,Koury K,Gulur P

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Postsurgical quality of recovery is worse in female than that in male patients. Duloxetine has been used successfully for the treatment of chronic pain conditions, but its use for preventing acute postoperative pain has been limited to a single previous study. More importantly, the effect of preoperative dul...

journal_title：Anesthesia and analgesia

authors： Castro-Alves LJ,Oliveira de Medeiros AC,Neves SP,Carneiro de Albuquerque CL,Modolo NS,De Azevedo VL,De Oliveira GS Jr

更新日期：2016-01-01 00:00:00

abstract：IMPLICATIONS:Postoperative management of sedation and analgesia in pediatric cardiac patients presents many challenges. This case report describes a child who experienced dramatic clinical improvement with the postoperative use of caudal morphine and clonidine after conventional therapy had failed. ...

journal_title：Anesthesia and analgesia

authors： Diaz LK,Cantu F

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:We have shown previously that either echocardiographic indices of diastolic dysfunction or increased preoperative brain natriuretic peptide (BNP) predict postoperative atrial fibrillation (POAF). Because these 2 predictors of POAF have not been evaluated together, our goal was to further elucidate their conc...

journal_title：Anesthesia and analgesia

authors： Brecher O,Gulati H,Roistacher N,Zhang H,Shi W,Thaler HT,Amar D

更新日期：2017-04-01 00:00:00

abstract：:Acute fatty liver of pregnancy (AFLP) is a late gestational complication with biochemical similarities to the inherited disorders of mitochondrial fatty acid oxidation and clinical similarities to fulminant hepatic failure. The following case illustrates our perioperative management of this rarely encountered disorder...

journal_title：Anesthesia and analgesia

authors： Holzman RS,Riley LE,Aron E,Fetherston J

更新日期：2001-05-01 00:00:00

abstract：:This study examined anesthetic development and hemodynamic changes during two techniques of hyperbaric lidocaine administration through 27-gauge intrathecal catheters for continuous spinal anesthesia in 55 elderly patients undergoing transurethral prostatic resection. Twenty-five patients were randomly assigned to rec...

journal_title：Anesthesia and analgesia

authors： Chan VW,Chung F,Gomez M,Seyone C,Baylon G

更新日期：1994-07-01 00:00:00

abstract：UNLABELLED:Thiamylal, a chiral thiobarbiturate, is marketed as a racemic product. We studied the serum protein binding and microsomal metabolism of thiamylal enantiomers in vitro. The unbound fraction of R(+)-thiamylal was greater than that of S(-)-thiamylal. The analysis of binding data revealed that both enantiomers ...

journal_title：Anesthesia and analgesia

authors： Sueyasu M,Fujito K,Shuto H,Mizokoshi T,Kataoka Y,Oishi R

更新日期：2000-09-01 00:00:00

abstract：:Previous studies have shown that bolus doses of fentanyl (50 and 100 micrograms) with epidural bupivacaine delay gastric emptying by up to 45 min. We studied the effect of the addition of small-dose fentanyl to epidural bupivacaine infusions on gastric emptying during labor. The acetaminophen absorption technique was ...

journal_title：Anesthesia and analgesia

authors： Zimmermann DL,Breen TW,Fick G

更新日期：1996-03-01 00:00:00

abstract：UNLABELLED:alpha(2) Adrenoceptor activity is involved in the mechanism of anesthesia. Clonidine, a alpha(2) adrenoceptor agonist, and yohimbine, a alpha(2) adrenoceptor antagonist, increase and decrease barbiturate-induced sleep times. In this study, we examined the effects of these drugs on propofol-induced sleep time...

journal_title：Anesthesia and analgesia

authors： Kushikata T,Hirota K,Yoshida H,Kubota T,Ishihara H,Matsuki A

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:The arterial pulse oximeter, which was introduced clinically in the 1970s, is a convenient, useful, and now ubiquitous anesthesia monitor. Unfortunately, although percent saturation of arterial hemoglobin is, along with cardiac output and concentration of hemoglobin, one of 3 components of oxygen delivery, i...

journal_title：Anesthesia and analgesia

authors： Thiele RH,Tucker-Schwartz JM,Lu Y,Gillies GT,Durieux ME

更新日期：2011-06-01 00:00:00

abstract：:Intraocular pressure (IOP) measurements in children are usually performed under nitrous oxide and halothane anesthesia. We studied the effects of both time and end-tidal halothane concentration on IOP in 80 children (mean age +/- SD = 4.5 +/- 2.9 yr), to determine the most optimal time to make such measurements in ane...

journal_title：Anesthesia and analgesia

authors： Watcha MF,Chu FC,Stevens JL,Forestner JE

更新日期：1990-08-01 00:00:00

abstract：:This study evaluated the role of nitric oxide (NO) in spinal cord nociceptive transmission during peripheral inflammation evoked by formalin injection into the rat paw, using N omega-nitro-L-arginine (N-Arg), an NO synthase inhibitor. Male rats were prepared with intrathecal (IT) catheters. To quantify the formalin re...

journal_title：Anesthesia and analgesia

authors： Yamamoto T,Shimoyama N,Mizuguchi T

更新日期：1993-11-01 00:00:00

abstract：UNLABELLED:We investigated the impact of cardiopulmonary bypass pump (CPB), hematocrit, gender, age, and body weight on blood use in patients undergoing coronary artery bypass graft surgery at a major university hospital. Participants were 1235 consecutive patients undergoing primary coronary artery surgery over a peri...

journal_title：Anesthesia and analgesia

authors： Scott BH,Seifert FC,Glass PS,Grimson R

更新日期：2003-10-01 00:00:00

abstract：:The management of severe pain may require "balanced analgesia," involving the use of analgesics with different modes of action. Clonidine, an alpha(2)-adrenoreceptor agonist produces analgesia by itself as well as when given with morphine and local anesthetics. Ketorolac is indicated for the management of moderately s...

journal_title：Anesthesia and analgesia

authors： Tejwani GA,Rattan AK

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Intrathecal neostigmine not only produces analgesia but also severe nausea. In contrast, epidural neostigmine enhances opioid and local anesthetic analgesia without causing nausea. Previous studies examined only single epidural neostigmine bolus administration and did not assess the efficacy of continuous ep...

journal_title：Anesthesia and analgesia

authors： Ross VH,Pan PH,Owen MD,Seid MH,Harris L,Clyne B,Voltaire M,Eisenach JC

更新日期：2009-08-01 00:00:00

abstract：:Contulakin-G is a novel conopeptide with an incompletely defined mechanism of action. To assess nociceptive activity we delivered Contulakin-G as a bolus intrathecally (0.03, 0.1, 0.3, 3 nmol) or epidurally (10, 30, 89 nmol) in rats. Intrathecal Contulakin G significantly decreased Phase II and, to a lesser degree, Ph...

journal_title：Anesthesia and analgesia

authors： Allen JW,Hofer K,McCumber D,Wagstaff JD,Layer RT,McCabe RT,Yaksh TL

更新日期：2007-06-01 00:00:00

abstract：:We investigated the incidence of transient neurologic symptoms (TNS) after the use of hyperbaric lidocaine as compared with hyperbaric bupivacaine in patients undergoing cesarean delivery under spinal anesthesia. Two hundred women scheduled for cesarean delivery were randomly allocated to receive spinal anesthesia wit...

journal_title：Anesthesia and analgesia

authors： Aouad MT,Siddik SS,Jalbout MI,Baraka AS

更新日期：2001-02-01 00:00:00