Anesthetic and hemodynamic effects of single bolus versus incremental titration of hyperbaric spinal lidocaine through microcatheter.


:This study examined anesthetic development and hemodynamic changes during two techniques of hyperbaric lidocaine administration through 27-gauge intrathecal catheters for continuous spinal anesthesia in 55 elderly patients undergoing transurethral prostatic resection. Twenty-five patients were randomly assigned to receive hyperbaric lidocaine 5% solution in a single bolus of 75 mg to achieve blockade to approximately T6, and 30 patients to receive hyperbaric lidocaine 2.5% solution in increments of 25 mg to achieve T6 or to a maximum of three doses. Hemodynamic measurements of arterial pressure, heart rate, cardiac output, stroke volume, and ejection fraction were made serially after the induction of spinal anesthesia. Anesthesia failed to spread beyond the sacral region in 9/25 (36%) patients in the single-dose group (SD), but was successfully induced in all patients given titrated doses (TD) at total doses of 50 mg (n = 15) (TD50) and 75 mg (n = 15) (TD75). The mean maximal level of sensory block in all three groups was comparable: T5, T4, and T6 in groups SD, TD50, and TD75, respectively. The onset and progression of sensory block were rapid and similar in the SD and TD50 groups, in contrast to a gradual, stepwise development of block in group TD75. Grade 3 motor block occurred in response to the first dose of 25 mg lidocaine in 7/30 (23%) patients receiving titrated doses, but the overall incidence of leg paralysis did not differ among the three groups by the end of lidocaine dosing. Mean arterial pressure (MAP) decreased significantly relative to baseline in all three groups.(ABSTRACT TRUNCATED AT 250 WORDS)


Anesth Analg


Anesthesia and analgesia


Chan VW,Chung F,Gomez M,Seyone C,Baylon G




Has Abstract


1994-07-01 00:00:00












  • Venous air embolism prophylaxis with a surface-active agent.

    abstract::The protective effect of a nonionic surface-active polyol agent (Pluronic F-68) against bolus injection and constant-rate IV infusion of air was studied in 21 dogs anesthetized with pentobarbital. Aortic, pulmonary artery and right ventricular pressures, cardiac output, end-tidal CO2 concentration, wasted ventilation,...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Perry JC,Munson ES,Malagodi MH,Shah DO

    更新日期:1975-11-01 00:00:00

  • Cost analysis of target-controlled infusion-based anesthesia compared with standard anesthesia regimens.

    abstract:UNLABELLED:With the development of new computer-assisted target-controlled infusion (TCI) systems and the availability of short-acting anesthetics, total IV anesthesia (TIVA) has become increasingly popular. The aim of this study was to compare costs of TCI-based anesthesia with two standard anesthesia regimens. Sixty ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验,收录出版


    authors: Suttner S,Boldt J,Schmidt C,Piper S,Kumle B

    更新日期:1999-01-01 00:00:00

  • Listening to music during anesthesia does not reduce the sevoflurane concentration needed to maintain a constant bispectral index.

    abstract:BACKGROUND:Music reduces stress responses in awake subjects. However, there remains controversy about the role of music or therapeutic suggestions during general anesthesia and postoperative recovery. We thus tested the hypothesis that intraoperative exposure to soothing music reduces the end-tidal concentration of sev...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Szmuk P,Aroyo N,Ezri T,Muzikant G,Weisenberg M,Sessler DI

    更新日期:2008-07-01 00:00:00

  • Clonidine decreases plasma catecholamines and improves outcome from incomplete ischemia in the rat.

    abstract::Clonidine decreases central sympathetic activity and anesthetic requirement. We tested whether clonidine improves outcome from incomplete ischemia of the brain in rats. Control rats were anesthetized with 25 of intravenous fentanyl and inhalation of 70% nitrous oxide (N2O). Clonidine-treated rats r...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Hoffman WE,Cheng MA,Thomas C,Baughman VL,Albrecht RF

    更新日期:1991-10-01 00:00:00

  • The intrathecally administered kappa-2 opioid agonist GR89696 and interleukin-10 attenuate bone cancer-induced pain through synergistic interaction.

    abstract:BACKGROUND:Although bone cancer-related pain is one of the most disruptive symptoms in patients with advanced cancer, patients are often refractory to pharmacological treatments; thus, more effective treatments for bone cancer pain are needed. We evaluated the analgesic efficacy of and interaction between intrathecal G...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kim WM,Jeong CW,Lee SH,Kim YO,Cui JH,Yoon MH

    更新日期:2011-10-01 00:00:00

  • Sevoflurane, but not propofol, significantly prolongs the Q-T interval.

    abstract:UNLABELLED:Prolongation of the Q-T interval may be associated with polymorphic ventricular tachycardia known as torsade de pointes, syncope and sudden death. Existing data show that isoflurane prolongs the Q-T interval, whereas halothane shortens it. The aim of this study was to determine whether sevoflurane or propofo...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kleinsasser A,Kuenszberg E,Loeckinger A,Keller C,Hoermann C,Lindner KH,Puehringer F

    更新日期:2000-01-01 00:00:00

  • The effects of benzodiazepines on human opioid receptor binding and function.

    abstract:UNLABELLED:We performed in vitro studies to investigate the potential interaction of benzodiazepines with cloned human opioid receptor subtypes. Midazolam, chlordiazepoxide, and diazepam directly displaced [(3)H]-diprenorphine binding from kappa and delta receptors, but not mu receptors, whereas flumazenil was inactive...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Cox RF,Collins MA

    更新日期:2001-08-01 00:00:00

  • Chinese Anesthesiologists Have High Burnout and Low Job Satisfaction: A Cross-Sectional Survey.

    abstract:BACKGROUND:The Chinese health care system must meet the needs of 19% of the world's population. Despite recent economic growth, health care resources are unevenly distributed. This creates the potential for job stress and burnout. We therefore conducted a survey among anesthesiologists in the Beijing-Tianjin-Hebei regi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Li H,Zuo M,Gelb AW,Zhang B,Zhao X,Yao D,Xia D,Huang Y

    更新日期:2018-03-01 00:00:00

  • Capnography during jet ventilation for laryngoscopy.

    abstract::Jet ventilation is often used during laryngoscopy to permit improved visualization of the larynx and to eliminate a potentially flammable endotracheal tube when laser surgery of the airway is performed. Observation of chest wall movement and blood gas analysis are the usual standards for assessing the adequacy of vent...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Gottschalk A,Mirza N,Weinstein GS,Edwards MW

    更新日期:1997-07-01 00:00:00

  • Erythrocyte fragility screening is not a tool for diagnosis of human malignant hyperthermia.

    abstract::The fragility of erythrocytes from 21 patients undergoing in vitro skeletal muscle contracture testing for malignant hyperthermia (MH) susceptibility was examined. Osmotic fragility was determined by the degree of hemolysis in buffered saline solutions of decreasing osmotic strength. Halothane-induced fragility was de...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kistler P,Fletcher JE,Rosenberg H

    更新日期:1987-10-01 00:00:00

  • Serotonergic activity in man as a function of pain, pain mechanisms, and depression.

    abstract::Lumbar cerebrospinal fluid levels of 5-hydroxyindoleacetic acid, which are used as indicators of central nervous system serotonergic neuronal activity, were significantly higher in 67 patients with chronic pain and in 32 patients with acute pain (23.6 +/- 3.3 and 23.1 +/- 3.8, respectively) than in 30 patients (8.8 +/...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Ghia JN,Mueller RA,Duncan GH,Scott DS,Mao W

    更新日期:1981-12-01 00:00:00

  • The care of patients with phantom limb pain in a pain clinic.

    abstract::Patients referred to the Pain Clinic at the University of Virginia Medical Center with genuine phantom pain rather than stump pain have been treated by a variety of technics. Simple revision of drug therapy has proved helpful in some instances, as has repeated injection of trigger areas or neuromata, though surgical e...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Blankenbaker WL

    更新日期:1977-11-01 00:00:00

  • Ketamine blocks currents through mammalian nicotinic acetylcholine receptor channels by interaction with both the open and the closed state.

    abstract::Single channel recordings have shown that ketamine (Ket) decreases the open time of the nicotinic acetylcholine receptor channel (nAChR). The present experiments on simultaneous openings of the nAChRs of mouse myotubes investigate the interaction of Ket with the open as well as with the closed state of the channels. T...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Scheller M,Bufler J,Hertle I,Schneck HJ,Franke C,Kochs E

    更新日期:1996-10-01 00:00:00

  • Transcutaneous monitoring of carbon dioxide tension after cardiothoracic surgery in infants and children.

    abstract:UNLABELLED:In this prospective investigation, we evaluated the efficacy and accuracy of transcutaneous monitoring of CO2 (TC-CO2) in infants and children after cardiothoracic surgery. Cardiothoracic surgery patients whose ETCO2 and arterial CO2 values did not correlate (gradient > or = 5 mm Hg) during the first postope...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Tobias JD,Wilson WR Jr,Meyer DJ

    更新日期:1999-03-01 00:00:00

  • The effects of tramadol and morphine on immune responses and pain after surgery in cancer patients.

    abstract:UNLABELLED:There has been growing interest in determining the possible immune consequences of opioid administration for the management of postoperative pain. We studied the effects of morphine and tramadol on pain and immune function during the postoperative period in 30 patients undergoing abdominal surgery for uterin...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Sacerdote P,Bianchi M,Gaspani L,Manfredi B,Maucione A,Terno G,Ammatuna M,Panerai AE

    更新日期:2000-06-01 00:00:00

  • Hyperbaric bupivacaine for spinal anesthesia in cesarean section.

    abstract::The efficacy and safety of 0.5% hyperbaric bupivacaine (Sensorcaine, Astra) was evaluated in 22 patients undergoing elective cesarean section under spinal anesthesia. The dose varied from 7.5 to 10 mg, (depending on the patient's height) which was significantly lower than previously reported. Patients were placed in h...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Santos A,Pedersen H,Finster M,Edström H

    更新日期:1984-11-01 00:00:00

  • Prevention of hypotension during spinal anesthesia: a comparison of intravascular administration of hetastarch versus lactated Ringer's solution.

    abstract::This study was designed to compare the efficacy of 6% hetastarch to that of crystalloid administration in reducing the incidence and severity of hypotension during spinal anesthesia. Forty ASA grade I patients scheduled for postpartum tubal ligations under spinal anesthesia were randomly allocated to receive either 50...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sharma SK,Gajraj NM,Sidawi JE

    更新日期:1997-01-01 00:00:00

  • Transversus Abdominis Plane Block Versus Wound Infiltration for Analgesia After Cesarean Delivery: A Randomized Controlled Trial.

    abstract:BACKGROUND:Transversus abdominis plane (TAP) block and local anesthetic wound infiltration provide analgesia after cesarean delivery. Studies comparing the 2 techniques are scarce, with conflicting results. This double-blind, randomized controlled trial aimed to compare bilateral ultrasound-guided TAP block with single...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Tawfik MM,Mohamed YM,Elbadrawi RE,Abdelkhalek M,Mogahed MM,Ezz HM

    更新日期:2017-04-01 00:00:00

  • Brachial artery catheterization: an assessment of use patterns and associated complications.

    abstract:BACKGROUND:Although studies have compared safety and outcomes of radial artery cannulation with other arterial catheterization locations, there is insufficient information describing brachial artery catheterization. In this study, we characterized the perioperative use patterns and the complication rates associated wit...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Handlogten KS,Wilson GA,Clifford L,Nuttall GA,Kor DJ

    更新日期:2014-02-01 00:00:00

  • The effects of olprinone (a phosphodiesterase III inhibitor) on hepatic vascular bed in a porcine model of endotoxemia.

    abstract:UNLABELLED:Decreased hepatic blood flow, and impaired hepatic oxygen delivery caused by endotoxin, result in hepatic metabolic deterioration followed by liver dysfunction and multiple organ failure. Among phosphodiesterase III inhibitors, only olprinone increases hepatosplanchnic blood flow. We evaluated the effects of...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Nagata E,Kakihana Y,Tobo K,Isowaki S,Kanmura Y

    更新日期:2001-03-01 00:00:00

  • Decision Support for the Capacity Management of Bronchoscopy Devices: Optimizing the Cost-Efficient Mix of Reusable and Single-Use Devices Through Mathematical Modeling.

    abstract:BACKGROUND:Increasing costs of material resources challenge hospitals to stay profitable. Particularly in anesthesia departments and intensive care units, bronchoscopes are used for various indications. Inefficient management of single- and multiple-use systems can influence the hospitals' material costs substantially....

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Edenharter GM,Gartner D,Pförringer D

    更新日期:2017-06-01 00:00:00

  • Sedation-analgesia with propofol and remifentanil: concentrations required to avoid gag reflex in upper gastrointestinal endoscopy.

    abstract:BACKGROUND:The purpose of this study was to identify optimal target propofol and remifentanil concentrations to avoid a gag reflex in response to insertion of an upper gastrointestinal endoscope. METHODS:Patients presenting for endoscopy received target-controlled infusions (TCI) of both propofol and remifentanil for ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Borrat X,Valencia JF,Magrans R,Gimenez-Mila M,Mellado R,Sendino O,Perez M,Nunez M,Jospin M,Jensen EW,Troconiz I,Gambus PL

    更新日期:2015-07-01 00:00:00

  • Prevention of atelectasis formation during induction of general anesthesia.

    abstract:UNLABELLED:General anesthesia promotes atelectasis formation, which is augmented by administration of large oxygen concentrations. We studied the efficacy of positive end-expiratory pressure (PEEP) application during the induction of general anesthesia (fraction of inspired oxygen [FIO(2)] 1.0) to prevent atelectasis. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Rusca M,Proietti S,Schnyder P,Frascarolo P,Hedenstierna G,Spahn DR,Magnusson L

    更新日期:2003-12-01 00:00:00

  • Electronic Audit and Feedback With Positive Rewards Improve Anesthesia Provider Compliance With a Barcode-Based Drug Safety System.

    abstract:BACKGROUND:We implemented a previously described barcode-based drug safety system in all of our anesthetizing locations. Providers were instructed to scan the barcode on syringes using our Anesthesia Information Management System before drug administration, but the rate of provider adherence was low. We studied an impl...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Bowdle TA,Jelacic S,Nair B,Zucker F,Bussey LS,Togashi K,Yang JT,Lang J

    更新日期:2019-08-01 00:00:00

  • Leg warming minimizes core hypothermia during abdominal surgery.

    abstract::The efficacy of leg skin warming in preventing hypothermia and shivering was evaluated in two separate prospective, randomized trials in patients undergoing abdominal surgery. In the first trial, 22 patients were randomized to receive no hypothermia prevention (control group) or active warming with an electric warming...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Camus Y,Delva E,Just B,Lienhart A

    更新日期:1993-11-01 00:00:00

  • A comparative study of enflurane and halothane using systolic time intervals.

    abstract::The effects of enflurane and halothane anesthesia on systolic time intervals were studied in 12 healthy patients. Cardiovascular measurements were made at equipotent levels of anesthesia: enflurane 1.23% end-tidal and halothane 0.65% end-tidal. These agents were studied first with 50% N2O and then without N2O. Systoli...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kaplan JA,Miller ED,Bailey DR

    更新日期:1976-03-01 00:00:00

  • Perioperative Management of the Patient With a Left Ventricular Assist Device for Noncardiac Surgery.

    abstract::The pandemic of heart failure and the limited options for treatment of end-stage disease have resulted in an increase in the utilization of left ventricular assist devices (LVADs). Improvements in device technology and patient survival have led to an expanding population of patients requiring noncardiac surgery while ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Chung M

    更新日期:2018-06-01 00:00:00

  • The inhibition of epidural morphine-induced pruritus by epidural droperidol.

    abstract:UNLABELLED:IV droperidol inhibits epidural morphine-induced pruritus, but this effect disappears when the dose is increased from 2.5 to 5.0 mg. This study was performed to determine whether epidural droperidol would have a similar effect. In this double-blinded study, we enrolled 140 patients undergoing Cesarean delive...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Horta ML,Ramos L,Gonçalves ZR

    更新日期:2000-03-01 00:00:00

  • Intravenous regional guanethidine in the treatment of reflex sympathetic dystrophy/causalgia: a randomized, double-blind study. Guanethidine Study Group.

    abstract::This double-blind, randomized, multicenter study was designed to determine the short-term and long-term efficacy of intravenous regional block with guanethidine in patients with reflex sympathetic dystrophy (RSD)/causalgia. Sixty patients were enrolled to receive four intravenous regional blocks at 4-day intervals wit...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Ramamurthy S,Hoffman J

    更新日期:1995-10-01 00:00:00

  • Cryoanalgesia: effect on postherniorrhaphy pain.

    abstract:UNLABELLED:Cryoanalgesia versus sham treatment was applied to the ilioinguinal and iliohypogastric nerves after mesh repair of an inguinal hernia under local anesthesia in 48 male patients in a prospective, randomized, and observer- and patient-blinded trial. Pain was scored daily during rest, while coughing, and durin...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Callesen T,Bech K,Thorup J,Andersen J,Nielsen R,Roikjaer O,Kehlet H

    更新日期:1998-10-01 00:00:00