Nitric oxide synthase inhibitor blocks spinal sensitization induced by formalin injection into the rat paw.

Abstract:

:This study evaluated the role of nitric oxide (NO) in spinal cord nociceptive transmission during peripheral inflammation evoked by formalin injection into the rat paw, using N omega-nitro-L-arginine (N-Arg), an NO synthase inhibitor. Male rats were prepared with intrathecal (IT) catheters. To quantify the formalin response, the instances of "flinching behavior" were counted at 5-min intervals for 60 min. IT N-Arg depressed the flinching behavior in a dose-dependent manner when N-Arg was administered 10 min before the formalin injection. This N-Arg effect was reversed with L-arginine but not D-arginine. We conclude that NO plays an important role in nociceptive transmission in the spinal cord during the formalin test.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Yamamoto T,Shimoyama N,Mizuguchi T

doi

10.1213/00000539-199311000-00003

subject

Has Abstract

pub_date

1993-11-01 00:00:00

pages

886-90

issue

5

eissn

0003-2999

issn

1526-7598

journal_volume

77

pub_type

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