Minimum alveolar anesthetic concentration of fluorinated alkanols in rats: relevance to theories of narcosis.


UNLABELLED:The Meyer-Overton hypothesis predicts that the potency of conventional inhaled anesthetics correlates inversely with lipophilicity: minimum alveolar anesthetic concentration (MAC) x the olive oil/gas partition coefficient equals a constant of approximately 1.82 +/- 0.56 atm (mean +/- SD), whereas MAC x the octanol/gas partition coefficient equals a constant of approximately 2.55 +/- 0.65 atm. MAC is the minimum alveolar concentration of anesthetic required to eliminate movement in response to a noxious stimulus in 50% of subjects. Although MAC x the olive oil/gas partition coefficient also equals a constant for normal alkanols from methanol through octanol, the constant (0.156 +/- 0.072 atm) is one-tenth that found for conventional anesthetics, whereas the product for MAC x the octanol/gas partition coefficient (1.72 +/- 1.19) is similar to that for conventional anesthetics. These normal alkanols also have much greater affinities for water (saline/gas partition coefficients equaling 708 [octanol] to 3780 [methanol]) than do conventional anesthetics. In the present study, we examined whether fluorination lowers alkanol saline/gas partition coefficients (i.e., decreases polarity) while sustaining or increasing lipid/gas partition coefficients, and whether alkanols with lower saline/gas partition coefficients had products of MAC x olive oil or octanol/gas partition coefficients that approached or exceeded those of conventional anesthetics. Fluorination decreased saline/gas partition coefficients to as low as 0.60 +/- 0.08 (CF3[CF2]6CH2OH) and, as hypothesized, increased the product of MAC x the olive oil or octanol/gas partition coefficients to values equaling or exceeding those found for conventional anesthetics. We conclude that the greater potency of many alkanols (greater than would be predicted from conventional inhaled anesthetics and the Meyer-Overton hypothesis) is associated with their greater polarity. IMPLICATIONS:Inhaled anesthetic potency correlates with lipophilicity, but potency of common alkanols is greater than their lipophilicity indicates, in part because alkanols have a greater hydrophilicity--i.e., a greater polarity.


Anesth Analg


Anesthesia and analgesia


Eger EI 2nd,Ionescu P,Laster MJ,Gong D,Hudlicky T,Kendig JJ,Harris RA,Trudell JR,Pohorille A




Has Abstract


1999-04-01 00:00:00












  • Subhypnotic doses of propofol do not relieve pruritus induced by intrathecal morphine after cesarean section.

    abstract:UNLABELLED:The purpose of this study was to determine whether subhypnotic doses of propofol effectively relieve pruritus in women who received intrathecal morphine for postoperative analgesia after cesarean delivery. Twenty-nine women who developed pruritus after undergoing an elective cesarean section and receiving in...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Beilin Y,Bernstein HH,Zucker-Pinchoff B,Zahn J,Zenzen WJ

    更新日期:1998-02-01 00:00:00

  • Reversal of central nervous system and cardiac toxicity after local anesthetic intoxication by lipid emulsion injection.

    abstract::A 91-yr-old man (57 kg, 156 cm, ASA III) received an infraclavicular brachial plexus block for surgery of bursitis of the olecranon. Twenty minutes after infraclavicular injection of 30 mL of mepivacaine 1% (Scandicain) and 5 min after supplementation of 10 mL of prilocaine 1% (Xylonest) using an axillary approach, th...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Litz RJ,Roessel T,Heller AR,Stehr SN

    更新日期:2008-05-01 00:00:00

  • Does arginine vasopressin influence the coagulation system in advanced vasodilatory shock with severe multiorgan dysfunction syndrome?

    abstract::Arginine vasopressin (AVP) is a potent supplementary vasopressor in advanced vasodilatory shock, but decreases in platelet count have been reported during AVP therapy. In this study we evaluated the effects of AVP infusion on the coagulation system in advanced vasodilatory shock when compared to norepinephrine (NE) in...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dünser MW,Fries DR,Schobersberger W,Ulmer H,Wenzel V,Friesenecker B,Hasibeder WR,Mayr AJ

    更新日期:2004-07-01 00:00:00

  • The additive pulmonary vasodilatory effects of inhaled prostacyclin and inhaled milrinone in postcardiac surgical patients with pulmonary hypertension.

    abstract:UNLABELLED:Selective pulmonary vasodilation is an advantageous therapeutic strategy for cardiac surgical patients with increased pulmonary vascular resistance (PVR) and right ventricular failure. We hypothesized that milrinone, an adenosine-3',5'-cyclic monophosphate (cAMP)-selective phosphodiesterase enzyme (PDE) inhi...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Haraldsson s A,Kieler-Jensen N,Ricksten SE

    更新日期:2001-12-01 00:00:00

  • Brain sodium, potassium, and osmolality: effects on anesthetic requirement.

    abstract::We determined the effects of hyperkalemia, hypernatremia, hyperosmolality and hypo-osmolality on halothane requirement (MAC) in dogs. Hyperkalemia did not change cerebrospinal fluid potassium or MAC. Hypernatremia proportionately increased cerebrospinal fluid sodium and osmolality. MAC concomitantly increased 43%. Ser...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Tanifuji Y,Eger EI 2nd

    更新日期:1978-07-01 00:00:00

  • Oral clonidine premedication enhances the quality of postoperative analgesia by intrathecal morphine.

    abstract::Since clonidine potentiates the analgesia by morphine, the current study was performed to investigate whether oral clonidine premedication would enhance the postoperative analgesia by intrathecal morphine. Twenty-six patients, aged 37-60 yr, schedule for abdominal total hysterectomy under spinal anesthesia, were studi...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Goyagi T,Nishikawa T

    更新日期:1996-06-01 00:00:00

  • Anesthesia as therapy for persistent hiccups.

    abstract:IMPLICATIONS:Chronic hiccups may be a serious therapeutic problem. Pharmacological treatment with increasing dosages of baclofen, carbamazepine, or gabapentin is not always successful. In this paper, the use of general anesthesia with positive-pressure ventilation and muscle relaxation for the termination of chronic hi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Lierz P,Felleiter P

    更新日期:2002-08-01 00:00:00

  • Emerging techniques in the management of acute pain: epidural analgesia.

    abstract::Epidural analgesia, often using opioids intraoperatively and postoperatively, is widely accepted as a valuable modality for perioperative pain management. In this review I present data from meta-analyses and recently published trials that evaluate the perioperative use of opioids administered epidurally or parenterall...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Viscusi ER

    更新日期:2005-11-01 00:00:00

  • The local peripheral antihyperalgesic effect of levetiracetam and its mechanism of action in an inflammatory pain model.

    abstract:BACKGROUND:We have recently shown that levetiracetam, administered systemically, exerts an antihyperalgesic effect in a rat inflammatory pain model. In this study, we examined whether levetiracetam has local peripheral antihyperalgesic/anti-edematous effects in the same model of localized inflammation and whether opioi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Stepanović-Petrović RM,Micov AM,Tomić MA,Ugrešić ND

    更新日期:2012-12-01 00:00:00

  • Sevoflurane, but not propofol, significantly prolongs the Q-T interval.

    abstract:UNLABELLED:Prolongation of the Q-T interval may be associated with polymorphic ventricular tachycardia known as torsade de pointes, syncope and sudden death. Existing data show that isoflurane prolongs the Q-T interval, whereas halothane shortens it. The aim of this study was to determine whether sevoflurane or propofo...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kleinsasser A,Kuenszberg E,Loeckinger A,Keller C,Hoermann C,Lindner KH,Puehringer F

    更新日期:2000-01-01 00:00:00

  • Circuit absorption of halothane, isoflurane, and sevoflurane.

    abstract:UNLABELLED:Uptake of inhaled anesthetics may be measured as the amount of anesthetic infused to maintain a constant alveolar concentration of anesthetic. This method assumes that the patient absorbs all of the infused anesthetic, and that none is lost to circuit components. Using a standard anesthetic circuit with a 3-...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Eger EI 2nd,Ionescu P,Gong D

    更新日期:1998-05-01 00:00:00

  • Perioperative Management of the Patient With a Left Ventricular Assist Device for Noncardiac Surgery.

    abstract::The pandemic of heart failure and the limited options for treatment of end-stage disease have resulted in an increase in the utilization of left ventricular assist devices (LVADs). Improvements in device technology and patient survival have led to an expanding population of patients requiring noncardiac surgery while ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Chung M

    更新日期:2018-06-01 00:00:00

  • A randomized controlled trial of the efficacy and respiratory effects of patient-controlled intravenous remifentanil analgesia and patient-controlled epidural analgesia in laboring women.

    abstract:BACKGROUND:Safe and effective alternatives are required in labor when epidural analgesia is not appropriate. We hypothesized that patient-controlled IV remifentanil labor analgesia would not be inferior to patient-controlled epidural labor analgesia. METHODS:This randomized nonblinded controlled noninferiority study i...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Stocki D,Matot I,Einav S,Eventov-Friedman S,Ginosar Y,Weiniger CF

    更新日期:2014-03-01 00:00:00

  • Comparison of resuscitation of sheep and dogs after bupivacaine-induced cardiovascular collapse.

    abstract::This study evaluated interspecies sensitivity and ability to resuscitate pentobarbital anesthetized sheep and dogs after cardiovascular toxic doses of bupivacaine. Every minute, 3 mg/kg of bupivacaine was injected into the right atrium over the course of 10 sec until cardiovascular collapse occurred. While the bupivac...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kasten GW,Martin ST

    更新日期:1986-10-01 00:00:00

  • A patient who received 191 spinal anesthetics over 5 years without evidence of neurologic complications by examination or magnetic resonance imaging.

    abstract::We present the case of a 50-year-old man who suffered a crush injury to his right lower extremity in 2002 and received 191 spinal anesthetics to date with no identifiable neurologic complications by physical examination or imaging. He has undergone >300 operations at our institution related to recurrent infection and ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Vacanti JC,Sodickson A,Kodali BS

    更新日期:2013-12-01 00:00:00

  • Onset, intensity of blockade and somatosensory evoked potential changes of the lumbosacral dermatomes after epidural anesthesia with alkalinized lidocaine.

    abstract::The onset and intensity of blockade of the lumbosacral dermatomes after epidural anesthesia with alkalinized lidocaine were investigated in a randomized, double-blind study in 26 patients. Control subjects (n = 13) received 20 mL of 1.37% lidocaine (1.5% lidocaine plus 1 mL saline per 10 mL lidocaine) with added 1:200...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Benzon HT,Toleikis JR,Dixit P,Goodman I,Hill JA

    更新日期:1993-02-01 00:00:00

  • A Randomized Controlled Trial Comparing Two Multimodal Analgesic Techniques in Patients Predicted to Have Severe Pain After Cesarean Delivery.

    abstract:BACKGROUND:Improved pain control after cesarean delivery remains a challenging objective. Poorly treated acute pain following delivery is associated with an increased risk of chronic pain and depression. This study was conducted to determine whether the addition of systemic acetaminophen and an increased dose of intrat...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Booth JL,Harris LC,Eisenach JC,Pan PH

    更新日期:2016-04-01 00:00:00

  • The effect of isoflurane or spinal anesthesia on indocyanine green disappearance rate in the elderly.

    abstract::This study was designed to measure the disappearance rate of indocyanine green (ICG) as an indicator of hepatic blood flow in elderly patients undergoing internal fixation of fractured neck of femur. All patients were aged 60-90 yr and were randomized to receive either spinal (n = 10) or isoflurane (n = 10) anesthesia...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Darling JR,Murray JM,Hainsworth AM,Trinick TR

    更新日期:1994-04-01 00:00:00

  • Activity changes in rat raphe magnus neurons at different concentrations of fentanyl in vitro.

    abstract::The nucleus raphe magnus (NRM) is an important descending pain inhibitory system. We postulated that the analgesic action of supraspinally administered opiates results from increased descending inhibitory control of the NRM. We tested whether fentanyl activates NRM neurons in the rat slice preparation using extra-cell...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Ohta Y,Alojado ME,Kemmotsu O

    更新日期:1995-05-01 00:00:00

  • The interaction of FK409, a novel nitric oxide releaser, and peripherally administered morphine during experimental inflammation.

    abstract:UNLABELLED:Nitric oxide (NO) may play an important role in central and peripheral nociceptive processes. However, its contribution to peripheral antinociception is still not clear. In the present study, we investigated the effect of peripherally administered FK409, a spontaneous NO releaser, and its interaction with pe...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Nozaki-Taguchi N,Yamamoto T

    更新日期:1998-02-01 00:00:00

  • The safety of immediate extubation after abdominal aortic surgery: a prospective, randomized trial.

    abstract:UNLABELLED:We performed this study to assess the safety of immediate extubation after elective abdominal aortic aneurysm surgery. Consecutive patients were prospectively randomized into two groups after surgery: Group 1 (n = 29) immediate extubation; and Group 2 (n = 21) delayed (at least 4 h) extubation. All patients ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cohen J,Loewinger J,Hutin K,Sulkes J,Zelikovski A,Singer P

    更新日期:2001-12-01 00:00:00

  • A single preoperative dose of gabapentin does not improve postcesarean delivery pain management: a randomized, double-blind, placebo-controlled dose-finding trial.

    abstract:BACKGROUND:A single preoperative dose of 600 mg gabapentin, combined with multimodal analgesia, has previously been shown to reduce postcesarean pain and improve maternal satisfaction but was associated with increased maternal sedation. We hypothesized that a lower dose of gabapentin may be effective with less sedation...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Short J,Downey K,Bernstein P,Shah V,Carvalho JC

    更新日期:2012-12-01 00:00:00

  • Comparison of morphine, meperidine, fentanyl, and sufentanil in balanced anesthesia: a double-blind study.

    abstract::A double-blind study comparing four narcotic analgesics of different potencies, meperidine, morphine, fentanyl, and sufentanil, was performed on consenting patients undergoing general or orthopedic surgery under balanced anesthesia. Blood pressure, measured through an indwelling arterial catheter, was recorded continu...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Flacke JW,Bloor BC,Kripke BJ,Flacke WE,Warneck CM,Van Etten AP,Wong DH,Katz RL

    更新日期:1985-09-01 00:00:00

  • Determination of the effective therapeutic dose of intrathecal sufentanil for extracorporeal shock wave lithotripsy.

    abstract:UNLABELLED:Intrathecal (IT) sufentanil provides effective analgesia for extracorporeal shock wave lithotripsy. However, the optimal dose of sufentanil has not been established. We designed a prospective, randomized, double-blinded study to determine the optimal dose of IT sufentanil. Sixty men were randomized to receiv...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lau WC,Green CR,Faerber GJ,Tait AR,Golembiewski JA

    更新日期:1999-10-01 00:00:00

  • The Amsterdam Preoperative Anxiety and Information Scale (APAIS)

    abstract::The purpose of the present study was to assess patients' anxiety level and information requirement in the preoperative phase. During routine preoperative screening, 320 patients were asked to assess their anxiety and information requirement on a six-item questionnaire, the Amsterdam Preoperative Anxiety and Informatio...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Moerman N,van Dam FS,Muller MJ,Oosting H

    更新日期:1996-03-01 00:00:00

  • Descriptive Statistics: Reporting the Answers to the 5 Basic Questions of Who, What, Why, When, Where, and a Sixth, So What?

    abstract::Descriptive statistics are specific methods basically used to calculate, describe, and summarize collected research data in a logical, meaningful, and efficient way. Descriptive statistics are reported numerically in the manuscript text and/or in its tables, or graphically in its figures. This basic statistical tutori...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Vetter TR

    更新日期:2017-11-01 00:00:00

  • Postoperative analgesia at home after ambulatory hand surgery: a controlled comparison of tramadol, metamizol, and paracetamol.

    abstract::We compared in a prospective, randomized, double-blinded study the analgesic efficacy of three drugs in 120 ASA I and II patients scheduled to undergo ambulatory hand surgery with IV regional anesthesia. At discharge, oral analgesic tablets were prescribed as follows: tramadol 100 mg every 6 h, metamizol 1 g every 6 h...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rawal N,Allvin R,Amilon A,Ohlsson T,Hallén J

    更新日期:2001-02-01 00:00:00

  • The use of transesophageal echocardiography for preload assessment in critically ill patients.

    abstract:UNLABELLED:IV volume is often administered to patients in an intensive care unit (ICU) to improve cardiovascular function. We investigated the relationship between stroke volume (SV) and left ventricular (LV) size by using transesophageal echocardiography (TEE) in a population of 20 ICU patients and 21 postoperative ca...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Tousignant CP,Walsh F,Mazer CD

    更新日期:2000-02-01 00:00:00

  • The importance of intraoperative transesophageal echocardiography in endovascular repair of thoracic aortic aneurysms.

    abstract:UNLABELLED:Endovascular repair of the aorta (EVAR) is a promising alternative to open repair. Transesophageal echocardiography (TEE) is a sensitive imaging modality for aortic disease. We reviewed our experience with TEE in thoracic EVAR. Seven patients underwent thoracic EVAR under general anesthesia. Intraoperative a...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Swaminathan M,Lineberger CK,McCann RL,Mathew JP

    更新日期:2003-12-01 00:00:00

  • Perioperative Diabetes Insipidus Caused by Anesthetic Medications: A Review of the Literature.

    abstract::Diabetes insipidus (DI) is an uncommon perioperative complication that can occur secondary to medications or surgical manipulation and can cause significant hypovolemia and electrolyte abnormalities. We reviewed and evaluated the current literature and identified 24 cases of DI related to medications commonly used in ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Van Decar LM,Reynolds EG,Sharpe EE,Harbell MW,Kosiorek HE,Kraus MB

    更新日期:2021-01-06 00:00:00