Minimum alveolar anesthetic concentration of fluorinated alkanols in rats: relevance to theories of narcosis.

Abstract:

UNLABELLED:The Meyer-Overton hypothesis predicts that the potency of conventional inhaled anesthetics correlates inversely with lipophilicity: minimum alveolar anesthetic concentration (MAC) x the olive oil/gas partition coefficient equals a constant of approximately 1.82 +/- 0.56 atm (mean +/- SD), whereas MAC x the octanol/gas partition coefficient equals a constant of approximately 2.55 +/- 0.65 atm. MAC is the minimum alveolar concentration of anesthetic required to eliminate movement in response to a noxious stimulus in 50% of subjects. Although MAC x the olive oil/gas partition coefficient also equals a constant for normal alkanols from methanol through octanol, the constant (0.156 +/- 0.072 atm) is one-tenth that found for conventional anesthetics, whereas the product for MAC x the octanol/gas partition coefficient (1.72 +/- 1.19) is similar to that for conventional anesthetics. These normal alkanols also have much greater affinities for water (saline/gas partition coefficients equaling 708 [octanol] to 3780 [methanol]) than do conventional anesthetics. In the present study, we examined whether fluorination lowers alkanol saline/gas partition coefficients (i.e., decreases polarity) while sustaining or increasing lipid/gas partition coefficients, and whether alkanols with lower saline/gas partition coefficients had products of MAC x olive oil or octanol/gas partition coefficients that approached or exceeded those of conventional anesthetics. Fluorination decreased saline/gas partition coefficients to as low as 0.60 +/- 0.08 (CF3[CF2]6CH2OH) and, as hypothesized, increased the product of MAC x the olive oil or octanol/gas partition coefficients to values equaling or exceeding those found for conventional anesthetics. We conclude that the greater potency of many alkanols (greater than would be predicted from conventional inhaled anesthetics and the Meyer-Overton hypothesis) is associated with their greater polarity. IMPLICATIONS:Inhaled anesthetic potency correlates with lipophilicity, but potency of common alkanols is greater than their lipophilicity indicates, in part because alkanols have a greater hydrophilicity--i.e., a greater polarity.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Eger EI 2nd,Ionescu P,Laster MJ,Gong D,Hudlicky T,Kendig JJ,Harris RA,Trudell JR,Pohorille A

doi

10.1097/00000539-199904000-00035

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

867-76

issue

4

eissn

0003-2999

issn

1526-7598

journal_volume

88

pub_type

杂志文章
  • CB1 and CB2 cannabinoid receptor agonists induce peripheral antinociception by activation of the endogenous noradrenergic system.

    abstract:BACKGROUND:Cannabinoid agonists induce norepinephrine release in central, spinal, and peripheral sites. Previous studies suggest an interaction between the cannabinoid and adrenergic systems on antinociception. In this study, we sought to verify whether the CB1 and CB2 cannabinoid receptor agonists anandamide and N-pal...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3182707859

    authors: Romero TR,Resende LC,Guzzo LS,Duarte ID

    更新日期:2013-02-01 00:00:00

  • Use of analgesic, anesthetic, and sedative medications during pediatric hospitalizations in the United States 2008.

    abstract:BACKGROUND:The wide need for analgesia, anesthesia, and sedation in children and the lack of pediatric labeling leads to widespread off-label use of medications for pain and sedation in children. Any attempt to address the lack of labeling will require national estimates of the numbers of children using each medication...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e31825b6fb2

    authors: Lasky T,Ernst FR,Greenspan J

    更新日期:2012-11-01 00:00:00

  • A North American survey of intravenous regional anesthesia.

    abstract:UNLABELLED:One thousand questionnaires concerning the techniques and complications of intravenous regional anesthesia (IVRA) were sent to 900 American and 100 Canadian anesthesiologists. Of the 321 respondents, 86% perform IVRA regularly. A wide variation in device-related and clinical aspects was found, ranging from a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199710000-00027

    authors: Henderson CL,Warriner CB,McEwen JA,Merrick PM

    更新日期:1997-10-01 00:00:00

  • Modification of suction-induced hemolysis during cell salvage.

    abstract:BACKGROUND:The efficiency of red blood cell collection during cell salvage is dictated by multiple variables, including suction pressure. In this study, we attempted to determine the influence of suction pressure on the efficiency of cell salvage and to identify methods for minimizing the impact of suction on salvaged ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000255208.96685.2e

    authors: Waters JH,Williams B,Yazer MH,Kameneva MV

    更新日期:2007-03-01 00:00:00

  • Extended femoral nerve sheath block after total hip arthroplasty: continuous versus patient-controlled techniques.

    abstract::We assessed the efficacy of patient-controlled analgesia (PCA) techniques for extended femoral nerve sheath block after total hip arthroplasty. Forty-five patients were divided into three groups of 15. Over 48 h, all patients received 0.125% bupivacaine with clonidine 1 microg/mL and sufentanil 0.1 microg/mL via a fem...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200102000-00033

    authors: Singelyn FJ,Vanderelst PE,Gouverneur JM

    更新日期:2001-02-01 00:00:00

  • Transnasal placement of biplane transesophageal echocardiography probe intraoperatively in an adolescent with congenital heart disease.

    abstract:UNLABELLED:Intraoperative transesophageal echocardiography (TEE) is frequently used in children with congenital heart disease (CHD). Although transnasal TEE is being used in various settings in the adult population, there are no descriptions of its use intraoperatively in patients with CHD. This report describes the su...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000086729.89284.45

    authors: Aronson LA

    更新日期:2003-12-01 00:00:00

  • Onset, intensity of blockade and somatosensory evoked potential changes of the lumbosacral dermatomes after epidural anesthesia with alkalinized lidocaine.

    abstract::The onset and intensity of blockade of the lumbosacral dermatomes after epidural anesthesia with alkalinized lidocaine were investigated in a randomized, double-blind study in 26 patients. Control subjects (n = 13) received 20 mL of 1.37% lidocaine (1.5% lidocaine plus 1 mL saline per 10 mL lidocaine) with added 1:200...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Benzon HT,Toleikis JR,Dixit P,Goodman I,Hill JA

    更新日期:1993-02-01 00:00:00

  • Quantification of Fibrinolysis Using Velocity Curves Measured with Thromboelastometry in Children with Congenital Heart Disease.

    abstract:BACKGROUND:In this pilot study, we hypothesized that velocity parameters obtained from changes in clot amplitude (A) and clot elasticity (E) measured with thromboelastometry (ROTEM, Tem International GmbH, Munich, Germany) could improve detection of fibrinolysis in whole blood obtained from children undergoing surgery ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000000795

    authors: Faraoni D,Van der Linden P,Ducloy-Bouthors AS,Goobie SM,DiNardo JA,Nielsen VG

    更新日期:2015-08-01 00:00:00

  • Esophageal insufflation with normal fiberoptic positioning of the ProSeal laryngeal mask airway.

    abstract:IMPLICATIONS:Esophageal insufflation can occur simultaneously with venting from the drain tube during positive pressure ventilation with the ProSeal laryngeal mask airway. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200204000-00050

    authors: Stix MS,Borromeo CJ,O'Connor CJ Jr

    更新日期:2002-04-01 00:00:00

  • Intracranial pressure effects of dexmedetomidine in rabbits.

    abstract::The alpha 2-adrenergic receptor agonist dexmedetomidine produces an anesthetic state in a variety of species. Although its effects on cerebral blood flow and the electroencephalogram have been investigated, the effect of this drug on intracranial pressure (ICP) has not been reported previously. Dexmedetomidine therefo...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199208000-00014

    authors: Zornow MH,Scheller MS,Sheehan PB,Strnat MA,Matsumoto M

    更新日期:1992-08-01 00:00:00

  • Kinetics of anesthetic onset measured with a direct index of neural activity.

    abstract:BACKGROUND:Previous modeling of the kinetics of uptake and elimination of anesthetic drugs from the site of action has used measures derived from the electroencephalogram. Such measures lag the current brain activity because of the time needed to acquire a signal sample and derive the measure. With a direct measure of ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3182549490

    authors: Drummond GB,Bleach L,Thomson AJ,Kennedy RR

    更新日期:2012-09-01 00:00:00

  • Meloxicam, a specific COX-2 inhibitor, does not enhance the isoflurane minimum alveolar concentration reduction produced by morphine in the rat.

    abstract:UNLABELLED:A synergistic effect of nonselective cyclooxygenase (COX) inhibitors on morphine-induced decrease of isoflurane minimum alveolar concentration (MAC(ISO)) has been observed in the rat. We studied the influence of specific COX-2 inhibitors on this decrease of MAC. Sixty-four female rats were anesthetized with ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000097849.18820.c4

    authors: Santos M,Kunkar V,García-Iturralde P,Tendillo FJ

    更新日期:2004-02-01 00:00:00

  • A New Approach to Pathogen Containment in the Operating Room: Sheathing the Laryngoscope After Intubation.

    abstract:BACKGROUND:Anesthesiologists may contribute to postoperative infections by means of the transmission of blood and pathogens to the patient and the environment in the operating room (OR). Our primary aims were to determine whether contamination of the IV hub, the anesthesia work area, and the patient could be reduced af...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0000000000000854

    authors: Birnbach DJ,Rosen LF,Fitzpatrick M,Carling P,Arheart KL,Munoz-Price LS

    更新日期:2015-11-01 00:00:00

  • Comparative hemodynamic depression of halothane versus isoflurane in neonates and infants: an echocardiographic study.

    abstract::The purpose of this study was to measure and compare the relationship of cardiovascular depression and dose during equal potent levels of halothane and isoflurane anesthesia in neonates (n = 19) (16.7 +/- 6.9 days) and infants (n = 54) (6.1 +/- 3.1 mo). Seventy-three children had heart rate, arterial blood pressure, a...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199203000-00003

    authors: Murray DJ,Forbes RB,Mahoney LT

    更新日期:1992-03-01 00:00:00

  • Hyperkalemic cardiac arrest after cardiopulmonary bypass in a child with unsuspected duchenne muscular dystrophy.

    abstract::Adverse reactions to volatile anesthetics and depolarizing muscle relaxants can occur in patients with Duchenne muscular dystrophy (DMD) resulting in acute rhabdomyolysis and hyperkalemia. We report a case of hyperkalemic cardiac arrest after cardiac surgery using cardiopulmonary bypass in a child with unsuspected DMD...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000146533.21771.2F

    authors: Nathan A,Ganesh A,Godinez RI,Nicolson SC,Greeley WJ

    更新日期:2005-03-01 00:00:00

  • Determination of the effective therapeutic dose of intrathecal sufentanil for extracorporeal shock wave lithotripsy.

    abstract:UNLABELLED:Intrathecal (IT) sufentanil provides effective analgesia for extracorporeal shock wave lithotripsy. However, the optimal dose of sufentanil has not been established. We designed a prospective, randomized, double-blinded study to determine the optimal dose of IT sufentanil. Sixty men were randomized to receiv...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199910000-00013

    authors: Lau WC,Green CR,Faerber GJ,Tait AR,Golembiewski JA

    更新日期:1999-10-01 00:00:00

  • Laryngeal mask airway or endotracheal tube for percutaneous dilatational tracheostomy: a comparison of visibility of intratracheal structures.

    abstract:PURPOSE:Some severe complications during percutaneous dilatational tracheostomy (PDT) may be related to poor visualization of tracheal structures. Subjectively, the bronchoscopical view obtained via a laryngeal mask airway (LMA) seems to be better than that obtained with an endotracheal tube (ETT). In this prospective,...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0b013e3181d27fb4

    authors: Linstedt U,Zenz M,Krull K,Häger D,Prengel AW

    更新日期:2010-04-01 00:00:00

  • The Effect of Dexmedetomidine on Propofol Requirements During Anesthesia Administered by Bispectral Index-Guided Closed-Loop Anesthesia Delivery System: A Randomized Controlled Study.

    abstract:BACKGROUND:Dexmedetomidine, a selective α2-adrenergic agonist currently approved for continuous intensive care unit sedation, is being widely evaluated for its role as a potential anesthetic. The closed-loop anesthesia delivery system (CLADS) is a method to automatically administer propofol total intravenous anesthesia...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0000000000003470

    authors: Dutta A,Sethi N,Sood J,Panday BC,Gupta M,Choudhary P,Puri GD

    更新日期:2019-07-01 00:00:00

  • Management of 1-Lung Ventilation-Variation and Trends in Clinical Practice: A Report From the Multicenter Perioperative Outcomes Group.

    abstract:BACKGROUND:Lung-protective ventilation (LPV) has been demonstrated to improve clinical outcomes in surgical patients. There are very limited data on the current use of LPV for patients undergoing 1-lung ventilation (1LV) despite evidence that 1LV may be a particularly important setting for its use. In this multicenter ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究

    doi:10.1213/ANE.0000000000002642

    authors: Colquhoun DA,Naik BI,Durieux ME,Shanks AM,Kheterpal S,Bender SP,Blank RS,MPOG Investigators.

    更新日期:2018-02-01 00:00:00

  • Bunegin-Albin catheter improves air retrieval and resuscitation from lethal venous air embolism in upright dogs.

    abstract::Three types of catheters, the Arrow multi-orifice catheter, the American Edwards 7 Fr Swan-Ganz catheter and the Cook Bunegin-Albin multi-orifice CVP catheter were evaluated for their ability to retrieve venous air emboli and effect on the success rate of resuscitation from venous air emboli. The catheters were insert...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Colley PS,Artru AA

    更新日期:1989-03-01 00:00:00

  • Statistical grand rounds: Importance of appropriately modeling procedure and duration in logistic regression studies of perioperative morbidity and mortality.

    abstract::Multiple logistic regression studies frequently are performed with duration (e.g., operative time) included as an independent variable. We use narrative review of the statistical literature to highlight that when the association between duration and outcome is presumptively significant, the procedure itself (e.g., vid...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0b013e318229d450

    authors: Dexter F,Dexter EU,Ledolter J

    更新日期:2011-11-01 00:00:00

  • Adenosine as a non-opioid analgesic in the perioperative setting.

    abstract::Adenosine, a ubiquitous metabolic intermediate in the body, is involved in nearly every aspect of cell function, including neuromodulation and neurotransmission. Adenosine A(1) and A(2) receptors are widely distributed in the brain and spinal cord, and are a novel, non-opiate target for pain management. The potential ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/01.ane.0000267260.00384.d9

    authors: Gan TJ,Habib AS

    更新日期:2007-08-01 00:00:00

  • Characterizing the Structural Integrity of Endotracheal Tube Taping Techniques: A Simulation Study.

    abstract:BACKGROUND:Endotracheal tubes (ETTs) are commonly secured with tape to prevent undesirable tube migration. Many methods of taping have been described, although little has been published comparing various methods of taping to one another. In this study, we evaluated several methods for securing ETTs with tape. We hypoth...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000004206

    authors: Matchett G,Yang JH,Sripathi NR,Simpkins L,Ruikar K,Minhajuddin A,Whitten CW

    更新日期:2020-08-01 00:00:00

  • Pulmonary effects of methylprednisolone in patients undergoing coronary artery bypass grafting and early tracheal extubation.

    abstract:UNLABELLED:Numerous clinical studies suggest that methylprednisolone may facilitate early tracheal extubation after cardiac surgery, yet no investigation has rigorously examined the use of the drug in this setting. In this prospective, randomized, double-blind, placebo-controlled study, we examined the pulmonary effect...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199807000-00007

    authors: Chaney MA,Nikolov MP,Blakeman B,Bakhos M,Slogoff S

    更新日期:1998-07-01 00:00:00

  • Intrathecal versus intravenous fentanyl for supplementation of subarachnoid block during cesarean delivery.

    abstract:UNLABELLED:Forty-eight healthy parturients scheduled for elective cesarean delivery were randomly allocated to receive intrathecally either 12 mg of hyperbaric bupivacaine plus 12.5 microg of fentanyl (n = 23) or bupivacaine alone (n = 25). In the latter group, IV 12.5 microg of fentanyl was administered immediately af...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200207000-00037

    authors: Siddik-Sayyid SM,Aouad MT,Jalbout MI,Zalaket MI,Berzina CE,Baraka AS

    更新日期:2002-07-01 00:00:00

  • Pharmacodynamics and pharmacokinetics of epidural ropivacaine in humans.

    abstract::The purpose of this study was to characterize the pharmacodynamics and pharmacokinetics of three concentrations of the new long-acting amide local anesthetic, ropivacaine, given epidurally in 15 physical status ASA I or II patients for elective lower-extremity orthopedic procedures using a nonrandomized open-label des...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199001000-00004

    authors: Katz JA,Bridenbaugh PO,Knarr DC,Helton SH,Denson DD

    更新日期:1990-01-01 00:00:00

  • Preserved CO(2) reactivity and increase in middle cerebral arterial blood flow velocity during laparoscopic surgery in children.

    abstract:UNLABELLED:In adult patients, the creation of pneumoperitoneum (PP) by means of carbon dioxide (CO(2)) insufflation leads to an increase in cerebral blood flow velocity (CBFV), which is thought to be caused by hypercapnia. We evaluated whether PP leads to an increase of CBFV in children, and whether this increase is di...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200202000-00005

    authors: Huettemann E,Terborg C,Sakka SG,Petrat G,Schier F,Reinhart K

    更新日期:2002-02-01 00:00:00

  • The effects of load on systolic mitral annular velocity by tissue Doppler imaging.

    abstract::Tissue Doppler Imaging (TDI) provides information on systolic function through its systolic mitral annulus velocity wave (Sm), reflecting the peak velocity of shortening of the myocardial fibers oriented in the longitudinal direction. In this study, we evaluated the effect of load changes on Sm. Forty-two cardiac surg...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/01.ANE.0000131972.99804.28

    authors: Amà R,Segers P,Roosens C,Claessens T,Verdonck P,Poelaert J

    更新日期:2004-08-01 00:00:00

  • Effects of Preoperative Gum Chewing on Sore Throat After General Anesthesia With a Supraglottic Airway Device: A Randomized Controlled Trial.

    abstract:BACKGROUND:Postoperative sore throat (POST) is not uncommon after general anesthesia with a supraglottic airway (SGA) device. Although it was reported that some pharmacological and nonpharmacological measures can reduce POST, because of limitations and variable success rates, we need to find a simpler and more effectiv...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0000000000004664

    authors: Wang T,Wang Q,Zhou H,Huang S

    更新日期:2020-12-01 00:00:00

  • Population pharmacokinetics of dexmedetomidine in infants after open heart surgery.

    abstract:BACKGROUND:Dexmedetomidine is a highly selective alpha(2)-agonist with hypnotic, analgesic, and anxiolytic properties. In adults, it provides sedation while preserving respiratory function facilitating extubation. Only limited pharmacokinetic data are available for pediatric patients. The primary aim of this study was ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181d783c8

    authors: Su F,Nicolson SC,Gastonguay MR,Barrett JS,Adamson PC,Kang DS,Godinez RI,Zuppa AF

    更新日期:2010-05-01 00:00:00