The local peripheral antihyperalgesic effect of levetiracetam and its mechanism of action in an inflammatory pain model.

abstract：:Using a standardized technique, spinal anesthesia was induced in 50 term parturients to study the correlation between patient height, weight, and body mass index (BMI) and the spread of sensory blockade. All patients received 12 mg hyperbaric bupivacaine while in the right lateral decubitus position on a horizontal op...

journal_title：Anesthesia and analgesia

authors： Norris MC

更新日期：1988-06-01 00:00:00

abstract：:Clonidine in spinal and epidural blocks prolongs anesthesia, but can cause hypotension and bradycardia. The aim of our study was to compare hemodynamic and analgesic effects of spinal versus epidural clonidine alone and after repetitive dosing. In a prospective, randomized, double-blind study, we evaluated 40 patients...

journal_title：Anesthesia and analgesia

authors： Klimscha W,Chiari A,Krafft P,Plattner O,Taslimi R,Mayer N,Weinstabl C,Schneider B,Zimpfer M

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Pilot studies applying point-of-care ultrasound (POCUS) in preeclampsia indicate the presence of pulmonary interstitial edema, cerebral edema, and cardiac dysfunction. Laboratory markers of oncotic pressure (albumin) and cardiac dysfunction (brain natriuretic peptide [BNP]) may be abnormal, but the clinical ...

journal_title：Anesthesia and analgesia

authors： Ortner CM,Krishnamoorthy V,Neethling E,Flint M,Swanevelder JL,Lombard C,Fawcus S,Dyer RA

更新日期：2019-06-01 00:00:00

abstract：:Acute fatty liver of pregnancy (AFLP) is a late gestational complication with biochemical similarities to the inherited disorders of mitochondrial fatty acid oxidation and clinical similarities to fulminant hepatic failure. The following case illustrates our perioperative management of this rarely encountered disorder...

journal_title：Anesthesia and analgesia

authors： Holzman RS,Riley LE,Aron E,Fetherston J

更新日期：2001-05-01 00:00:00

abstract：UNLABELLED:Recent investigations have sought to improve intrathecal analgesia by combining opioids with other classes of analgesics. In this study we assessed the ability of intrathecal midazolam to increase the potency and duration of the analgesic effects of intrathecal fentanyl without causing adverse effects. Thirt...

journal_title：Anesthesia and analgesia

authors： Tucker AP,Mezzatesta J,Nadeson R,Goodchild CS

更新日期：2004-06-01 00:00:00

abstract：UNLABELLED:Previous reports indicate that cyclosporine increases sleeping time from barbiturate administration, and analgesia from fentanyl administration, suggesting a possible contribution of cyclosporine to anesthesia. Accordingly, we determined whether cyclosporine pretreatment decreases isoflurane MAC (the minimum...

journal_title：Anesthesia and analgesia

authors： Niemann CU,Stabernack C,Serkova N,Jacobsen W,Christians U,Eger EI 2nd

更新日期：2002-10-01 00:00:00

abstract：UNLABELLED:We performed this study to assess the safety of immediate extubation after elective abdominal aortic aneurysm surgery. Consecutive patients were prospectively randomized into two groups after surgery: Group 1 (n = 29) immediate extubation; and Group 2 (n = 21) delayed (at least 4 h) extubation. All patients ...

journal_title：Anesthesia and analgesia

authors： Cohen J,Loewinger J,Hutin K,Sulkes J,Zelikovski A,Singer P

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:The cellular mechanisms underlying the sedative effect of general anesthetics are not completely understood. Accumulating evidence indicates that the ventrolateral preoptic area (VLPO) of the hypothalamus plays a critical role. The VLPO contains 2 major types of neurons, the noradrenalin-inhibited GABAergic ...

journal_title：Anesthesia and analgesia

authors： Liu YW,Zuo W,Ye JH

更新日期：2013-08-01 00:00:00

abstract：:A parametric study was performed in cats comparing the effects on the brainstem auditory evoked response of four anesthetic agents used either in the operating room or the laboratory: sodium pentobarbital, ketamine, halothane, and chloralose. Each anesthetic agent was administered to each of four cats in varying seque...

journal_title：Anesthesia and analgesia

authors： Cohen MS,Britt RH

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:Many clinical pain states that are difficult to treat share a common feature of sensitization of nociceptive pathways. Drugs that could normalize hyperexcitable neural activity (e.g., antiepileptic drugs) may be useful in relieving these pain states. Eslicarbazepine acetate (ESL) is a novel antiepileptic dru...

journal_title：Anesthesia and analgesia

authors： Tomić MA,Pecikoza UB,Micov AM,Stepanović-Petrović RM

更新日期：2015-12-01 00:00:00

abstract：:Despite the exhaustive search for an acceptable substitute to erythrocyte transfusion, neither chemical-based products such as perfluorocarbons nor hemoglobin-based oxygen carriers have succeeded in providing a reasonable alternative to allogeneic blood transfusion. However, there remain scenarios in which blood trans...

journal_title：Anesthesia and analgesia

authors： Jahr JS,Guinn NR,Lowery DR,Shore-Lesserson L,Shander A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Although the bronchodilatory actions of volatile anesthetics, such as halothane, isoflurane, and sevoflurane, have been well documented in previous studies, the properties of desflurane remain controversial. The aim of this study was to investigate the effects of desflurane at different concentrations and du...

journal_title：Anesthesia and analgesia

authors： Zhou J,Iwasaki S,Yamakage M

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Nerve injury can generate neuropathic pain. The accompanying mechanical allodynia may be reduced by the intrathecal administration of adenosine. The neuroprotective effects of adenosine are mediated by the adenosine triphosphate (ATP)-sensitive potassium (K(ATP)) channel. We assessed the relationship between...

journal_title：Anesthesia and analgesia

authors： Song JG,Hahm KD,Kim YK,Leem JG,Lee C,Jeong SM,Park PH,Shin JW

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Cannabinoid agonists induce norepinephrine release in central, spinal, and peripheral sites. Previous studies suggest an interaction between the cannabinoid and adrenergic systems on antinociception. In this study, we sought to verify whether the CB1 and CB2 cannabinoid receptor agonists anandamide and N-pal...

journal_title：Anesthesia and analgesia

authors： Romero TR,Resende LC,Guzzo LS,Duarte ID

更新日期：2013-02-01 00:00:00

abstract：:The tandem pore domain K channel family mediates background K currents present in excitable cells. Currents passed by certain members of the family are enhanced by volatile anesthetics, thus suggesting a novel mechanism of anesthesia. The newest member of the family, termed TRESK (TWIK [tandem pore domain weak inward ...

journal_title：Anesthesia and analgesia

authors： Liu C,Au JD,Zou HL,Cotten JF,Yost CS

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:A new benzodiazepine, remimazolam, which is rapidly metabolized by tissue esterases to an inactive metabolite, has been developed to permit a fast onset, a short, predictable duration of sedative action, and a more rapid recovery profile than currently available drugs. We report on modeling of the data and s...

journal_title：Anesthesia and analgesia

authors： Wiltshire HR,Kilpatrick GJ,Tilbrook GS,Borkett KM

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:The ability to identify the correct vertebral level through examination is an important skill for clinicians who are performing nerve blocks without fluoroscopy. The conventional palpation method, which identifies the most prominent cervical spinous process as the seventh cervical (C7) spinous process is unr...

journal_title：Anesthesia and analgesia

authors： Shin S,Yoon DM,Yoon KB

更新日期：2011-05-01 00:00:00

abstract：UNLABELLED:The purpose of this study was to investigate whether propofol protects rat hepatocyte suspensions against an oxidant attack by a free radical generator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH). Rat hepatocyte suspensions (2 x 10(6) cells/mL) were prepared using Seglen's collagenase perfusion tec...

journal_title：Anesthesia and analgesia

authors： Navapurkar VU,Skepper JN,Jones JG,Menon DK

更新日期：1998-11-01 00:00:00

abstract：:A quest for a systems-level neuroscientific basis of anesthetic-induced loss and return of consciousness has been in the forefront of research for the past 2 decades. Recent advances toward the discovery of underlying mechanisms have been achieved using experimental electrophysiology, multichannel electroencephalograp...

journal_title：Anesthesia and analgesia

authors： Hudetz AG,Mashour GA

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:In patients undergoing total knee arthroplasty under spinal anesthesia, we compared the postoperative analgesic effect of intraoperative sedation with dexmedetomidine versus propofol. We hypothesized that sedation with dexmedetomidine would result in lower postoperative opioid analgesic consumption than with...

journal_title：Anesthesia and analgesia

authors： Shin HJ,Do SH,Lee JS,Kim TK,Na HS

更新日期：2019-12-01 00:00:00

abstract：UNLABELLED:Patients undergoing vascular surgery have a high risk of suffering major postoperative cardiac events. Preoperative myocardial ischemia as detected by Holter monitoring identifies a high-risk subgroup whose postoperative ischemia, similarly detected, seems to herald major cardiac events. In this study, we de...

journal_title：Anesthesia and analgesia

authors： Raby KE,Brull SJ,Timimi F,Akhtar S,Rosenbaum S,Naimi C,Whittemore AD

更新日期：1999-03-01 00:00:00

abstract：UNLABELLED:Because perfluorocarbon (PFC) liquid contacts closely with the alveolar capillaries during partial liquid ventilation (PLV), PLV with cold PFC may be used for the induction of hypothermia. Twenty rabbits were randomized to PFC-induced hypothermia (PH) (n = 7; core temperature 35 degrees +/- 1 degrees C), sur...

journal_title：Anesthesia and analgesia

authors： Hong SB,Koh Y,Shim TS,Lee SD,Kim WS,Kim DS,Kim WD,Lim CM

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Xenon has many characteristics that make it very attractive as an anesthetic and therapeutic drug. Unfortunately, the supply of xenon is fixed, and therefore reclamation and recovery from even the most efficient breathing circuits is desirable. We built and evaluated a cryogenic device to recover xenon from ...

journal_title：Anesthesia and analgesia

authors： Dingley J,Mason RS

更新日期：2007-11-01 00:00:00

abstract：UNLABELLED:Our aim in this study, performed using a closed cranial window preparation, was to investigate the effect of systemic pretreatment with dexmedetomidine on cerebrovascular response to isoflurane or sevoflurane. After instrumentation under pentobarbital anesthesia, 48 dogs were assigned to one of two groups: t...

journal_title：Anesthesia and analgesia

authors： Ohata H,Iida H,Dohi S,Watanabe Y

更新日期：1999-08-01 00:00:00

abstract：:In the perioperative period, artificial colloids are most often infused in doses of 500-1000 mL intravenously. This randomized study compared the effects on intravascular volume and coagulation of approximately 2000 mL of two isooncotic artificial colloids: 6% hydroxyethyl starch (HES; MW 200,000; substitution ratio 0...

journal_title：Anesthesia and analgesia

authors： Mortelmans YJ,Vermaut G,Verbruggen AM,Arnout JM,Vermylen J,Van Aken H,Mortelmans LA

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Skeletal muscle failure in critical illness (intensive care unit-acquired weakness) is a well-known complication developing early during intensive care unit stay. However, muscle weakness during the perioperative setting has not yet been investigated. METHODS:We performed a subgroup investigation of a prosp...

journal_title：Anesthesia and analgesia

authors： Lachmann G,Mörgeli R,Kuenz S,Piper SK,Spies C,Kurpanik M,Weber-Carstens S,Wollersheim T,BIOCOG Consortium.

更新日期：2020-02-01 00:00:00

abstract：UNLABELLED:We performed in vitro studies to investigate the potential interaction of benzodiazepines with cloned human opioid receptor subtypes. Midazolam, chlordiazepoxide, and diazepam directly displaced [(3)H]-diprenorphine binding from kappa and delta receptors, but not mu receptors, whereas flumazenil was inactive...

journal_title：Anesthesia and analgesia

authors： Cox RF,Collins MA

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:In children, postoperative respiratory rate (RR) monitoring by transthoracic impedance (TI), capnography, and manual counting has limitations. The rainbow acoustic monitor (RAM) measures continuous RR noninvasively by a different methodology. Our primary aim was to compare the degree of agreement and accurac...

journal_title：Anesthesia and analgesia

authors： Patino M,Kalin M,Griffin A,Minhajuddin A,Ding L,Williams T,Ishman S,Mahmoud M,Kurth CD,Szmuk P

更新日期：2017-06-01 00:00:00

abstract：UNLABELLED:Impaired in vivo immunity is often observed after major surgery and is multifactorial. We conducted a randomized clinical study to determine the independent effects of general anesthesia (GA) and of lumbar epidural anesthesia (LEA) on human immune function in the absence of surgical trauma. Nineteen healthy ...

journal_title：Anesthesia and analgesia

authors： Procopio MA,Rassias AJ,DeLeo JA,Pahl J,Hildebrandt L,Yeager MP

更新日期：2001-08-01 00:00:00

abstract：:The existence of a dose-response relation between nitrous oxide concentration and regional dysfunction in compromised myocardium, and whether or not halothane-induced myocardial depression alleviated this regional dysfunction was examined. Nitrous oxide was administered to eight dogs with experimentally induced left a...

journal_title：Anesthesia and analgesia

authors： Leone BJ,Philbin DM,Lehot JJ,Foëx P,Ryder WA

更新日期：1988-09-01 00:00:00