Effects of H2-receptor blockers on response of cerebral blood flow to normocapnic hypoxia.


:Cimetidine blunts the increase in cerebral blood flow (CBF) normally observed during hypoxia. It is important, therefore, to know whether other H2-blockers also affect the cerebral circulation adaptation to hypoxia. Cerebral blood flow was measured in 24 awake dogs after an intravenous injection of either saline (control) or one of three H2-blockers: 1 mg/kg ranitidine, 0.4 mg/kg famotidine, or 1 mg/kg roxatidine. These doses are equipotent blockers of H2-gastric receptors. Each dog was studied during normoxia and after 2 and 4 h of normocapnic hypoxia (FIO2, 0.10; FICO2, 0.035). During each set of experimental conditions, a bolus of either saline or one of the anti-H2 drugs was administered, and, 15 min later, radiolabeled microspheres (ruthenium 103, scandium 46, and cerium 141) were injected into the left atrium for measurement of regional CBF. After death by an overdose of thiopental, each dog's brain was excised and fixed in 10% formaldehyde; it was then weighed and dissected by region, with the radioactivity measured in each region using a gamma counter. During hypoxia, PaO2 ranged from 45 to 50 mm Hg, and pH, PaCO2, and hematocrit were within the normal limits. In the control group CBF increased 34% above normoxic baseline levels after 2 h and 31% after 4 h of hypoxia. Ranitidine (1 mg/kg) did not prevent the increase in CBF during hypoxia, but famotidine and roxatidine prevented it. When the dose of ranitidine was doubled (2 mg/kg), it too abolished the increase of CBF induced by hypoxia. In conclusion, H2-receptor blockers could interfere with the adaptation of CBF during hypoxia.


Anesth Analg


Anesthesia and analgesia


Audibert G,Saunier C,Hartemann D,Bigard O,Haberer JP




Has Abstract


1991-04-01 00:00:00












  • Brain sodium, potassium, and osmolality: effects on anesthetic requirement.

    abstract::We determined the effects of hyperkalemia, hypernatremia, hyperosmolality and hypo-osmolality on halothane requirement (MAC) in dogs. Hyperkalemia did not change cerebrospinal fluid potassium or MAC. Hypernatremia proportionately increased cerebrospinal fluid sodium and osmolality. MAC concomitantly increased 43%. Ser...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Tanifuji Y,Eger EI 2nd

    更新日期:1978-07-01 00:00:00

  • The effects of perioperative pain management techniques on food consumption and body weight after laparotomy in rats.

    abstract:UNLABELLED:We examined the effects of two perioperative pain management techniques on recovery after laparotomy, as assessed by body weight (BW) and food consumption (FC). All rats received a preoperative intrathecal mixture of morphine plus bupivacaine combined with one of two treatments: (a) injection of slow-release...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Shavit Y,Fish G,Wolf G,Mayburd E,Meerson Y,Yirmiya R,Beilin B

    更新日期:2005-10-01 00:00:00

  • High-dose hydromorphone (Dilaudid) for coronary artery bypass surgery.

    abstract::The hemodynamic effects of high-dose hydromorphone hydrochloride (H), 1.25 mg/kg, were investigated in 10 patients with normal ventricular function undergoing coronary artery bypass graft (CABG) surgery. One patient with unstable angina was excluded from the study because of hypotension and facial flushing after a 6-m...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Welti RS,Moldenhauer CC,Hug CC Jr,Kaplan JA,Holbrook GW

    更新日期:1984-01-01 00:00:00

  • FOCUS: the Society of Cardiovascular Anesthesiologists' initiative to improve quality and safety in the cardiovascular operating room.

    abstract::The Society of Cardiovascular Anesthesiologists (SCA) introduced the FOCUS initiative (Flawless Operative Cardiovascular Unified Systems) in 2005 in response to the need for a rigorous scientific approach to improve quality and safety in the cardiovascular operating room (CVOR). The goal of the project, which is suppo...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Barbeito A,Lau WT,Weitzel N,Abernathy JH 3rd,Wahr J,Mark JB

    更新日期:2014-10-01 00:00:00

  • Effects of patient age, pH of cerebrospinal fluid, and vasopressors on onset and duration of spinal anesthesia.

    abstract::Two hundred twenty-two spinal anesthesias were administered with 10 mg. of tetracaine and 1 ml. of 10 percent dextrose to investigate the effects of vasopressors, patients age, and pH of cerebrospinal fluid on the onset and duration of spinal anesthesia. Neither the differences in overall age, cerebrospinal fluid pH, ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Park WY,Balingit PE,Macnamara TE

    更新日期:1975-07-01 00:00:00

  • A new highly reliable instrument for the assessment of pre- and postoperative gynecological pain.

    abstract:UNLABELLED:In this study, we evaluated the reliability of a newly developed method for pain assessment, which is based on perceptual matching by Pain Matcher, Cefar Medical AB, Lund, Sweden, during minor gynecological surgery. In addition, the responsiveness to two different anesthetic methods-electro-acupuncture or a ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Stener-Victorin E,Kowalski J,Lundeberg T

    更新日期:2002-07-01 00:00:00

  • Oral clonidine premedication enhances the quality of postoperative analgesia by intrathecal morphine.

    abstract::Since clonidine potentiates the analgesia by morphine, the current study was performed to investigate whether oral clonidine premedication would enhance the postoperative analgesia by intrathecal morphine. Twenty-six patients, aged 37-60 yr, schedule for abdominal total hysterectomy under spinal anesthesia, were studi...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Goyagi T,Nishikawa T

    更新日期:1996-06-01 00:00:00

  • Intravenous droperidol causes a reduction in the bispectral index in propofol-sedated patients during spinal anesthesia.

    abstract:UNLABELLED:We investigated the effect of IV droperidol on the bispectral index (BIS) in conscious and propofol-sedated patients during spinal anesthesia. Thirty minutes after the induction of spinal anesthesia, 20 patients were given 2 mg of droperidol IV without administration of other sedatives (conscious group). Ano...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nakayama M,Kanaya N,Ichinose H,Yamamoto S,Namiki A

    更新日期:2003-03-01 00:00:00

  • Culture-Negative and Culture-Positive Sepsis: A Comparison of Characteristics and Outcomes.

    abstract:BACKGROUND:The primary objective of this study was to compare the characteristics of culture-positive and culture-negative status in septic patients. We also determined whether culture status is associated with mortality and whether unique variables are associated with mortality in culture-positive and culture-negative...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Sigakis MJG,Jewell E,Maile MD,Cinti SK,Bateman BT,Engoren M

    更新日期:2019-11-01 00:00:00

  • New Strategies to Expand and Optimize Heart Donor Pool: Ex Vivo Heart Perfusion and Donation After Circulatory Death: A Review of Current Research and Future Trends.

    abstract::Heart transplantation remains the definitive management for end-stage heart failure refractory to medical therapy. While heart transplantation cases are increasing annually worldwide, there remains a deficiency in organ availability with significant patient mortality while on the waiting list. Attempts have therefore ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Beuth J,Falter F,Pinto Ribeiro RV,Badiwala M,Meineri M

    更新日期:2019-03-01 00:00:00

  • Continuous intravenous administration of ketorolac reduces pain and morphine consumption after total hip or knee arthroplasty.

    abstract::The purpose of this study was to determine the analgesic efficacy, opioid-sparing effect, and tolerability of ketorolac administered as an intravenous (i.v.) bolus followed by a continuous infusion after total hip or knee arthroplasty. After general anesthesia, patients received either placebo or ketorolac 30 mg i.v. ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Etches RC,Warriner CB,Badner N,Buckley DN,Beattie WS,Chan VW,Parsons D,Girard M

    更新日期:1995-12-01 00:00:00

  • Do new anesthesia ventilators deliver small tidal volumes accurately during volume-controlled ventilation?

    abstract:BACKGROUND:During mechanical ventilation of infants and neonates, small changes in tidal volume may lead to hypo- or hyperventilation, barotrauma, or volutrauma. Partly because breathing circuit compliance and fresh gas flow affect tidal volume delivery by traditional anesthesia ventilators in volume-controlled ventila...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Bachiller PR,McDonough JM,Feldman JM

    更新日期:2008-05-01 00:00:00

  • Intrathecal morphine reduces infarct size in a rat model of ischemia-reperfusion injury.

    abstract:UNLABELLED:Systemically-administered morphine reduces infarct size in rat models of myocardial ischemia-reperfusion. We sought to determine whether much smaller doses of spinally-administered morphine offer a similar cardioprotective benefit. Barbiturate-anesthetized, open-chested, Wistar rats with chronic indwelling t...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Groban L,Vernon JC,Butterworth J

    更新日期:2004-04-01 00:00:00

  • Left ventricular systolic and diastolic function is unaltered during propofol infusion in newborn swine.

    abstract:UNLABELLED:Propofol is a cardiac depressant with minimal diastolic effects in the adult myocardium. Cardiac effects of propofol in the newborn are unknown. We examined hemodynamic variables and systolic and diastolic left ventricular function in 12 newborn pigs exposed to propofol at three different infusion rates (7.5...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Graham MR,Thiessen DB,Mutch WA

    更新日期:1998-04-01 00:00:00

  • Duration of intrathecal labor analgesia: early versus advanced labor.

    abstract::Early first-stage labor pain is primarily visceral in origin. Increasing pain intensity and transition to somatic nociceptive input characterizes late first- and second-stage labor pain. The effect of this change in nociceptive input on the duration of intrathecal labor analgesia has not been well studied. This prospe...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Viscomi CM,Rathmell JP,Pace NL

    更新日期:1997-05-01 00:00:00

  • Bispectral-index-guided versus clinically guided remifentanil/propofol analgesia/sedation for interventional radiological procedures: an observer-blinded randomized study.

    abstract::Patients undergoing potentially painful interventional radiological procedures generally require a combination of analgesia and sedation. This sedation/analgesia should allow the patient to communicate while also remaining calm. Bispectral index (BIS) monitoring could be useful in achieving this. The primary end-point...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Dahaba AA,Lischnig U,Kronthaler R,Bornemann H,Georgiev V,Rehak PH,Metzler H

    更新日期:2006-08-01 00:00:00

  • Analgesic Effects of Oxycodone Relative to Those of Sufentanil, in the Presence of Midazolam, During Endoscopic Injection Sclerotherapy for Patients With Cirrhosis and Esophageal Varices.

    abstract:BACKGROUND:We evaluated the efficacy and gastroenterologist/patient satisfaction of midazolam combined with oxycodone, relative to that of midazolam combined with sufentanil, for anesthesia during endoscopic injection sclerotherapy (EIS) in patients with cirrhosis and esophageal varices. METHODS:Patients with cirrhosi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Quan Z,Luo C,Chi P,Wang L,He H

    更新日期:2018-08-01 00:00:00

  • A single adrenocorticotropic hormone stimulation test does not reveal adrenal insufficiency in septic shock.

    abstract::The diagnosis of adrenocortical insufficiency in critically ill patients is complex. The adrenocorticotropic hormone (ACTH) stimulation test is a widely accepted method for assessing the adequacy of adrenal function in intensive care units, but it is possible that there may be wide variations in responses to the test ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Loisa P,Uusaro A,Ruokonen E

    更新日期:2005-12-01 00:00:00

  • Blood Substitutes and Oxygen Therapeutics: A Review.

    abstract::Despite the exhaustive search for an acceptable substitute to erythrocyte transfusion, neither chemical-based products such as perfluorocarbons nor hemoglobin-based oxygen carriers have succeeded in providing a reasonable alternative to allogeneic blood transfusion. However, there remain scenarios in which blood trans...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Jahr JS,Guinn NR,Lowery DR,Shore-Lesserson L,Shander A

    更新日期:2021-01-01 00:00:00

  • Cardiac sympathovagal balance and peripheral sympathetic vasoconstriction: epidural versus general anesthesia.

    abstract::Both epidural and general anesthetics alter autonomic balance. However, the relative differences between epidural (EA) and general anesthetics (GA) with regard to cardiac and peripheral sympathovagal balance have not been described. Twenty consecutive patients scheduled for radical retropubic prostatectomy were random...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Fleisher LA,Frank SM,Shir Y,Estafanous M,Kelly S,Raja SN

    更新日期:1994-07-01 00:00:00

  • Continuous infusion epidural analgesia in labor: the effect of adding sufentanil to 0.125% bupivacaine.

    abstract::The purpose of this study was to determine if the addition of sufentanil would improve the quality of analgesia obtained with 0.125% epidural bupivacaine infusions given to women in active labor. Forty healthy laboring women were randomly assigned to two equal groups. Group 1 had epidural analgesia instituted with the...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Phillips G

    更新日期:1988-05-01 00:00:00

  • Orthostatic hypotension during postoperative continuous thoracic epidural bupivacaine-morphine in patients undergoing abdominal surgery.

    abstract::Fifty patients undergoing colonic surgery received combined thoracic epidural and general anesthesia followed by continuous epidural bupivacaine 0.25% and morphine 0.05 mg/mL, 4 mL/h, for 96 h postoperatively plus oral tenoxicam 20 mg daily. Heart rate (HR) and arterial blood pressure (BP) were measured at supine rest...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Crawford ME,Møiniche S,Orbaek J,Bjerrum H,Kehlet H

    更新日期:1996-11-01 00:00:00

  • The effect of fresh gas flow and anesthetic technique on the ability to control acute hemodynamic responses during surgery.

    abstract:UNLABELLED:We evaluated the effect of the fresh gas flow (FGF) rate and the anesthetic technique on the ability to control the acute hyperdynamic response to a specific surgical stimulus during surgery in 90 consenting ASA physical status I-III patients undergoing lower abdominal procedures. After the administration of...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Avramov MN,Griffin JD,White PF

    更新日期:1998-09-01 00:00:00

  • Comparison of kinetics of sevoflurane and isoflurane in humans.

    abstract::The low solubility of sevoflurane in blood suggests that this agent should enter and leave the body more rapidly than isoflurane. However, the closeness of sevoflurane and isoflurane tissue/blood partition coefficients suggests that the rates of equilibration with and elimination from tissues should be similar. We tes...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Yasuda N,Lockhart SH,Eger EI 2nd,Weiskopf RB,Liu J,Laster M,Taheri S,Peterson NA

    更新日期:1991-03-01 00:00:00

  • The time-dependent effects of midazolam on regional cerebral glucose metabolism in rats.

    abstract:BACKGROUND:Midazolam has hypnotic and sedative activities, which may be mediated by different neuronal structures. We investigated the time course effect of a hypnotic dose of midazolam on conscious motor behavior and on patterns of brain metabolism. METHODS:Loss of nociceptive reflexes and impairment of spontaneous l...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Freo U,Dam M,Ori C

    更新日期:2008-05-01 00:00:00

  • Generative Retrieval Improves Learning and Retention of Cardiac Anatomy Using Transesophageal Echocardiography.

    abstract:BACKGROUND:Transesophageal echocardiography (TEE) is a valuable monitor for patients undergoing cardiac and noncardiac surgery as it allows for evaluation of cardiovascular compromise in the perioperative period. It is challenging for anesthesiology residents and medical students to learn to use and interpret TEE in th...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Kleiman AM,Forkin KT,Bechtel AJ,Collins SR,Ma JZ,Nemergut EC,Huffmyer JL

    更新日期:2017-05-01 00:00:00

  • Ropivacaine continuous wound infusion versus epidural morphine for postoperative analgesia after cesarean delivery: a randomized controlled trial.

    abstract:BACKGROUND:The infusion of local anesthetic in the surgical wound is helpful in the multimodal management of postoperative pain. We hypothesized that local anesthetic wound infusion after cesarean delivery would provide better pain control than epidural morphine analgesia. METHODS:Healthy, term women scheduled for ele...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: O'Neill P,Duarte F,Ribeiro I,Centeno MJ,Moreira J

    更新日期:2012-01-01 00:00:00

  • Fast-tracking after outpatient laparoscopy: reasons for failure after propofol, sevoflurane, and desflurane anesthesia.

    abstract:IMPLICATIONS:In this study, although 41%-94% of the patients were fast-track eligible after laparoscopic surgery, only 35%-53% of the patients actually bypassed the postanesthesia care unit (PACU) because of anesthetic-related factors and surgical complications. Residual sedation was the most common anesthetic-related ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Coloma M,Zhou T,White PF,Markowitz SD,Forestner JE

    更新日期:2001-07-01 00:00:00

  • Effect-site concentration of propofol for recovery of consciousness is virtually independent of fentanyl effect-site concentration.

    abstract:UNLABELLED:Fentanyl reduces the amount of propofol necessary to prevent responses to surgical stimuli. However, opioids have relatively little effect on consciousness. We, therefore, tested the hypothesis that fentanyl minimally alters the effect-site concentration of propofol associated with awakening. Fifty women hav...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Iwakiri H,Nagata O,Matsukawa T,Ozaki M,Sessler DI

    更新日期:2003-06-01 00:00:00

  • Sevoflurane or halothane anesthesia: can we tell the difference?

    abstract:UNLABELLED:This study was performed to evaluate the ability of anesthesiologists to differentiate between sevoflurane, a newer, more expensive anesthetic, and halothane. A total of 113 assessments were made by 36 anesthesiologists on 58 children, aged 6 mo to 6 yr, scheduled for bilateral myringotomy and tube placement...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bacher A,Burton AW,Uchida T,Zornow MH

    更新日期:1997-12-01 00:00:00