The inhibitory effect of bupivacaine on prostaglandin E(2) (EP(1)) receptor functioning: mechanism of action.

abstract：BACKGROUND:In patients with mitral regurgitation (MR), the effective regurgitant orifice area can be estimated by measuring the vena contracta area (VCA). We hypothesize that the VCA has characteristic temporal dynamics related to the underlying mechanism of functional mitral regurgitation (FMR) versus degenerative mit...

journal_title：Anesthesia and analgesia

authors： Cobey FC,Ashihkmina E,Edrich T,Fox J,Shook D,Bollen B,Breeze JL,Ursprung WW,Shernan SK

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle calcium regulation associated primarily, but not exclusively, with mutations in the skeletal muscle ryanodine receptor. Associated environmental factors, however, may also be important for expression of the syndrome. METHODS AND RE...

journal_title：Anesthesia and analgesia

authors： Capacchione JF,Radimer MC,Sagel JS,Kraus GP,Sambuughin N,Muldoon SM

更新日期：2009-03-01 00:00:00

abstract：:Prior studies have suggested that the antifibrinolytic drug aprotinin increases the infarct size after ischemia and reperfusion (I/R) and attenuates the effect of ischemic preconditioning (IPC). Aprotinin was replaced by tranexamic acid (TXA) in clinical practice. Here, we investigated whether TXA influences I/R injur...

journal_title：Anesthesia and analgesia

authors： van Caster P,Eiling S,Boekholt Y,Behmenburg F,Dorsch M,Heinen A,Hollmann MW,Huhn R

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:In vivo animal assays are a cornerstone of preclinical pain research. An optimal stimulus for determining the activity of potential analgesics would produce responses of a consistent magnitude on repeated testing. Intraplantar (i.pl.) injection of hypertonic saline (HS) in mice produces robust nociceptive re...

journal_title：Anesthesia and analgesia

authors： Asiri YI,Fung T,Schwarz SKW,Barr AM,Puil E,MacLeod BA

更新日期：2019-07-01 00:00:00

abstract：UNLABELLED:The purpose of our study was to investigate the effects of sodium nitroprusside-induced hypotension on splanchnic perfusion and hepatocellular integrity. Thirty patients undergoing radical prostatectomy were allocated randomly to a sodium nitroprusside (SNP) or control group (control). Regional pco2 was meas...

journal_title：Anesthesia and analgesia

authors： Suttner SW,Boldt J,Schmidt CC,Piper SN,Schuster P,Kumle B

更新日期：1999-12-01 00:00:00

abstract：:Interscalene brachial plexus anesthesia for shoulder surgery routinely includes sensory anesthesia of the fourth and fifth cervical nerves. The authors reasoned that some degree of diaphragm paralysis should result from interscalene blocks that produce surgical C3-C5 sensory anesthesia. In this investigation, ultrason...

journal_title：Anesthesia and analgesia

authors： Urmey WF,Talts KH,Sharrock NE

更新日期：1991-04-01 00:00:00

abstract：UNLABELLED:Cryoanalgesia versus sham treatment was applied to the ilioinguinal and iliohypogastric nerves after mesh repair of an inguinal hernia under local anesthesia in 48 male patients in a prospective, randomized, and observer- and patient-blinded trial. Pain was scored daily during rest, while coughing, and durin...

journal_title：Anesthesia and analgesia

authors： Callesen T,Bech K,Thorup J,Andersen J,Nielsen R,Roikjaer O,Kehlet H

更新日期：1998-10-01 00:00:00

abstract：UNLABELLED:Propofol and thiopental have been used clinically in combination for induction of anesthesia. Studies suggest that this mixture has synergistic activity, recovery characteristics similar to propofol alone, and bactericidal effects on multiple organisms. It may therefore be both clinically useful and cost-eff...

journal_title：Anesthesia and analgesia

authors： Lazar ER,Jolly DT,Tam YK,Hrazdil J,Tawfik SR,Clanachan AS

更新日期：1998-02-01 00:00:00

abstract：:Increased attention has been directed at the quality of randomized controlled trials (RCTs) and how they are being reported. We examined leading anesthesiology journals to identify if there were specific areas for improvement in the design and analysis of published clinical studies. All RCTs that appeared between Janu...

journal_title：Anesthesia and analgesia

authors： Greenfield ML,Rosenberg AL,O'Reilly M,Shanks AM,Sliwinski MJ,Nauss MD

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Oral opioid formulations contribute to postoperative analgesia. In this study, we evaluated the perioperative application of oral controlled-release oxycodone to reduce postoperative IV morphine consumption and opioid side effects after lumbar discectomy. METHODS:Forty patients scheduled for elective lumbar...

journal_title：Anesthesia and analgesia

authors： Blumenthal S,Min K,Marquardt M,Borgeat A

更新日期：2007-07-01 00:00:00

abstract：UNLABELLED:We conducted a randomized, controlled, cross-over cadaver study to test the hypothesis that the efficacy of seal for ventilation and airway protection, anatomic position, and airway patency with the flexible laryngeal mask airway (FLMA) are altered by the application of a Boyle Davis (B-D) gag. We also deter...

journal_title：Anesthesia and analgesia

authors： Brimacombe JR,Keller C,Gunkel AR,Pühringer F

更新日期：1999-07-01 00:00:00

abstract：:We studied the feasibility of recording motor evoked responses to transcranial electrical stimulation (tce-MERs) during partial neuromuscular blockade (NMB). In 11 patients, compound muscle action potentials were recorded from the tibialis anterior muscle in response to transcranial electrical stimulation during vario...

journal_title：Anesthesia and analgesia

authors： Kalkman CJ,Drummond JC,Kennelly NA,Patel PM,Partridge BL

更新日期：1992-10-01 00:00:00

abstract：:In pregnant patients with myasthenia gravis and respiratory compromise, neuraxial anesthesia for lower abdominal surgery can risk further respiratory depression. We report the use of epidural anesthesia for dilation and curettage and tubal ligation in a 26-yr-old woman with a 12-wk intrauterine pregnancy with severe m...

journal_title：Anesthesia and analgesia

authors： Warren J,Sharma SK

更新日期：2006-03-01 00:00:00

abstract：UNLABELLED:We studied the ability of zonisamide (Zonegran) to relieve thermal hyperalgesia and/or mechanical allodynia in the chronic constriction injury model of neuropathic pain. Zonisamide (25, 50, or 100 mg/kg) or saline was administered in a blinded, randomized manner by intraperitoneal injection on postoperative ...

journal_title：Anesthesia and analgesia

authors： Hord AH,Denson DD,Chalfoun AG,Azevedo MI

更新日期：2003-06-01 00:00:00

abstract：:Primary sensory nerves transmit information to both the periphery and central nervous systems, and they mediate neurogenic inflammation by release of neurotransmitters, such as tachykinins, in the periphery. Because the effect of local anesthetics on neurogenic inflammation is a subject of controversy, we investigated...

journal_title：Anesthesia and analgesia

authors： Takakura K,Mizogami M,Morishima S,Muramatsu I

更新日期：2006-09-01 00:00:00

abstract：:We examined the percentage of tactile detection of fade in response to train-of-four (TOF), double burst stimulation3,3 (DBS3,3), or DBS3,2 at the index finger compared with that at the thumb during continuous infusion of vecuronium. One hundred five adult patients were studied. At TOF ratios (T4/T1) of 0.41-0.70, fad...

journal_title：Anesthesia and analgesia

authors： Saitoh Y,Nakazawa K,Makita K,Tanaka H,Amaha K

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Atelectasis occurs regularly after induction of general anesthesia, persists postoperatively, and may contribute to significant postoperative morbidity and additional health care costs. Laparoscopic surgery has been reported to be associated with an increased incidence of postoperative atelectasis. It has be...

journal_title：Anesthesia and analgesia

authors： Talab HF,Zabani IA,Abdelrahman HS,Bukhari WL,Mamoun I,Ashour MA,Sadeq BB,El Sayed SI

更新日期：2009-11-01 00:00:00

abstract：:The purpose of this canine study was to examine the cerebral vascular and metabolic effects of adding nitrous oxide to isoflurane from 1.4% expired (1 MAC) up to a concentration giving an isoelectric electroencephalogram (EEG). Cerebral blood flow (CBF) and cerebral metabolic rate for oxygen (CMRO2) were determined us...

journal_title：Anesthesia and analgesia

authors： Roald OK,Forsman M,Heier MS,Steen PA

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:The number of elderly patients with frank or incipient Alzheimer's disease (AD) requiring surgery is growing as the population ages. General anesthesia may exacerbate symptoms of and the pathology underlying AD, so minimizing anesthetic exposure may be important. This requires knowledge of whether the contin...

journal_title：Anesthesia and analgesia

authors： Bianchi SL,Caltagarone BM,Laferla FM,Eckenhoff RG,Kelz MB

更新日期：2010-02-01 00:00:00

abstract：UNLABELLED:We tested the ability of electroconvulsive treatment (ECT) to block thermal hyperalgesia and mechanical allodynia in rats with peripheral neuropathy. Repeated ECT (six times daily) significantly reduced thermal hyperalgesia 48 h after the end of the final treatment but had no significant effects on mechanica...

journal_title：Anesthesia and analgesia

authors： Shibata M,Wakisaka S,Inoue T,Shimizu T,Yoshiya I

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Recent randomized controlled trials have shown no benefit for transfusion to a hemoglobin >10 g/dL compared with lower hemoglobin thresholds in the perioperative period, even among older adults. Nevertheless, physicians may choose to transfuse older adults more liberally than younger adults. It is unclear wh...

journal_title：Anesthesia and analgesia

authors： Brown CH 4th,Savage WJ,Masear CG,Walston JD,Tian J,Colantuoni E,Hogue CW,Frank SM

更新日期：2014-06-01 00:00:00

abstract：UNLABELLED:Whether tracheal intubation is more difficult in obese patients is debatable. We compared the incidence of difficult tracheal intubation in obese and lean patients by using a recently validated objective scale, the intubation difficulty scale (IDS). We studied 134 lean (body mass index, <30 kg/m2) and 129 ob...

journal_title：Anesthesia and analgesia

authors： Juvin P,Lavaut E,Dupont H,Lefevre P,Demetriou M,Dumoulin JL,Desmonts JM

更新日期：2003-08-01 00:00:00

abstract：:This study reports plasma bupivacaine concentrations in 13 neonates who received lumbar epidural anesthesia during major abdominal surgery. A bolus of 1.8 mg/kg of bupivacaine (2.5 mg/mL) was administered after induction of anesthesia, followed by a continuous infusion of 0.2 mg.kg-1.h-1 (1.25 mg/mL). Plasma concentra...

journal_title：Anesthesia and analgesia

authors： Larsson BA,Lönnqvist PA,Olsson GL

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:IV lipid emulsion has demonstrated to be effective therapy for bupivacaine-induced cardiotoxicity. However, the role of epinephrine when coadministered with lipid emulsion in toxin-induced cardiac arrest is unclear. We postulated superior resuscitation outcome in the absence of epinephrine in a rabbit model ...

journal_title：Anesthesia and analgesia

authors： Harvey M,Cave G,Prince G,Lahner D

更新日期：2010-09-01 00:00:00

abstract：:Morphine given intracerebroventricularly releases spinal dynorphin A (Dyn) in mice. The present study was undertaken to determine whether morphine given intrathecally (IT) released Dyn. We demonstrated that the antinociceptive action of morphine was enhanced by procedures that are known to attenuate Dyn action. First,...

journal_title：Anesthesia and analgesia

authors： Holmes BB,Fujimoto JM

更新日期：1993-12-01 00:00:00

abstract：:Virchow's triad is traditionally invoked to explain pathophysiologic mechanisms leading to thrombosis, alleging concerted roles for abnormalities in blood composition, vessel wall components, and blood flow in the development of arterial and venous thrombosis. Given the tissue-specific bleeding observed in hemophilia ...

journal_title：Anesthesia and analgesia

authors： Wolberg AS,Aleman MM,Leiderman K,Machlus KR

更新日期：2012-02-01 00:00:00

abstract：:Computer simulations for the technique of estimating minimum alveolar anesthetic concentration (MAC) in patients (quantal design) suggest that incremental concentration changes and the number of crossovers affect MAC. We hypothesized that these variables may also apply to estimating MAC in rats (bracketing design). Th...

journal_title：Anesthesia and analgesia

authors： Leon A,Mayzler O,Benifla M,Semionov M,Fuxman Y,Eilig I,Passuga V,Doitchinova MK,Gurevich B,Artru AA,Shapira Y

更新日期：2004-12-01 00:00:00

abstract：:We studied 60 nonophthalmologic patients, allocated to six treatment groups, to assess the effects of atracurium and vecuronium on intraocular pressure (IOP). All patients had IOP measured while awake, using pneumotonometry. In group 1, anesthesia was induced with thiopental, 5 mg/kg, and maintained with N2O, 70% in O...

journal_title：Anesthesia and analgesia

authors： Schneider MJ,Stirt JA,Finholt DA

更新日期：1986-08-01 00:00:00

abstract：:The nasal route is preferred for fiberoptic intubation. Placing a lubricated endotracheal tube through the nostril can guide the fiberoptic scope towards the larynx. It would be helpful for optimal visualization of the vocal cord when the scope is passed through the endotracheal tube if the length of nares-vocal cord ...

journal_title：Anesthesia and analgesia

authors： Han DW,Shim YH,Shin CS,Lee YW,Lee JS,Ahn SW

更新日期：2005-05-01 00:00:00

abstract：:Practicing anesthesiologists are at high risk of hepatitis B infection, but the risk for anesthesia residents has not been assessed. Anesthesia residents at seven universities were surveyed to study the epidemiology of hepatitis B in these trainees. Hepatitis B virus markers in serum were measured and data from questi...

journal_title：Anesthesia and analgesia

authors： Berry AJ,Isaacson IJ,Kane MA,Schatz GC,Clark BT,Beaupre P,Derrer S,Kapur P,Thompson J,Martin D

更新日期：1985-07-01 00:00:00