Inhaled anesthetic potency in aged Alzheimer mice.

Abstract:

BACKGROUND:The number of elderly patients with frank or incipient Alzheimer's disease (AD) requiring surgery is growing as the population ages. General anesthesia may exacerbate symptoms of and the pathology underlying AD, so minimizing anesthetic exposure may be important. This requires knowledge of whether the continuing AD pathogenesis alters anesthetic potency. METHODS:We determined the induction potency and emergence time for isoflurane, halothane, and sevoflurane using the minimum alveolar anesthetic concentration for loss of righting reflex as an end point in 12- to 14-mo-old triple transgenic Alzheimer (3xTgAD) mice and wild type C57BL6 controls. 3xTgAD mice model AD by harboring three distinct mutations: the APP(Swe), Tau, and PS1 human transgenes, each of which has been associated with familial forms of human AD. RESULTS:The 3xTgAD mice exhibited mild resistance (from 8% to 30%) to volatile anesthetics but displayed indistinguishable emergence patterns from all three inhaled anesthetics. CONCLUSIONS:These results show that the genetic vulnerabilities and neuropathology associated with AD produce a small but significant decrease in sensitivity to the hypnotic actions of three inhaled anesthetics. Emergence times were not altered.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Bianchi SL,Caltagarone BM,Laferla FM,Eckenhoff RG,Kelz MB

doi

10.1213/ANE.0b013e3181b5a292

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

427-30

issue

2

eissn

0003-2999

issn

1526-7598

pii

ANE.0b013e3181b5a292

journal_volume

110

pub_type

杂志文章
  • Long-term metoprolol therapy and neuroleptanesthesia in coronary artery surgery: withdrawal versus maintenance of beta 1-adrenoreceptor blockade.

    abstract::Patients receiving metoprolol before cardiac revascularization surgery were randomly divided into those in whom metoprolol was discontinued before the operation (N = 10) and those in whom metoprolol was continued up to the time of operation (N = 10). Cardiovascular responses to neuroleptanesthesia and sternotomy were ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Pontén J,Häggendal J,Milocco I,Waldenström A

    更新日期:1983-04-01 00:00:00

  • A cost-effective screening method for preoperative hyperglycemia.

    abstract:INTRODUCTION:The preoperative encounter may offer a cost-effective opportunity for diabetes screening. METHODS:Three hundred forty-seven fasting patients had a preoperative glucose measurement determined from blood residue left on the IV needle, measured with an Accu-Chek glucometer (Roche Diagnostics, Indianapolis, I...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181b7c626

    authors: Grek S,Gravenstein N,Morey TE,Rice MJ

    更新日期:2009-11-01 00:00:00

  • Preanesthetic evaluation and management of malignant hyperthermia in the pig experimental model.

    abstract::Fifty-three swine from the University of Missouri Sinclair Medical Research Farm were used in experimentation to determine their susceptibility to malignant hyperthermia, to determine appropriate anesthetic agents for susceptible swine and to investigate appropriate pharmaceutical agents which could protect against th...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197609000-00007

    authors: Short CE,Paddleford RR,McGrath CJ,Williams CH

    更新日期:1976-09-01 00:00:00

  • Development and Evaluation of a Risk-Adjusted Measure of Intraoperative Hypotension in Patients Having Nonemergent, Noncardiac Surgery.

    abstract:BACKGROUND:Intraoperative hypotension is common and associated with organ injury and death, although randomized data showing a causal relationship remain sparse. A risk-adjusted measure of intraoperative hypotension may therefore contribute to quality improvement efforts. METHODS:The measure we developed defines hypot...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000005287

    authors: Christensen AL,Jacobs E,Maheshwari K,Xing F,Zhao X,Simon SE,Domino KB,Posner KL,Stewart AF,Sanford JA,Sessler DI

    更新日期:2020-11-23 00:00:00

  • Intracranial pressure effects of dexmedetomidine in rabbits.

    abstract::The alpha 2-adrenergic receptor agonist dexmedetomidine produces an anesthetic state in a variety of species. Although its effects on cerebral blood flow and the electroencephalogram have been investigated, the effect of this drug on intracranial pressure (ICP) has not been reported previously. Dexmedetomidine therefo...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199208000-00014

    authors: Zornow MH,Scheller MS,Sheehan PB,Strnat MA,Matsumoto M

    更新日期:1992-08-01 00:00:00

  • The effects of load on systolic mitral annular velocity by tissue Doppler imaging.

    abstract::Tissue Doppler Imaging (TDI) provides information on systolic function through its systolic mitral annulus velocity wave (Sm), reflecting the peak velocity of shortening of the myocardial fibers oriented in the longitudinal direction. In this study, we evaluated the effect of load changes on Sm. Forty-two cardiac surg...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/01.ANE.0000131972.99804.28

    authors: Amà R,Segers P,Roosens C,Claessens T,Verdonck P,Poelaert J

    更新日期:2004-08-01 00:00:00

  • The effects of halothane on single human neuronal L-type calcium channels.

    abstract:UNLABELLED:We investigated halothane's effects on the function of L-type Ca2+ channels in a human neuronal cell line, SH-SY5Y, by using the cell-attached patch voltage clamp configuration and Ba2+ as the charge carrier. In multiple-channel patches, halothane decreased the peak and persistent Ba2+ currents, accelerated ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199804000-00038

    authors: Nikonorov IM,Blanck TJ,Recio-Pinto E

    更新日期:1998-04-01 00:00:00

  • The inhibitory effects of local anesthetics on primary sensory nerve and parasympathetic nerve in rabbit eye.

    abstract::Primary sensory nerves transmit information to both the periphery and central nervous systems, and they mediate neurogenic inflammation by release of neurotransmitters, such as tachykinins, in the periphery. Because the effect of local anesthetics on neurogenic inflammation is a subject of controversy, we investigated...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000230600.30384.ce

    authors: Takakura K,Mizogami M,Morishima S,Muramatsu I

    更新日期:2006-09-01 00:00:00

  • Intrathecal midazolam II: combination with intrathecal fentanyl for labor pain.

    abstract:UNLABELLED:Recent investigations have sought to improve intrathecal analgesia by combining opioids with other classes of analgesics. In this study we assessed the ability of intrathecal midazolam to increase the potency and duration of the analgesic effects of intrathecal fentanyl without causing adverse effects. Thirt...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ane.0000112434.68702.e4

    authors: Tucker AP,Mezzatesta J,Nadeson R,Goodchild CS

    更新日期:2004-06-01 00:00:00

  • The efficiency of CO2 elimination during high-frequency jet ventilation for laryngeal microsurgery.

    abstract:UNLABELLED:For adequate and safe use of high-frequency jet ventilation (HFJV), reliable monitoring of the PCO2 status and course is necessary. Because of improved handling and performance, recently available transcutaneous PCO2 monitoring devices such as MicroGas 7650 (Kontron Instruments Medical Sensors, Basel, Switze...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-199807000-00037

    authors: Biro P,Eyrich G,Rohling RG

    更新日期:1998-07-01 00:00:00

  • Height, weight, and the spread of subarachnoid hyperbaric bupivacaine in the term parturient.

    abstract::Using a standardized technique, spinal anesthesia was induced in 50 term parturients to study the correlation between patient height, weight, and body mass index (BMI) and the spread of sensory blockade. All patients received 12 mg hyperbaric bupivacaine while in the right lateral decubitus position on a horizontal op...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Norris MC

    更新日期:1988-06-01 00:00:00

  • The effects of general anesthesia and surgery on basal and interferon stimulated natural killer cell activity of humans.

    abstract:UNLABELLED:Natural killer (NK) cells can lyse certain tumor cells as well as virally infected cells without prior sensitization. Animal studies have shown that general anesthesia (GA) alone or GA followed by surgery decreases both basal NK cytotoxicity and enhancement of NK activity by interferon (IFN). The purpose of ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199710000-00037

    authors: Kutza J,Gratz I,Afshar M,Murasko DM

    更新日期:1997-10-01 00:00:00

  • Desflurane hepatitis associated with hapten and autoantigen-specific IgG4 antibodies.

    abstract:BACKGROUND:Three cases of drug-induced liver injury (DILI) have been reported after desflurane anesthesia. However, no previous reports have detected serum autoantibodies such as that reported with DILI from halothane or isoflurane. METHODS AND RESULTS:We describe the first documentation of cytochrome P450 2E1 IgG4 au...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000263275.10081.47

    authors: Anderson JS,Rose NR,Martin JL,Eger EI,Njoku DB

    更新日期:2007-06-01 00:00:00

  • The effect of concomitant radiofrequency ablation and surgical technique (repair versus replacement) on release of cardiac biomarkers during mitral valve surgery.

    abstract::All patients undergoing heart surgery experience a certain amount of nonspecific myocardial injury documented by the release of cardiac biomarkers and associated with poor outcome. We investigated the role of unipolar radiofrequency ablation of atrial fibrillation on the release of cardiac biomarkers in 71 patients un...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000155959.42236.B8

    authors: Zangrillo A,Crescenzi G,Landoni G,Benussi S,Crivellari M,Pappalardo F,Dorigo E,Pappone C,Alfieri O

    更新日期:2005-07-01 00:00:00

  • Systemic mexiletine relieves chronic allodynialike symptoms in rats with ischemic spinal cord injury.

    abstract::We have recently reported a chronic allodynialike symptom in rats after ischemic spinal cord injury. This pain-related behavior is resistant to a number of pharmacologic treatments, including morphine, clonidine, carbamazepine, baclofen, and muscimol. In the present report, we present evidence indicating that systemic...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199205000-00005

    authors: Xu XJ,Hao JX,Seiger A,Arnér S,Lindblom U,Wiesenfeld-Hallin Z

    更新日期:1992-05-01 00:00:00

  • The effect of isoflurane or spinal anesthesia on indocyanine green disappearance rate in the elderly.

    abstract::This study was designed to measure the disappearance rate of indocyanine green (ICG) as an indicator of hepatic blood flow in elderly patients undergoing internal fixation of fractured neck of femur. All patients were aged 60-90 yr and were randomized to receive either spinal (n = 10) or isoflurane (n = 10) anesthesia...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199404000-00016

    authors: Darling JR,Murray JM,Hainsworth AM,Trinick TR

    更新日期:1994-04-01 00:00:00

  • Reversal of combination nondepolarized neuromuscular block.

    abstract::The antagonism of a pancuronium-curare (P + C) neuromuscular block was assessed and compared to the antagonism of a pancuronium (P) block. One group of seven patients received P + C (0.024 mg/kg + 0.144 mg/kg); another similar group of seven patients received P (0.07 mg/kg). Both groups were anesthetized with nitrous ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Vitez TS,Difrancesco LV

    更新日期:1983-12-01 00:00:00

  • A randomized trial comparing colloid preload to coload during spinal anesthesia for elective cesarean delivery.

    abstract:BACKGROUND:Hypotension after spinal anesthesia for cesarean delivery is common. Previous studies have demonstrated that a crystalloid fluid "coload" (rapid administration of a fluid bolus starting at the time of intrathecal injection) is superior to the conventional crystalloid preload (fluid administered before the in...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ane.0b013e3181b2bd6b

    authors: Siddik-Sayyid SM,Nasr VG,Taha SK,Zbeide RA,Shehade JM,Al Alami AA,Mokadem FH,Abdallah FW,Baraka AS,Aouad MT

    更新日期:2009-10-01 00:00:00

  • Nitric oxide synthase inhibitor blocks spinal sensitization induced by formalin injection into the rat paw.

    abstract::This study evaluated the role of nitric oxide (NO) in spinal cord nociceptive transmission during peripheral inflammation evoked by formalin injection into the rat paw, using N omega-nitro-L-arginine (N-Arg), an NO synthase inhibitor. Male rats were prepared with intrathecal (IT) catheters. To quantify the formalin re...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199311000-00003

    authors: Yamamoto T,Shimoyama N,Mizuguchi T

    更新日期:1993-11-01 00:00:00

  • Small-dose ketamine reduces the pain of propofol injection.

    abstract:BACKGROUND:I.v. injection of propofol during anesthetic induction induces pain. Ketamine has been shown to reduce injection pain. In this study, we established the optimal dose of ketamine to prevent the pain of injection with propofol. METHODS:Two hundred forty patients presenting for elective surgery were randomly a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ane.0000243334.83816.53

    authors: Koo SW,Cho SJ,Kim YK,Ham KD,Hwang JH

    更新日期:2006-12-01 00:00:00

  • Droperidol causes a dose-dependent prolongation of the QT interval.

    abstract::To further investigate possible prolongation of the frequency-corrected QT interval (QTc interval) after administration of droperidol (DRO), we studied 40 surgical patients who were randomly assigned to one of three groups, receiving an intravenous (IV) injection of either 0.1 mg/kg (Group 1, n = 10), 0.175 mg/kg (Gro...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199411000-00028

    authors: Lischke V,Behne M,Doelken P,Schledt U,Probst S,Vettermann J

    更新日期:1994-11-01 00:00:00

  • Increases in spinal cerebrospinal fluid potassium concentration do not increase isoflurane minimum alveolar concentration in rats.

    abstract:BACKGROUND:Previous studies demonstrated that MAC for isoflurane directly correlates with the concentration of Na(+) in cerebrospinal fluid surrounding the spinal cord, the primary site for mediation of the immobility produced by inhaled anesthetics. If this correlation resulted from increased irritability of the cord,...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e3181815f2b

    authors: Shnayderman D,Laster MJ,Eger EI 2nd,Oh I,Zhang Y,Jinks SL,Antognini JF,Raines DE

    更新日期:2008-09-01 00:00:00

  • Transversus Abdominis Plane Block Versus Wound Infiltration for Analgesia After Cesarean Delivery: A Randomized Controlled Trial.

    abstract:BACKGROUND:Transversus abdominis plane (TAP) block and local anesthetic wound infiltration provide analgesia after cesarean delivery. Studies comparing the 2 techniques are scarce, with conflicting results. This double-blind, randomized controlled trial aimed to compare bilateral ultrasound-guided TAP block with single...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0000000000001724

    authors: Tawfik MM,Mohamed YM,Elbadrawi RE,Abdelkhalek M,Mogahed MM,Ezz HM

    更新日期:2017-04-01 00:00:00

  • Hemodynamic effects of dobutamine in patients following mitral valve replacement.

    abstract::Mitral valve replacement is frequently complicated by a low cardiac output syndrome and elevated pulmonary arterial pressures. In the present study, we used dobutamine to increase cardiac index and measured the pulmonary hemodynamic effects in 10 patients with increased pulmonary vascular tone following mitral valve r...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Schwenzer KJ,Miller ED Jr

    更新日期:1989-04-01 00:00:00

  • Pharmacokinetics of thiopental and pentobarbital enantiomers after intravenous administration of racemic thiopental.

    abstract::We studied the pharmacokinetics of thiopental enantiomers in 14 healthy patients aged 37-73 yr receiving racemic thiopental by intravenous (IV) bolus or IV infusion. Plasma concentration of each enantiomer was measured by chiral high-performance liquid chromatography. After IV bolus, the total plasma clearance (CL) (2...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199609000-00020

    authors: Nguyen KT,Stephens DP,McLeish MJ,Crankshaw DP,Morgan DJ

    更新日期:1996-09-01 00:00:00

  • Clonidine added to a continuous interscalene ropivacaine perineural infusion to improve postoperative analgesia: a randomized, double-blind, controlled study.

    abstract::Although clonidine has been shown to increase the duration of local anesthetic action and prolong postoperative analgesia when included in single-injection nerve blocks, the only controlled investigation of the efficacy of this practice to improve analgesia for continuous perineural local anesthetic infusion failed to...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.ASN.0000145571.41015.D5

    authors: Ilfeld BM,Morey TE,Thannikary LJ,Wright TW,Enneking FK

    更新日期:2005-04-01 00:00:00

  • Closed-Loop Delivery Systems Versus Manually Controlled Administration of Total IV Anesthesia: A Meta-analysis of Randomized Clinical Trials.

    abstract::Bispectral Index Scale (BIS)-guided closed-loop delivery of anesthetics has been extensively studied. We performed a meta-analysis of all the randomized clinical trials comparing efficacy and performance between BIS-guided closed-loop delivery and manually controlled administration of total IV anesthesia. Scopus, PubM...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1213/ANE.0000000000001394

    authors: Pasin L,Nardelli P,Pintaudi M,Greco M,Zambon M,Cabrini L,Zangrillo A

    更新日期:2017-02-01 00:00:00

  • Subhypnotic doses of propofol do not relieve pruritus induced by intrathecal morphine after cesarean section.

    abstract:UNLABELLED:The purpose of this study was to determine whether subhypnotic doses of propofol effectively relieve pruritus in women who received intrathecal morphine for postoperative analgesia after cesarean delivery. Twenty-nine women who developed pruritus after undergoing an elective cesarean section and receiving in...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199802000-00018

    authors: Beilin Y,Bernstein HH,Zucker-Pinchoff B,Zahn J,Zenzen WJ

    更新日期:1998-02-01 00:00:00

  • Endotracheal epinephrine: a call for larger doses.

    abstract:UNLABELLED:Endotracheal administration of epinephrine 0.02 mg/kg (twice the IV dose) is recommended when IV access is unavailable during cardiopulmonary resuscitation. The standard IV dose has been considered too small for the endotracheal route by causing a detrimental decrease of arterial blood pressure (BP), presuma...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200210000-00045

    authors: Manisterski Y,Vaknin Z,Ben-Abraham R,Efrati O,Lotan D,Berkovitch M,Barak A,Barzilay Z,Paret G

    更新日期:2002-10-01 00:00:00

  • Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine.

    abstract:BACKGROUND:Sugammadex is a modified [gamma] cyclodextrin compound, which encapsulates rocuronium to provide for a rapid reversal of residual neuromuscular blockade. We tested the hypothesis that sugammadex would provide for a more rapid reversal of a moderately profound residual rocuronium-induced blockade than the com...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ane.0000248224.42707.48

    authors: Sacan O,White PF,Tufanogullari B,Klein K

    更新日期:2007-03-01 00:00:00