Desflurane hepatitis associated with hapten and autoantigen-specific IgG4 antibodies.

Abstract:

BACKGROUND:Three cases of drug-induced liver injury (DILI) have been reported after desflurane anesthesia. However, no previous reports have detected serum autoantibodies such as that reported with DILI from halothane or isoflurane. METHODS AND RESULTS:We describe the first documentation of cytochrome P450 2E1 IgG4 autoantibodies, as well as 58 kDa endoplasmic reticulum protein and trifluoroacetyl chloride hapten-specific IgG4 antibodies, in a patient who developed DILI after desflurane anesthesia. CONCLUSIONS:These findings suggest that allergic and autoimmune mechanisms have critical roles in the development of desflurane DILI.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Anderson JS,Rose NR,Martin JL,Eger EI,Njoku DB

doi

10.1213/01.ane.0000263275.10081.47

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

1452-3, table of contents

issue

6

eissn

0003-2999

issn

1526-7598

pii

104/6/1452

journal_volume

104

pub_type

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