A thromboelastometric evaluation of the effects of hypothermia on the coagulation system.


BACKGROUND:Hypothermia may be accidental or therapeutic. Therapeutic hypothermia is increasingly used as treatment for various conditions, e.g., neuroprotection after cardiac arrest. Hypothermia leads to an impairment of the coagulation system, but the degree of impairment has been difficult to determine. Most studies have been performed on plasma instead of whole blood. We therefore evaluated whole blood investigating the effects of hypothermia on the coagulation system over a wide range of temperatures (25-40 degrees C). METHODS:Blood was drawn from six healthy volunteers into citrated test tubes. Samples were then placed in water baths with temperatures ranging from 25 to 40 degrees C for 30 min before the coagulation system was studied using rotational thromboelastometry. A contact activator (Ellagic acid) was used for initiation of coagulation. Clotting time, clot formation time, alpha angle, and maximum clot strength were measured. All tests were run for 60 min and they were performed at the same temperature as the temperature in the water bath. RESULTS:Coagulation was increasingly impaired with decreasing temperatures in the temperature range studied. All variables measured were significantly impaired in a stepwise pattern (P < 0.0001). CONCLUSIONS:Evaluation using a whole blood analysis shows that hypothermia progressively impairs the coagulation system.


Anesth Analg


Anesthesia and analgesia


Rundgren M,Engström M




Has Abstract


2008-11-01 00:00:00














  • Minimum alveolar anesthetic concentration of fluorinated alkanols in rats: relevance to theories of narcosis.

    abstract:UNLABELLED:The Meyer-Overton hypothesis predicts that the potency of conventional inhaled anesthetics correlates inversely with lipophilicity: minimum alveolar anesthetic concentration (MAC) x the olive oil/gas partition coefficient equals a constant of approximately 1.82 +/- 0.56 atm (mean +/- SD), whereas MAC x the o...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Eger EI 2nd,Ionescu P,Laster MJ,Gong D,Hudlicky T,Kendig JJ,Harris RA,Trudell JR,Pohorille A

    更新日期:1999-04-01 00:00:00

  • The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation.

    abstract:BACKGROUND:Neurotropin, a nonprotein extract isolated from inflamed skin of rabbits inoculated with vaccinia virus, is widely used in Japan to treat chronic pain such as neuropathic pain. Although some studies have been conducted on the mechanism of the antiallodynic action of Neurotropin, this mechanism has yet to be ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Okazaki R,Namba H,Yoshida H,Okai H,Miura T,Kawamura M

    更新日期:2008-09-01 00:00:00

  • The incidental finding of a patent foramen ovale during cardiac surgery: should it always be repaired? A core review.

    abstract::With the increased use of intraoperative transesophageal echocardiography, patent foramen ovale (PFO) has become a common finding during heart surgery. This finding presents a difficult dilemma for cardiac surgeons, since the impact of intraoperatively diagnosed PFOs on postoperative outcome is unknown. Changes in the...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Sukernik MR,Bennett-Guerrero E

    更新日期:2007-09-01 00:00:00

  • Impact of changes in operating pressure during high-frequency jet ventilation.

    abstract::Fifteen critically ill patients with acute respiratory failure were ventilated with high-frequency jet ventilation (HFJV; frequency 100 breaths/min; I/E ratio 0.43; 1.8-mm internal diameter injector cannula). The patients were divided into two groups according to their initial PaO2 during intermittent positive pressur...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Benhamou D,Ecoffey C,Rouby JJ,Fusciardi J,Viars P

    更新日期:1984-01-01 00:00:00

  • A clinical profile of a cohort of patients referred to an anesthesiology-based pediatric chronic pain medicine program.

    abstract:BACKGROUND:Pediatric chronic pain is very common and results in significant health care costs. Pediatric chronic pain is both an individual and a public health concern. The primary objective of this study was to generate a descriptive clinical profile of the patients referred to an anesthesiology-based pediatric chroni...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Vetter TR

    更新日期:2008-03-01 00:00:00

  • The breaking of an intrathecally-placed epidural catheter during extraction.

    abstract:IMPLICATIONS:Misplacement of an epidural catheter into the subarachnoid space is a recognized complication. However, breakage of an intrathecal epidural catheter during removal presents a dilemma. Appropriate imaging, a neurosurgical consultation, and aggressive surgical exploration and extraction of the retained piece...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Ugboma S,Au-Truong X,Kranzler LI,Rifai SH,Joseph NJ,Salem MR

    更新日期:2002-10-01 00:00:00

  • Antinociceptive interaction between spinal clonidine and lidocaine in the rat formalin test: an isobolographic analysis.

    abstract:UNLABELLED:Clinical and basic science studies suggest that spinal alpha-2-adrenergic receptor agonists and local anesthetics produce analgesia, but interaction between alpha-2-adrenergic receptor agonists and local anesthetics in the persistent pain model has not been examined. In the present study, using isobolographi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Hao S,Takahata O,Iwasaki H

    更新日期:2001-03-01 00:00:00

  • The relationship between cardiac output measured by the thermodilution method and that measured by the carbon dioxide rebreathing technique during laparoscopic surgery.

    abstract::Carbon dioxide insufflation during laparoscopic surgery may interfere with the accuracy of the cardiac output value measured by the NICO2 system. The authors simultaneously measured cardiac output by the thermodilution method and by the carbon dioxide rebreathing technique during laparoscopic adrenalectomy in a patien...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Suzuki M,Koda S,Nakamura Y,Kawamura N,Shimada Y

    更新日期:2005-05-01 00:00:00

  • The effect of heart rate control on myocardial ischemia among high-risk patients after vascular surgery.

    abstract:UNLABELLED:Patients undergoing vascular surgery have a high risk of suffering major postoperative cardiac events. Preoperative myocardial ischemia as detected by Holter monitoring identifies a high-risk subgroup whose postoperative ischemia, similarly detected, seems to herald major cardiac events. In this study, we de...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Raby KE,Brull SJ,Timimi F,Akhtar S,Rosenbaum S,Naimi C,Whittemore AD

    更新日期:1999-03-01 00:00:00

  • A comparison of the effects of alfentanil applied to the spinal cord and intravenous alfentanil on noxiously evoked activity of dorsal horn neurons in the cat spinal cord.

    abstract::The purpose of this study was to examine the effects of alfentanil applied to the surface of the spinal cord and the effects of intravenously administered alfentanil on noxiously evoked activity of dorsal horn neurons. Extracellular single neuron recordings were obtained from wide dynamic range neurons in 26 decerebra...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Matsumoto M,Collins JG,Kitahata LM,Yuge O,Tanaka A

    更新日期:1986-02-01 00:00:00

  • Lack of CNS depression from large doses of trimethaphan in sheep.

    abstract::It is not uncommon to observe prolonged CNS depression for several hours following controlled hypotension and halothane anesthesia for neurosurgery. The present study evaluates possible contribution of large doses of trimethaphan to CNS depression. Four adult sheep were placed on transapical left ventricular bypass (T...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Wong KC,Peters JL,Roberts TS,McRea JC,Fukumasu H

    更新日期:1977-01-01 00:00:00

  • Nitrous oxide attenuates pressor but augments norepinephrine response to laryngoscopy and endotracheal intubation.

    abstract:UNLABELLED:Nitrous oxide (N(2)O) exerts a sympathomimetic action. We investigated whether N(2)O modifies the cardiovascular responses to tracheal intubation during general anesthesia. One-hundred healthy patients were assigned randomly to receive one of four concentrations (0%, 25%, 50%, or 75%; n = 25 each) of N(2)O i...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Yoo KY,Jeong ST,Ha IH,Lee J

    更新日期:2003-05-01 00:00:00

  • Nitrous oxide minimum alveolar anesthetic concentration in rats is greater than previously reported.

    abstract::Recent determinations of the minimum alveolar anesthetic concentration (MAC) for nitrous oxide in rats yield values of 1.51-1.55 atm. When combined with results from other reports, these results suggest a deviation from linear additivity, and call into question the unitary theory of narcosis. The present report provid...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Gonsowski CT,Eger EI 2nd

    更新日期:1994-10-01 00:00:00

  • Within-patient variability of myogenic motor-evoked potentials to multipulse transcranial electrical stimulation during two levels of partial neuromuscular blockade in aortic surgery.

    abstract:UNLABELLED:Intraoperative recording of myogenic motor responses evoked by transcranial electrical stimulation (tcMEPs) is a method of assessing the integrity of the motor pathways during aortic surgery. To identify conditions for optimal spinal cord monitoring, we investigated the effects of manipulating the level of n...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: van Dongen EP,ter Beek HT,Schepens MA,Morshuis WJ,Langemeijer HJ,de Boer A,Boezeman EH

    更新日期:1999-01-01 00:00:00

  • Comparison of the fascia iliaca compartment block with the 3-in-1 block in children.

    abstract::A new single injection procedure, the fascia iliaca compartment block, is described for blocking the femoral, lateral cutaneous, and obturator nerves. The technique consists of injecting a local anesthetic immediately behind the fascia iliaca at the union of the lateral with the two medial thirds of the inguinal ligam...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Dalens B,Vanneuville G,Tanguy A

    更新日期:1989-12-01 00:00:00

  • Takuo Aoyagi: discovery of pulse oximetry.

    abstract::In the 1930s and 1940s, photo cells permitted German, English, and American physiologists to construct ear oximeters with red and infrared light, requiring calibration. In 1940 Squire recognized that changes of red and infrared light transmission caused by pneumatic tissue compression permitted saturation to be comput...

    journal_title:Anesthesia and analgesia

    pub_type: 传,历史文章,杂志文章


    authors: Severinghaus JW

    更新日期:2007-12-01 00:00:00

  • Significance of electrocardiographic ST elevation during coronary artery bypass surgery.

    abstract::The aim of this study was to determine the significance of new electrocardiographic (ECG) ST elevation during coronary artery bypass surgery. Multilead ECGs were recorded intraoperatively approximately every 3 min on 105 patients. Cases of new ST elevation were divided into ischemic and those considered to be due to n...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Jain U,Wallis DE,Moran JF

    更新日期:1994-04-01 00:00:00

  • Labor epidural analgesia and maternal fever.

    abstract::Women in labor who receive epidural analgesia are more likely to experience hyperthermia and overt clinical fever. The gradual development of modest hyperthermia observed in laboring women with epidural analgesia is not seen in those electing other forms of analgesia or unmedicated labor. Clinical fever is also far mo...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Segal S

    更新日期:2010-12-01 00:00:00

  • Comparison of nalbuphine and fentanyl anesthesia for coronary artery bypass surgery. Hemodynamics, hormonal response, and postoperative respiratory depression.

    abstract::To determine whether nalbuphine might replace fentanyl as the principal opioid for anesthesia during coronary artery bypass surgery, 20 patients undergoing myocardial revascularization were anesthetized with flunitrazepam and with a continuous infusion of either nalbuphine (an opioid agonist-antagonist) or fentanyl (a...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Weiss BM,Schmid ER,Gattiker RI

    更新日期:1991-11-01 00:00:00

  • Atrial fibrillation after coronary artery bypass graft surgery is unrelated to cardiac abnormalities detected by transesophageal echocardiography.

    abstract:UNLABELLED:Atrial fibrillation is a common complication of coronary artery bypass graft (CABG) surgery that is associated with adverse patient outcomes. We evaluated whether preexisting abnormalities of cardiac structure or function detected with transesophageal echocardiography (TEE) are prevalent in patients later de...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Skubas NJ,Barzilai B,Hogue CW Jr

    更新日期:2001-07-01 00:00:00

  • Effects of fentanyl, naloxone, and clonidine on hemodynamics and plasma catecholamine levels in dogs.

    abstract::A 50-micrograms/kg dose of fentanyl, given intravenously in divided doses to dogs under enflurane-nitrous oxide anesthesia caused sharp decreases in heart rate (HR), arterial blood pressure (AP), left ventricular dP/dt, and plasma levels of catecholamines. Naloxone, 20 micrograms/kg given 65-70 min later, completely a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Flacke JW,Flacke WE,Bloor BC,Olewine S

    更新日期:1983-03-01 00:00:00

  • Changes in respiratory mechanics during cardiac surgery.

    abstract:UNLABELLED:We investigated the role of cardiopulmonary bypass (CPB) in compromised lung function associated with cardiac surgery. Low-frequency respiratory impedance (Zrs) was measured in patients undergoing cardiac surgery with (n = 30; CPB group) or without (n = 29; off-pump coronary artery bypass [OPCAB] group) CPB....

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Babik B,Asztalos T,Peták F,Deák ZI,Hantos Z

    更新日期:2003-05-01 00:00:00

  • The effect of lidocaine on early postoperative cognitive dysfunction after coronary artery bypass surgery.

    abstract:UNLABELLED:We investigated the effect of lidocaine on the incidence of cognitive dysfunction in the early postoperative period after cardiac surgery. One-hundred-eighteen patients undergoing elective coronary artery bypass surgery with cardiopulmonary bypass (CPB) were randomized to receive either lidocaine (1.5 mg/kg ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wang D,Wu X,Li J,Xiao F,Liu X,Meng M

    更新日期:2002-11-01 00:00:00

  • Changes in cerebral blood flow velocity after release of intraoperative tourniquets in humans: a transcranial Doppler study.

    abstract::The effect of release of intraoperative thigh tourniquets on velocity of blood flow in the middle cerebral artery was examined in five patients given general anesthesia with controlled ventilation for lower extremity orthopedic procedures using transcranial Doppler sonography. Middle cerebral artery blood flow velocit...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Hirst RP,Slee TA,Lam AM

    更新日期:1990-11-01 00:00:00

  • Determining minimum alveolar anesthetic concentration of halothane in rats: the effect of incremental change in halothane concentration and number of crossovers.

    abstract::Computer simulations for the technique of estimating minimum alveolar anesthetic concentration (MAC) in patients (quantal design) suggest that incremental concentration changes and the number of crossovers affect MAC. We hypothesized that these variables may also apply to estimating MAC in rats (bracketing design). Th...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Leon A,Mayzler O,Benifla M,Semionov M,Fuxman Y,Eilig I,Passuga V,Doitchinova MK,Gurevich B,Artru AA,Shapira Y

    更新日期:2004-12-01 00:00:00

  • Assessing the Association Between Blood Loss and Postoperative Hemoglobin After Cesarean Delivery: A Prospective Study of 4 Blood Loss Measurement Modalities.

    abstract:BACKGROUND:Visual estimation and gravimetric methods are commonly used to quantify the volume of blood loss during cesarean delivery (CD). However, the correlation between blood loss and post-CD hemoglobin (Hb) is poorly studied, and it is unclear whether the correlation varies according to how blood loss is measured. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Fedoruk K,Seligman KM,Carvalho B,Butwick AJ

    更新日期:2019-05-01 00:00:00

  • Perioperative Management of the Patient With a Left Ventricular Assist Device for Noncardiac Surgery.

    abstract::The pandemic of heart failure and the limited options for treatment of end-stage disease have resulted in an increase in the utilization of left ventricular assist devices (LVADs). Improvements in device technology and patient survival have led to an expanding population of patients requiring noncardiac surgery while ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Chung M

    更新日期:2018-06-01 00:00:00

  • The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial.

    abstract:BACKGROUND:Clonidine is an alpha(2) adrenoreceptor and imidazoline receptor agonist, which has analgesic, sedative, and minimum alveolar anesthetic concentration-sparing effects. It has been used orally, IV, and epidurally. In spinal surgery, there is a reluctance to use local anesthetic-based epidural analgesia postop...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Farmery AD,Wilson-MacDonald J

    更新日期:2009-02-01 00:00:00

  • Propofol anesthesia for children undergoing magnetic resonance imaging: a comparison with isoflurane, nitrous oxide, and a laryngeal mask airway.

    abstract:BACKGROUND:Both propofol infusions with oxygen delivered through nasal cannula and isoflurane/N2O (nitrous oxide) delivered via a laryngeal mask airway (LMA) are used to provide anesthesia for children undergoing magnetic resonance imaging scans. We compared the incidence of adverse events and perioperative physiologic...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Heard C,Harutunians M,Houck J,Joshi P,Johnson K,Lerman J

    更新日期:2015-01-01 00:00:00

  • Repeated Testing With the Hypertonic Saline Assay in Mice for Screening of Analgesic Activity.

    abstract:BACKGROUND:In vivo animal assays are a cornerstone of preclinical pain research. An optimal stimulus for determining the activity of potential analgesics would produce responses of a consistent magnitude on repeated testing. Intraplantar (i.pl.) injection of hypertonic saline (HS) in mice produces robust nociceptive re...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Asiri YI,Fung T,Schwarz SKW,Barr AM,Puil E,MacLeod BA

    更新日期:2019-07-01 00:00:00