The effect of sevoflurane on dynamic cerebral blood flow autoregulation assessed by spectral and transfer function analysis.

Abstract:

:Sevoflurane reduces autonomic neural control, which plays a significant role in cerebral autoregulation. Therefore, we hypothesized that sevoflurane influences cerebral autoregulation. We investigated the effects of sevoflurane on dynamic cerebral blood flow (CBF) autoregulation by using spectral and transfer function analysis between blood pressure variability and CBF velocity variability. Eleven healthy male subjects received 0.5%, 1.0%, and 1.5% sevoflurane via facemask. Dynamic cerebral autoregulation was evaluated by transfer function gain, phase, and coherence between CBF velocity in the middle cerebral artery measured by transcranial Doppler, and blood pressure in the radial artery. Coherence in the very low-frequency range (0.02-0.07 Hz) increased above 0.5 during administration of 0.5% and 1.0% sevoflurane. Transfer function gain in this frequency range (0.02-0.07 Hz), as an index of dynamic cerebral autoregulation, increased significantly with 0.5% and 1.0% sevoflurane. Transfer function gain and coherence in the low- and high-frequency ranges, however, remained unchanged during administration of sevoflurane. These results suggest that sevoflurane impairs dynamic cerebral autoregulation in the very-low-frequency range even with small concentrations, whereas dynamic cerebral autoregulation in the low- and high-frequency ranges remained unchanged.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Ogawa Y,Iwasaki K,Shibata S,Kato J,Ogawa S,Oi Y

doi

10.1213/01.ane.0000189056.96273.48

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

552-9

issue

2

eissn

0003-2999

issn

1526-7598

pii

102/2/552

journal_volume

102

pub_type

杂志文章
  • The dose-response of nitrous oxide in postoperative nausea in patients undergoing gynecologic laparoscopic surgery: a preliminary study.

    abstract:BACKGROUND:Whether nitrous oxide (N(2)O) increases the incidence of postoperative nausea and vomiting (PONV) after laparoscopic gynecologic surgery is still controversial, which may be due to the administration of different concentrations of inspired N(2)O. We investigated whether N(2)O results in a dose-response incre...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ane.0b013e318181f4aa

    authors: Mraovic B,Simurina T,Sonicki Z,Skitarelic N,Gan TJ

    更新日期:2008-09-01 00:00:00

  • Patient-controlled epidural analgesia after abdominal surgery: ropivacaine versus bupivacaine.

    abstract:UNLABELLED:In this randomized, double-blinded study we sought to assess the analgesic efficacy of ropivacaine and bupivacaine in combination with sufentanil and the efficacy of ropivacaine alone after major abdominal surgery. Sixty patients undergoing major abdominal surgery received standardized general anesthesia com...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200112000-00055

    authors: Pouzeratte Y,Delay JM,Brunat G,Boccara G,Vergne C,Jaber S,Fabre JM,Colson P,Mann C

    更新日期:2001-12-01 00:00:00

  • The effect of breath termination criterion on breathing patterns and the work of breathing during pressure support ventilation.

    abstract:UNLABELLED:With pressure support ventilation (PSV), each PSV breath is flow-cycled, and the breath termination criterion (TC) is usually nonadjustable. When TC does not match the interaction between the patient's inspiratory-expiratory efforts to the opening and closing of the inspiratory and expiratory valves, patient...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-200101000-00031

    authors: Tokioka H,Tanaka T,Ishizu T,Fukushima T,Iwaki T,Nakamura Y,Kosogabe Y

    更新日期:2001-01-01 00:00:00

  • Changing Default Ventilator Settings on Anesthesia Machines Improves Adherence to Lung-Protective Ventilation Measures.

    abstract::Perioperative lung-protective ventilation (LPV) can reduce perioperative pulmonary morbidity. We hypothesized that modifying default anesthesia machine ventilator settings would increase the use of intraoperative LPV. Default tidal volume settings on our anesthesia machines were decreased from 600 to 400 mL, and defau...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000002575

    authors: Chiao SS,Colquhoun DA,Naik BI,Ma JZ,Nemergut EC,Durieux ME,Blank RS,Forkin KT

    更新日期:2018-04-01 00:00:00

  • The young: neuroapoptosis induced by anesthetics and what to do about it.

    abstract::Millions of human fetuses, infants, and children are exposed to anesthetic drugs every year in the United States and throughout the world. Anesthesia administered during critical stages of neurodevelopment has been considered safe and without adverse long-term consequences. However, recent reports provide mounting evi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181c6b9ca

    authors: Creeley CE,Olney JW

    更新日期:2010-02-01 00:00:00

  • A Novel Approach for the Control of Inflammatory Pain: Prostaglandin E2 Complexation by Randomly Methylated β-Cyclodextrins.

    abstract:BACKGROUND:Inhibitors of cyclooxygenase, which block the formation of prostaglandin (PG) E2, are the standard treatment of inflammatory pain. These drugs, however, have serious gastrointestinal, renal, and cardiovascular side effects that limit their clinical use. Cyclodextrins are neutral glucose oligomers that form a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000001674

    authors: Sauer RS,Rittner HL,Roewer N,Sohajda T,Shityakov S,Brack A,Broscheit JA

    更新日期:2017-02-01 00:00:00

  • Ilioinguinal iliohypogastric nerve blocks--before or after cesarean delivery under spinal anesthesia?

    abstract::Preoperative local anesthetic blockade of somatosensory pathways involved with skin incision and other noxious perioperative stimuli may "preempt" or attenuate the postoperative pain response. Since the Pfannenstiel incision lies within the L1 dermatome, bilateral ilioinguinal, iliohypogastric nerve blocks (IINBs) sho...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199601000-00003

    authors: Huffnagle HJ,Norris MC,Leighton BL,Arkoosh VA

    更新日期:1996-01-01 00:00:00

  • The potency of succinylcholine in obese adolescents.

    abstract:UNLABELLED:We constructed a single-dose response curve for succinylcholine in 30 obese adolescents during thiopental-fentanyl anesthesia administration by using 100 microg/kg, 150 microg/kg, or 250 microg/kg IV. The maximal response (percent depression of neuromuscular function) of the adductor pollicis to supramaximal...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200003000-00015

    authors: Rose JB,Theroux MC,Katz MS

    更新日期:2000-03-01 00:00:00

  • Hyperglycemia impairs isoflurane-induced adenosine triphosphate-sensitive potassium channel activation in vascular smooth muscle cells.

    abstract:BACKGROUND:Isoflurane activates vascular adenosine triphosphate sensitive potassium (K(ATP)) channels, and may induce vasodilation. In the present study, we investigated whether hyperglycemia modifies isoflurane activation of vascular K(ATP) channel. METHODS:We used a cell-attached patch-clamp configuration to test th...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e318163fd5b

    authors: Kawano T,Tanaka K,Mawatari K,Oshita S,Takahashi A,Nakaya Y

    更新日期:2008-03-01 00:00:00

  • Intravenous administration of flurbiprofen does not affect cerebral blood flow velocity and cerebral oxygenation under isoflurane and propofol anesthesia.

    abstract:UNLABELLED:Flurbiprofen, a nonsteroidal antiinflammatory drug (NSAID), has been used to treat rheumatic and osteoarthritic pain and to reduce postoperative pain. Although other NSAIDs, such as indomethacin, reduce cerebral blood flow (CBF), the effect of flurbiprofen on CBF is unknown. In the present study, we investig...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ane.0000099755.97885.3c

    authors: Yoshitani K,Kawaguchi M,Tatsumi K,Sasaoka N,Kurumatani N,Furuya H

    更新日期:2004-02-01 00:00:00

  • Protein binding and the metabolism of thiamylal enantiomers in vitro.

    abstract:UNLABELLED:Thiamylal, a chiral thiobarbiturate, is marketed as a racemic product. We studied the serum protein binding and microsomal metabolism of thiamylal enantiomers in vitro. The unbound fraction of R(+)-thiamylal was greater than that of S(-)-thiamylal. The analysis of binding data revealed that both enantiomers ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200009000-00045

    authors: Sueyasu M,Fujito K,Shuto H,Mizokoshi T,Kataoka Y,Oishi R

    更新日期:2000-09-01 00:00:00

  • Dexmedetomidine reduces propofol and remifentanil requirements during bispectral index-guided closed-loop anesthesia: a double-blind, placebo-controlled trial.

    abstract:BACKGROUND:The α2-adrenergic agonist dexmedetomidine is a sedative and can be used as an adjunct to anesthetics. Our primary goal was thus to determine the extent to which dexmedetomidine reduces the requirement for propofol and remifentanil. METHODS:This double-blinded, randomized study (NCT00921284) used an automate...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0000000000000185

    authors: Le Guen M,Liu N,Tounou F,Augé M,Tuil O,Chazot T,Dardelle D,Laloë PA,Bonnet F,Sessler DI,Fischler M

    更新日期:2014-05-01 00:00:00

  • The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms.

    abstract::The Meyer-Overton hypothesis predicts that anesthetic potency correlates inversely with lipophilicity; e.g., MAC times the olive oil/gas partition coefficient equals a constant of approximately 1.82 +/- 0.56 atm (mean +/- sd) for conventional inhaled anesthetics. MAC is the minimum alveolar concentration of anesthetic...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000204258.00676.98

    authors: Won A,Oh I,Liao M,Sonner JM,Harris RA,Laster MJ,Brosnan R,Trudell JR,Eger EI 2nd

    更新日期:2006-05-01 00:00:00

  • Perioperative management of patients undergoing transsphenoidal pituitary surgery.

    abstract::Pituitary adenomas often present with the symptoms of hormonal hypersecretion, and although medical therapy is available for most hyperfunctioning states, it is not curative. As a result, transsphenoidal pituitary surgery has become a commonly performed neurosurgical procedure with unique challenges for the anesthesio...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/01.ane.0000166976.61650.ae

    authors: Nemergut EC,Dumont AS,Barry UT,Laws ER

    更新日期:2005-10-01 00:00:00

  • Maximizing prediction probability PK as an alternative semiparametric approach to estimate the plasma effect-site equilibration rate constant ke0.

    abstract:BACKGROUND:The k(e)(0) value is the first order rate constant determining the equilibration of drugs between plasma or end-tidal concentration and effect-site (e.g., brain) concentration. Parametric and semiparametric approaches have been used for estimating individual k(e)(0) values and describing the drug-response cu...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181b61efd

    authors: Ellerkmann RK,Bruhn J,Soehle M,Kehrer M,Hoeft A,Kreuer S

    更新日期:2009-11-01 00:00:00

  • Errors and omissions in anesthesia: a pilot study using a pilot's checklist.

    abstract::There are recent concerns that anesthesiologists are becoming less skilled in providing general anesthesia for Cesarean delivery. We considered whether a verbal checklist would help in the preparation for this event. We created a list of items to be checked when preparing to administer general anesthesia for a Cesarea...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000156567.24800.0B

    authors: Hart EM,Owen H

    更新日期:2005-07-01 00:00:00

  • Operating room nursing directors' influence on anesthesia group operating room productivity.

    abstract:BACKGROUND:Implementation of initiatives to increase anesthesia group productivity depends not just on anesthesia groups, but on operating room (OR) nursing administration. OR nursing directors may encourage organizational change based on the needs of their hospitals and nurses. These changes may differ from those that...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e31818874a8

    authors: Masursky D,Dexter F,Nussmeier NA

    更新日期:2008-12-01 00:00:00

  • Methadone for the induction of anesthesia: plasma histamine concentration, arterial blood pressure, and heart rate.

    abstract:UNLABELLED:Despite the widespread use of methadone for the treatment of acute and chronic pain, the hemodynamic effects of methadone administered by IV bolus have not been studied. We compared the hemodynamic effects of an IV bolus of methadone 20 mg with those of fentanyl 10 microg/kg for the induction of anesthesia i...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ane.0000114085.20751.20

    authors: Bowdle TA,Even A,Shen DD,Swardstrom M

    更新日期:2004-06-01 00:00:00

  • A secure method of nasotracheal tube fixation using an infant feeding tube.

    abstract::A well secured endotracheal tube is very essential for the safe conduct of anesthesia. In maxillofacial surgeries, providing secure fixation of the nasotracheal tube has always been a problem. We have used an infant feeding tube that goes around the nasal septum for the fixation of the nasal endotracheal tube. This me...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/01.ANE.0000134801.87404.3F

    authors: Bhat VR,Venkateshwaran G

    更新日期:2004-11-01 00:00:00

  • Effects of adenosine-induced hypotension on myocardial hemodynamics and metabolism during cerebral aneurysm surgery.

    abstract::The effects of adenosine-induced hypotension on central as well as myocardial hemodynamics and metabolism were studied in five neurolept-anesthetized patients without known heart or lung diseases, who were undergoing cerebral aneurysm surgery. Adenosine (217 +/- 32 micrograms.kg-1.min-1) decreased mean arterial pressu...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Owall A,Lagerkranser M,Sollevi A

    更新日期:1988-03-01 00:00:00

  • An ultrasound evaluation of laryngeal mask airway position in pediatric patients: an observational study.

    abstract:BACKGROUND:In children, the laryngeal mask airway (LMA) is frequently displaced within the hypopharynx, resulting in repositioning of the device. When the tip of the LMA is placed in the esophageal inlet, the arytenoids are moved ventrally. When the LMA is rotated or deviated, the ventral movement of the arytenoids may...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000000551

    authors: Kim J,Kim JY,Kim WO,Kil HK

    更新日期:2015-02-01 00:00:00

  • Heparin induces release of phospholipase A(2) into the splanchnic circulation.

    abstract:UNLABELLED:Cardiopulmonary bypass results in increased plasma activity of phospholipase A(2) (PLA(2)) that appears to be caused by the administration of heparin. High PLA(2) activity may be responsible for increased production of eicosanoids and, thus, may be implicated in various pathophysiologic events associated wit...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-200009000-00005

    authors: Kern H,Johnen W,Braun J,Frey B,Rüstow B,Kox WJ,Schlame M

    更新日期:2000-09-01 00:00:00

  • A comparison of lighted stylet (Surch-Lite) and direct laryngoscopic intubation in patients with high Mallampati scores.

    abstract:BACKGROUND:A lighted stylet is an effective alternative to a direct laryngoscope and has been reported to be particularly useful in patients with difficult airways. A high Mallampati class indicates poor visibility of the oropharyngeal structures. Because a lighted stylet does not require direct oropharyngeal visualiza...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ane.0b013e3181994fba

    authors: Rhee KY,Lee JR,Kim J,Park S,Kwon WK,Han S

    更新日期:2009-04-01 00:00:00

  • Comparison of the effects of halothane, isoflurane, and sevoflurane on atrioventricular conduction times in pentobarbital-anesthetized dogs.

    abstract::It is not known how sevoflurane affects the cardiac conduction system. We compared the effects of halothane, isoflurance, and sevoflurane on specialized atrioventricular (AV) conduction times in eight pentobarbital-anesthetized dogs. AV conduction times with three inhaled anesthetics at end-tidal concentrations of 1 a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199508000-00007

    authors: Nakaigawa Y,Akazawa S,Shimizu R,Ishii R,Yamato R

    更新日期:1995-08-01 00:00:00

  • Effects of sodium pentobarbital, ketamine, halothane, and chloralose on brainstem auditory evoked responses.

    abstract::A parametric study was performed in cats comparing the effects on the brainstem auditory evoked response of four anesthetic agents used either in the operating room or the laboratory: sodium pentobarbital, ketamine, halothane, and chloralose. Each anesthetic agent was administered to each of four cats in varying seque...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Cohen MS,Britt RH

    更新日期:1982-04-01 00:00:00

  • Procoagulant activity in hemostasis and thrombosis: Virchow's triad revisited.

    abstract::Virchow's triad is traditionally invoked to explain pathophysiologic mechanisms leading to thrombosis, alleging concerted roles for abnormalities in blood composition, vessel wall components, and blood flow in the development of arterial and venous thrombosis. Given the tissue-specific bleeding observed in hemophilia ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0b013e31823a088c

    authors: Wolberg AS,Aleman MM,Leiderman K,Machlus KR

    更新日期:2012-02-01 00:00:00

  • Cochrane corner: sugammadex, a selective reversal medication for preventing postoperative residual neuromuscular blockade.

    abstract:BACKGROUND:Sugammadex is the first selective relaxant binding agent that has been studied for reversal of neuromuscular blockade induced by rocuronium and other steroidal non-depolarizing neuromuscular blocking agents (NMBAs). OBJECTIVES:To assess the efficacy and safety of sugammadex in reversing neuromuscular blocka...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析

    doi:10.1213/ANE.0b013e3181ce8d5e

    authors: Abrishami A,Ho J,Wong J,Yin L,Chung F

    更新日期:2010-04-01 00:00:00

  • The anesthetic potency of lidocaine in the rat.

    abstract::The anesthetic effect of lidocaine was evaluated in rats by determining the change in anesthetic requirement of cyclopropane MAC that was produced by blood concentrations of lidocaine in the clinically useful range. A linear reduction in anesthetic requirement was produced with concentrations up to 1 mug/ml. Further i...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197611000-00016

    authors: DiFazio CA,Neiderlehner JR,Burney RG

    更新日期:1976-11-01 00:00:00

  • The influence of endotracheal tube tip design on nasal trauma during nasotracheal intubation: magill-tip versus murphy-tip.

    abstract:UNLABELLED:We performed this study to assess the influence of endotracheal tube (ETT) tip design (Murphy-tip versus Magill-tip) on nasal trauma during nasotracheal intubation with a conventional polyvinyl chloride ETT. Patients were randomly allocated to one of four groups (n = 25 each): Magill-tipped ETT and Murphy-ti...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ane.0000169293.59514.28

    authors: Lee JH,Kim CH,Bahk JH,Park KS

    更新日期:2005-10-01 00:00:00

  • Transdiscal lumbar sympathetic block: a new technique for a chemical sympathectomy.

    abstract:UNLABELLED:Genitofemoral neuritis, which occurs when the neurolytic solution spreads into the psoas muscle, is the most common complication after neurolytic lumbar sympathetic block. We developed a transdiscal approach for neurolytic lumbar sympathetic block to reduce the danger of genitofemoral neuritis by making a sy...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199712000-00024

    authors: Ohno K,Oshita S

    更新日期:1997-12-01 00:00:00