The young: neuroapoptosis induced by anesthetics and what to do about it.

abstract：UNLABELLED:The effect of opioid administration on the bispectral index (BIS) during general anesthesia is controversial. Several investigators have reported BIS to be insensitive to opioid addition, whereas others have found a hypnotic response. We designed this study to examine the effect of remifentanil on BIS during...

journal_title：Anesthesia and analgesia

authors： Koitabashi T,Johansen JW,Sebel PS

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Conventional concept suggests that infused crystalloid fluid is first distributed in the plasma volume and then, since the capillary permeability for fluid is very high, almost instantly equilibrates with the extracellular fluid space. We challenge whether this view is consistent with findings based on volum...

journal_title：Anesthesia and analgesia

authors： Svensen CH,Rodhe PM,Olsson J,Børsheim E,Aarsland A,Hahn RG

更新日期：2009-01-01 00:00:00

abstract：:A pharmacokinetic evaluation of bupivacaine was carried out after intercostal nerve blocks performed on 28 occasions in 27 children varying in age from 3 months to 16 yr. Bupivacaine HCl, 0.5%, with epinephrine 1:200,000 was employed. Doses of 2 mg/kg, 3 mg/kg, and 4 mg/kg resulted in peak whole blood arterial bupivac...

journal_title：Anesthesia and analgesia

authors： Rothstein P,Arthur GR,Feldman HS,Kopf GS,Covino BG

更新日期：1986-06-01 00:00:00

abstract：:The tandem pore domain K channel family mediates background K currents present in excitable cells. Currents passed by certain members of the family are enhanced by volatile anesthetics, thus suggesting a novel mechanism of anesthesia. The newest member of the family, termed TRESK (TWIK [tandem pore domain weak inward ...

journal_title：Anesthesia and analgesia

authors： Liu C,Au JD,Zou HL,Cotten JF,Yost CS

更新日期：2004-12-01 00:00:00

abstract：:Nicardipine is used in the treatment of premature labor. There are no previous reports in the anesthesia literature of serious side effects associated with this drug. We report a case of pulmonary edema induced by nicardipine therapy for tocolysis in a pregnant 27-yr-old patient admitted to our hospital for preterm la...

journal_title：Anesthesia and analgesia

authors： Bal L,Thierry S,Brocas E,Adam M,Van de Louw A,Tenaillon A

更新日期：2004-09-01 00:00:00

abstract：:Attempted pulmonary artery catheterization via the left internal jugular vein resulted in a misdiagnosis of pulmonary hypertension before transesophageal echocardiography revealed the catheter positioned in the ascending aorta. Inadvertent aortic cannulation through an unusual type of partial anomalous pulmonary venou...

journal_title：Anesthesia and analgesia

authors： Siegmueller C,Bell A,Mittal T,George S

更新日期：2008-01-01 00:00:00

abstract：UNLABELLED:We studied the effect of fluvoxamine and erythromycin on the pharmacokinetics of ropivacaine in a double-blinded, randomized, four-way cross-over study. Eight healthy volunteers ingested daily 1500 mg erythromycin for 6 days, 100 mg fluvoxamine for 5 days (Days 2-6), both erythromycin and fluvoxamine, or pla...

journal_title：Anesthesia and analgesia

authors： Jokinen MJ,Ahonen J,Neuvonen PJ,Olkkola KT

更新日期：2000-11-01 00:00:00

abstract：INTRODUCTION:Exposure to isoflurane before and during early reperfusion protects against myocardial infarction by activating phosphatidylinositol-3-kinase (PI3K)-mediated signaling. The apoptotic protein, p53, is regulated by PI3K, and inhibition of p53 protects against ischemic injury. We tested the hypothesis that p5...

journal_title：Anesthesia and analgesia

authors： Venkatapuram S,Wang C,Krolikowski JG,Weihrauch D,Kersten JR,Warltier DC,Pratt PF Jr,Pagel PS

更新日期：2006-12-01 00:00:00

abstract：:A parametric study was performed in cats comparing the effects on the brainstem auditory evoked response of four anesthetic agents used either in the operating room or the laboratory: sodium pentobarbital, ketamine, halothane, and chloralose. Each anesthetic agent was administered to each of four cats in varying seque...

journal_title：Anesthesia and analgesia

authors： Cohen MS,Britt RH

更新日期：1982-04-01 00:00:00

abstract：:Quantitative electroencephalogram (qEEG) monitors are often used to estimate depth of anesthesia and intraoperative recall during general anesthesia. As with any monitor, the processed numerical output is often misleading and has to be interpreted within a clinical context. For the safe clinical use of these monitors,...

journal_title：Anesthesia and analgesia

authors： Bennett C,Voss LJ,Barnard JP,Sleigh JW

更新日期：2009-08-01 00:00:00

abstract：:The purpose of this study was to determine if the addition of sufentanil would improve the quality of analgesia obtained with 0.125% epidural bupivacaine infusions given to women in active labor. Forty healthy laboring women were randomly assigned to two equal groups. Group 1 had epidural analgesia instituted with the...

journal_title：Anesthesia and analgesia

authors： Phillips G

更新日期：1988-05-01 00:00:00

abstract：:Patients receiving metoprolol before cardiac revascularization surgery were randomly divided into those in whom metoprolol was discontinued before the operation (N = 10) and those in whom metoprolol was continued up to the time of operation (N = 10). Cardiovascular responses to neuroleptanesthesia and sternotomy were ...

journal_title：Anesthesia and analgesia

authors： Pontén J,Häggendal J,Milocco I,Waldenström A

更新日期：1983-04-01 00:00:00

abstract：UNLABELLED:We selected bis [N-(3,4-diacetoxybenzyl) tropanium-3alpha-yl] glutarate dibromide (TAAC3) from many new tropinyl diester derivatives to evaluate its neuromuscular blocking (NMB) and autonomic side effects on anesthetized rats, rabbits, guinea pigs, cats, pigs, dogs, and monkeys. NMB potency, onset, recovery ...

journal_title：Anesthesia and analgesia

authors： Gyermek L,Lee C,Cho YM,Nguyen N,Tsai SK

更新日期：2002-04-01 00:00:00

abstract：:This study evaluates the changes of oxygen saturation (SpO2) after intravenous administration of methylene blue in 103 patients undergoing open repair of thoracoabdominal aortic aneurysms. We found that SpO2 decreased by a median (interquartile range [IQR]) of 49% (37%-81%) <1 minute after methylene blue administratio...

journal_title：Anesthesia and analgesia

authors： Rong LQ,Mauer E,Mustapich TL,White RS,Di Franco A,Girardi LN,Gaudino M,Pryor KO

更新日期：2019-11-01 00:00:00

abstract：:Either epidural analgesia or femoral nerve blockade improves analgesia and rehabilitation after total knee arthroplasty. No study has evaluated the combination of femoral nerve blockade and epidural analgesia. In this prospective, randomized, blinded study we investigated combining femoral nerve blockade with epidural...

journal_title：Anesthesia and analgesia

authors： YaDeau JT,Cahill JB,Zawadsky MW,Sharrock NE,Bottner F,Morelli CM,Kahn RL,Sculco TP

更新日期：2005-09-01 00:00:00

abstract：:Transesophageal echocardiography (TEE) is increasingly used intraoperatively as a monitor of ventricular function and volume. Despite its increasing use, whether data from TEE monitoring can be interpreted accurately on-line in real-time is unknown. We studied the performance of five community-based, full-time cardiac...

journal_title：Anesthesia and analgesia

authors： Bergquist BD,Leung JM,Bellows WH

更新日期：1996-06-01 00:00:00

abstract：UNLABELLED:Manufacturer's instructions recommend discarding unused portions of sodium thiopental 24 h after reconstitution. Heeding this recommendation may result in the disposal of a large proportion of prepared thiopental. Although thiopental is relatively inexpensive, the volume prepared by many anesthesia departmen...

journal_title：Anesthesia and analgesia

authors： Haws JL,Herman N,Clark Y,Bjoraker R,Jones D

更新日期：1998-01-01 00:00:00

abstract：:The analgesic effects of butorphanol tartrate and morphine sulfate were compared in 127 patients judged to have moderate to severe pain following major operations. The study was double-blind, and the drugs were given IM at several dosage levels. Scores for pain intensity and relief, as well as pain-intensity differenc...

journal_title：Anesthesia and analgesia

authors： Tavakoli M,Corssen G,Caruso FS

更新日期：1976-05-01 00:00:00

abstract：INTRODUCTION:The preoperative encounter may offer a cost-effective opportunity for diabetes screening. METHODS:Three hundred forty-seven fasting patients had a preoperative glucose measurement determined from blood residue left on the IV needle, measured with an Accu-Chek glucometer (Roche Diagnostics, Indianapolis, I...

journal_title：Anesthesia and analgesia

authors： Grek S,Gravenstein N,Morey TE,Rice MJ

更新日期：2009-11-01 00:00:00

abstract：:To determine the pharmacokinetics of local anesthetics after lumbar sympathetic blocks, total and free (unbound) plasma concentrations of bupivacaine in venous blood samples were measured in 12 patients using a high-performance liquid chromatography (HPLC) technique. Administration of 30 mL of plain bupivacaine 0.175%...

journal_title：Anesthesia and analgesia

authors： Wulf H,Gleim M,Schele HA

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Various different interventions can be used to reduce surgical blood loss; however, there is no "gold standard" for accurately measuring the volume of perioperative blood loss, and this makes it difficult to assess the efficacy of these interventions. METHODS:We used data from a previous multicenter double-...

journal_title：Anesthesia and analgesia

authors： Lopez-Picado A,Albinarrate A,Barrachina B

更新日期：2017-07-01 00:00:00

abstract：:In this study we attempted to define the minimal dosage of alfentanil (AF) needed in combination with nitrous oxide to provide satisfactory anesthetic conditions for lower abdominal gynecologic surgery. General anesthesia was induced in 12 women with AF (150 micrograms X kg-1) and 66% N2O in O2. An infusion of AF was ...

journal_title：Anesthesia and analgesia

authors： Ausems ME,Hug CC Jr,de Lange S

更新日期：1983-11-01 00:00:00

abstract：UNLABELLED:The effects of intravascular volume replacement regimens on tissue oxygen tension (ptiO(2)) are not definitely known. Forty-two consecutive patients scheduled for elective major abdominal surgery were prospectively randomized to receive either 6% hydroxyethyl starch (HES) (mean molecular weight 130 kd, degre...

journal_title：Anesthesia and analgesia

authors： Lang K,Boldt J,Suttner S,Haisch G

更新日期：2001-08-01 00:00:00

abstract：UNLABELLED:The Anesthetic Conserving Device (ACD) is a high-flow anesthesia system closed to volatile anesthetics only. We compared the ACD with a circle system under different fresh gas flow (FGF) conditions. Eighty-one patients undergoing major surgery were randomly allocated to receive sevoflurane from a circle circ...

journal_title：Anesthesia and analgesia

authors： Tempia A,Olivei MC,Calza E,Lambert H,Scotti L,Orlando E,Livigni S,Guglielmotti E

更新日期：2003-04-01 00:00:00

abstract：UNLABELLED:A microscope will be used for the first case of the day in operating room (OR) 1 and then may be used in the second case of the day by a different surgeon in a different OR, OR 2. Provided that the probability is reasonably high that the first case of the day in OR 2 will last longer than the first case in O...

journal_title：Anesthesia and analgesia

authors： Dexter F,Traub RD

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:The goal of this study was to determine a set of timing, shape, and statistical features available through noninvasive monitoring of maternal electrocardiogram and photoplethysmography that identifies preeclamptic patients. METHODS:Pregnant women admitted to Labor and Delivery were monitored with pulse oxim...

journal_title：Anesthesia and analgesia

authors： Euliano TY,Michalopoulos K,Singh S,Gregg AR,Del Rio M,Vasilopoulos T,Johnson AM,Onkala A,Darmanjian S,Euliano NR,Ho M

更新日期：2018-03-01 00:00:00

abstract：:A method involving sodium fusion and analysis by fluoride electrode, which has been used for the determination of total fluorinated metabolites of fluorine-containing drugs in physiologic fluids, is shown to be inapplicable to volatile fluorinated metabolites of volatile fluorinated anesthetic agents. The yields of in...

journal_title：Anesthesia and analgesia

authors： Ivanetich KM,Bradshaw JJ,Brittain T

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND:Safe and effective alternatives are required in labor when epidural analgesia is not appropriate. We hypothesized that patient-controlled IV remifentanil labor analgesia would not be inferior to patient-controlled epidural labor analgesia. METHODS:This randomized nonblinded controlled noninferiority study i...

journal_title：Anesthesia and analgesia

authors： Stocki D,Matot I,Einav S,Eventov-Friedman S,Ginosar Y,Weiniger CF

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Mounting evidence from animal studies shows that anesthetic exposure in early life leads to apoptosis in the developing nervous system. This loss of neurons has functional consequences in adulthood. Clinical retrospective reviews have suggested that multiple anesthetic exposures in early childhood are associ...

journal_title：Anesthesia and analgesia

authors： Gentry KR,Steele LM,Sedensky MM,Morgan PG

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Increasing evidence suggests that patients with eating disorders are more likely to develop chronic pain. A misaligned diet has been reported to disrupt the sleep-awake rhythms. Combined with our previous investigation on circadian pain, we aimed to investigate the role of misaligned diet in the pain sensiti...

journal_title：Anesthesia and analgesia

authors： Xu F,Zhao X,Liu H,Shao X,Chu S,Gong X,Ma Z,Gu X

更新日期：2018-07-01 00:00:00