The anesthetic potency of lidocaine in the rat.

Abstract:

:The anesthetic effect of lidocaine was evaluated in rats by determining the change in anesthetic requirement of cyclopropane MAC that was produced by blood concentrations of lidocaine in the clinically useful range. A linear reduction in anesthetic requirement was produced with concentrations up to 1 mug/ml. Further increases in lidocaine up to 5.5 mug/ml resulted in no further decrease in cyclopropane requirement. Lidocaine was found to contribute a maximum MAC fraction of 0.4.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

DiFazio CA,Neiderlehner JR,Burney RG

doi

10.1213/00000539-197611000-00016

subject

Has Abstract

pub_date

1976-11-01 00:00:00

pages

818-21

issue

6

eissn

0003-2999

issn

1526-7598

journal_volume

55

pub_type

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