Abstract:
BACKGROUND:Previous studies demonstrated that MAC (the minimum alveolar concentration of an inhaled anesthetic that produces immobility in 50% of subjects exposed to noxious stimulation) for halothane directly correlates with the central nervous system concentration of Na+. However, those studies globally altered Na+ concentrations, and thus did not distinguish effects on the spinal cord from cerebral effects. This is an important distinction because the cord appears to be the primary site for mediation of the immobility produced by inhaled anesthetics. Accordingly, in the present study, we examined the effect of altering intrathecal versus intracerebroventricular concentrations of Na+ on MAC. METHODS:In rats prepared with chronic indwelling catheters or stylets, we infused solutions deficient in Na+ and with an excess of Na+ into the lumbar subarachnoid and intracerebroventricular spaces and measured MAC for isoflurane before, during, and after infusion. RESULTS:MAC of isoflurane correlated directly with concentrations of Na+ infused intrathecally but did not correlate with concentrations infused intracerebroventricularly. CONCLUSION:The results are consistent with a mediation or modulation of MAC by Na+ channels. These might include voltage-gated or ligand-gated channels or other Na-sensitive targets (e.g., pumps, transporters, exchangers).
journal_name
Anesth Analgjournal_title
Anesthesia and analgesiaauthors
Laster MJ,Zhang Y,Eger EI 2nd,Shnayderman D,Sonner JMdoi
10.1213/01.ane.0000278090.88402.26subject
Has Abstractpub_date
2007-09-01 00:00:00pages
661-5issue
3eissn
0003-2999issn
1526-7598pii
105/3/661journal_volume
105pub_type
杂志文章abstract:UNLABELLED:Several pharmacological interventions reduce perioperative stress hormone release during surgery under general anesthesia. Listening to music and therapeutic suggestions were also studied, but mostly in awake patients, and these have a positive effect on postoperative recovery and the need for analgesia. In ...
journal_title:Anesthesia and analgesia
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Anesthesia and analgesia
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Anesthesia and analgesia
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journal_title:Anesthesia and analgesia
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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