The influence of p38 mitogen-activated protein kinase inhibitor on synthesis of inflammatory cytokine tumor necrosis factor alpha in spinal cord of rats with chronic constriction injury.


BACKGROUND:Tumor necrosis factor alpha (TNF-alpha) could trigger p38 mitogen-activated protein kinase (MAPK) activation. Conversely phosphorylated p38 (p-p38) could induce the upregulation of TNF-alpha. In this study, we examined the hypothesis that chronic constrictive injury (CCI) of the sciatic nerve could promote spinal cord release of TNF-alpha and produce allodynia via the p38 MAPK pathway. METHODS:Sprague-Dawley rats were divided into five groups: 1) naïve control rats, 2) sham surgery rats, 3) CCI surgery rats without treatment, 4) CCI surgery rats with saline (0.9%) treatment, and 5) CCI surgery rats with the p38 MAPK inhibitor SB203580 treatment. In treatment groups, saline or SB203580 (2 microg, twice a day) was given intrathecally starting 1 day before or 1 day or 7 days after CCI. All rats were killed at different times after surgery to examine p38 MAPK activity and TNF-alpha levels in the spinal cord by Western blot analysis or immunohistochemistry. Mechanical allodynia was tested by a series of von Frey hairs 3, 7, and 14 days after surgery. RESULTS:p-p38 MAPK was significantly increased at 3, 7, and 14 days after CCI surgery compared with time-matched shams (P < 0.05). Peripheral nerve injury induced mechanical allodynia and enhanced spinal concentrations of TNF-alpha (P < 0.05). Pretreatment or early treatment with SB203580 inhibited p38 MAPK activity, resulting in reduction of TNF-alpha synthesis and attenuation of mechanical allodynia (P < 0.05). CONCLUSION:p38 MAPK activation is one aspect of the signaling cascade that culminates in TNF-alpha synthesis and contributes to mechanical allodynia after peripheral nerve injury.


Anesth Analg


Anesthesia and analgesia


Xu L,Huang Y,Yu X,Yue J,Yang N,Zuo P




Has Abstract


2007-12-01 00:00:00


1838-44, table of contents












  • Risk factors assessment of the difficult airway: an italian survey of 1956 patients.

    abstract::Over the last decade, there has been a heightened awareness and an increase in the amount of literature being published on recognition and prediction of the difficult airway. During the preoperative evaluation of the airway, a thorough history and physical specifically related to the airway should be performed. Variou...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Cattano D,Panicucci E,Paolicchi A,Forfori F,Giunta F,Hagberg C

    更新日期:2004-12-01 00:00:00

  • Resveratrol regulates N-methyl-D-aspartate receptor expression and suppresses neuroinflammation in morphine-tolerant rats.

    abstract:BACKGROUND:In the present study, we examined the effects and mechanisms of the Chinese herb resveratrol on attenuation of morphine tolerance in rats. METHODS:Male Wistar rats were implanted with 2 intrathecal catheters; one catheter was connected to a mini-osmotic pump, used for either morphine (15 μg/h) or saline (1 ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Tsai RY,Chou KY,Shen CH,Chien CC,Tsai WY,Huang YN,Tao PL,Lin YS,Wong CS

    更新日期:2012-10-01 00:00:00

  • Decreased incidence and mortality of anaphylaxis to chymopapain.

    abstract::A recognized side effect of chemonucleolysis is life-threatening anaphylaxis to chymopapain. In the clinical trials of chymopapain, 13 cases of anaphylaxis were reported in 1585 administrations (0.82%). Two patients died. Data from a postmarketing survey (48,239 questionnaires) were reviewed to identify factors influe...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Moss J,Roizen MF,Nordby EJ,Thisted R,Apfelbaum JL,Schreider BD,McDermott DJ

    更新日期:1985-12-01 00:00:00

  • Knockdown of synaptic scaffolding protein Homer 1b/c attenuates secondary hyperalgesia induced by complete Freund's adjuvant in rats.

    abstract:BACKGROUND:Previous studies have demonstrated that Homer 1b/c, a postsynaptic molecular scaffolding protein that binds and clusters metabotropic glutamate receptors at neuronal synapses, has an important role in the metabotropic glutamate receptor signaling process. In the current study, we investigated the possible in...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Yao YX,Jiang Z,Zhao ZQ

    更新日期:2011-12-01 00:00:00

  • The efficacy of a resistive heating under-patient blanket versus a forced-air warming system: a randomized controlled trial.

    abstract:BACKGROUND:We compared temperature changes in patients undergoing hip replacement during warming with a resistive heating blanket or air-forced system. METHODS:Fifty-six patients were enrolled. Patients were randomly allocated to the "forced-air group" (forced-air system) or to the "heating-blanket group" (resistive h...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Fanelli A,Danelli G,Ghisi D,Ortu A,Moschini E,Fanelli G

    更新日期:2009-01-01 00:00:00

  • Pathogenic Link Between Postextubation Pneumonia and Ventilator-Associated Pneumonia: An Experimental Study.

    abstract:BACKGROUND:The presence of an endotracheal tube is the main cause for developing ventilator-associated pneumonia (VAP), but pneumonia can still develop in hospitalized patients after endotracheal tube removal (postextubation pneumonia [PEP]). We hypothesized that short-term intubation (24 hours) can play a role in the ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Rezoagli E,Zanella A,Cressoni M,De Marchi L,Kolobow T,Berra L

    更新日期:2017-04-01 00:00:00

  • Tertiary Pediatric Academic Institution's Experience With Intraoperative Neuromonitoring for Nonspinal Surgery in Children With Mucopolysaccharidosis, Based on a Novel Evidence-Based Care Algorithm.

    abstract:BACKGROUND:Musculoskeletal deformities in mucopolysaccharidoses (MPSs) patients pose unique challenges when patients present for surgery, especially nonspinal surgery. MPS patients have developed postsurgical neurological deficits after nonspinal surgery. While the incidence of neurological deficits after nonspinal sur...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kandil AI,Pettit CS,Berry LN,Busso VO,Careskey M,Chesnut E,Buck DW,Leslie ND,Tamai J,McAuliffe JJ,Chidambaran V

    更新日期:2020-06-01 00:00:00

  • Xenon Anesthesia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    abstract:BACKGROUND:Xenon anesthesia has been studied for decades. However, no meta-analysis of randomized controlled trials (RCTs) on xenon anesthesia has been conducted. The aim of this study was to systematically review all available evidence from RCTs comparing xenon and other inhaled and IV anesthetics on anesthetic outcom...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析,评审


    authors: Law LS,Lo EA,Gan TJ

    更新日期:2016-03-01 00:00:00

  • Nitrogen purging of oxygen pipelines: an unusual cause of intraoperative hypoxia.

    abstract::Intraoperative hypoxia occurred in two patients during the maintenance of the medical gas system. Engineers were purging oxygen pipelines with nitrogen to remove particulate debris but were unaware of a connection to operating room pipelines. This case illustrates the importance of communication between anesthesia pro...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Elizaga AM,Frerichs RL

    更新日期:2000-07-01 00:00:00

  • Residual neuromuscular block: lessons unlearned. Part I: definitions, incidence, and adverse physiologic effects of residual neuromuscular block.

    abstract::In this review, we summarize the clinical implications of residual neuromuscular block. Data suggest that residual neuromuscular block is a common complication in the postanesthesia care unit, with approximately 40% of patients exhibiting a train-of-four ratio <0.9. Volunteer studies have demonstrated that small degre...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Murphy GS,Brull SJ

    更新日期:2010-07-01 00:00:00

  • The discriminant power of simultaneous monitoring of spontaneous electroencephalogram and evoked potentials as a predictor of different clinical states of general anesthesia.

    abstract::Spontaneous or evoked electrical brain activity is increasingly used to monitor general anesthesia. Previous studies investigated the variables from spontaneous electroencephalogram (EEG), acoustic (AEP), or somatosensory evoked potentials (SSEP). But, by monitoring them separately, the available information from simu...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究


    authors: Jeleazcov C,Schneider G,Daunderer M,Scheller B,Schüttler J,Schwilden H

    更新日期:2006-10-01 00:00:00

  • Culture-Negative and Culture-Positive Sepsis: A Comparison of Characteristics and Outcomes.

    abstract:BACKGROUND:The primary objective of this study was to compare the characteristics of culture-positive and culture-negative status in septic patients. We also determined whether culture status is associated with mortality and whether unique variables are associated with mortality in culture-positive and culture-negative...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Sigakis MJG,Jewell E,Maile MD,Cinti SK,Bateman BT,Engoren M

    更新日期:2019-11-01 00:00:00

  • Pharmacokinetics and pharmacokinetic-dynamic relationship between rapacuronium (Org 9487) and its 3-desacetyl metabolite (Org 9488).

    abstract:UNLABELLED:Rapacuronium (Org 9487) is a rapid-onset and short- to intermediate-acting muscle relaxant. Its 3-desacetyl metabolite, Org 9488, also exerts neuromuscular-blocking activity that may become apparent after prolonged maintenance of relaxation with rapacuronium. In this study, the pharmacokinetic behavior (n = ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Schiere S,Proost JH,Schuringa M,Wierda JM

    更新日期:1999-03-01 00:00:00

  • The effectiveness of a perioperative smoking cessation program: a randomized clinical trial.

    abstract:BACKGROUND:Cigarette smoking by surgical patients is associated with increased complications, particularly perioperative respiratory problems and poor wound healing. In this study, we sought to determine whether a pragmatic perioperative smoking cessation intervention designed for a busy preadmission clinic would be su...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Lee SM,Landry J,Jones PM,Buhrmann O,Morley-Forster P

    更新日期:2013-09-01 00:00:00

  • Carbon Dioxide Absorption During Inhalation Anesthesia: A Modern Practice.

    abstract::CO2 absorbents were introduced into anesthesia practice in 1924 and are essential when using a circle system to minimize waste by reducing fresh gas flow to allow exhaled anesthetic agents to be rebreathed. For many years, absorbent formulations consisted of calcium hydroxide combined with strong bases like sodium and...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Feldman JM,Hendrickx J,Kennedy RR

    更新日期:2020-09-14 00:00:00

  • Choice of electrocardiography lead does not affect the usefulness of the T-wave criterion for detecting intravascular injection of an epinephrine test dose in anesthetized children.

    abstract:UNLABELLED:Accidental intravascular injection of an epinephrine-containing test dose increases T-wave amplitude of lead II electrocardiogram (EKG) in anesthetized children. We designed this study to test whether the choice of EKG lead would affect the usefulness of simulated intravascular test dose. We studied 32 ASA p...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ogasawara K,Tanaka M,Nishikawa T

    更新日期:2003-08-01 00:00:00

  • A method for testing for epinephrine-induced arrhythmias in rats.

    abstract::Evaluation of a new inhaled anesthetic requires determination of the anesthetic's potential to predispose to ventricular (and other) arrhythmias in an animal model. This need poses logistic and economic burdens if the effects of large numbers of new anesthetics are to be surveyed. We have devised a technique for deter...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Laster MJ,Johnson BH,Eger EI 2nd,Taheri S

    更新日期:1990-06-01 00:00:00

  • The effect of spinal ibuprofen on opioid withdrawal in the rat.

    abstract:UNLABELLED:This study examines the effect of spinal ibuprofen on the behavioral manifestations associated with the opioid abstinence syndrome. Rats (n = 8 per group) were infused for 5 days with morphine and then pretreated with a spinal bolus dose of ibuprofen before systemic naloxone antagonism (300 microg). Groups i...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Dunbar SA,Karamov IG,Buerkle H

    更新日期:2000-08-01 00:00:00

  • Hypertension and decreased renal blood flow following methylene blue injection.

    abstract::Renal blood flow (RBF) and arterial blood pressure (BP) were monitored in 12 patients undergoing nephrolithotomy in the lateral flexed position. All patients were preoxygenated and were anesthetized with sodium thiopental, N2O, O2, and fentanyl. Maintenance relaxation was obtained with pancuronium bromide. Arterial pr...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Birch AA,Boyce WH

    更新日期:1976-09-01 00:00:00

  • Time course of action and endotracheal intubating conditions of Org 9487, a new short-acting steroidal muscle relaxant; a comparison with succinylcholine.

    abstract::In a randomized study, we evaluated lag time (time from the end of injection of muscle relaxant until the first depression of the train-of-four response [TOF]), onset time (time from the end of injection of muscle relaxant until the maximum depression of the first twitch of the TOF [T1]), neuromuscular block, and endo...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wierda JM,van den Broek L,Proost JH,Verbaan BW,Hennis PJ

    更新日期:1993-09-01 00:00:00

  • Reassessment of the assumed A-V oxygen content difference in the shunt calculation.

    abstract::A study was undertaken in 15 patients to compare measured and assumed arteriovenous oxygen (A-V O2) content differences and their effects on resultant shunt calculations. All patients were on volume ventilators and demonstrated a stable cardiovascular state. Simultaneous measurements of the O2 content of a pulmonary a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Harrison RA,Davison R,Shapiro BA,Meyers SN

    更新日期:1975-03-01 00:00:00

  • The effects of sevoflurane and halothane anesthesia on cerebral blood flow velocity in children.

    abstract:UNLABELLED:We compared cerebral blood flow velocity during anesthesia with sevoflurane and halothane in 23 children admitted for elective surgery (age, 0.4-9.7 yr; median age, 1.9 yr; ASA physical status I-II). Inhaled induction was performed in a randomized sequence with sevoflurane or halothane. Under steady-state co...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Mönkhoff M,Schwarz U,Gerber A,Fanconi S,Bänziger O

    更新日期:2001-04-01 00:00:00

  • A Novel Approach for the Control of Inflammatory Pain: Prostaglandin E2 Complexation by Randomly Methylated β-Cyclodextrins.

    abstract:BACKGROUND:Inhibitors of cyclooxygenase, which block the formation of prostaglandin (PG) E2, are the standard treatment of inflammatory pain. These drugs, however, have serious gastrointestinal, renal, and cardiovascular side effects that limit their clinical use. Cyclodextrins are neutral glucose oligomers that form a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Sauer RS,Rittner HL,Roewer N,Sohajda T,Shityakov S,Brack A,Broscheit JA

    更新日期:2017-02-01 00:00:00

  • Pain on injection of lipid-free propofol and propofol emulsion containing medium-chain triglyceride: a comparative study.

    abstract:UNLABELLED:Pain on injection of propofol continues to be a problem for anesthesiologists. A lipid-free formulation of propofol and a propofol emulsion containing medium-chain triglyceride have become available in the Indian market. We performed this study to assess the pain on injection of propofol emulsion containing ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dubey PK,Kumar A

    更新日期:2005-10-01 00:00:00

  • Neuroendocrine stress hormones do not recreate the postoperative hypercoagulable state.

    abstract:UNLABELLED:Surgery causes changes in hemostasis, leading to a hypercoagulable state that has been linked to both arterial and venous thrombotic complications. The etiology of this state is unknown, but many investigators have hypothesized that perioperative neuroendocrine changes are responsible. We have previously dem...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rosenfeld BA,Nguyen ND,Sung I,Faraday N

    更新日期:1998-03-01 00:00:00

  • The incidence of intraoperative awareness in children: childhood awareness and recall evaluation.

    abstract:BACKGROUND:There is a considerable discrepancy between the reported incidences of awareness under anesthesia in children (0.2%-2.7%). In this prospective, observational, cohort study we evaluated 1) the incidence of awareness during general anesthesia in children across three settings, 2) factors contributing to awaren...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究


    authors: Malviya S,Galinkin JL,Bannister CF,Burke C,Zuk J,Popenhagen M,Brown S,Voepel-Lewis T

    更新日期:2009-11-01 00:00:00

  • Comparison of lidocaine and bupivacaine depression of sinoatrial nodal activity during hypoxia and acidosis in adult and neonatal guinea pigs.

    abstract::High blood concentrations of local anesthetics are cardiotoxic. The aim of this study was to compare the effects of lidocaine and bupivacaine on the intrinsic pacemaker activity of in vitro sinoatrial nodal cells of the adult and neonatal guinea pig in the presence and absence of hypoxia and acidosis. Fifteen pairs of...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Bosnjak ZJ,Stowe DF,Kampine JP

    更新日期:1986-09-01 00:00:00

  • Spine Surgery and Blood Loss: Systematic Review of Clinical Evidence.

    abstract::Spine surgery has been growing rapidly as a neurosurgical operation, with an increase of 220% over a 15-year period. Intraoperative blood transfusion is a major outcome determinant of spine procedures. Various approaches, including pharmacologic and nonpharmacologic therapies, have been tested to decrease both intraop...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Willner D,Spennati V,Stohl S,Tosti G,Aloisio S,Bilotta F

    更新日期:2016-11-01 00:00:00

  • Perioperative care of a patient with acute fatty liver of pregnancy.

    abstract::Acute fatty liver of pregnancy (AFLP) is a late gestational complication with biochemical similarities to the inherited disorders of mitochondrial fatty acid oxidation and clinical similarities to fulminant hepatic failure. The following case illustrates our perioperative management of this rarely encountered disorder...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Holzman RS,Riley LE,Aron E,Fetherston J

    更新日期:2001-05-01 00:00:00

  • Preoperative laboratory testing of children undergoing elective surgery.

    abstract::The routine preoperative evaluation of pediatric patients often includes a history, physical examination, complete blood count, and urinalysis (UA). We retrospectively reviewed the records of 486 elective surgeries in children to determine the role of abnormal preoperative laboratory test results in perioperative mana...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: O'Connor ME,Drasner K

    更新日期:1990-02-01 00:00:00