A Methyltransferase Inhibitor (Decitabine) Alleviates Intergenerational Effects of Paternal Neonatal Exposure to Anesthesia With Sevoflurane.

abstract：:Only 1 in about 110 sex acts results in a conception and 1 in 270 in a live birth. Of all conceptions, 40% result in live births, 5% in stillbirths, and 55% never develop. 1/3 of all known conceptions ends in abortion, spontaneous or induced. It appears that the population problem depends on a small fraction of the...

journal_title：Anesthesia and analgesia

authors： Berelson B

更新日期：1971-07-01 00:00:00

abstract：:Epidural clonidine produces analgesia in humans with acute and chronic pain. Its use is limited because of short-lasting analgesia, hemodynamic depression, sedation, and respiratory depression. Intrathecal guanfacine has a longer duration of action than intrathecal clonidine. The present study compares these two drugs...

journal_title：Anesthesia and analgesia

authors： Smith BD,Baudendistel LJ,Gibbons JJ,Schweiss JF

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Given the controversy regarding the use of droperidol and the high cost of the 5-HT3 antagonists, a cost-effective alternative for routine use as a prophylactic antiemetic would be desirable. We designed two parallel, randomized, double-blind sham and placebo-controlled studies to compare the early and late ...

journal_title：Anesthesia and analgesia

authors： White PF,Tang J,Song D,Coleman JE,Wender RH,Ogunnaike B,Sloninsky A,Kapu R,Shah M,Webb T

更新日期：2007-01-01 00:00:00

abstract：:A 19-year-old African American man with a T12 spinal cord lesion underwent a T4-L5 thoracolumbar spinal fusion. Intraoperatively, his arterial blood pressure acutely increased from 110/60 to 260/130 mm Hg without a change in heart rate. The patient did not have pheochromocytoma, carcinoid syndrome, or thyroid storm. T...

journal_title：Anesthesia and analgesia

authors： Blacker SN,Brown CQ,Tarant NS

更新日期：2010-11-01 00:00:00

abstract：UNLABELLED:Although isoflurane is a known vasodilator, the mechanism of isoflurane-induced vasodilation is not clear. One of the most important systems in this context is the nitric oxide (NO)-mediated vasodilation. The activity of this system is regulated by the agonist-induced Ca(2+) influx rather than Ca(2+) release...

journal_title：Anesthesia and analgesia

authors： Tas PW,Stöbetael C,Roewer N

更新日期：2003-08-01 00:00:00

abstract：:The extent of sensory and motor blockades was examined in 195 patients 5 and 20 min after four different techniques of brachial plexus block using 50 ml of 0.5% bupivacaine. The interscalene technique of Winnie (N = 50) resulted in a preferential blockade of the caudad portions of the cervical plexus and the cephalad ...

journal_title：Anesthesia and analgesia

authors： Lanz E,Theiss D,Jankovic D

更新日期：1983-01-01 00:00:00

abstract：:Noma (cancrum oris) is a disease of poverty and malnutrition, which predominantly affects children younger than 10 years in developing countries. Although the majority of sufferers die of sepsis at the time of the initial infection, or of subsequent starvation due to severe trismus and an inability to eat, a small min...

journal_title：Anesthesia and analgesia

authors： Coupe MH,Johnson D,Seigne P,Hamlin B

更新日期：2013-07-01 00:00:00

abstract：:Prostaglandin E(2) receptors, subtype EP(1) (PGE(2)EP(1)) have been linked to several physiologic responses, such as fever, inflammation, and mechanical hyperalgesia. Local anesthetics modulate these responses, which may be due to direct interaction of local anesthetics with PGE(2)EP(1) receptor signaling. We sought t...

journal_title：Anesthesia and analgesia

authors： Hönemann CW,Heyse TJ,Möllhoff T,Hahnenkamp K,Berning S,Hinder F,Linck B,Schmitz W,van Aken H

更新日期：2001-09-01 00:00:00

abstract：:Fifteen critically ill patients with acute respiratory failure were ventilated with high-frequency jet ventilation (HFJV; frequency 100 breaths/min; I/E ratio 0.43; 1.8-mm internal diameter injector cannula). The patients were divided into two groups according to their initial PaO2 during intermittent positive pressur...

journal_title：Anesthesia and analgesia

authors： Benhamou D,Ecoffey C,Rouby JJ,Fusciardi J,Viars P

更新日期：1984-01-01 00:00:00

abstract：:Two hundred adults undergoing laparoscopic cholecystectomy were enrolled in a prospectively randomized, double-blind investigation comparing ondansetron, 4 mg (Group O) with the combination of droperidol, 0.625 mg, and metoclopramide, 10 mg (Group DM). Antiemetic drugs were administered intravenously (IV) after induct...

journal_title：Anesthesia and analgesia

authors： Steinbrook RA,Freiberger D,Gosnell JL,Brooks DC

更新日期：1996-11-01 00:00:00

abstract：:The effects of midazolam on atrial rate and contractile force in the isolated canine atrium perfused with donor blood were investigated. When midazolam in a dose range of 100-1000 micrograms was injected directly into the sinus node artery of the isolated atrium, biphasic (negative followed by positive) chronotropic a...

journal_title：Anesthesia and analgesia

authors： Saegusa K,Furukawa Y,Ogiwara Y,Takeda M,Chiba S

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:Central poststroke pain (CPSP) is a disabling morbidity occurring in 8%-14% of patients with stroke. It is infrequently recognized and difficult to manage. OBJECTIVE:We systematically reviewed the pathophysiology and treatment of CPSP. METHODS:We conducted a Medline search using the key words "central post...

journal_title：Anesthesia and analgesia

authors： Kumar B,Kalita J,Kumar G,Misra UK

更新日期：2009-05-01 00:00:00

abstract：:The effects of enflurane and halothane anesthesia on systolic time intervals were studied in 12 healthy patients. Cardiovascular measurements were made at equipotent levels of anesthesia: enflurane 1.23% end-tidal and halothane 0.65% end-tidal. These agents were studied first with 50% N2O and then without N2O. Systoli...

journal_title：Anesthesia and analgesia

authors： Kaplan JA,Miller ED,Bailey DR

更新日期：1976-03-01 00:00:00

abstract：:Heart transplantation remains the definitive management for end-stage heart failure refractory to medical therapy. While heart transplantation cases are increasing annually worldwide, there remains a deficiency in organ availability with significant patient mortality while on the waiting list. Attempts have therefore ...

journal_title：Anesthesia and analgesia

authors： Beuth J,Falter F,Pinto Ribeiro RV,Badiwala M,Meineri M

更新日期：2019-03-01 00:00:00

abstract：:Transesophageal echocardiography (TEE) is increasingly used intraoperatively as a monitor of ventricular function and volume. Despite its increasing use, whether data from TEE monitoring can be interpreted accurately on-line in real-time is unknown. We studied the performance of five community-based, full-time cardiac...

journal_title：Anesthesia and analgesia

authors： Bergquist BD,Leung JM,Bellows WH

更新日期：1996-06-01 00:00:00

abstract：UNLABELLED:Because succinylcholine has obvious advantages for facilitating endotracheal intubation in the ambulatory setting (e.g., low cost, fast onset, and no need for reversal of neuromuscular block), it is important to determine whether this muscle relaxant is indeed associated with an increased incidence of postop...

journal_title：Anesthesia and analgesia

authors： Mikat-Stevens M,Sukhani R,Pappas AL,Fluder E,Kleinman B,Stevens RA

更新日期：2000-08-01 00:00:00

abstract：:Propofol is associated with a low incidence of postoperative nausea and vomiting. In a prospective, randomized, double-blind, placebo-controlled study, we investigated the possible direct antiemetic properties of a subhypnotic dose of propofol. Fifty-two ASA physical status I or II patients, aged 15-60 yr with nausea ...

journal_title：Anesthesia and analgesia

authors： Borgeat A,Wilder-Smith OH,Saiah M,Rifat K

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Although local anesthetics (LAs) are generally accepted as being safe, incidental neuronal damage has been reported for all LAs in humans. Therefore, in this study, we compared the dose corresponding to 50% cell lethality (LD50) of articaine, lidocaine, mepivacaine, bupivacaine, prilocaine, and ropivacaine i...

journal_title：Anesthesia and analgesia

authors： Malet A,Faure MO,Deletage N,Pereira B,Haas J,Lambert G

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:QT interval prolongation is associated with torsades des pointes (TdP), but is a poor predictor of drug torsadogenicity. Susceptibility to TdP arises from increased transmural dispersion of repolarization (TDR) across the myocardial wall, rather than QT interval prolongation per se. TDR can be measured on th...

journal_title：Anesthesia and analgesia

authors： Whyte SD,Sanatani S,Lim J,Booker PD

更新日期：2007-02-01 00:00:00

abstract：UNLABELLED:We investigated the direct effects of midazolam and diazepam on cardiac excitation-contraction coupling in adult rat ventricular myocytes. Freshly isolated rat ventricular myocytes were loaded with fura-2/AM and field-stimulated at 28 degrees C. Intracellular Ca(2+) transients (340:380 ratio) and myocyte sho...

journal_title：Anesthesia and analgesia

authors： Kanaya N,Murray PA,Damron DS

更新日期：2002-12-01 00:00:00

abstract：:Bradykinin, an endogenous nonapeptide and an important mediator of inflammation, is also implicated in the initiation and maintenance of pain. Both des-Arg(8), Leu(8)-bradykinin (dALBK) and HOE-140, the prototypic bradykinin B1 and B2 receptor antagonists, respectively, have been shown to reduce pain behaviors and inf...

journal_title：Anesthesia and analgesia

authors： Leonard PA,Arunkumar R,Brennan TJ

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Cigarette smoking by surgical patients is associated with increased complications, particularly perioperative respiratory problems and poor wound healing. In this study, we sought to determine whether a pragmatic perioperative smoking cessation intervention designed for a busy preadmission clinic would be su...

journal_title：Anesthesia and analgesia

authors： Lee SM,Landry J,Jones PM,Buhrmann O,Morley-Forster P

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:In cardiac surgery, pulmonary hypertension is an important prognostic factor for which several treatments have been suggested over time. In this systematic review and meta-analysis, we compared the efficacy of inhaled aerosolized vasodilators to intravenously administered agents and to placebo in the treatme...

journal_title：Anesthesia and analgesia

authors： Elmi-Sarabi M,Deschamps A,Delisle S,Ased H,Haddad F,Lamarche Y,Perrault LP,Lambert J,Turgeon AF,Denault AY

更新日期：2017-08-01 00:00:00

abstract：:Renal blood flow (RBF) and arterial blood pressure (BP) were monitored in 12 patients undergoing nephrolithotomy in the lateral flexed position. All patients were preoxygenated and were anesthetized with sodium thiopental, N2O, O2, and fentanyl. Maintenance relaxation was obtained with pancuronium bromide. Arterial pr...

journal_title：Anesthesia and analgesia

authors： Birch AA,Boyce WH

更新日期：1976-09-01 00:00:00

abstract：:We studied 60 nonophthalmologic patients, allocated to six treatment groups, to assess the effects of atracurium and vecuronium on intraocular pressure (IOP). All patients had IOP measured while awake, using pneumotonometry. In group 1, anesthesia was induced with thiopental, 5 mg/kg, and maintained with N2O, 70% in O...

journal_title：Anesthesia and analgesia

authors： Schneider MJ,Stirt JA,Finholt DA

更新日期：1986-08-01 00:00:00

abstract：:Dantrolene effectively treats malignant hyperthermia (MH) hut the current form, Dantrium, must be dissolved to a 0.33 mg/mL, pH 9.5 solution. This study describes lecithin-coated microcrystal formulations of sodium dantrolene (MC-NaD) and neutral dantrolene (MC-D) which reconstitute to 200 mg/mL within 1 min. In rats,...

journal_title：Anesthesia and analgesia

authors： Karan SM,Lojeski EW,Haynes DH,Bina S,Wesche DL,Boedeker BH,Muldoon SM

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus (HIV)-related painful sensory neuropathies primarily consist of the HIV infection-related distal sensory polyneuropathy and antiretroviral toxic neuropathies. Pharmacotherapy provides only partial relief of pain in patients with HIV/acquired immune deficiency syndrome because lit...

journal_title：Anesthesia and analgesia

authors： Kanao M,Kanda H,Huang W,Liu S,Yi H,Candiotti KA,Lubarsky DA,Levitt RC,Hao S

更新日期：2015-06-01 00:00:00

abstract：:Virchow's triad is traditionally invoked to explain pathophysiologic mechanisms leading to thrombosis, alleging concerted roles for abnormalities in blood composition, vessel wall components, and blood flow in the development of arterial and venous thrombosis. Given the tissue-specific bleeding observed in hemophilia ...

journal_title：Anesthesia and analgesia

authors： Wolberg AS,Aleman MM,Leiderman K,Machlus KR

更新日期：2012-02-01 00:00:00

abstract：IMPLICATIONS:Tizanidine was given systemically to rats with experimental postoperative pain. Partial pain relief was obtained, but the effect was not clinically significant. Although systemic tizanidine is effective in relieving experimental neuropathic pain, it is not as effective for postoperative pain. ...

journal_title：Anesthesia and analgesia

authors： Hord AH,Denson DD,Azevedo MI

更新日期：2001-11-01 00:00:00

abstract：IMPLICATIONS:The performance of regional blockade on a patient with a preexisting neurologic condition or a history of neurologic complications after regional anesthesia is controversial. We present a case of recurring brachial plexus neuropathy in a diabetic patient after two shoulder procedures performed 4 mo apart. ...

journal_title：Anesthesia and analgesia

authors： Horlocker TT,O'Driscoll SW,Dinapoli RP

更新日期：2000-09-01 00:00:00