Subhypnotic doses of propofol possess direct antiemetic properties.

Abstract:

:Propofol is associated with a low incidence of postoperative nausea and vomiting. In a prospective, randomized, double-blind, placebo-controlled study, we investigated the possible direct antiemetic properties of a subhypnotic dose of propofol. Fifty-two ASA physical status I or II patients, aged 15-60 yr with nausea and vomiting after minor gynecologic, orthopedic, or digestive tract surgery, were included in the study and received either propofol (10 mg = 1 mL) or placebo (1 mL Intralipid) intravenously in the postanesthesia care unit. Patients treated with propofol experienced a larger reduction in nausea and vomiting than patients treated with placebo (81% vs 35% success rate; P less than 0.05). Patients successfully treated had a similar incidence of relapse (propofol 28%; placebo 22%) within the first 30 min after therapy. Thirty-three percent of the propofol-treated patients and 44% of the placebo-treated patients showed a minor increase in sedation. The level of postoperative pain did not change in either group. Hemodynamic values remained unchanged in both groups. Pain on injection (7.6%) or dizziness (3.6%) only occurred in the propofol group. We conclude that propofol has significant direct antiemetic properties.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Borgeat A,Wilder-Smith OH,Saiah M,Rifat K

doi

10.1213/00000539-199204000-00013

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

539-41

issue

4

eissn

0003-2999

issn

1526-7598

journal_volume

74

pub_type

临床试验,杂志文章,随机对照试验
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