Hemodynamic effects of desflurane/nitrous oxide anesthesia in volunteers.

Abstract:

:We determined the cardiovascular effects of 0.91, 1.34, and 1.74 MAC of desflurane/nitrous oxide anesthesia (60% inspired nitrous oxide contributed 0.5 MAC at each level) in 12 healthy, normocapnic male volunteers. Desflurane/nitrous oxide anesthesia decreased systemic blood pressures, cardiac index, stroke volume index, systemic vascular resistance, and left ventricular stroke work index, and increased pulmonary arterial pressures and central venous pressure in a dose-dependent fashion, while heart rate was 10%-12% and mixed venous oxygen tension was 2-4 mm Hg higher at all MAC levels than at baseline (awake). Desflurane/nitrous oxide anesthesia modestly increased left ventricular end-diastolic cross-sectional area (preload) and decreased velocity of left ventricular circumferential fiber shortening, systolic wall stress (afterload), and area ejection fraction; this combination of changes indicates myocardial depression. At approximately comparable MAC levels, heart rate was lower and systemic blood pressures, central venous pressure, left ventricular stroke work index, and systemic vascular resistance usually were significantly higher during anesthesia with desflurane and nitrous oxide than during desflurane anesthesia alone (same volunteers, data collected in crossover design). After 7 h of anesthesia, regardless of the background gas, somewhat less cardiovascular depression and/or modest stimulation was apparent: cardiac index, area ejection fraction, and velocity of left ventricular circumferential fiber shortening recovered to or toward awake values, whereas heart rate was further increased. Evidence of circulatory insufficiency did not develop in any volunteers during the study. Segmental left ventricular function was normal at baseline, and no segmental wall-motion abnormalities, ST-segment change, or dysrhythmias developed.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Cahalan MK,Weiskopf RB,Eger EI 2nd,Yasuda N,Ionescu P,Rampil IJ,Lockhart SH,Freire B,Peterson NA

doi

10.1213/00000539-199108000-00008

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

157-64

issue

2

eissn

0003-2999

issn

1526-7598

journal_volume

73

pub_type

杂志文章
  • Palliative Care and End-of-Life Considerations for the Frail Patient.

    abstract::Patients with frailty experience substantial physical and emotional distress related to their condition and face increased morbidity and mortality compared with their nonfrail peers. Palliative care is an interdisciplinary medical specialty focused on improving quality of life for patients with serious illness, includ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000004763

    authors: Crooms RC,Gelfman LP

    更新日期:2020-06-01 00:00:00

  • Central venous access: the effects of approach, position, and head rotation on internal jugular vein cross-sectional area.

    abstract:UNLABELLED:We investigated the effects of approach (lateral versus anterior), position (supine versus Trendelenburg), and head rotation (0 degrees, 20 degrees, and maximum) during central venous catheterization on the area of the right internal jugular vein. Twenty-four patients were placed in supine position, followed...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200212000-00010

    authors: Suarez T,Baerwald JP,Kraus C

    更新日期:2002-12-01 00:00:00

  • Cryoanalgesia: effect on postherniorrhaphy pain.

    abstract:UNLABELLED:Cryoanalgesia versus sham treatment was applied to the ilioinguinal and iliohypogastric nerves after mesh repair of an inguinal hernia under local anesthesia in 48 male patients in a prospective, randomized, and observer- and patient-blinded trial. Pain was scored daily during rest, while coughing, and durin...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199810000-00028

    authors: Callesen T,Bech K,Thorup J,Andersen J,Nielsen R,Roikjaer O,Kehlet H

    更新日期:1998-10-01 00:00:00

  • Rapid and accurate detection of atypical and Kalow variants in the butyrylcholinesterase gene using denaturing high performance liquid chromatography.

    abstract:BACKGROUND:Variations in the butyrylcholinesterase (BCHE) gene can prolong neuromuscular block after the administration of the neuromuscular blocking drugs succinylcholine and mivacurium. The most frequent variations in the BCHE gene are the atypical (A) and Kalow (K) variants. We, therefore, developed a detection appr...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000296455.31211.bd

    authors: Levano S,Keller D,Schobinger E,Urwyler A,Girard T

    更新日期:2008-01-01 00:00:00

  • Verifying correct endotracheal intubation by measurement of end-tidal carbon dioxide during an ex utero intrapartum treatment procedure.

    abstract::The ex utero intrapartum treatment (EXIT) procedure provides time to secure the airway of the fetus while utero-placental circulation supplies the fetus with oxygen. We report the anesthetic management of a fetus with a large neck mass during an EXIT procedure in which the confirmation of correct endotracheal intubati...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000175206.91231.77

    authors: Eschertzhuber S,Keller C,Mitterschiffthaler G,Jochberger S,Kühbacher G

    更新日期:2005-09-01 00:00:00

  • Anesthetic action of opiates: correlations of lipid solubility and spectral edge.

    abstract::The ability of opiates to be a complete anesthetic has been assessed in animals. These studies have investigated the serum levels of opiate required to produce a decrease in anesthetic requirement for a concomitantly administered inhalation anesthetic. A linear dose-response relation has been observed between opiate s...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Stone DJ,DiFazio CA

    更新日期:1988-07-01 00:00:00

  • Comparison of Thrombelastography-Derived Fibrinogen Values at Rewarming and Following Cardiopulmonary Bypass in Cardiac Surgery Patients.

    abstract:BACKGROUND:The inflated costs and documented deleterious effects of excess perioperative transfusion have led to the investigation of targeted coagulation factor replacement strategies. One particular coagulation factor of interest is factor I (fibrinogen). Hypofibrinogenemia is typically tested for using time-consumin...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/ANE.0000000000001465

    authors: Fabbro M 2nd,Gutsche JT,Miano TA,Augoustides JG,Patel PA

    更新日期:2016-09-01 00:00:00

  • Plasma concentrations of lidocaine associated with cervical, thoracic, and lumbar epidural anesthesia.

    abstract::We measured arterial plasma concentrations of lidocaine by enzyme immunoassay when 10 ml of 2% lidocaine without epinephrine was injected into the cervical, thoracic, or lumbar epidural spaces in 30 patients. There was no difference in the time courses of plasma levels of lidocaine. Peak concentrations were achieved 1...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Mayumi T,Dohi S,Takahashi T

    更新日期:1983-06-01 00:00:00

  • The effect of spinal ibuprofen on opioid withdrawal in the rat.

    abstract:UNLABELLED:This study examines the effect of spinal ibuprofen on the behavioral manifestations associated with the opioid abstinence syndrome. Rats (n = 8 per group) were infused for 5 days with morphine and then pretreated with a spinal bolus dose of ibuprofen before systemic naloxone antagonism (300 microg). Groups i...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200008000-00035

    authors: Dunbar SA,Karamov IG,Buerkle H

    更新日期:2000-08-01 00:00:00

  • Hemodynamic dose-responses to halothane and isoflurane are different in swine with and without critical coronary artery stenosis.

    abstract::This study examined global hemodynamic responses to increasing concentrations of halothane and isoflurane in pigs with an acute critical coronary stenosis (CCS) on the left anterior descending coronary artery (LAD). The CCS was caused by graded inflation of an hydraulic occluder to the point where no hyperemic respons...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Gilbert M,Mori M,Myhre ES

    更新日期:1989-06-01 00:00:00

  • Femoral vein cannulation performed by residents: a comparison between ultrasound-guided and landmark technique in infants and children undergoing cardiac surgery.

    abstract:BACKGROUND:Percutaneous cannulation of the femoral vein, in the pediatric age group, can be technically challenging, especially when performed by residents in training. We examined whether the use of real-time ultrasound guidance is superior to a landmark technique for femoral vein catheterization in children undergoin...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0b013e3181e9c475

    authors: Aouad MT,Kanazi GE,Abdallah FW,Moukaddem FH,Turbay MJ,Obeid MY,Siddik-Sayyid SM

    更新日期:2010-09-01 00:00:00

  • Pro- and anticonvulsant effects of anesthetics (Part I)

    abstract::Many inhaled anesthetics and intravenous analgesics have been alleged to produce both proconvulsant and anticonvulsant activity in humans. The reasons for these contrasting actions on the CNS are poorly understood at the present time. However, biologic variability plays an important role in determining individual pati...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/00000539-199003000-00013

    authors: Modica PA,Tempelhoff R,White PF

    更新日期:1990-03-01 00:00:00

  • Pharmacologic basis of responses to midazolam in the isolated, cross-perfused, canine right atrium.

    abstract::The effects of midazolam on atrial rate and contractile force in the isolated canine atrium perfused with donor blood were investigated. When midazolam in a dose range of 100-1000 micrograms was injected directly into the sinus node artery of the isolated atrium, biphasic (negative followed by positive) chronotropic a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Saegusa K,Furukawa Y,Ogiwara Y,Takeda M,Chiba S

    更新日期:1987-08-01 00:00:00

  • Prevalence and characteristics of pain induced by percutaneous liver biopsy.

    abstract:UNLABELLED:Percutaneous needle liver biopsy is an important procedure for the diagnosis and evaluation of liver disease and is frequently associated with pain. In this prospective study, we investigated the prevalence and characteristics of this pain syndrome. Fifty-four subjects, who underwent liver biopsy under ultra...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/01.ane.0000060453.74744.17

    authors: Eisenberg E,Konopniki M,Veitsman E,Kramskay R,Gaitini D,Baruch Y

    更新日期:2003-05-01 00:00:00

  • The out-of-hospital esophageal and endobronchial intubations performed by emergency physicians.

    abstract:BACKGROUND:Rapid establishment of a patent airway in ill or injured patients is a priority for prehospital rescue personnel. Out-of-hospital tracheal intubation can be challenging. Unrecognized esophageal intubation is a clinical disaster. METHODS:We performed an observational, prospective study of consecutive patient...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000253523.80050.e9

    authors: Timmermann A,Russo SG,Eich C,Roessler M,Braun U,Rosenblatt WH,Quintel M

    更新日期:2007-03-01 00:00:00

  • Pharmacodynamics and pharmacokinetics of epidural ropivacaine in humans.

    abstract::The purpose of this study was to characterize the pharmacodynamics and pharmacokinetics of three concentrations of the new long-acting amide local anesthetic, ropivacaine, given epidurally in 15 physical status ASA I or II patients for elective lower-extremity orthopedic procedures using a nonrandomized open-label des...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199001000-00004

    authors: Katz JA,Bridenbaugh PO,Knarr DC,Helton SH,Denson DD

    更新日期:1990-01-01 00:00:00

  • The volatile anesthetic isoflurane inhibits the histamine-induced Ca2+ influx in primary human endothelial cells.

    abstract:UNLABELLED:Although isoflurane is a known vasodilator, the mechanism of isoflurane-induced vasodilation is not clear. One of the most important systems in this context is the nitric oxide (NO)-mediated vasodilation. The activity of this system is regulated by the agonist-induced Ca(2+) influx rather than Ca(2+) release...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000068826.97781.ce

    authors: Tas PW,Stöbetael C,Roewer N

    更新日期:2003-08-01 00:00:00

  • Knockdown of synaptic scaffolding protein Homer 1b/c attenuates secondary hyperalgesia induced by complete Freund's adjuvant in rats.

    abstract:BACKGROUND:Previous studies have demonstrated that Homer 1b/c, a postsynaptic molecular scaffolding protein that binds and clusters metabotropic glutamate receptors at neuronal synapses, has an important role in the metabotropic glutamate receptor signaling process. In the current study, we investigated the possible in...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e31822c0b98

    authors: Yao YX,Jiang Z,Zhao ZQ

    更新日期:2011-12-01 00:00:00

  • The breaking of an intrathecally-placed epidural catheter during extraction.

    abstract:IMPLICATIONS:Misplacement of an epidural catheter into the subarachnoid space is a recognized complication. However, breakage of an intrathecal epidural catheter during removal presents a dilemma. Appropriate imaging, a neurosurgical consultation, and aggressive surgical exploration and extraction of the retained piece...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200210000-00055

    authors: Ugboma S,Au-Truong X,Kranzler LI,Rifai SH,Joseph NJ,Salem MR

    更新日期:2002-10-01 00:00:00

  • Pressure control ventilation: three anesthesia ventilators compared using an infant lung model.

    abstract:UNLABELLED:We compared three ventilators-Servo 900C (Siemens Medical Systems, Danvers, MA), Aestiva 3000 (Datex-Ohmeda, Madison, WI), and NAD 6000 (North American Dräger, Telford, PA)-set to deliver pressure control ventilation using an infant test lung model. Ventilator settings were selected to test "near-maximum" se...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200011000-00020

    authors: Stayer SA,Bent ST,Skjonsby BS,Frolov A,Andropoulos DB

    更新日期:2000-11-01 00:00:00

  • The screening of propofol in MHS swine.

    abstract::This study investigated the use of propofol in swine genetically susceptible to malignant hyperthermia (MH). Thirteen animals were exposed to 2% halothane in inspired air, a propofol infusion of 12 mg.kg-1.hr-1 for up to 45 min, or a combination of both. When MH was triggered the animals were treated with dantrolene. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Raff M,Harrison GG

    更新日期:1989-06-01 00:00:00

  • Glyburide, a KATP channel antagonist, attenuates the cardioprotective effects of isoflurane in stunned myocardium.

    abstract::This investigation examined the role of myocardial adenosine triphosphate-regulated potassium (KATP) channels in isoflurane-induced enhancement of myocardial function after reversible tissue injury produced by a 15-min left anterior descending coronary artery occlusion (LAD) and reperfusion. Dogs (n = 14) were chronic...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199607000-00006

    authors: Kersten JR,Lowe D,Hettrick DA,Pagel PS,Gross GJ,Warltier DC

    更新日期:1996-07-01 00:00:00

  • Postoperative analgesia at home after ambulatory hand surgery: a controlled comparison of tramadol, metamizol, and paracetamol.

    abstract::We compared in a prospective, randomized, double-blinded study the analgesic efficacy of three drugs in 120 ASA I and II patients scheduled to undergo ambulatory hand surgery with IV regional anesthesia. At discharge, oral analgesic tablets were prescribed as follows: tramadol 100 mg every 6 h, metamizol 1 g every 6 h...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200102000-00013

    authors: Rawal N,Allvin R,Amilon A,Ohlsson T,Hallén J

    更新日期:2001-02-01 00:00:00

  • Lack of CNS depression from large doses of trimethaphan in sheep.

    abstract::It is not uncommon to observe prolonged CNS depression for several hours following controlled hypotension and halothane anesthesia for neurosurgery. The present study evaluates possible contribution of large doses of trimethaphan to CNS depression. Four adult sheep were placed on transapical left ventricular bypass (T...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197701000-00005

    authors: Wong KC,Peters JL,Roberts TS,McRea JC,Fukumasu H

    更新日期:1977-01-01 00:00:00

  • Systemic tizanidine hydrochloride (Zanaflex) partially decreases experimental postoperative pain in rats.

    abstract:IMPLICATIONS:Tizanidine was given systemically to rats with experimental postoperative pain. Partial pain relief was obtained, but the effect was not clinically significant. Although systemic tizanidine is effective in relieving experimental neuropathic pain, it is not as effective for postoperative pain. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200111000-00056

    authors: Hord AH,Denson DD,Azevedo MI

    更新日期:2001-11-01 00:00:00

  • Routine cleaning and autoclaving does not remove protein deposits from reusable laryngeal mask devices.

    abstract:UNLABELLED:We tested the hypothesis that routine cleaning and autoclaving does not remove protein deposits from reusable laryngeal mask airways (LMAs). All previously used classic and flexible LMAs from a single hospital were tested. Each LMA was hand-washed in an enzymatic solution for 3 min, machine-washed with a dis...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000080154.76349.5b

    authors: Clery G,Brimacombe J,Stone T,Keller C,Curtis S

    更新日期:2003-10-01 00:00:00

  • Whole Blood Point-of-Care Testing for Incomplete Reversal With Idarucizumab in Supratherapeutic Dabigatran.

    abstract:BACKGROUND:Incomplete reversal with a recommended 5-g dose of idarucizumab has been reported in patients with excessively high dabigatran concentrations. A timely detection of reversal failure after idarucizumab using whole blood (WB) coagulation testing is clinically useful. The aims of this study were to determine re...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000004419

    authors: Takeshita S,Tanaka KA,Sawa T,Sanda M,Mizobe T,Ogawa S

    更新日期:2020-02-01 00:00:00

  • Analgesia before performing a spinal block in the sitting position in patients with femoral shaft fracture: a comparison between femoral nerve block and intravenous fentanyl.

    abstract::We conducted this prospective, randomized study to compare the analgesic effect of femoral nerve block and IV fentanyl administration when given to facilitate the sitting position for spinal anesthesia in patients undergoing surgery for femoral shaft fracture. Five minutes before the placement of spinal block, group F...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ANE.0000134812.00471.44

    authors: Sia S,Pelusio F,Barbagli R,Rivituso C

    更新日期:2004-10-01 00:00:00

  • Pressure-heart rate relationship in intact and after stepwise elimination of three major baroreflex loops in dogs.

    abstract::Systemic arterial blood pressure (BP)-heart rate (HR) relationship (the pressor test) is often used as an index of baroreflex. We evaluated this index by simultaneously comparing BP-HR, right carotid sinus pressure (CSP)-nerve action potentials (NAP), and NAP-HR relationship in dogs anesthetized with pentobarbital. BP...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199611000-00012

    authors: Behnia R,Koushanpour E,Sinclair DM

    更新日期:1996-11-01 00:00:00

  • Effect of enflurane on contractile reactivity in isolated canine mesenteric arteries and veins.

    abstract::The effects of enflurane on responses of isolated canine mesenteric arteries and veins to transmural nerve stimulation and to exogenously administered norepinephrine (a mixed alpha 1- and alpha 2-adrenoceptor agonist), phenylephrine (a selective alpha 1-adrenoceptor agonist), and tyramine were studied. The contractile...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199005000-00011

    authors: Kobayashi Y,Yoshida K,Noguchi M,Wakasugi Y,Ito H,Okabe E

    更新日期:1990-05-01 00:00:00