Knockdown of synaptic scaffolding protein Homer 1b/c attenuates secondary hyperalgesia induced by complete Freund's adjuvant in rats.

Abstract:

BACKGROUND:Previous studies have demonstrated that Homer 1b/c, a postsynaptic molecular scaffolding protein that binds and clusters metabotropic glutamate receptors at neuronal synapses, has an important role in the metabotropic glutamate receptor signaling process. In the current study, we investigated the possible involvement of Homer 1b/c in secondary hyperalgesia induced by complete Freund's adjuvant (CFA). METHODS:Chronic inflammation was induced by injecting CFA into the left hind ankle of Wistar rats. Homer 1b/c antisense or missense oligonucleotides were intrathecally administrated (antisense, 10 μg/10 μL, 5 μg/10 μL, or 2.5 μg/10 μL, once a day; missense, 10 μg/10 μL) from 5 to 8 days after the onset of inflammation. The withdrawal threshold and withdrawal latency to mechanical or thermal stimuli were determined before and after the intrathecal administration. The expression and distribution of Homer 1b/c were examined in the spinal cord using immunological techniques. RESULTS:Mechanical allodynia and thermal hyperalgesia were induced within 24 hours and maintained for >2 weeks after the CFA injection. The expression of Homer 1b/c reached the highest level 7 days after inflammation and returned to baseline at day 28. Intrathecal administration of Homer 1b/c antisense oligonucleotides markedly reduced the expression of Homer 1b/c protein in the spinal cord. Additionally, administration of Homer 1b/c antisense oligonucleotides attenuated secondary mechanical hypersensitization on days 2 to 5 and reduced thermal hypersensitization on days 3 to 4. There were no effects of missense oligonucleotides on hypersensitization and the expression of Homer 1b/c. In the naïve rats, Homer 1b/c antisense oligonucleotides did not affect the mechanical and thermal responses or locomotor activity. CONCLUSIONS:These novel results demonstrate that Homer 1b/c in the spinal cord contributes to the maintenance of secondary hyperalgesia induced by CFA and suggest that Homer 1b/c may be a novel target for pain therapy.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Yao YX,Jiang Z,Zhao ZQ

doi

10.1213/ANE.0b013e31822c0b98

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

1501-8

issue

6

eissn

0003-2999

issn

1526-7598

pii

ANE.0b013e31822c0b98

journal_volume

113

pub_type

杂志文章
  • Ultrasound-guided peripheral nerve stimulator placement in two soldiers with acute battlefield neuropathic pain.

    abstract::Acute peripheral neuropathic pain after combat-related polytrauma is a common occurrence in the United States military that is often refractory to current drugs and regional anesthesia. Both spinal cord and peripheral nerve stimulation are successfully used for chronic neuropathic pain states, but are not reported for...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e318247f6b2

    authors: Kent M,Upp J,Spevak C,Shannon C,Buckenmaier C 3rd

    更新日期:2012-04-01 00:00:00

  • Recurring brachial plexus neuropathy in a diabetic patient after shoulder surgery and continuous interscalene block.

    abstract:IMPLICATIONS:The performance of regional blockade on a patient with a preexisting neurologic condition or a history of neurologic complications after regional anesthesia is controversial. We present a case of recurring brachial plexus neuropathy in a diabetic patient after two shoulder procedures performed 4 mo apart. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200009000-00035

    authors: Horlocker TT,O'Driscoll SW,Dinapoli RP

    更新日期:2000-09-01 00:00:00

  • The carbon dioxide absorption capacity of Amsorb is half that of soda lime.

    abstract:UNLABELLED:A new CO(2) absorbent, Amsorb (A), which does not contain monovalent bases, is ideal because it does not degrade volatile anesthetics to either Compound A (from sevoflurane) or carbon monoxide (from desflurane, enflurane, or isoflurane). The CO(2) absorption capacity of A, however, has not been investigated ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200107000-00044

    authors: Higuchi H,Adachi Y,Arimura S,Kanno M,Satoh T

    更新日期:2001-07-01 00:00:00

  • Hydroxyethyl starch: the effect of molecular weight and degree of substitution on intravascular retention in vivo.

    abstract:BACKGROUND:Hydroxyethyl starch (HES) solution is characterized by its mean molecular weight (MW), concentration, and degree of substitution (DS). This character varies worldwide. METHODS:After binding fluorescein-isothiocyanate (FITC-HES), we evaluated the retention rate of three types of 6% HES in the A2 and V2 blood...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000275198.84094.ad

    authors: Hitosugi T,Saito T,Suzuki S,Kubota I,Shoda E,Shimizu T,Oi Y

    更新日期:2007-09-01 00:00:00

  • The evolution of perioperative transfusion testing and blood ordering.

    abstract::The evolution of modern anesthesia and surgical practices has been accompanied by enhanced supportive procedures in blood banking and transfusion medicine. There is increased focus on the preparation and the use of blood components including, but not limited to, preventing unnecessary type and screen/crossmatch orders...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000000619

    authors: White MJ,Hazard SW 3rd,Frank SM,Boyd JS,Wick EC,Ness PM,Tobian AA

    更新日期:2015-06-01 00:00:00

  • Continuous infraclavicular perineural infusion with clonidine and ropivacaine compared with ropivacaine alone: a randomized, double-blinded, controlled study.

    abstract::Although clonidine has been shown to increase the duration of local anesthetic action and prolong postoperative analgesia when included in single-injection nerve blocks, a controlled investigation of the efficacy of this practice to improve analgesia for continuous perineural local anesthetic infusion has not been rep...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ane.0000075840.52964.a7

    authors: Ilfeld BM,Morey TE,Enneking FK

    更新日期:2003-09-01 00:00:00

  • The time-dependent effects of midazolam on regional cerebral glucose metabolism in rats.

    abstract:BACKGROUND:Midazolam has hypnotic and sedative activities, which may be mediated by different neuronal structures. We investigated the time course effect of a hypnotic dose of midazolam on conscious motor behavior and on patterns of brain metabolism. METHODS:Loss of nociceptive reflexes and impairment of spontaneous l...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e31816a64a8

    authors: Freo U,Dam M,Ori C

    更新日期:2008-05-01 00:00:00

  • The reliability of the current perception threshold in volunteers and its applicability in a clinical setting.

    abstract:BACKGROUND:Even though current perception threshold (CPT) has been used for evaluating the effectiveness of sensory block in patients before surgery, its reliability under controlled conditions has not been investigated. Two independent investigations were performed. The primary objective of the first study was to dete...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1213/ANE.0000000000000575

    authors: Gaudreault F,Drolet P,Fallaha M,Varin F

    更新日期:2015-03-01 00:00:00

  • Catheter-associated masses in patients receiving intrathecal analgesic therapy.

    abstract:UNLABELLED:A cohort of seven patients receiving intrathecal analgesic drug therapy for chronic intractable pain underwent radiocontrast myelography and computed tomography (CT) scanning to screen for catheter-associated intrathecal masses. Three of seven patients examined had intraspinal masses associated with the tip ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200301000-00039

    authors: McMillan MR,Doud T,Nugent W

    更新日期:2003-01-01 00:00:00

  • The reliability of the Bellhouse test for evaluating extension capacity of the occipitoatlantoaxial complex.

    abstract:UNLABELLED:We examined the reliability of an airway evaluation test to assess the occipitoatlantoaxial (OAA) extension capacity described by Bellhouse et al. (Bellhouse test) in 20 adult volunteers with normal cervical spines. Each subject sat upright with the head in the neutral position and was then asked to extend t...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-200211000-00062

    authors: Urakami Y,Takenaka I,Nakamura M,Fukuyama H,Aoyama K,Kadoya T

    更新日期:2002-11-01 00:00:00

  • A randomized, double-blinded study of remifentanil versus fentanyl for tonsillectomy and adenoidectomy surgery in pediatric ambulatory surgical patients.

    abstract:UNLABELLED:We compared, in a double-blinded manner, the anesthetic maintenance and recovery properties of remifentanil with a clinically comparable fentanyl-based anesthetic technique in pediatric ambulatory surgical patients. Anesthesia was induced with either halothane or sevoflurane and nitrous oxide and oxygen. Pat...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00000539-200004000-00017

    authors: Davis PJ,Finkel JC,Orr RJ,Fazi L,Mulroy JJ,Woelfel SK,Hannallah RS,Lynn AM,Kurth CD,Moro M,Henson LG,Goodman DK,Decker MD

    更新日期:2000-04-01 00:00:00

  • Topical lidocaine-prilocaine cream (EMLA) versus local infiltration anesthesia for radial artery cannulation.

    abstract:UNLABELLED:In a randomized trial, we compared topical anesthesia by a lidocaine-prilocaine cream (EMLA; Laboratorie ASTRA, Manterre, France) with subcutaneous local lidocaine infiltration for radial artery cannulation. Patients included 538 adults scheduled for coronary angiography using a radial approach. EMLA was app...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199808000-00032

    authors: Joly LM,Spaulding C,Monchi M,Ali OS,Weber S,Benhamou D

    更新日期:1998-08-01 00:00:00

  • Central administration of minocycline and riluzole prevents morphine-induced tolerance in rats.

    abstract:BACKGROUND:Long-term exposure to opiates induces tolerance to the analgesic effect. The neurobiological mechanism of this phenomenon is not completely clear. In this study, we evaluated the effects of central administration of minocycline (a tetracycline derivative) and riluzole (an antiglutamatergic drug) on morphine-...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e3181ae5f13

    authors: Habibi-Asl B,Hassanzadeh K,Charkhpour M

    更新日期:2009-09-01 00:00:00

  • Comparison of resuscitation of sheep and dogs after bupivacaine-induced cardiovascular collapse.

    abstract::This study evaluated interspecies sensitivity and ability to resuscitate pentobarbital anesthetized sheep and dogs after cardiovascular toxic doses of bupivacaine. Every minute, 3 mg/kg of bupivacaine was injected into the right atrium over the course of 10 sec until cardiovascular collapse occurred. While the bupivac...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Kasten GW,Martin ST

    更新日期:1986-10-01 00:00:00

  • The effects of glycopyrrolate on oral mucous host defenses in healthy volunteers.

    abstract:UNLABELLED:We studied the effects of glycopyrrolate on oral mucous host defenses. Single IV doses of glycopyrrolate (4 microg/kg) or placebo were administered to 12 healthy volunteers in a randomized, double-blinded, cross-over study. Salivary flow rates and the concentrations/activities of total protein, amylase, and ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200008000-00045

    authors: Lähteenmäki MT,Salo MS,Tenovuo JO,Helminen AV,Vilja PJ,Huupponen RK

    更新日期:2000-08-01 00:00:00

  • Ipsilateral shoulder pain after thoracotomy with epidural analgesia: the influence of phrenic nerve infiltration with lidocaine.

    abstract:UNLABELLED:Patients receiving effective thoracic epidural analgesia for postthoracotomy pain may still complain of severe ipsilateral shoulder pain. The etiology of this pain is unclear. In this randomized, double-blinded, placebo-controlled study, we investigated the effect of phrenic nerve infiltration with lidocaine...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200108000-00004

    authors: Scawn ND,Pennefather SH,Soorae A,Wang JY,Russell GN

    更新日期:2001-08-01 00:00:00

  • Safety and Efficacy of Volatile Anesthetic Agents Compared With Standard Intravenous Midazolam/Propofol Sedation in Ventilated Critical Care Patients: A Meta-analysis and Systematic Review of Prospective Trials.

    abstract:BACKGROUND:Inhalation agents are being used in place of intravenous agents to provide sedation in some intensive care units. We performed a systematic review and meta-analysis of prospective randomized controlled trials, which compared the use of volatile agents versus intravenous midazolam or propofol in critical care...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1213/ANE.0000000000001634

    authors: Jerath A,Panckhurst J,Parotto M,Lightfoot N,Wasowicz M,Ferguson ND,Steel A,Beattie WS

    更新日期:2017-04-01 00:00:00

  • Right Ventricular Longitudinal Strain Is Depressed in a Bovine Model of Pulmonary Hypertension.

    abstract:BACKGROUND:Pulmonary hypertension and resulting right ventricular (RV) dysfunction are associated with significant perioperative morbidity and mortality. Although echocardiography permits real-time, noninvasive assessment of RV function, objective and comparative measures are underdeveloped, and appropriate animal mode...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000001215

    authors: Bartels K,Brown RD,Fox DL,Bull TM,Neary JM,Dorosz JL,Fonseca BM,Stenmark KR

    更新日期:2016-05-01 00:00:00

  • Pneumothorax during laparoscopic fundoplication: diagnosis and treatment with positive end-expiratory pressure.

    abstract::Pneumothorax can develop during laparoscopy, particularly during laparoscopic fundoplication, since the left parietal pleura is exposed and can be torn during dissection in the diaphragmatic hiatus. Such an event will result in specific pathophysiologic changes, since CO2, under pressure in the abdominal cavity, will ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199511000-00017

    authors: Joris JL,Chiche JD,Lamy ML

    更新日期:1995-11-01 00:00:00

  • Bupivacaine and other amide local anesthetics inhibit the hydrolysis of chloroprocaine by human serum.

    abstract::The rate of hydrolysis of chloroprocaine by human serum was studied in the presence and absence of a number of aminde local anesthetics and their metabolites. Bupivacaine (2.4 microgram/ml) and etidocaine (2.3 microgram/ml) caused 38% and 21% inhibition respectively of the rate of chloroprocaine hydrolysis. Circulatin...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197809000-00004

    authors: Lalka D,Vicuna N,Burrow SR,Jones DJ,Ludden TM,Haegele KD,McNay JL

    更新日期:1978-09-01 00:00:00

  • Educating Patients Regarding Pain Management and Safe Opioid Use After Surgery: A Narrative Review.

    abstract::In recent years, there have been escalating concerns related to the opioid epidemic. With a steadily increasing opioid supply, it is critical to provide proper education to patients who are prescribed these medications. Education should be emphasized as a means of ensuring safe use and potentially as a strategy for cu...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000004436

    authors: Lee BH,Wu CL

    更新日期:2020-03-01 00:00:00

  • Global end-diastolic volume during different loading conditions in a pediatric animal model.

    abstract:BACKGROUND:Estimating volume status in infants and neonates is challenging. Global end-diastolic volume (GEDV) and dynamic variables of preload, such as pulse pressure variation (PPV), may be alternative variables for estimating cardiac preload and fluid responsiveness. Therefore, we designed the present study to evalu...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000281152.72734.d0

    authors: Renner J,Meybohm P,Gruenewald M,Steinfath M,Scholz J,Boening A,Bein B

    更新日期:2007-11-01 00:00:00

  • Supplemental intravenous crystalloid administration does not reduce the risk of surgical wound infection.

    abstract::Wound perfusion and oxygenation are important determinants of the development of postoperative wound infections. Supplemental fluid administration significantly increases tissue oxygenation in surrogate wounds in the subcutaneous tissue of the upper arm in perioperative surgical patients. We tested the hypothesis that...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ANE.0000180217.57952.FE

    authors: Kabon B,Akça O,Taguchi A,Nagele A,Jebadurai R,Arkilic CF,Sharma N,Ahluwalia A,Galandiuk S,Fleshman J,Sessler DI,Kurz A

    更新日期:2005-11-01 00:00:00

  • Efficacy of high-frequency jet ventilation in cardiac tamponade.

    abstract::To evaluate the effects of high-frequency jet ventilation (HFJV) (f = 60, 120 breaths/min) and conventional mechanical ventilation (CMV) (f = 10, 20) during equivalent conditions of cardiac tamponade, stroke index (SI), intrapericardial pressure (IPP), airway pressure (P(aw)), and cardiac pressures were measured in an...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199004000-00006

    authors: Goto K,Goto H,Benson KT,Unruh GK,Arakawa K

    更新日期:1990-04-01 00:00:00

  • The pain visual analog scale: is it linear or nonlinear?

    abstract:UNLABELLED:The visual analog scale (VAS) is a tool widely used to measure pain, yet controversy surrounds whether the VAS score is ratio or ordinal data. We studied 52 postoperative patients and measured their pain intensity using the VAS. We then asked them to consider different amounts of pain (conceptually twice as ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-199912000-00038

    authors: Myles PS,Troedel S,Boquest M,Reeves M

    更新日期:1999-12-01 00:00:00

  • R(+)-, Rac-, and S(-)-bupivacaine stereostructure-specifically interact with membrane lipids at cardiotoxically relevant concentrations.

    abstract::It remains questionable whether local anesthetics can interact with membrane lipids at clinically relevant concentrations to show the difference between enantiomers. We compared the effects of bupivacaine stereoisomers on biomimetic membranes containing cardiolipin and cholesterol. Bupivacaine interacted with the memb...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e31823ed410

    authors: Tsuchiya H,Mizogami M

    更新日期:2012-02-01 00:00:00

  • A comparison of the antinociceptive and behavioral effects of intrathecally administered opiates, alpha-2-adrenergic agonists, and local anesthetics in mice and rats.

    abstract::This study was undertaken to compare the antinociceptive and behavioral effects of intrathecally administered opiates, alpha-2-adrenergic agonists, and local anesthetics injected by lumbar puncture in the mouse and rat. Antinociception was determined by observing the response to a clamp applied to the tail (Haffner te...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Ossipov MH,Suarez LJ,Spaulding TC

    更新日期:1988-07-01 00:00:00

  • Bunegin-Albin catheter improves air retrieval and resuscitation from lethal venous air embolism in upright dogs.

    abstract::Three types of catheters, the Arrow multi-orifice catheter, the American Edwards 7 Fr Swan-Ganz catheter and the Cook Bunegin-Albin multi-orifice CVP catheter were evaluated for their ability to retrieve venous air emboli and effect on the success rate of resuscitation from venous air emboli. The catheters were insert...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Colley PS,Artru AA

    更新日期:1989-03-01 00:00:00

  • Recovery of the swallowing reflex after propofol anesthesia.

    abstract::The swallowing reflex is depressed by anesthetics. During recovery from anesthesia the rapid return of laryngeal and upper airway reflexes is important to protect the lower airway from aspiration. This study measures the recovery of the swallowing reflex after propofol anesthesia. Fifteen patients undergoing a colonos...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199411000-00007

    authors: Rimaniol JM,D'Honneur G,Duvaldestin P

    更新日期:1994-11-01 00:00:00

  • Total knee arthroplasty as an overnight-stay procedure using continuous femoral nerve blocks at home: a prospective feasibility study.

    abstract::The average duration of hospitalization after total knee arthroplasty (TKA) in the United States is 4-5 days. In this two-phase study we investigated the feasibility of converting TKA into an overnight-stay procedure using a continuous femoral nerve block provided at home through postoperative day 4. Nine of 10 patien...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000189562.86969.9f

    authors: Ilfeld BM,Gearen PF,Enneking FK,Berry LF,Spadoni EH,George SZ,Vandenborne K

    更新日期:2006-01-01 00:00:00