Knockdown of synaptic scaffolding protein Homer 1b/c attenuates secondary hyperalgesia induced by complete Freund's adjuvant in rats.

abstract：BACKGROUND:Capsaicin, the active component of chili peppers, can produce sensory-selective peripheral nerve blockade. Coadministration of capsaicin and tetrodotoxin, a site-1 sodium channel blocker, can achieve a synergistic effect on duration of nerve blocks. However, capsaicin can be neurotoxic, and tetrodotoxin can ...

journal_title：Anesthesia and analgesia

authors： Shomorony A,Santamaria CM,Zhao C,Rwei AY,Mehta M,Zurakowski D,Kohane DS

更新日期：2019-09-01 00:00:00

abstract：:Colloids and crystalloids are usually administered as treatment for hypovolemia in severely injured patients. However, dilution of clotting factors and platelets together with impaired fibrinogen polymerization are associated with fluid therapy and may aggravate hemorrhage, thus worsening final outcome of these patien...

journal_title：Anesthesia and analgesia

authors： Fries D,Innerhofer P,Reif C,Streif W,Klingler A,Schobersberger W,Velik-Salchner C,Friesenecker B

更新日期：2006-02-01 00:00:00

abstract：UNLABELLED:We compared the effects of oral clonidine (4 microg/kg) and midazolam (0.5 mg/kg) on the preanesthetic sedation and postoperative recovery profile in children during tonsillectomy with or without adenoidectomy. In a double-blinded, double-dummy study design, 134 ASA physical status I-II children aged 4-12 yr...

journal_title：Anesthesia and analgesia

authors： Fazi L,Jantzen EC,Rose JB,Kurth CD,Watcha MF

更新日期：2001-01-01 00:00:00

abstract：:Our goal in this study was to develop a robotic intubation system and to conduct a feasibility pilot study on the use of a robotic intubation system for endotracheal intubations. The Kepler Intubation System was developed, consisting of a remote control center (joystick and intubation cockpit) linked to a standard vid...

journal_title：Anesthesia and analgesia

authors： Hemmerling TM,Wehbe M,Zaouter C,Taddei R,Morse J

更新日期：2012-03-01 00:00:00

abstract：:It is not uncommon to observe prolonged CNS depression for several hours following controlled hypotension and halothane anesthesia for neurosurgery. The present study evaluates possible contribution of large doses of trimethaphan to CNS depression. Four adult sheep were placed on transapical left ventricular bypass (T...

journal_title：Anesthesia and analgesia

authors： Wong KC,Peters JL,Roberts TS,McRea JC,Fukumasu H

更新日期：1977-01-01 00:00:00

abstract：INTRODUCTION:Decompression illness (DCI) is caused by bubble formation in the blood or tissues after a reduction in ambient pressure. Clinically, DCI may range from a trivial illness to paralysis, loss of consciousness, cardiovascular collapse, and death. Recompression is the universally accepted standard for the treat...

journal_title：Anesthesia and analgesia

authors： Bennett MH,Lehm JP,Mitchell SJ,Wasiak J

更新日期：2010-09-01 00:00:00

abstract：:This study evaluates the changes of oxygen saturation (SpO2) after intravenous administration of methylene blue in 103 patients undergoing open repair of thoracoabdominal aortic aneurysms. We found that SpO2 decreased by a median (interquartile range [IQR]) of 49% (37%-81%) <1 minute after methylene blue administratio...

journal_title：Anesthesia and analgesia

authors： Rong LQ,Mauer E,Mustapich TL,White RS,Di Franco A,Girardi LN,Gaudino M,Pryor KO

更新日期：2019-11-01 00:00:00

abstract：IMPLICATIONS:Chronic hiccups may be a serious therapeutic problem. Pharmacological treatment with increasing dosages of baclofen, carbamazepine, or gabapentin is not always successful. In this paper, the use of general anesthesia with positive-pressure ventilation and muscle relaxation for the termination of chronic hi...

journal_title：Anesthesia and analgesia

authors： Lierz P,Felleiter P

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:N-methyl-D-aspartate receptor (NMDARs)-dependent central sensitization plays an important role in cancer pain. Binding of NMDAR subunit 2B (NR2B) by postsynaptic density protein-95 (PSD-95) can couple NMDAR activity to intracellular enzymes, such as neuronal nitric oxide synthase (nNOS), facilitate downstrea...

journal_title：Anesthesia and analgesia

authors： Liu Y,Cui X,Sun YE,Yang X,Ni K,Zhou Y,Ma Z,Gu X

更新日期：2014-06-01 00:00:00

abstract：UNLABELLED:The National Institute for Occupational Safety and Health-recommended exposure levels for nitrous oxide exposure are 25 ppm as a time-weighted average over the time of exposure. The exposure limit for halogenated anesthetics (without concomitant nitrous oxide exposure) is 2 ppm. Inhaled sevoflurane provides ...

journal_title：Anesthesia and analgesia

authors： Hoerauf KH,Wallner T,Akça O,Taslimi R,Sessler DI

更新日期：1999-04-01 00:00:00

abstract：:The common treatment for postoperative pain is prescription opioids. Yet, these drugs have limited effect in preventing chronic pain from surgical intervention and have in part contributed to the opioid epidemic. Recently, preemptive analgesia and multimodal analgesia have been proposed with widely gained acceptance i...

journal_title：Anesthesia and analgesia

authors： Horn A,Kaneshiro K,Tsui BCH

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle calcium regulation associated primarily, but not exclusively, with mutations in the skeletal muscle ryanodine receptor. Associated environmental factors, however, may also be important for expression of the syndrome. METHODS AND RE...

journal_title：Anesthesia and analgesia

authors： Capacchione JF,Radimer MC,Sagel JS,Kraus GP,Sambuughin N,Muldoon SM

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Recently, we reported a new technique to augment motor-evoked potentials (MEPs) under general anesthesia, posttetanic MEP (p-MEP), in which tetanic stimulation of the peripheral nerve before transcranial stimulation enlarged amplitudes of MEPs from the muscle innervated by the nerve subjected to tetanic stim...

journal_title：Anesthesia and analgesia

authors： Hayashi H,Kawaguchi M,Yamamoto Y,Inoue S,Koizumi M,Ueda Y,Takakura Y,Furuya H

更新日期：2008-07-01 00:00:00

abstract：UNLABELLED:IV droperidol inhibits epidural morphine-induced pruritus, but this effect disappears when the dose is increased from 2.5 to 5.0 mg. This study was performed to determine whether epidural droperidol would have a similar effect. In this double-blinded study, we enrolled 140 patients undergoing Cesarean delive...

journal_title：Anesthesia and analgesia

authors： Horta ML,Ramos L,Gonçalves ZR

更新日期：2000-03-01 00:00:00

abstract：:The pharmacokinetics of lidocaine were studied in nonpregnant and pregnant ewes. The maternal femoral vessels were cannulated and, on the day of study, the urinary bladder was catheterized. Lidocaine HCl, 4-5 mg/kg, was administered by IV injection over 60 seconds. Serial samples of arterial blood and urine were colle...

journal_title：Anesthesia and analgesia

authors： Santos AC,Pedersen H,Morishima HO,Finster M,Arthur GR,Covino BG

更新日期：1988-12-01 00:00:00

abstract：UNLABELLED:We present the case of a 57-yr-old patient who suffered an unexplained cerebrovascular event 3 days after being struck by a motor vehicle. Workup demonstrated a previously unknown patient foramen ovale. The etiologies of paradoxical embolism in trauma are discussed. IMPLICATIONS:Paradoxical embolism after m...

journal_title：Anesthesia and analgesia

authors： Price MD,Kanake P,Talmor D

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:The infusion of local anesthetic in the surgical wound is helpful in the multimodal management of postoperative pain. We hypothesized that local anesthetic wound infusion after cesarean delivery would provide better pain control than epidural morphine analgesia. METHODS:Healthy, term women scheduled for ele...

journal_title：Anesthesia and analgesia

authors： O'Neill P,Duarte F,Ribeiro I,Centeno MJ,Moreira J

更新日期：2012-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the effects of preemptive and postlesion sympathectomy in the sciatic cryoneurolysis (SCN) model of neuropathic pain in rats. SCN in rats produces a prolonged significant mechanical allodynia (hypersensitivity to previously non-noxious mechanical stimuli) with no thermal hyper...

journal_title：Anesthesia and analgesia

authors： Willenbring S,Beauprie IG,DeLeo JA

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Neonates undergoing cardiac surgery are especially prone to the hemostatic alterations of cardiopulmonary bypass (CPB) and are at high risk for post-CPB bleeding. An immature coagulation system, significant hemodilution from the CPB prime, long CPB times at low temperatures, and extensive suture lines increa...

journal_title：Anesthesia and analgesia

authors： Guzzetta NA,Allen NN,Wilson EC,Foster GS,Ehrlich AC,Miller BE

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Tissue damage associated with surgery often produces peripheral and central sensitization that may outlast the stimuli, leading to exaggerated postoperative pain. Paradoxically, the use of opioid analgesia, which is essential for surgical pain management may induce pain sensitization leading to enhanced post...

journal_title：Anesthesia and analgesia

authors： Laboureyras E,Chateauraynaud J,Richebé P,Simonnet G

更新日期：2009-08-01 00:00:00

abstract：:The low solubility of desflurane contributes to rapid emergence after outpatient anesthesia. Compared with isoflurane, recovery times to eye opening, response to verbal commands, and orientation to person, place, and time have been significantly shorter. Even when compared with the rapid, short-acting intravenous anes...

journal_title：Anesthesia and analgesia

authors： White PF

更新日期：1992-10-01 00:00:00

abstract：:Cardioprotection by anesthetic preconditioning (APC) can be abolished by nitric oxide (NO*) synthase inhibitors or by reactive oxygen species (ROS) scavengers. We previously reported attenuated mitochondrial electron transport (ET) and increased ROS generation during preconditioning sevoflurane exposure as part of the...

journal_title：Anesthesia and analgesia

authors： Riess ML,Kevin LG,McCormick J,Jiang MT,Rhodes SS,Stowe DF

更新日期：2005-01-01 00:00:00

abstract：:Adverse reactions to volatile anesthetics and depolarizing muscle relaxants can occur in patients with Duchenne muscular dystrophy (DMD) resulting in acute rhabdomyolysis and hyperkalemia. We report a case of hyperkalemic cardiac arrest after cardiac surgery using cardiopulmonary bypass in a child with unsuspected DMD...

journal_title：Anesthesia and analgesia

authors： Nathan A,Ganesh A,Godinez RI,Nicolson SC,Greeley WJ

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Operating rooms contribute significantly to the increasing volumes and costs of hospital waste. Little is known, however, about doctors' views of hospital waste recycling despite their potential influence in improving recycling programs. We surveyed the waste recycling views held by anesthesiologists in Aust...

journal_title：Anesthesia and analgesia

authors： McGain F,White S,Mossenson S,Kayak E,Story D

更新日期：2012-05-01 00:00:00

abstract：:We compared the systemic toxicity of bupivacaine, levobupivacaine, and ropivacaine in anesthetized rats. We also compared the ability to resuscitate rats after lethal doses of these local anesthetics. Bupivacaine, levobupivacaine, or ropivacaine was infused at a rate of 2 mg. kg(-1). min(-1) while electrocardiogram, e...

journal_title：Anesthesia and analgesia

authors： Ohmura S,Kawada M,Ohta T,Yamamoto K,Kobayashi T

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Previous studies demonstrated that MAC (the minimum alveolar concentration of an inhaled anesthetic that produces immobility in 50% of subjects exposed to noxious stimulation) for halothane directly correlates with the central nervous system concentration of Na+. However, those studies globally altered Na+ c...

journal_title：Anesthesia and analgesia

authors： Laster MJ,Zhang Y,Eger EI 2nd,Shnayderman D,Sonner JM

更新日期：2007-09-01 00:00:00

abstract：:In the vasodilated and septic patient, the impedance method of measuring cardiac output (CO) may underestimate the true value. In this study, we sought to determine whether impedance CO (COIC) measurements are influenced by total peripheral resistance (TPR). In eight anesthetized and ventilated dogs, a high-precision ...

journal_title：Anesthesia and analgesia

authors： Critchley LA,Peng ZY,Fok BS,James AE

更新日期：2005-06-01 00:00:00

abstract：UNLABELLED:The sciatic nerve (SN) originates from the L4-S3 roots in the form of two nerve trunks: the tibial nerve (TN) and the common peroneal nerve (CPN). The TN and CPN are encompassed by a single epineural sheath and eventually separate (divide) in the popliteal fossa. This division of the SN occurs at a variable ...

journal_title：Anesthesia and analgesia

authors： Vloka JD,Hadzić A,April E,Thys DM

更新日期：2001-01-01 00:00:00

abstract：:The assessment of sympathetic denervation to the upper extremities during surgery for hyperhidrosis is essential in predicting postoperative outcome, particularly for endoscopic thoracic chain sympathotomy, a recently described, minimally destructive technique that minimizes postoperative compensatory hyperhidrosis. T...

journal_title：Anesthesia and analgesia

authors： Eisenach JH,Pike TL,Wick DE,Dietz NM,Fealey RD,Atkinson JL,Charkoudian N

更新日期：2005-01-01 00:00:00

abstract：:The insertion of implantable cardioverter/defibrillators (ICD) requires induction of repeated episodes of ventricular fibrillation (VF). The neuropsychological repercussions associated with repeated inducement of hypotension and cerebral ischemia are unknown. In this prospective clinical trial, 1 day prior to ICD asse...

journal_title：Anesthesia and analgesia

authors： Murkin JM,Baird DL,Martzke JS,Yee R

更新日期：1997-06-01 00:00:00