Supplemental intravenous crystalloid administration does not reduce the risk of surgical wound infection.

Abstract:

:Wound perfusion and oxygenation are important determinants of the development of postoperative wound infections. Supplemental fluid administration significantly increases tissue oxygenation in surrogate wounds in the subcutaneous tissue of the upper arm in perioperative surgical patients. We tested the hypothesis that supplemental fluid administration during and after elective colon resections decreases the incidence of postoperative wound infections. Patients undergoing open colon resection were randomly assigned to small-volume (n = 124, 8 mL.kg(-1).h(-1)) or large-volume (n = 129, 16-18 mL.kg(-1).h(-1)) fluid management. Our major outcomes were two distinct criteria for diagnosis of surgical wound infections: 1) purulent exudate combined with a culture positive for pathogenic bacteria, and 2) Center for Disease Control criteria for diagnosis of surgical wound infections. All wound infections diagnosed using either criterion by a blinded observer in the 15 days after surgery were considered in the analysis. Wound healing was evaluated with the ASEPSIS scoring system. Of the patients given small fluid administration, 14 had surgical wound infections; 11 given large fluid therapy had infections, P = 0.46. ASEPSIS wound-healing scores were similar in both groups: 7 +/- 16 (small volume) versus 8 +/- 14 (large volume), P = 0.70. Our results suggest that supplemental hydration in the range tested does not impact wound infection rate.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Kabon B,Akça O,Taguchi A,Nagele A,Jebadurai R,Arkilic CF,Sharma N,Ahluwalia A,Galandiuk S,Fleshman J,Sessler DI,Kurz A

doi

10.1213/01.ANE.0000180217.57952.FE

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

1546-53

issue

5

eissn

0003-2999

issn

1526-7598

pii

101/5/1546

journal_volume

101

pub_type

临床试验,杂志文章,随机对照试验
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    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

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  • The quality of randomized controlled trials in major anesthesiology journals.

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    doi:

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  • Effects of halothane on intraocular pressure in anesthetized children.

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    更新日期:1990-08-01 00:00:00

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    doi:

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    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

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    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 临床试验,杂志文章,随机对照试验

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    doi:

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    doi:10.1213/00000539-199303000-00022

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    doi:10.1097/00000539-199804000-00008

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