Joint hypothesis testing and gatekeeping procedures for studies with multiple endpoints.

abstract：:We studied 60 nonophthalmologic patients, allocated to six treatment groups, to assess the effects of atracurium and vecuronium on intraocular pressure (IOP). All patients had IOP measured while awake, using pneumotonometry. In group 1, anesthesia was induced with thiopental, 5 mg/kg, and maintained with N2O, 70% in O...

journal_title：Anesthesia and analgesia

authors： Schneider MJ,Stirt JA,Finholt DA

更新日期：1986-08-01 00:00:00

abstract：:Heart transplantation remains the definitive management for end-stage heart failure refractory to medical therapy. While heart transplantation cases are increasing annually worldwide, there remains a deficiency in organ availability with significant patient mortality while on the waiting list. Attempts have therefore ...

journal_title：Anesthesia and analgesia

authors： Beuth J,Falter F,Pinto Ribeiro RV,Badiwala M,Meineri M

更新日期：2019-03-01 00:00:00

abstract：:The hemodynamic effects of esmolol were studied in 40 patients scheduled for elective coronary artery surgery to determine whether the administration of esmolol in chronically beta-blocked patients would result in additional attenuation of sympathetically mediated hemodynamic stress responses to noxious stimuli. Patie...

journal_title：Anesthesia and analgesia

authors： de Bruijn NP,Croughwell N,Reves JG

更新日期：1987-02-01 00:00:00

abstract：UNLABELLED:The National Institute for Occupational Safety and Health-recommended exposure levels for nitrous oxide exposure are 25 ppm as a time-weighted average over the time of exposure. The exposure limit for halogenated anesthetics (without concomitant nitrous oxide exposure) is 2 ppm. Inhaled sevoflurane provides ...

journal_title：Anesthesia and analgesia

authors： Hoerauf KH,Wallner T,Akça O,Taslimi R,Sessler DI

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Statistical heterogeneity can increase the uncertainty of results and reduce the quality of evidence derived from systematic reviews. At present, it is uncertain what the major factors are that account for heterogeneity in meta-analyses of analgesic adjuncts. Therefore, the aim of this review was to identify...

journal_title：Anesthesia and analgesia

authors： Doleman B,Sutton AJ,Sherwin M,Lund JN,Williams JP

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:Exposure to isoflurane before and during early reperfusion protects against myocardial infarction by activating phosphatidylinositol-3-kinase (PI3K)-mediated signaling. The apoptotic protein, p53, is regulated by PI3K, and inhibition of p53 protects against ischemic injury. We tested the hypothesis that p5...

journal_title：Anesthesia and analgesia

authors： Venkatapuram S,Wang C,Krolikowski JG,Weihrauch D,Kersten JR,Warltier DC,Pratt PF Jr,Pagel PS

更新日期：2006-12-01 00:00:00

abstract：:Increased attention has been directed at the quality of randomized controlled trials (RCTs) and how they are being reported. We examined leading anesthesiology journals to identify if there were specific areas for improvement in the design and analysis of published clinical studies. All RCTs that appeared between Janu...

journal_title：Anesthesia and analgesia

authors： Greenfield ML,Rosenberg AL,O'Reilly M,Shanks AM,Sliwinski MJ,Nauss MD

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Cigarette smoking by surgical patients is associated with increased complications, particularly perioperative respiratory problems and poor wound healing. In this study, we sought to determine whether a pragmatic perioperative smoking cessation intervention designed for a busy preadmission clinic would be su...

journal_title：Anesthesia and analgesia

authors： Lee SM,Landry J,Jones PM,Buhrmann O,Morley-Forster P

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The Chinese health care system must meet the needs of 19% of the world's population. Despite recent economic growth, health care resources are unevenly distributed. This creates the potential for job stress and burnout. We therefore conducted a survey among anesthesiologists in the Beijing-Tianjin-Hebei regi...

journal_title：Anesthesia and analgesia

authors： Li H,Zuo M,Gelb AW,Zhang B,Zhao X,Yao D,Xia D,Huang Y

更新日期：2018-03-01 00:00:00

abstract：UNLABELLED:As medical costs continue to escalate, there is willingness to consider the role played by nontraditional factors in health. We investigated the usefulness of tape-recorded hypnosis instruction on perioperative outcome in surgical patients in a prospective, randomized, and partially blinded study. Sixty pati...

journal_title：Anesthesia and analgesia

authors： Ghoneim MM,Block RI,Sarasin DS,Davis CS,Marchman JN

更新日期：2000-01-01 00:00:00

abstract：UNLABELLED:We tested the hypothesis that an insulin infusion would effectively treat bupivacaine-induced cardiac depression in dogs. In 24 mongrel dogs anesthetized with pentobarbital (5 mgkg(-1)h(-1), IV), 0.5% bupivacaine was administrated at a rate of 0.5 mgkg(-1)min(-1) until the mixed venous oxygen saturation decr...

journal_title：Anesthesia and analgesia

authors： Cho HS,Lee JJ,Chung IS,Shin BS,Kim JA,Lee KH

更新日期：2000-11-01 00:00:00

abstract：:In recent years the off-label use of recombinant activated factor VII (rFVIIa) has markedly increased, particularly in pediatric cardiac surgery patients, and practitioners differ widely in their usage of the drug. In 2009, the Congenital Cardiac Anesthesia Society (CCAS) assembled a task force to review the literatur...

journal_title：Anesthesia and analgesia

authors： Guzzetta NA,Russell IA,Williams GD

更新日期：2012-08-01 00:00:00

abstract：:Either epidural analgesia or femoral nerve blockade improves analgesia and rehabilitation after total knee arthroplasty. No study has evaluated the combination of femoral nerve blockade and epidural analgesia. In this prospective, randomized, blinded study we investigated combining femoral nerve blockade with epidural...

journal_title：Anesthesia and analgesia

authors： YaDeau JT,Cahill JB,Zawadsky MW,Sharrock NE,Bottner F,Morelli CM,Kahn RL,Sculco TP

更新日期：2005-09-01 00:00:00

abstract：UNLABELLED:Propofol (Diprivan(TM); AstraZeneca, Wilmington, DE) is a commonly used drug for the induction of general anesthesia in the ambulatory setting. With the availability of a new bisulfite-containing generic formulation of propofol, questions have arisen regarding its cost effectiveness and safety compared with ...

journal_title：Anesthesia and analgesia

authors： Shao X,Li H,White PF,Klein KW,Kulstad C,Owens A

更新日期：2000-10-01 00:00:00

abstract：:This study investigated the use of propofol in swine genetically susceptible to malignant hyperthermia (MH). Thirteen animals were exposed to 2% halothane in inspired air, a propofol infusion of 12 mg.kg-1.hr-1 for up to 45 min, or a combination of both. When MH was triggered the animals were treated with dantrolene. ...

journal_title：Anesthesia and analgesia

authors： Raff M,Harrison GG

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:Prolonged continuous oxytocin administration during labor may induce oxytocin receptor desensitization, which attenuates the response of the myometrium to further oxytocin, increasing the risk of postpartum hemorrhage. The literature comparing pulsatile (intermittent) versus continuous oxytocin administratio...

journal_title：Anesthesia and analgesia

authors： Talati C,Carvalho JCA,Luca A,Balki M

更新日期：2019-04-01 00:00:00

abstract：:The respiratory variations in the plethysmographic (PLET) waveform of the pulse oximeter during mechanical ventilation can be automatically quantified as the PLET variation index (PVI(®)). Like other dynamic variables, the PVI may provide useful information about fluid responsiveness but only when the patient is recei...

journal_title：Anesthesia and analgesia

authors： Perel A

更新日期：2014-12-01 00:00:00

abstract：:There are quantitative deficiencies in the coagulation system for at least the first 6 mo of life. Clinical experience, however, does not indicate an increased risk of excessive bleeding during surgical procedures. Thrombelastography, a test providing a functional evaluation of coagulation, was used to assess the hemo...

journal_title：Anesthesia and analgesia

authors： Miller BE,Bailey JM,Mancuso TJ,Weinstein MS,Holbrook GW,Silvey EM,Tosone SR,Levy JH

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:We determined whether whole blood impedance aggregometry using the Multiplate detects the effects of antiplatelet drugs as reliably as does classical light transmission aggregometry (LTA) or the platelet function analyzer PFA-100(R). METHODS:Multiplate (M) assays, measuring changes in electrical resistance ...

journal_title：Anesthesia and analgesia

authors： Velik-Salchner C,Maier S,Innerhofer P,Streif W,Klingler A,Kolbitsch C,Fries D

更新日期：2008-12-01 00:00:00

abstract：:The swallowing reflex is depressed by anesthetics. During recovery from anesthesia the rapid return of laryngeal and upper airway reflexes is important to protect the lower airway from aspiration. This study measures the recovery of the swallowing reflex after propofol anesthesia. Fifteen patients undergoing a colonos...

journal_title：Anesthesia and analgesia

authors： Rimaniol JM,D'Honneur G,Duvaldestin P

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Although music is frequently used to promote a relaxing environment during labor and delivery, the effect of its use during the placement of neuraxial techniques is unknown. Our study sought to determine the effects of music use on laboring parturients during epidural catheter placement, with the hypothesis ...

journal_title：Anesthesia and analgesia

authors： Drzymalski DM,Tsen LC,Palanisamy A,Zhou J,Huang CC,Kodali BS

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Modulation of γ-aminobutyric acid type A receptors (GABAARs) by general anesthetics may contribute to their ability to produce amnesia. Receptors containing α5 subunits, which mediate tonic and slow synaptic inhibition, are co-localized with β3 and γ2 subunits in dendritic layers of the hippocampus and are s...

journal_title：Anesthesia and analgesia

authors： Burkat PM,Lor C,Perouansky M,Pearce RA

更新日期：2014-12-01 00:00:00

abstract：:Qualitative arterial waveform analysis has been in existence for millennia; quantitative arterial waveform analysis techniques, which can be traced back to Euler's work in the 18th century, have not been widely used by anesthesiologists and other clinicians. This is likely attributable, in part, to the widespread use ...

journal_title：Anesthesia and analgesia

authors： Thiele RH,Durieux ME

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:In this prospective study, we compared the relationship between propofol concentrations and bispectral index (BIS) in children versus young adults anesthetized with target-controlled infusion (TCI) of propofol. METHODS:Forty-five prepubertal subjects (children) and 45 postpubertal subjects (adults) were stu...

journal_title：Anesthesia and analgesia

authors： Rigouzzo A,Girault L,Louvet N,Servin F,De-Smet T,Piat V,Seeman R,Murat I,Constant I

更新日期：2008-04-01 00:00:00

abstract：:Intraocular pressure (IOP) measurements in children are usually performed under nitrous oxide and halothane anesthesia. We studied the effects of both time and end-tidal halothane concentration on IOP in 80 children (mean age +/- SD = 4.5 +/- 2.9 yr), to determine the most optimal time to make such measurements in ane...

journal_title：Anesthesia and analgesia

authors： Watcha MF,Chu FC,Stevens JL,Forestner JE

更新日期：1990-08-01 00:00:00

abstract：:Availability of physiologic monitoring equipment to ensure the safe administration of anesthesia is an expected standard in many parts of the world. Many hospitals in China may not have an adequate quantity and variety of anesthesia delivery and patient monitoring equipment to assure safe administration of anesthesia ...

journal_title：Anesthesia and analgesia

authors： Juan X,Xinqiao F,Shanglong Y,Yuguang H,Buwei Y,Shiying Y,Pengqian F,Hanqing Z

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Blood hemoglobin can be monitored continuously and noninvasively with a noninvasive spectrophotometric sensor (Masimo SpHb). The perfusion index (PI) of the finger is directly related to the clinical accuracy of SpHb. We evaluated those variables that influence PI without the influences of surgery and anesth...

journal_title：Anesthesia and analgesia

authors： Miller RD,Ward TA,McCulloch CE,Cohen NH

更新日期：2014-04-01 00:00:00

abstract：:Sevoflurane reduces autonomic neural control, which plays a significant role in cerebral autoregulation. Therefore, we hypothesized that sevoflurane influences cerebral autoregulation. We investigated the effects of sevoflurane on dynamic cerebral blood flow (CBF) autoregulation by using spectral and transfer function...

journal_title：Anesthesia and analgesia

authors： Ogawa Y,Iwasaki K,Shibata S,Kato J,Ogawa S,Oi Y

更新日期：2006-02-01 00:00:00

abstract：UNLABELLED:Previous studies of samples from cranial meninges have created doubts about the existence of a virtual subdural space. We examined the ultrastructure of spinal meninges from three human cadavers immediately after death to see whether there is a virtual subdural space at this level. The arachnoid mater had tw...

journal_title：Anesthesia and analgesia

authors： Reina MA,De Leon Casasola O,López A,De Andrés JA,Mora M,Fernández A

更新日期：2002-04-01 00:00:00

abstract：:Both epidural and general anesthetics alter autonomic balance. However, the relative differences between epidural (EA) and general anesthetics (GA) with regard to cardiac and peripheral sympathovagal balance have not been described. Twenty consecutive patients scheduled for radical retropubic prostatectomy were random...

journal_title：Anesthesia and analgesia

authors： Fleisher LA,Frank SM,Shir Y,Estafanous M,Kelly S,Raja SN

更新日期：1994-07-01 00:00:00