The screening of propofol in MHS swine.

Abstract:

:This study investigated the use of propofol in swine genetically susceptible to malignant hyperthermia (MH). Thirteen animals were exposed to 2% halothane in inspired air, a propofol infusion of 12 mg.kg-1.hr-1 for up to 45 min, or a combination of both. When MH was triggered the animals were treated with dantrolene. Mean onset time of malignant hyperthermia on exposure to halothane alone was 7.2 min +/- 3.0 min and onset with propofol and halothane was 5.0 +/- 2.5 min. In no instance did propofol alone trigger the syndrome nor was there a statistical difference (P less than 0.05) in onset time when the drug was used in conjunction with halothane. On the basis of these results, we conclude that propofol is almost certainly safe for use in humans who are susceptible to MH.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Raff M,Harrison GG

subject

Has Abstract

pub_date

1989-06-01 00:00:00

pages

750-1

issue

6

eissn

0003-2999

issn

1526-7598

journal_volume

68

pub_type

杂志文章
  • A characterization of motion affecting pulse oximetry in 350 patients.

    abstract::As part of an oximetry research effort in which plethysmographic data were collected from moving patients, a wide variety of patient motion affecting pulse oximetry was observed and characterized by the clinical incidence, type, severity and duration of patient motion. 350 patients were observed for movement in clinic...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Tobin RM,Pologe JA,Batchelder PB

    更新日期:2002-01-01 00:00:00

  • Prolonged Duration Local Anesthesia by Combined Delivery of Capsaicin- and Tetrodotoxin-Loaded Liposomes.

    abstract:BACKGROUND:Capsaicin, the active component of chili peppers, can produce sensory-selective peripheral nerve blockade. Coadministration of capsaicin and tetrodotoxin, a site-1 sodium channel blocker, can achieve a synergistic effect on duration of nerve blocks. However, capsaicin can be neurotoxic, and tetrodotoxin can ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000004108

    authors: Shomorony A,Santamaria CM,Zhao C,Rwei AY,Mehta M,Zurakowski D,Kohane DS

    更新日期:2019-09-01 00:00:00

  • Comparison of lidocaine and bupivacaine depression of sinoatrial nodal activity during hypoxia and acidosis in adult and neonatal guinea pigs.

    abstract::High blood concentrations of local anesthetics are cardiotoxic. The aim of this study was to compare the effects of lidocaine and bupivacaine on the intrinsic pacemaker activity of in vitro sinoatrial nodal cells of the adult and neonatal guinea pig in the presence and absence of hypoxia and acidosis. Fifteen pairs of...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Bosnjak ZJ,Stowe DF,Kampine JP

    更新日期:1986-09-01 00:00:00

  • Novel small molecule α9α10 nicotinic receptor antagonist prevents and reverses chemotherapy-evoked neuropathic pain in rats.

    abstract:BACKGROUND:Peripheral neuropathy is a common dose-limiting side effect of chemotherapy. There are no clinically proven analgesics for the treatment of this condition. Drugs from different classes have been tested with mixed results. Identification of novel molecular targets for analgesic(s) is important. Antagonism of ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e31825a3c72

    authors: Wala EP,Crooks PA,McIntosh JM,Holtman JR Jr

    更新日期:2012-09-01 00:00:00

  • A prospective, randomized, controlled trial comparing ultrasound versus nerve stimulator guidance for interscalene block for ambulatory shoulder surgery for postoperative neurological symptoms.

    abstract:BACKGROUND:Visualization with ultrasound during regional anesthesia may reduce the risk of intraneural injection and subsequent neurological symptoms but has not been formally assessed. Thus, we performed this randomized clinical trial comparing ultrasound versus nerve stimulator-guided interscalene blocks for shoulder...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ane.0b013e3181a3272c

    authors: Liu SS,Zayas VM,Gordon MA,Beathe JC,Maalouf DB,Paroli L,Liguori GA,Ortiz J,Buschiazzo V,Ngeow J,Shetty T,Ya Deau JT

    更新日期:2009-07-01 00:00:00

  • Significance, Errors, Power, and Sample Size: The Blocking and Tackling of Statistics.

    abstract::Inferential statistics relies heavily on the central limit theorem and the related law of large numbers. According to the central limit theorem, regardless of the distribution of the source population, a sample estimate of that population will have a normal distribution, but only if the sample is large enough. The rel...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000002741

    authors: Mascha EJ,Vetter TR

    更新日期:2018-02-01 00:00:00

  • The influence of prone positioning on the accuracy of calibrated and uncalibrated pulse contour-derived cardiac index measurements.

    abstract:BACKGROUND:Patients with lung failure who undergo prone positioning often receive extended hemodynamic monitoring. We investigated the influence of modified prone positioning (135°) on the accuracy of pulse contour-derived calibrated cardiac index (CIPC) and uncalibrated cardiac index (CIVIG) in this patient population...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e31827fe77e

    authors: Grensemann J,Bruecken U,Treszl A,Wappler F,Sakka SG

    更新日期:2013-04-01 00:00:00

  • Chemical dependency treatment outcomes of residents in anesthesiology: results of a survey.

    abstract::Substance abuse is a potentially lethal occupational hazard confronting anesthesiology residents. We present the results of a survey sent to all United States anesthesiology training programs regarding experience with and outcomes of chemically dependent residents from 1991 to 2001. The response rate was 66%. Eighty p...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000180837.78169.04

    authors: Collins GB,McAllister MS,Jensen M,Gooden TA

    更新日期:2005-11-01 00:00:00

  • Blood pressure, not cardiac output, determines blood loss during induced hypotension.

    abstract::Cardiac output characteristically decreases during trimethaphan infusion but is well maintained or increased during sodium nitroprusside infusion. We postulated that at similar levels of mean arterial pressure, sodium nitroprusside might be associated with greater blood loss than trimethaphan due to the increase in ca...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Sivarajan M,Amory DW,Everett GB,Buffington C

    更新日期:1980-03-01 00:00:00

  • Effects of adenosine-induced hypotension on myocardial hemodynamics and metabolism during cerebral aneurysm surgery.

    abstract::The effects of adenosine-induced hypotension on central as well as myocardial hemodynamics and metabolism were studied in five neurolept-anesthetized patients without known heart or lung diseases, who were undergoing cerebral aneurysm surgery. Adenosine (217 +/- 32 micrograms.kg-1.min-1) decreased mean arterial pressu...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Owall A,Lagerkranser M,Sollevi A

    更新日期:1988-03-01 00:00:00

  • Factors associated with unanticipated day of surgery deaths in Department of Veterans Affairs hospitals.

    abstract:BACKGROUND:Patients of ASA physical status 1, 2, and 3 undergoing elective surgery do not have underlying conditions that are a constant threat to life, and hence should not be expected to be at significant risk for death on the day of surgery. METHODS:We analyzed 815,077 ASA physical status 1, 2, and 3 elective surge...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e31818af8f3

    authors: Bishop MJ,Souders JE,Peterson CM,Henderson WG,Domino KB

    更新日期:2008-12-01 00:00:00

  • Inhibition of postoperative pain by continuous low-dose intravenous infusion of lidocaine.

    abstract::Intravenous lidocaine has been reported previously to inhibit postoperative pain when given either as single injections or as short infusions in amounts usually causing adverse reactions. To determine the efficacy of a continuous low-dose (2 mg/kg) intravenous infusion of lidocaine, postoperative pain (visual analogue...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Cassuto J,Wallin G,Högström S,Faxén A,Rimbäck G

    更新日期:1985-10-01 00:00:00

  • Posterior tibial nerve sensory blockade duration prolonged by adding dexmedetomidine to ropivacaine.

    abstract:BACKGROUND:Dexmedetomidine, an α(2)-receptor agonist, prolongs analgesia when used in neuraxial and IV blocks. We evaluated the effect of dexmedetomidine added to ropivacaine for tibial nerve block on the duration of the sensory blockade. METHODS:For this prospective, randomized, controlled, double-blind, crossover tr...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0b013e318265bab7

    authors: Rancourt MP,Albert NT,Côté M,Létourneau DR,Bernard PM

    更新日期:2012-10-01 00:00:00

  • Coordination of appointments for anesthesia care outside of operating rooms using an enterprise-wide scheduling system.

    abstract:BACKGROUND:An anesthesia department implemented scheduling of anesthetics outside of operating rooms (non-OR) by clerks and nurses from other departments using its hospital's enterprise-wide scheduling system. METHODS:Observational studies chronicled the change over 2 yr as non-OR time was allocated by specialty, and ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000287686.23187.3f

    authors: Dexter F,Xiao Y,Dow AJ,Strader MM,Ho D,Wachtel RE

    更新日期:2007-12-01 00:00:00

  • The use of transesophageal echocardiography for preload assessment in critically ill patients.

    abstract:UNLABELLED:IV volume is often administered to patients in an intensive care unit (ICU) to improve cardiovascular function. We investigated the relationship between stroke volume (SV) and left ventricular (LV) size by using transesophageal echocardiography (TEE) in a population of 20 ICU patients and 21 postoperative ca...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-200002000-00021

    authors: Tousignant CP,Walsh F,Mazer CD

    更新日期:2000-02-01 00:00:00

  • Testing anal sphincter tone predicts the effectiveness of caudal analgesia in children.

    abstract:UNLABELLED:In this study, we examined the effectiveness of caudal blocks and correlated it with the laxity of the patients' anal sphincter before emergence from anesthesia in 178 children undergoing inguinal and/or penile surgery. Bupivacaine 0.25% in a volume of 0.6-1.25 mL/kg was used in all patients. The presence of...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200205000-00019

    authors: Verghese ST,Mostello LA,Patel RI,Kaplan RF,Patel KM

    更新日期:2002-05-01 00:00:00

  • Epidural labor analgesia and neonatal sepsis evaluation rate: a quality improvement study.

    abstract:UNLABELLED:Labor epidural analgesia (LEA) is allegedly associated with maternal fever and an increase in the newborn sepsis work-up (SWU) rate. In this study, we evaluated whether LEA causes an increase in the SWU rate compared with a Control group given parenteral narcotics for labor pain. Maternal and neonatal data w...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200110000-00038

    authors: Kaul B,Vallejo M,Ramanathan S,Mandell G

    更新日期:2001-10-01 00:00:00

  • Intravenous administration of flurbiprofen does not affect cerebral blood flow velocity and cerebral oxygenation under isoflurane and propofol anesthesia.

    abstract:UNLABELLED:Flurbiprofen, a nonsteroidal antiinflammatory drug (NSAID), has been used to treat rheumatic and osteoarthritic pain and to reduce postoperative pain. Although other NSAIDs, such as indomethacin, reduce cerebral blood flow (CBF), the effect of flurbiprofen on CBF is unknown. In the present study, we investig...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ane.0000099755.97885.3c

    authors: Yoshitani K,Kawaguchi M,Tatsumi K,Sasaoka N,Kurumatani N,Furuya H

    更新日期:2004-02-01 00:00:00

  • Short-term administration of ethanol does not affect functional recovery from myocardial stunning in awake dogs.

    abstract:UNLABELLED:Chronic ingestion of small doses of ethanol protects the myocardium from ischemic damage. It was demonstrated that short-term administration of ethanol (SAE) enhances the recovery of stunned myocardium in acutely instrumented, anesthetized dogs. It is unclear whether this beneficial effect of SAE also occurs...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000048712.95074.cd

    authors: Weber TP,Hartlage MA,Rolf N,Booke M,Berendes E,Van Aken H,Meissner A

    更新日期:2003-03-01 00:00:00

  • Desflurane affords greater protection than halothane in the function of mitochondria against forebrain ischemia reperfusion injury in rats.

    abstract:BACKGROUND:Halothane and desflurane have been shown to attenuate neuronal injury; however, the effects of these anesthetics on mitochondria are unclear. We investigated whether halothane and desflurane affect the function of mitochondria after cerebral ischemia in rats. METHODS:Forty male Wistar rats were randomly div...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e318164f2a5

    authors: Zhang B,Wei X,Cui X,Zhou H,Ding W,Li W

    更新日期:2008-04-01 00:00:00

  • A transdermal nicotine patch is not effective for postoperative pain management in smokers: a pilot dose-ranging study.

    abstract:BACKGROUND:Nicotine has an antinociceptive effect in animal models. The analgesic effect in humans has been examined, but studies have had mixed results. A proposed etiology is variability in chronic nicotine exposure because of differences in tobacco smoking rates and second-hand smoke exposure. In this study, we exam...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0b013e3181bd1612

    authors: Olson LC,Hong D,Conell-Price JS,Cheng S,Flood P

    更新日期:2009-12-01 00:00:00

  • The incidence and prediction of automatically detected intraoperative cardiovascular events in noncardiac surgery.

    abstract:UNLABELLED:The objective of this study was to evaluate prognostic models for quality assurance purposes in predicting automatically detected intraoperative cardiovascular events (CVE) in 58458 patients undergoing noncardiac surgery. To this end, we assessed the performance of two established models for risk assessment ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000103262.26387.9c

    authors: Röhrig R,Junger A,Hartmann B,Klasen J,Quinzio L,Jost A,Benson M,Hempelmann G

    更新日期:2004-03-01 00:00:00

  • Age and the spread of local anesthetic solutions in the epidural space.

    abstract::Sensory level of anesthesia following the injection of 20 ml of 1.5% lidocaine with epinephrine (1:200,000) in 238 adult males averaged T7.7, T5.6, and T5.1 at 10, 20, and 30 minutes, respectively. Patient age had no significant effect on local anesthetic requirements per spinal segment per unit height until age 40 ye...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Park WY,Massengale M,Kim SI,Poon KC,Macnamara TE

    更新日期:1980-10-01 00:00:00

  • Venodilation contributes to propofol-mediated hypotension in humans.

    abstract::The present investigation explored the possibility that the commonly observed hypotension that occurs during induction of anesthesia with propofol might be related to its ability to produce venodilation. Thirty-six ASA I and II patients who received no premedication were studied. The first 20 patients were divided int...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199206000-00017

    authors: Muzi M,Berens RA,Kampine JP,Ebert TJ

    更新日期:1992-06-01 00:00:00

  • Beta-adrenergic receptor function is acutely altered in surgical patients.

    abstract::Catecholamine-induced desensitization of beta-adrenergic receptors resulting in hyporesponsiveness to further stimulation has been frequently reported after an increase in endogenous catecholamines. To examine the possibility of beta-adrenoceptor desensitization due to intraoperative adrenergic activation (surgical st...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199007000-00001

    authors: Marty J,Nimier M,Rocchiccioli C,Mantz J,Luscombe F,Henzel D,Loiseau A,Desmonts JM

    更新日期:1990-07-01 00:00:00

  • Hemodynamic effects of esmolol in chronically beta-blocked patients undergoing aortocoronary bypass surgery.

    abstract::The hemodynamic effects of esmolol were studied in 40 patients scheduled for elective coronary artery surgery to determine whether the administration of esmolol in chronically beta-blocked patients would result in additional attenuation of sympathetically mediated hemodynamic stress responses to noxious stimuli. Patie...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: de Bruijn NP,Croughwell N,Reves JG

    更新日期:1987-02-01 00:00:00

  • The ulinastatin-induced effect on neuromuscular block caused by vecuronium.

    abstract:UNLABELLED:We examined the effect of ulinastatin, a protease inhibitor purified from human urine, on neuromuscular block caused by vecuronium. Sixty adult patients were randomly divided into four groups of 15 patients each: ulinastatin-posttetanic count (U-PTC), ulinastatin-train-of-four (U-TOF), control-posttetanic co...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验,收录出版

    doi:10.1097/00000539-199912000-00048

    authors: Saitoh Y,Fujii Y,Oshima T

    更新日期:1999-12-01 00:00:00

  • The Role of MicroRNAs in Acute Respiratory Distress Syndrome and Sepsis, From Targets to Therapies: A Narrative Review.

    abstract::Acute respiratory distress syndrome (ARDS) is a significant cause of morbidity and mortality in the intensive care unit (ICU) and is characterized by lung epithelial and endothelial cell injury, with increased permeability of the alveolar-capillary membrane, leading to pulmonary edema, severe hypoxia, and difficulty w...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000005146

    authors: Lee LK,Medzikovic L,Eghbali M,Eltzschig HK,Yuan X

    更新日期:2020-11-01 00:00:00

  • Cognitive reversal of expected nitrous oxide analgesia for acute pain.

    abstract::In a laboratory experiment, the expected analgesic action of 33% nitrous oxide was reversed by creating the expectancy of heightened awareness of bodily sensations. Pain threshold and tolerance of electrical tooth-pulp stimulation were significantly reduced. Results from a control study gave us a basis for comparison ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Dworkin SF,Chen AC,LeResche L,Clark DW

    更新日期:1983-12-01 00:00:00

  • Lecture practices in United States anesthesiology residencies.

    abstract::We obtained data on lecture practices from 100 of the 110 university-affiliated anesthesiology residency programs certified in the United States in 1988. Of these residency programs, 36% had a majority of their lectures before the operating room schedule began, 57% had no lectures at all in this early time slot, and 7...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199201000-00018

    authors: Landers DF,Becker GL,Newland MC,Peters KR

    更新日期:1992-01-01 00:00:00